Statistical analysis
AGC, AY
23 3 2021
Last updated: 2022-02-21
Checks: 7 0
Knit directory: CePTER_RNASeq/
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home = getwd()Statistical analysis
Which genes are differentially regualted upon KO of DEPDC5
Modelling the KO in all different combinations
if(reanalyze | !file.exists(paste0(home,"/output/ResTabs_KO.RData"))){
# calculate all combinations
CellLines=c("D62","D244","ReN")
Rapamycin=c("noRAPA", "RAPA")
Differentiation=c("noDIFF", "DIFF")
Type_sgRNA<-list(c("sgNTC","sg2.1"),c("sgNTC","sg2.2"))
target="KO"
r = Rapamycin[1]
d = Differentiation[1]
Tp = Type_sgRNA[1]
# no random effects included
for(r in Rapamycin){
Rapafilter = SampleInfo$RAPA %in% r
for(d in Differentiation){
Difffilter = SampleInfo$DIFF %in% d
for(Tp in Type_sgRNA){
sgRNAfilter = SampleInfo$gRNA %in% Tp
vs_label=paste0(Tp, sep="", collapse="_")
for(Cl in CellLines){
Celllinefilter = SampleInfo$CellLine %in% Cl
Set = rownames(SampleInfo)[Rapafilter&Difffilter&
sgRNAfilter&Celllinefilter]
lab = paste("restab", Cl, vs_label, d,r, sep="_")
print(lab)
assign(lab,
comparison(dds_object = ddsMat, samples = Set,
target =target,randomeffect = c()))
}
}
}
}
comparisons= apropos("restab")
save(list = comparisons, file = paste0(home,"/output/ResTabs_KO.RData"))
} else
load(file = paste0(home,"/output/ResTabs_KO.RData"))[1] "restab_D62_sgNTC_sg2.1_noDIFF_noRAPA"
[1] "restab_D244_sgNTC_sg2.1_noDIFF_noRAPA"
[1] "restab_ReN_sgNTC_sg2.1_noDIFF_noRAPA"
[1] "restab_D62_sgNTC_sg2.2_noDIFF_noRAPA"
[1] "restab_D244_sgNTC_sg2.2_noDIFF_noRAPA"
[1] "restab_ReN_sgNTC_sg2.2_noDIFF_noRAPA"
[1] "restab_D62_sgNTC_sg2.1_DIFF_noRAPA"
[1] "restab_D244_sgNTC_sg2.1_DIFF_noRAPA"
[1] "restab_ReN_sgNTC_sg2.1_DIFF_noRAPA"
[1] "restab_D62_sgNTC_sg2.2_DIFF_noRAPA"
[1] "restab_D244_sgNTC_sg2.2_DIFF_noRAPA"
[1] "restab_ReN_sgNTC_sg2.2_DIFF_noRAPA"
[1] "restab_D62_sgNTC_sg2.1_noDIFF_RAPA"
[1] "restab_D244_sgNTC_sg2.1_noDIFF_RAPA"
[1] "restab_ReN_sgNTC_sg2.1_noDIFF_RAPA"
[1] "restab_D62_sgNTC_sg2.2_noDIFF_RAPA"
[1] "restab_D244_sgNTC_sg2.2_noDIFF_RAPA"
[1] "restab_ReN_sgNTC_sg2.2_noDIFF_RAPA"
[1] "restab_D62_sgNTC_sg2.1_DIFF_RAPA"
[1] "restab_D244_sgNTC_sg2.1_DIFF_RAPA"
[1] "restab_ReN_sgNTC_sg2.1_DIFF_RAPA"
[1] "restab_D62_sgNTC_sg2.2_DIFF_RAPA"
[1] "restab_D244_sgNTC_sg2.2_DIFF_RAPA"
[1] "restab_ReN_sgNTC_sg2.2_DIFF_RAPA"samesign <- function(x) {abs(sum(sign(x)))==length(x)}
mypval=0.05
colors <- rev(colorRampPalette(brewer.pal(9, "Spectral"))(255))
genelists=lapply(list.files(paste0(home,"/data/genelists_to_test"), full.names = T),
function(x){read.table(x, header=T)})
names(genelists) = gsub(".txt", "", list.files(paste0(home,"/data/genelists_to_test")))
geneids=rownames(restab_D244_sgNTC_sg2.1_noDIFF_noRAPA)
getlinmodoutput = function(targetline,
targetdiff,
targetrapa){
samplesincl = SampleInfo$DIFF==targetdiff &
SampleInfo$RAPA==targetrapa &
SampleInfo$CellLine== targetline
pvalrep= get(paste0("restab_",
targetline, "_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$padj<mypval &
get(paste0("restab_",
targetline, "_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$padj<mypval
betarep = apply(cbind(get(paste0("restab_",
targetline, "_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$log2FoldChange,
get(paste0("restab_",
targetline, "_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$log2FoldChange), 1,
samesign)
idx=which(betarep & pvalrep)
hits=geneids[idx]
restab=data.frame(
entrezgene = geneids[idx],
genname=rowData(ddsMat)[hits,"hgnc"],
log2FC_2.1 = get(paste0("restab_",
targetline, "_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$log2FoldChange[idx],
fdr_2.1 = get(paste0("restab_",
targetline, "_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$padj[idx],
log2FC_2.2 = get(paste0("restab_",
targetline, "_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$log2FoldChange[idx],
fdr_2.2 = get(paste0("restab_",
targetline, "_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$padj[idx])
print(restab)
write.xlsx(restab, file=paste0(output, "/Restab_",
targetline,"_",
targetdiff, "_",
targetrapa, ".xlsx"))
SamplesSet=SampleInfo[samplesincl,]
plotmatrix = log_2cpm[hits,rownames(SamplesSet)]
rownames(SamplesSet)=SamplesSet$label_rep
colnames(plotmatrix)=SamplesSet$label_rep
rownames(plotmatrix)=rowData(ddsMat)[hits,"hgnc"]
cellcol = Dark8[1:nlevels(SampleInfo$CellLine)]
names(cellcol) = levels(SampleInfo$CellLine)
cellcol = cellcol[as.character(unique(SamplesSet$CellLine))]
gRNAcol = Dark8[c(1:nlevels(SampleInfo$gRNA))+nlevels(SampleInfo$CellLine)]
names(gRNAcol) = levels(SampleInfo$gRNA)
gRNAcol = gRNAcol[as.character(unique(SamplesSet$gRNA))]
diffcol = brewer.pal(3,"Set1")[1:nlevels(SampleInfo$DIFF)]
names(diffcol) = levels(SampleInfo$DIFF)
diffcol = diffcol[as.character(unique(SamplesSet$DIFF))]
rapacol = brewer.pal(3,"Set2")[1:nlevels(SampleInfo$RAPA)]
names(rapacol) = levels(SampleInfo$RAPA)
rapacol = rapacol[as.character(unique(SamplesSet$RAPA))]
ann_colors = list(
DIFF = diffcol,
RAPA = rapacol,
gRNA = gRNAcol,
CellLine=cellcol)
collabels = SamplesSet[,c("CellLine","DIFF","RAPA", "gRNA")] %>%
mutate_all(as.character) %>% as.data.frame()
rownames(collabels)=SamplesSet$label_rep
idx=order(SamplesSet$gRNA)
pheatmap(plotmatrix[,idx],
border_color = NA,
annotation_col = collabels[idx,],show_rownames = F, show_colnames = F,
annotation_colors = ann_colors,
clustering_method = "ward.D2",
cluster_cols = F,
col = colors,
scale = "row",
main = paste("Normalized log2 counts", targetline, targetdiff, targetrapa))
gene_univers = rownames(ddsMat)
gostres = getGOresults(hits, gene_univers)
toptab = gostres$result
write.xlsx2(toptab, file = paste0(output, "/GOres_",targetline,targetdiff,targetrapa,".xlsx"), sheetName = "GO_enrichment")
idx = grepl("GO|KEGG", toptab$source)
titlename = paste(targetline,targetdiff,targetrapa)
if(!any(idx)){
p = ggplot() + annotate("text", x = 4, y = 25, size=4,
label = "no significant GO term") +
ggtitle(titlename)+theme_void()+
theme(plot.title = element_text(hjust = 0.5))
} else {
p=GOplot(toptab[idx, ], 10, Title = titlename)
}
print(p)
## enrichment test for genelist
Resall=data.frame()
for (gl in names(genelists)){
tmp=table(signif=geneids %in% hits, targetgene=geneids %in% genelists[[gl]]$ENTREZ_ID)
resfish=fisher.test(tmp)
res = c(resfish$estimate, unlist(resfish$conf.int), resfish$p.value)
Resall = rbind(Resall, res)
}
colnames(Resall)=c("OR", "CI95L", "CI95U", "P")
rownames(Resall)=names(genelists)
Resall$Beta = log(Resall$OR)
Resall$SE = (log(Resall$OR)-log(Resall$CI95L))/1.96
Resall$Padj=p.adjust(Resall$P, method = "bonferroni")
print(Resall)
multiORplot(Resall, Pval = "P", Padj = "Padj", beta="Beta",SE = "SE",
pheno=paste(targetline, targetdiff, targetrapa))
}
geneids=rownames(restab_D244_sgNTC_sg2.1_noDIFF_noRAPA)KO effect in noDIFF noRAPA
D62
getlinmodoutput(targetline = "D62",targetdiff = "noDIFF",targetrapa = "noRAPA") entrezgene genname log2FC_2.1 fdr_2.1 log2FC_2.2 fdr_2.2
1 64856 VWA1 1.0887369 3.357074e-12 0.7289010 3.093542e-06
2 26038 CHD5 2.6317640 1.274240e-07 1.4617556 1.601009e-02
3 3925 STMN1 -0.8137179 4.487672e-11 -0.4038794 1.435877e-04
4 90853 SPOCD1 1.5412353 1.172424e-05 0.9562654 4.592191e-02
5 23499 MACF1 0.3842645 4.982204e-02 0.3351333 2.463005e-02
6 59269 HIVEP3 0.8394967 5.265490e-03 0.7742331 8.323388e-04
7 11004 KIF2C -1.4726626 3.069666e-06 -1.2743887 6.113960e-08
8 5052 PRDX1 -0.5768855 1.130289e-09 -0.4276079 7.426535e-09
9 9077 DIRAS3 1.8022039 1.130961e-14 1.5359253 9.571880e-21
10 81849 ST6GALNAC5 -0.7860855 1.743212e-10 -0.4107442 1.195027e-05
11 64123 ADGRL4 1.3765063 1.449484e-03 1.8278999 5.108277e-10
12 2633 GBP1 4.3469675 1.478239e-04 4.0111487 9.206477e-05
13 84722 PSRC1 -0.4544078 8.415406e-04 -0.3012023 1.048519e-02
14 3321 IGSF3 -0.8447306 8.186979e-04 -0.5463340 7.250332e-03
15 10628 TXNIP -1.3807391 3.855992e-05 -1.1462088 4.458761e-07
16 140576 S100A16 0.8907779 7.208856e-10 0.3327141 4.177523e-02
17 10763 NES 0.7597404 9.985796e-14 0.4268953 7.990741e-07
18 57863 CADM3 -2.0291449 1.345453e-03 -1.0765544 3.564895e-02
19 400793 C1orf226 0.8128065 6.289715e-03 0.6009301 2.626275e-02
20 4921 DDR2 -0.8517003 3.949753e-02 -0.8841425 8.323388e-04
21 5999 RGS4 2.1839355 3.625474e-08 2.0253972 1.178328e-07
22 6004 RGS16 1.3221396 1.734986e-11 0.5614850 2.148512e-02
23 64710 NUCKS1 -0.4841646 2.456791e-06 -0.2907053 1.390388e-03
24 1063 CENPF -1.1466936 3.609332e-13 -0.4539131 2.168138e-04
25 149111 CNIH3 1.0685427 4.092541e-03 1.0633895 4.535816e-04
26 84886 C1orf198 0.5477246 3.424084e-02 0.5164650 2.383525e-02
27 4811 NID1 -1.5148942 1.904365e-03 -1.0105930 2.296366e-02
28 22944 KIN -2.0047172 5.502120e-04 -1.1833437 1.036235e-02
29 5660 PSAP 0.7103618 1.949853e-20 0.1806493 7.600955e-03
30 54541 DDIT4 1.0549545 3.214122e-03 0.8462576 2.066682e-02
31 5328 PLAU 1.2381776 1.514050e-02 1.0763653 3.554633e-02
32 84858 ZNF503 1.8248076 3.757224e-04 1.5518196 1.304512e-03
33 3988 LIPA 1.0229774 1.258333e-04 0.6516045 3.554633e-02
34 143282 FGFBP3 0.6236312 2.454262e-04 0.4636031 4.197354e-03
35 26509 MYOF 1.7150966 3.176843e-02 2.0884036 1.376061e-03
36 9124 PDLIM1 1.1007675 7.192111e-04 1.1011312 2.589242e-06
37 83742 MARVELD1 -0.8437692 1.245102e-02 -0.6506239 3.298481e-02
38 6319 SCD 0.5326328 1.598335e-05 0.3381076 1.082659e-03
39 6468 FBXW4 1.1765193 1.364798e-03 0.7725283 3.557110e-02
40 259217 HSPA12A 1.8426634 3.216693e-03 1.6189322 2.216133e-02
41 642938 INSYN2A 0.4021455 4.047089e-02 0.7784115 7.692471e-10
42 4288 MKI67 -1.0125441 1.226143e-06 -0.5883143 5.751303e-03
43 977 CD151 1.2624849 1.664143e-27 0.3302487 9.754474e-03
44 6240 RRM1 -0.8821072 1.121684e-02 -1.0392511 1.970332e-04
45 4004 LMO1 -2.3548878 2.048639e-07 -2.7124074 9.680117e-22
46 10553 HTATIP2 1.9347967 1.616995e-02 2.0024902 5.325513e-04
47 5080 PAX6 -0.9174372 1.022465e-02 -0.8138011 2.649379e-03
48 960 CD44 1.4577320 5.415566e-16 1.1687918 9.473981e-16
49 79026 AHNAK 1.5854085 1.414586e-09 0.9180973 4.510473e-04
50 1717 DHCR7 0.7292135 2.901922e-04 0.3966686 2.999299e-02
51 26011 TENM4 1.7228097 2.374904e-02 1.5164792 4.490345e-02
52 11098 PRSS23 0.8783873 1.873156e-02 0.9009730 3.505038e-04
53 1410 CRYAB 1.1162846 2.410543e-12 0.5939001 9.419441e-05
54 6876 TAGLN 0.6535509 1.315854e-13 0.3428368 4.037341e-08
55 1656 DDX6 -0.4627267 1.974148e-02 -0.3685693 5.784508e-03
56 2012 EMP1 0.6467583 1.466047e-02 1.1892730 8.967278e-13
57 196410 METTL7B 1.5592188 2.247789e-12 0.7194504 2.135379e-03
58 967 CD63 0.9012238 5.749064e-40 0.2548988 9.247364e-06
59 4035 LRP1 0.6450656 5.103070e-05 0.5926954 2.393841e-07
60 4193 MDM2 0.6720729 4.176205e-05 0.3624504 1.186010e-02
61 160335 TMTC2 -1.6150650 5.031119e-06 -1.0540218 1.594156e-04
62 490 ATP2B1 -0.7884871 1.345453e-03 -0.6051893 4.758216e-04
63 5829 PXN 0.7635220 3.848152e-04 0.5831564 7.783165e-03
64 3146 HMGB1 -0.7290124 6.419766e-16 -0.3207209 7.050456e-07
65 8848 TSC22D1 0.5605586 4.645096e-04 0.6643643 1.133959e-11
66 8660 IRS2 0.4095870 2.096683e-05 0.2994912 4.758216e-04
67 28526 <NA> 1.9269222 1.459106e-07 1.9184477 1.771068e-11
68 54916 TMEM260 -1.0305660 3.898016e-02 -0.9100269 3.893809e-02
69 57570 TRMT5 -0.6823055 1.092744e-04 -0.3822535 7.374547e-03
70 23224 SYNE2 -1.3797637 2.074033e-06 -0.7351991 6.014667e-05
71 64093 SMOC1 0.7195505 1.391368e-07 0.3608222 8.928172e-04
72 9369 NRXN3 -1.7172025 2.028184e-05 -1.0867269 7.910845e-04
73 55384 MEG3 1.6236408 2.580979e-22 1.1925473 2.944858e-15
74 113146 AHNAK2 2.2305093 1.032644e-04 2.6588628 1.577622e-14
75 11245 GPR176 2.1627304 3.572180e-03 2.0993058 1.663975e-03
76 90417 KNSTRN -1.3211373 3.587749e-03 -0.8164001 4.080416e-02
77 51203 NUSAP1 -1.3679769 1.839058e-06 -0.5187317 8.823202e-03
78 2628 GATM 0.6518976 3.394949e-02 1.0425253 7.502761e-12
79 302 ANXA2 0.3958604 1.837163e-04 0.3001945 9.344256e-03
80 7168 TPM1 0.5157933 2.102621e-02 0.4722003 1.661191e-03
81 9768 PCLAF -1.6219457 5.811956e-04 -1.0914799 3.160828e-03
82 3671 ISLR 1.4575124 6.307058e-08 0.8572040 9.297192e-04
83 23205 ACSBG1 0.6910454 1.236709e-02 0.5932626 2.935875e-02
84 9055 PRC1 -0.7447847 1.733945e-02 -0.5062243 4.744675e-02
85 56963 RGMA 1.6169697 1.508787e-22 0.7278730 4.458761e-07
86 23336 SYNM 0.7042096 6.696236e-05 0.7291826 2.725960e-08
87 51330 TNFRSF12A 1.4047167 1.598984e-20 0.9561323 4.156772e-16
88 2013 EMP2 -0.7553862 7.112681e-05 -0.4957736 7.600955e-03
89 26471 NUPR1 2.3604930 1.275840e-12 1.0670195 2.296366e-02
90 4313 MMP2 0.8695009 2.490348e-09 0.4227913 6.023638e-03
91 6376 CX3CL1 0.8933944 1.364798e-03 0.5525095 1.857524e-02
92 794 CALB2 -4.6134518 1.676816e-06 -2.1153464 2.076907e-03
93 23406 COTL1 0.7985791 1.235229e-09 0.4709035 1.578005e-06
94 79007 DBNDD1 1.9194455 9.495285e-25 0.6782882 1.055840e-03
95 9212 AURKB -1.2410536 2.093176e-03 -1.1951322 1.663975e-03
96 9423 NTN1 1.4853260 2.410543e-12 0.6565916 6.359039e-03
97 9953 HS3ST3B1 -0.7873216 1.713457e-04 -0.4180975 7.956870e-03
98 5376 PMP22 0.5562334 2.753659e-03 0.4810478 1.442876e-03
99 125144 SNHG29 -0.5333552 6.646735e-03 -0.2828075 2.579931e-02
100 7153 TOP2A -0.9719652 2.450201e-11 -0.8228819 1.091862e-15
101 284119 CAVIN1 1.0598237 1.045027e-04 0.6193031 4.515208e-02
102 2670 GFAP 1.0680802 1.138551e-30 0.2611641 4.975830e-03
103 6426 SRSF1 -0.9535097 1.971245e-06 -0.5774088 6.881405e-04
104 54549 SDK2 -0.9457414 4.464916e-02 -0.8399915 4.106571e-02
105 283991 UBALD2 0.5562493 2.846519e-05 0.3803418 3.807842e-03
106 332 BIRC5 -1.2794951 4.036746e-04 -0.7407098 8.323388e-04
107 284184 NDUFAF8 0.8491433 5.692768e-12 0.3481626 7.808378e-03
108 11031 RAB31 0.3240090 2.195959e-03 0.2517174 1.169403e-02
109 1000 CDH2 0.2476283 2.926897e-02 0.3202481 4.270465e-08
110 115106 HAUS1 -1.6978514 1.572448e-03 -0.9650103 8.536814e-03
111 4645 MYO5B -1.4849117 9.083405e-03 -0.8087432 3.513141e-02
112 5596 MAPK4 -1.1651266 3.734472e-03 -0.9121994 1.970914e-02
113 976 ADGRE5 1.5558481 1.840861e-10 0.9709443 2.429572e-04
114 9518 GDF15 1.7726956 9.495285e-25 0.9120218 2.725960e-08
115 348 APOE 2.0354059 3.708190e-20 1.2386377 5.932062e-11
116 83987 CCDC8 -2.7542907 4.471965e-04 -2.1432234 2.880361e-04
117 27113 BBC3 1.5019300 2.885492e-09 1.1144906 4.741474e-06
118 23645 PPP1R15A 0.7984083 3.369973e-04 0.5185689 3.082708e-02
119 79784 MYH14 -3.2167632 4.355945e-07 -3.3864313 8.830222e-10
120 151354 LRATD1 0.9969107 2.744760e-09 0.8078464 5.025839e-08
121 6432 SRSF7 -0.5313444 1.694898e-02 -0.4872875 3.135324e-02
122 91461 PKDCC -0.5131526 2.577269e-04 -0.4124175 7.177574e-05
123 25927 CNRIP1 -6.6985860 1.150131e-03 -5.2247905 2.200852e-03
124 3099 HK2 -1.7911145 3.646131e-03 -1.1136392 3.778682e-03
125 343990 CRACDL 1.5489677 8.186979e-04 1.5058582 5.099405e-06
126 164832 LONRF2 0.8056629 9.967899e-04 0.6150822 1.054530e-02
127 4175 MCM6 -1.2006023 1.142748e-02 -1.0394463 6.465256e-03
128 130574 LYPD6 -1.2615303 4.390729e-02 -1.6173378 8.961483e-03
129 114793 FMNL2 0.8386577 2.025151e-08 0.5693890 1.320261e-05
130 55854 ZC3H15 -0.6073926 1.028732e-02 -0.4319460 3.689260e-02
131 26010 SPATS2L 0.4040408 4.069513e-02 0.5241896 6.406613e-04
132 389073 C2orf80 -0.6860560 3.021141e-05 -0.3989007 4.037353e-03
133 1373 CPS1 -2.4113344 3.135118e-02 -1.5363111 1.115901e-02
134 2637 GBX2 0.9261028 4.130967e-03 0.6671906 2.396204e-02
135 10267 RAMP1 1.3715391 8.566720e-12 0.8507912 2.765416e-05
136 2280 FKBP1A 0.6962166 2.508668e-05 0.3635890 4.886965e-02
137 5834 PYGB 1.0709729 1.027140e-07 0.6084430 2.308014e-02
138 22974 TPX2 -1.3233710 9.234264e-04 -0.7952465 5.345927e-03
139 1299 COL9A3 0.5755993 4.365583e-05 0.2846454 7.126419e-03
140 3785 KCNQ2 -0.6122840 2.104394e-03 -0.6171374 3.496026e-05
141 140578 CHODL -2.8003063 5.155278e-04 -1.5315831 2.071870e-02
142 116448 OLIG1 0.9333397 1.715356e-05 0.5884338 1.490735e-02
143 5121 PCP4 -1.5668394 7.672433e-03 -1.1879093 4.314608e-02
144 1826 DSCAM 1.5768898 6.716536e-04 2.1033772 2.500117e-11
145 80781 COL18A1 1.3174083 2.148859e-07 0.8091186 6.369037e-03
146 1312 COMT 0.5102825 1.021327e-05 0.3237802 7.783165e-03
147 23467 NPTXR 1.1213183 7.857622e-13 0.5433013 8.323388e-04
148 10752 CHL1 -1.0508060 2.599907e-12 -0.4931137 1.022821e-05
149 23171 GPD1L -1.6693632 7.709013e-04 -1.2523108 8.503905e-04
150 56992 KIF15 -1.1480147 1.244552e-02 -1.3058315 1.073764e-02
151 151887 CCDC80 0.7861593 3.884032e-08 0.5444540 5.158658e-06
152 2596 GAP43 1.6359187 4.388269e-60 1.0807341 3.797828e-33
153 11343 MGLL 0.9202739 4.176205e-05 0.6135539 8.415630e-03
154 5947 RBP1 -0.4686005 1.883104e-02 -0.7458186 2.387617e-07
155 10051 SMC4 -1.3308521 1.625283e-13 -0.5794336 1.187866e-03
156 8646 CHRD 1.6849809 3.167966e-02 1.7586855 2.058539e-03
157 6480 ST6GAL1 -4.2853399 1.578328e-02 -7.1401341 4.510762e-04
158 131583 FAM43A 1.7595220 8.504312e-05 1.2640110 5.157637e-03
159 10460 TACC3 -0.9068362 1.481627e-02 -0.9370790 5.973781e-05
160 80333 KCNIP4 -2.1218707 7.016198e-05 -1.2832211 3.364399e-02
161 5099 PCDH7 -2.6030063 5.882622e-03 -1.5811041 1.989404e-02
162 5156 PDGFRA -0.9547393 5.308860e-08 -0.4376841 5.750365e-04
163 3490 IGFBP7 1.4844042 6.295374e-19 1.8282513 1.823991e-53
164 79966 SCD5 0.4041952 1.713457e-04 0.7016327 2.148795e-28
165 8404 SPARCL1 2.1771329 5.091908e-10 2.1524214 3.073504e-16
166 3015 H2AZ1 -0.7067496 1.619655e-07 -0.4982645 2.218205e-05
167 1062 CENPE -2.1763776 6.800897e-20 -0.5713744 4.814100e-03
168 55013 MCUB -0.8277119 5.244963e-03 -0.6410976 1.125196e-03
169 2983 GUCY1B1 -1.9361826 9.943220e-03 -1.3455314 1.857524e-02
170 4889 NPY5R -1.2095153 3.665877e-02 -1.3273711 1.082659e-03
171 3148 HMGB2 -1.4512300 1.165034e-07 -0.5867647 1.795939e-04
172 55714 TENM3 -2.5366838 1.320516e-13 -0.5545306 2.331545e-02
173 1767 DNAH5 5.8173464 3.510642e-02 5.6528496 4.391011e-02
174 7204 TRIO 0.7074614 8.165427e-03 0.5640108 7.126419e-03
175 6507 SLC1A3 -0.5136744 3.320557e-07 -0.3891983 7.545064e-07
176 102467080 <NA> -2.2092766 4.296921e-02 -2.7772256 4.319364e-03
177 728723 <NA> 7.3304049 8.902443e-04 6.3859247 2.080350e-02
178 22836 RHOBTB3 -0.4283098 3.503150e-02 -0.3687419 6.599365e-04
179 4001 LMNB1 -1.2374118 4.005049e-11 -0.6979132 4.107474e-06
180 2201 FBN2 -1.3303062 5.846515e-03 -1.1768395 9.520106e-03
181 10112 KIF20A -1.3666360 7.533915e-05 -1.0740840 4.450953e-04
182 84418 CYSTM1 0.7223302 1.783180e-03 0.4655625 2.834089e-02
183 113829 SLC35A4 1.2354645 5.331330e-06 0.6330907 3.365639e-02
184 57717 PCDHB16 -1.3035828 4.956212e-04 -0.7859098 1.366067e-02
185 2246 FGF1 0.7326434 7.533915e-05 0.6738093 5.559947e-05
186 202374 STK32A 1.6464199 2.344297e-03 1.3008830 6.632451e-03
187 6678 SPARC 0.7424626 1.147023e-25 0.6113324 3.363226e-23
188 9232 PTTG1 -0.6683855 1.662312e-03 -0.5329348 4.107474e-06
189 221749 PXDC1 0.5202967 1.478111e-02 0.4275719 3.689260e-02
190 51299 NRN1 2.8330955 2.792238e-04 2.7357805 1.364090e-04
191 10590 SCGN -3.2952996 5.370178e-03 -1.0156297 2.414624e-06
192 222698 NKAPL 3.5957149 1.430573e-02 3.5843063 2.429572e-04
193 7726 TRIM26 6.5707922 2.067838e-03 6.5391753 2.715268e-03
194 221491 SMIM29 0.9411454 1.543927e-04 0.4827715 4.565178e-02
195 1026 CDKN1A 1.7451782 3.284453e-77 0.8937057 6.528518e-32
196 3910 LAMA4 0.4073207 4.502692e-02 0.4391435 1.254131e-02
197 57224 NHSL1 1.4575446 5.239096e-03 1.2023725 2.635414e-02
198 6196 RPS6KA2 0.8469458 2.974890e-07 0.4754517 4.349091e-03
199 221833 SP8 -0.9894228 5.967473e-06 -0.6121173 1.825002e-03
200 55536 CDCA7L -0.7781443 2.217032e-04 -0.5020097 1.625640e-02
201 10457 GPNMB 1.5149068 1.625164e-04 1.2501414 9.350606e-04
202 4852 NPY -1.6633964 1.919357e-08 -1.3042111 9.287714e-08
203 64409 GALNT17 2.4288004 4.072252e-06 1.4306650 3.090657e-02
204 23089 PEG10 0.3625560 1.736585e-02 0.5081485 6.768817e-09
205 5054 SERPINE1 1.2466133 5.238666e-15 1.2036148 1.243155e-18
206 5764 PTN 0.3452771 1.414878e-03 0.3264906 6.316862e-07
207 8795 TNFRSF10B 0.7811169 2.729630e-02 0.8057251 1.868080e-03
208 4741 NEFM 1.8233265 2.462344e-04 1.4783114 1.580777e-03
209 4747 NEFL 1.3034626 1.191912e-07 0.8377696 5.373116e-04
210 2185 PTK2B 1.8426546 1.929829e-13 1.0408686 8.209092e-05
211 1191 CLU 0.6341170 6.617167e-18 0.3197075 7.692471e-10
212 157570 ESCO2 -2.3357895 2.102632e-02 -1.5653693 9.297192e-04
213 5327 PLAT 0.5763984 4.705205e-04 0.4548138 1.342556e-03
214 10434 LYPLA1 -1.2319618 1.398297e-03 -0.6131828 4.010407e-02
215 11075 STMN2 -4.7702715 1.699120e-02 -4.3532595 1.785601e-02
216 5375 PMP2 -1.3014515 1.685462e-45 -0.2556988 2.445849e-03
217 1345 COX6C 0.4021484 2.102484e-04 0.2373740 2.160260e-03
218 29028 ATAD2 -1.3181418 6.171433e-04 -0.8511346 1.138536e-02
219 114907 FBXO32 0.7491730 1.467707e-02 0.9139246 7.397547e-06
220 169044 COL22A1 1.0211618 8.035480e-03 0.9891097 1.371098e-03
221 340371 NRBP2 0.8880338 4.727206e-06 0.5516024 4.241716e-02
222 286343 LURAP1L -6.4879486 1.743746e-02 -6.4904645 1.246119e-02
223 11168 PSIP1 -0.7578417 4.857954e-05 -0.3471516 1.758778e-02
224 6194 RPS6 -0.4735103 1.393820e-07 -0.1948928 3.245436e-02
225 9568 GABBR2 1.8836534 3.992926e-19 1.7700974 1.993618e-26
226 10592 SMC2 -1.5510976 6.965430e-07 -0.7484702 1.290462e-02
227 2934 GSN 0.9575078 3.658505e-03 0.8546227 7.231943e-05
228 64855 NIBAN2 1.0028233 3.331896e-07 0.4470281 1.500068e-02
229 56262 LRRC8A 1.0105367 2.351635e-15 0.3698767 6.306425e-03
230 5730 PTGDS 1.3848729 1.610059e-13 0.7796929 2.800884e-05
231 4571 <NA> 0.9819432 6.551433e-07 0.8385856 2.779733e-06
232 27286 SRPX2 6.4021162 4.092541e-03 6.4458707 7.808378e-03
233 51186 TCEAL9 0.9494553 5.497590e-13 0.3992640 4.511053e-05
234 27018 BEX3 0.2307380 1.488369e-02 0.2425153 1.364090e-04
235 1641 DCX -0.8995534 1.452689e-07 -0.7023485 1.328081e-05
236 5358 PLS3 0.6066581 1.358155e-02 0.7933757 5.554753e-08
237 10178 TENM1 -1.2340255 5.833969e-04 -1.1143038 2.019523e-05Lade nötiges Paket: gprofiler2
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 1.2877778 0.67089320 2.265422 3.358363e-01
02_TSC2_KO_Grabole_2016 1.7609750 1.34915108 2.296746 2.386415e-05
03_TSC2_Grabole-2016 1.9069744 1.44663760 2.529356 2.004220e-06
04_TSC2-tuber-Martin2017 3.8271742 1.48539266 8.292766 3.510059e-03
05_TSC2-SEN_SEGA-Martin2017 3.4990654 2.63839571 4.614603 2.952492e-17
06_all_EpilepsyGene 1.0615534 0.41907282 2.244720 8.409409e-01
07_high_conf_EpilepsyGene 0.9200612 0.10953205 3.432846 1.000000e+00
08_ASD_Epilepsy_EpilepsyGene 2.0229316 0.53726746 5.394379 1.458285e-01
09_Epi25_dataset 0.7008096 0.01745322 4.056387 1.000000e+00
10_SFARI_all 1.4771654 0.53098887 3.314241 3.117218e-01
11_SFARI_score4plus 1.3191449 0.35239855 3.485018 5.523534e-01
12_DeRubeis_RDNV 0.7379154 0.01836559 4.277341 1.000000e+00
13_Iossifov_RDNV 1.8942387 1.05548957 3.176803 2.242883e-02
14_FMRP_Darnell 1.4954934 0.87804477 2.409682 1.126561e-01
15_Voineagu_M12 0.4950929 0.10085139 1.477499 2.928806e-01
16_Voineagu_M16 2.8924093 1.60547796 4.875310 3.356070e-04
17_ID_genes_Neel 1.0612878 0.38257756 2.371358 8.287312e-01
18_ID_genes_pinto2014 0.4674959 0.05596242 1.726565 4.495240e-01
19_Fromer_SCZ_FunDN 1.4286915 0.72212593 2.569114 2.185662e-01
20_Cocchi_Pruning 3.3528738 1.05171443 8.246960 2.075668e-02
Beta SE Padj
01_Swaminathan2018_DEPDC5KO 0.25291812 0.3326854 1.000000e+00
02_TSC2_KO_Grabole_2016 0.56586763 0.1359143 4.772831e-04
03_TSC2_Grabole-2016 0.64551788 0.1409571 4.008440e-05
04_TSC2-tuber-Martin2017 1.34212672 0.4828814 7.020117e-02
05_TSC2-SEN_SEGA-Martin2017 1.25249590 0.1440433 5.904983e-16
06_all_EpilepsyGene 0.05973332 0.4742061 1.000000e+00
07_high_conf_EpilepsyGene -0.08331512 1.0858280 1.000000e+00
08_ASD_Epilepsy_EpilepsyGene 0.70454776 0.6764321 1.000000e+00
09_Epi25_dataset -0.35551902 1.8840367 1.000000e+00
10_SFARI_all 0.39012496 0.5220098 1.000000e+00
11_SFARI_score4plus 0.27698373 0.6734573 1.000000e+00
12_DeRubeis_RDNV -0.30392608 1.8843625 1.000000e+00
13_Iossifov_RDNV 0.63881702 0.2983736 4.485766e-01
14_FMRP_Darnell 0.40245616 0.2716907 1.000000e+00
15_Voineagu_M12 -0.70300986 0.8117844 1.000000e+00
16_Voineagu_M16 1.06208981 0.3003410 6.712140e-03
17_ID_genes_Neel 0.05948303 0.5205647 1.000000e+00
18_ID_genes_pinto2014 -0.76036464 1.0830154 1.000000e+00
19_Fromer_SCZ_FunDN 0.35675900 0.3481198 1.000000e+00
20_Cocchi_Pruning 1.20981783 0.5915287 4.151336e-01
D244
getlinmodoutput(targetline = "D244",targetdiff = "noDIFF",targetrapa = "noRAPA") entrezgene genname log2FC_2.1 fdr_2.1 log2FC_2.2 fdr_2.2
1 54587 MXRA8 0.6447968 2.417795e-04 0.8182123 8.068229e-09
2 29101 SSU72 -0.9173927 2.763334e-03 -1.1082136 3.902258e-04
3 6497 SKI -0.8845508 3.016017e-07 -0.6570484 1.356475e-03
4 6146 RPL22 -0.3928134 4.692890e-03 -0.3572827 1.769757e-03
5 11315 PARK7 0.7491252 2.382166e-07 0.9060148 1.735854e-09
6 54206 ERRFI1 -1.1311270 4.743810e-04 -1.5296696 3.956574e-05
7 116362 RBP7 -2.2047409 4.864802e-02 -3.1121688 1.783481e-02
8 5226 PGD 0.5841230 2.843889e-03 0.5161229 7.892916e-03
9 23254 KAZN 1.2395553 8.332913e-08 0.9477767 1.053143e-03
10 23013 SPEN 0.9310611 4.471650e-04 0.8396755 3.787657e-03
11 84809 CROCCP2 -1.5358070 1.360397e-02 -1.9735378 3.140571e-02
12 5322 PLA2G5 0.8623372 3.016658e-04 0.7073064 1.489937e-03
13 55450 CAMK2N1 -0.4760729 1.275178e-03 -0.3857468 2.115330e-02
14 3399 ID3 1.7363641 2.589742e-06 1.8690969 1.464050e-08
15 6135 RPL11 -0.7132936 1.062736e-07 -0.4687796 2.108482e-03
16 25949 SYF2 -0.7167441 1.511816e-02 -0.8043068 1.057270e-03
17 57035 RSRP1 -0.6728268 5.240177e-03 -0.8006806 2.983479e-03
18 115572 TENT5B 5.7757449 1.505061e-02 5.7453215 4.484713e-02
19 2537 IFI6 1.5154830 8.533680e-13 0.7509509 2.270194e-06
20 93974 ATP5IF1 -0.6277827 6.324018e-05 -0.6097138 2.218699e-05
21 576 ADGRB2 1.5365554 5.780987e-05 1.0365313 3.807495e-02
22 3065 HDAC1 1.0545766 1.850515e-03 1.2706873 1.113050e-04
23 100128071 FAM229A 2.4783232 3.543597e-05 2.0452880 1.394958e-02
24 9202 ZMYM4 1.0336719 2.195512e-05 0.8845453 4.879582e-04
25 79647 AKIRIN1 -0.7141641 1.205169e-03 -0.8110174 1.386699e-04
26 643314 <NA> 2.0744004 3.544727e-06 2.7357402 2.704298e-11
27 65243 ZFP69B 2.8905770 4.750402e-02 3.2942760 2.060043e-02
28 59269 HIVEP3 -0.6210249 9.434418e-03 -0.4876863 2.914884e-02
29 4904 YBX1 -0.9467104 6.795124e-08 -0.5458329 8.100894e-03
30 6513 SLC2A1 -1.3114147 9.396373e-08 -0.5778601 8.917614e-03
31 9682 KDM4A 1.0221643 3.807963e-06 0.8188846 3.666041e-04
32 533 ATP6V0B -0.9324481 1.850625e-05 -0.6054301 5.726330e-03
33 7388 UQCRH -0.7643152 2.275698e-08 -0.5590674 1.200126e-03
34 9372 ZFYVE9 1.7869975 4.394748e-04 1.3874004 3.632698e-02
35 23318 TUT4 1.3570764 5.741589e-04 1.5929014 3.426310e-06
36 9528 TMEM59 -0.7735560 1.113853e-06 -1.0347099 2.281178e-11
37 51253 MRPL37 0.8619145 1.669471e-02 0.8493102 2.255944e-02
38 3725 JUN -0.8660046 1.153798e-10 -0.6198280 3.435749e-06
39 205 AK4 -2.6000671 2.034789e-17 -2.6459012 1.091889e-26
40 54741 LEPROT -0.5864790 1.389160e-02 -0.8981080 2.698948e-05
41 1647 GADD45A -1.3372732 1.155478e-14 -1.2436412 3.969845e-11
42 9295 SRSF11 -0.5021908 3.315065e-04 -0.6646528 2.036300e-06
43 257194 NEGR1 -0.5568808 2.555949e-02 -1.2006262 1.165253e-07
44 8880 FUBP1 0.9133557 2.452354e-02 1.0009577 1.840663e-02
45 64123 ADGRL4 -0.6100016 2.514503e-03 -0.3874754 3.217051e-02
46 2787 GNG5 -0.7878362 2.720673e-06 -0.5055382 4.065131e-03
47 3491 CCN1 -3.0068915 7.328821e-18 -1.6483774 9.005478e-07
48 9403 SELENOF -0.7382150 5.132402e-03 -0.6091142 3.288201e-02
49 2633 GBP1 2.0297059 2.515639e-02 2.0883616 2.907452e-02
50 7813 EVI5 0.9892861 3.443154e-03 1.1575739 3.326752e-04
51 6125 RPL5 -0.9418765 1.845797e-16 -0.7957400 1.667338e-09
52 9411 ARHGAP29 1.3663253 8.827226e-07 1.5754461 9.957316e-09
53 55119 PRPF38B -0.8389182 3.574626e-02 -1.2758728 2.312138e-08
54 6884 TAF13 2.7356784 5.595284e-13 2.1871193 1.826509e-05
55 84722 PSRC1 0.5366573 5.989141e-03 0.6938829 1.406718e-04
56 4893 NRAS -0.6826022 3.574626e-02 -0.7518060 2.671759e-02
57 4853 NOTCH2 -0.7896977 2.066373e-03 -0.8400555 5.425043e-04
58 9939 RBM8A 0.4701716 9.940688e-04 0.5115748 8.431092e-04
59 171423 <NA> 1.1888731 1.909574e-06 0.8145796 3.609831e-03
60 200030 NBPF11 -0.9055856 2.475034e-04 -0.6924015 9.653887e-03
61 51107 APH1A 1.2012888 3.693130e-24 1.0658835 2.574346e-18
62 29956 CERS2 -0.8834474 3.564355e-02 -0.9301237 4.595949e-03
63 10962 MLLT11 -1.5811599 3.095660e-09 -1.6835795 2.362632e-12
64 8991 SELENBP1 1.2547867 1.093970e-03 1.2207704 1.173326e-02
65 6281 S100A10 -1.9846326 3.813423e-18 -1.3322505 1.272432e-05
66 6282 S100A11 -0.6564485 1.243054e-04 -0.5045169 1.029874e-02
67 5872 RAB13 -0.5469641 2.903671e-03 -0.5719559 6.150246e-04
68 3782 KCNN3 1.1943319 2.086004e-04 1.2761001 1.077648e-03
69 54344 DPM3 1.0757316 2.723404e-05 1.0672900 1.201889e-04
70 23623 RUSC1 1.0832154 1.840788e-03 1.1752003 2.248440e-03
71 55870 ASH1L 0.9321681 9.934063e-06 0.9727356 1.165253e-07
72 112770 GLMP 0.7879062 3.886354e-02 1.1774971 3.818671e-05
73 10485 MIR9-1HG 1.1489320 8.257954e-11 1.6085905 9.168998e-20
74 63827 BCAN 1.8394101 8.450589e-03 1.8162346 6.072456e-03
75 10763 NES 0.3475318 2.516866e-03 0.6871561 1.662445e-11
76 8407 TAGLN2 0.8636301 5.565527e-03 1.0888752 9.437931e-05
77 477 ATP1A2 0.2746303 5.643269e-03 0.2505707 1.451028e-02
78 844 CASQ1 2.5185491 8.954515e-03 2.2659897 3.825698e-02
79 223 ALDH9A1 0.4402993 2.846024e-03 0.3789553 1.585687e-02
80 481 ATP1B1 0.7427634 3.407070e-09 1.5134022 1.486661e-46
81 9910 RABGAP1L 1.0777722 2.392776e-02 1.3284105 3.013888e-03
82 27101 CACYBP -0.8641518 4.606050e-03 -0.9597235 1.451028e-02
83 460 ASTN1 -0.5115954 1.305351e-02 -1.0060898 4.272994e-06
84 9857 CEP350 1.0052533 2.712106e-04 0.9324754 3.608563e-03
85 2752 GLUL -0.4312720 5.544555e-03 -0.5914626 2.878473e-04
86 10092 ARPC5 -0.6949867 1.364559e-05 -0.3897436 2.723603e-02
87 116496 NIBAN1 1.5849445 5.983495e-18 2.2824818 2.588458e-38
88 7175 TPR 0.8931670 3.382992e-06 0.8617858 2.095923e-05
89 9928 KIF14 2.2993429 4.224364e-02 2.2651655 4.949889e-02
90 6635 SNRPE -0.8584755 2.925472e-03 -0.6879693 4.496959e-02
91 64710 NUCKS1 0.9234332 8.264264e-09 0.6271025 3.258650e-11
92 947 CD34 6.8539720 2.178733e-03 6.8519457 7.351875e-03
93 5362 PLXNA2 1.6424306 2.145378e-07 1.5953150 5.867470e-07
94 3756 KCNH1 -7.3468321 3.699570e-04 -5.4322710 8.750087e-03
95 127018 LYPLAL1 -0.9879165 1.100170e-02 -0.8062422 4.027357e-02
96 6726 SRP9 -1.4157014 1.111334e-11 -1.0645445 7.213889e-08
97 2052 EPHX1 1.6046594 7.584594e-07 1.6860167 1.235717e-05
98 8476 CDC42BPA 0.6142316 1.179130e-03 0.5479464 1.451028e-02
99 2590 GALNT2 -0.7731319 6.670422e-05 -0.7149193 7.456542e-04
100 57568 SIPA1L2 0.9257859 1.890555e-04 0.6949482 2.554943e-02
101 9804 TOMM20 -0.4554094 2.820720e-02 -0.4458038 3.795679e-02
102 4811 NID1 -0.7110318 4.728859e-02 -1.2334604 3.579051e-03
103 116228 COX20 -1.8357792 2.152770e-07 -1.6485115 1.657246e-06
104 5209 PFKFB3 -1.3459402 2.238208e-09 -1.1345488 1.047416e-07
105 10659 CELF2 0.9977678 5.541618e-09 0.7432419 5.406799e-04
106 10006 ABI1 -0.7545308 2.849425e-02 -1.0733793 1.546463e-02
107 22931 RAB18 -0.5623941 1.961020e-02 -0.6927329 1.694852e-02
108 8829 NRP1 -0.8238021 2.178641e-05 -1.6445711 7.436750e-14
109 56288 PARD3 -1.0587320 2.799879e-03 -0.8265191 6.534399e-04
110 3185 HNRNPF -0.6858026 6.083684e-04 -0.6222294 1.412559e-02
111 220992 ZNF485 -6.3580771 1.320149e-02 -6.3600448 1.778639e-02
112 8031 NCOA4 -0.8830717 1.209904e-09 -0.8563953 6.575711e-08
113 288 ANK3 1.7275115 2.718835e-04 1.7514353 3.440427e-04
114 1959 EGR2 -3.0778980 1.216571e-06 -2.0601500 1.416154e-03
115 221035 REEP3 0.5389792 6.107508e-03 0.6018794 1.858649e-03
116 3189 HNRNPH3 -0.6417893 2.411780e-04 -1.0536549 2.235016e-07
117 80312 TET1 1.6967383 2.491949e-08 1.0827774 1.765652e-02
118 55749 CCAR1 -0.6191236 4.013120e-03 -0.8670215 3.794006e-06
119 9806 SPOCK2 1.4613572 3.499828e-09 0.9301164 1.207277e-03
120 5033 P4HA1 -1.7335366 3.370544e-12 -1.4498884 3.303972e-20
121 51021 MRPS16 0.7786055 9.652363e-05 0.5836621 5.868213e-03
122 7417 VDAC2 -0.6988929 9.794086e-03 -0.5341689 1.534269e-02
123 6229 RPS24 -0.6916832 3.106627e-10 -0.5704100 4.402772e-07
124 143244 EIF5AL1 1.5659324 5.049334e-03 1.6170947 5.558383e-03
125 2894 GRID1 -1.1036645 2.294590e-02 -1.3336066 4.951310e-04
126 27063 ANKRD1 -5.5137933 2.042192e-06 -8.6731657 7.834159e-08
127 80351 TNKS2 1.0299364 9.853310e-04 0.9336473 1.112778e-04
128 9849 ZNF518A 1.2378271 1.049081e-04 1.0746867 4.907204e-03
129 81894 SLC25A28 1.6968344 1.867188e-03 2.1183528 1.720933e-05
130 282991 BLOC1S2 -0.9321229 1.726778e-05 -0.9034756 2.252307e-04
131 55719 SLF2 1.2106297 6.250822e-20 1.0480260 2.875912e-10
132 6468 FBXW4 0.7390090 2.525435e-02 0.7973168 1.758357e-02
133 22984 PDCD11 0.8541384 2.583306e-02 0.9151997 2.759905e-02
134 374354 NHLRC2 1.3669600 4.767746e-02 1.8331192 6.306577e-03
135 340719 NANOS1 -1.3795954 1.639025e-02 -1.7742895 2.723133e-03
136 404636 DENND10 -0.9829849 1.678137e-04 -0.6144156 4.018666e-02
137 10935 PRDX3 -0.7389465 1.762494e-05 -0.5166271 2.564062e-03
138 2869 GRK5 -0.3854062 2.781705e-02 -0.4515866 8.548647e-03
139 9531 BAG3 -0.8898873 4.364275e-04 -0.7296086 2.123028e-03
140 10579 TACC2 0.9597943 3.319996e-03 0.8975968 4.173990e-02
141 5654 HTRA1 1.2390580 4.298624e-48 0.9493183 3.645379e-31
142 56647 BCCIP 0.9776739 1.284575e-03 0.7147603 4.706219e-02
143 664 BNIP3 -2.6809234 3.831802e-32 -2.5143484 5.095257e-33
144 5719 PSMD13 0.7484132 1.997567e-03 0.7823334 1.307554e-03
145 10581 IFITM2 1.8767842 2.456134e-14 1.0570806 1.018303e-02
146 100506211 MIR210HG -8.2586434 4.188804e-07 -8.2608220 7.402432e-07
147 6888 TALDO1 0.3771442 3.508497e-02 0.4072823 1.748263e-02
148 977 CD151 0.4651951 1.184530e-03 0.4485379 5.268446e-03
149 1509 CTSD 0.6420202 1.122989e-05 0.7755858 1.678842e-10
150 1200 TPP1 0.3684342 1.225323e-02 0.4018636 5.869324e-03
151 4004 LMO1 1.4755595 2.239385e-17 0.9912803 4.247282e-06
152 133 ADM -1.1528000 6.884112e-10 -0.8817726 8.411273e-07
153 100463486 MTRNR2L8 2.0760591 4.973333e-99 1.6383439 4.273056e-66
154 1982 EIF4G2 0.3431180 1.393095e-02 0.2990074 2.085604e-02
155 1315 COPB1 -0.7498241 9.088462e-03 -0.7499982 1.076310e-02
156 5682 PSMA1 -1.1672370 2.712690e-05 -0.7845991 5.267303e-04
157 55553 SOX6 0.6675824 1.383113e-03 0.5561424 8.674927e-03
158 6207 RPS13 -0.5854896 2.454053e-06 -0.3564525 8.678934e-03
159 3939 LDHA -3.4833879 5.917882e-07 -3.9180145 1.520274e-64
160 89797 NAV2 -1.9991799 7.869335e-07 -1.4428593 1.924487e-04
161 55366 LGR4 -0.6078966 1.919318e-03 -0.7625720 2.118318e-04
162 10480 EIF3M -1.2875213 3.990990e-02 -1.5846814 1.320877e-02
163 79832 QSER1 1.0949413 5.265493e-03 0.9822547 2.085115e-02
164 966 CD59 -0.4744186 3.538368e-03 -0.4490270 5.599200e-03
165 4005 LMO2 -0.7454562 1.728969e-06 -1.2056432 1.324486e-13
166 25841 ABTB2 -2.9561254 4.556237e-18 -2.2965434 8.098361e-17
167 24147 FJX1 -1.4503240 2.971714e-14 -1.3802161 1.799033e-14
168 2132 EXT2 0.9578585 4.364275e-04 1.3618098 6.821122e-08
169 3732 CD82 0.9955247 3.179847e-03 1.4382645 1.762720e-06
170 9793 CKAP5 1.3396702 6.779571e-05 0.8674058 1.371972e-02
171 4038 LRP4 -0.6929678 1.501417e-02 -0.5339822 4.390481e-02
172 53 ACP2 1.2286673 8.368271e-07 1.0066536 1.233090e-03
173 5795 PTPRJ -1.3350452 2.281039e-09 -1.0137659 6.996018e-05
174 710 SERPING1 1.9340720 4.385201e-20 1.1556381 8.334356e-05
175 219988 PATL1 -0.8415953 1.961020e-02 -1.8290073 3.685195e-05
176 2495 FTH1 -0.8232078 1.133042e-16 -0.7118784 3.813248e-12
177 51035 UBXN1 0.6918226 1.194236e-03 0.7230134 3.434057e-03
178 10963 STIP1 0.6548338 1.354956e-02 0.6768599 2.446924e-02
179 7423 VEGFB -0.8179653 1.047089e-04 -0.7177995 7.969386e-03
180 9379 NRXN2 1.4451059 7.683417e-14 0.9673922 9.412433e-04
181 823 CAPN1 1.0471023 2.863462e-04 1.0289059 2.279615e-04
182 11007 CCDC85B 0.5987630 1.440810e-02 0.7023948 1.763983e-03
183 10992 SF3B2 0.4417597 1.790684e-02 0.6146819 1.715440e-04
184 81876 RAB1B 0.8176175 3.056053e-02 0.8925297 1.230919e-02
185 9973 CCS 1.2196574 2.872499e-05 1.0860124 1.244910e-03
186 80194 TMEM134 0.6108532 4.654633e-03 0.5198541 1.739753e-02
187 2950 GSTP1 0.5971709 8.296952e-06 0.5144516 2.118318e-04
188 1374 CPT1A 0.9761002 3.474505e-21 0.8179089 1.851823e-16
189 116985 ARAP1 1.2395372 3.364267e-02 1.6189185 2.408494e-03
190 23201 FAM168A -0.6428070 2.296398e-02 -0.8234691 2.532603e-03
191 58473 PLEKHB1 0.5634513 1.372037e-02 0.6180136 2.117641e-02
192 408 ARRB1 1.7228956 8.174253e-03 1.7450086 9.636809e-03
193 6188 RPS3 0.6341066 1.870823e-07 0.7436506 5.681190e-10
194 5547 PRCP -1.3820226 5.954745e-23 -1.1224384 3.896844e-18
195 1740 DLG2 1.2647359 1.079473e-10 1.0743873 2.641466e-07
196 58487 CREBZF -1.1063279 1.804999e-03 -0.8379902 1.726749e-02
197 619383 SCARNA9 4.5607292 4.140064e-48 4.3806064 1.013526e-41
198 51503 CWC15 -0.8597363 9.142555e-04 -0.6153302 1.478114e-02
199 143686 SESN3 1.5739109 1.216622e-17 1.0316799 6.585544e-06
200 8898 MTMR2 -1.4221861 1.160066e-03 -1.3564063 6.961040e-04
201 80310 PDGFD -3.7537703 3.356242e-05 -1.6779752 3.840022e-02
202 5805 PTS -0.8402808 3.945673e-03 -0.9625137 5.917697e-03
203 4684 NCAM1 -1.0844064 6.229755e-04 -0.9184914 1.385297e-03
204 23705 CADM1 -1.2238272 4.691888e-23 -0.9632451 1.309892e-18
205 6330 SCN4B 1.6567324 1.733395e-06 1.6734741 1.432735e-07
206 10632 ATP5MG -0.4537306 5.381304e-04 -0.3536292 1.254254e-02
207 6230 RPS25 -0.8169508 3.441897e-08 -0.7294416 1.786325e-06
208 51399 TRAPPC4 -1.2063504 1.910954e-07 -1.0159225 6.123254e-05
209 6309 SC5D -1.7740606 1.143566e-13 -1.2179568 2.871699e-07
210 3312 HSPA8 -0.6503167 1.151615e-09 -0.3512107 5.901605e-04
211 9538 EI24 0.4420814 1.193928e-02 0.6816923 8.210376e-06
212 9743 ARHGAP32 -1.9969232 4.245443e-02 -1.4621260 3.491379e-02
213 50863 NTM 1.9202919 6.351849e-13 1.2243360 2.086549e-02
214 27087 B3GAT1 1.4140518 2.316604e-09 1.1640871 5.957845e-06
215 894 CCND2 0.4996225 2.743922e-04 0.6658611 6.640099e-10
216 4908 NTF3 -6.1515947 3.993723e-02 -6.1536348 4.936620e-02
217 928 CD9 -1.4717770 1.147028e-23 -1.7946156 2.531330e-31
218 7167 TPI1 -0.7463220 5.863670e-05 -0.7067538 4.273139e-04
219 2026 ENO2 -0.9007238 9.258185e-09 -0.6579910 2.930540e-04
220 1822 ATN1 -1.3915260 1.279368e-06 -1.2751632 3.949562e-06
221 715 C1R 0.9070775 1.895855e-11 1.0631194 4.060994e-11
222 6515 SLC2A3 -0.7474001 8.467466e-03 -0.7162774 9.403404e-03
223 8531 YBX3 -0.7778992 2.458787e-05 -0.5092774 1.087899e-02
224 51202 DDX47 -1.3307240 3.925541e-02 -1.3989661 2.478382e-02
225 2012 EMP1 -1.9226605 1.040745e-08 -1.5446940 1.635205e-09
226 55729 ATF7IP 0.9243519 1.184530e-03 1.2911304 2.936539e-07
227 5800 PTPRO -6.9596645 1.859337e-03 -6.9616527 2.648940e-03
228 11171 STRAP -0.5301000 4.645608e-02 -0.5421234 2.922212e-02
229 51026 GOLT1B -1.6521299 2.653729e-03 -1.0956044 2.030822e-02
230 3709 ITPR2 1.1914972 5.026342e-03 1.1596578 2.568866e-03
231 55297 CCDC91 -0.9491800 5.115343e-03 -0.8213005 7.732515e-03
232 441631 TSPAN11 1.1981092 2.743922e-04 1.5514002 2.602915e-07
233 636 BICD1 0.8302369 1.420847e-04 0.8885961 1.528456e-06
234 85437 ZCRB1 -0.7997047 1.833369e-04 -0.6686395 6.600812e-03
235 51564 HDAC7 -0.9381597 3.820831e-03 -0.8288939 2.974436e-02
236 1280 COL2A1 -2.0440771 3.180110e-05 -2.2969663 9.941474e-07
237 9416 DDX23 0.8370554 3.846728e-03 1.1092867 5.816490e-04
238 7009 TMBIM6 0.5951983 2.983066e-11 0.7133874 7.518873e-17
239 51474 LIMA1 -1.1029540 5.398832e-09 -0.6859229 2.347144e-03
240 57609 DIP2B 1.1206196 5.326370e-06 0.7783899 6.304220e-03
241 25840 METTL7A 1.1450889 2.028174e-13 0.8840038 1.737575e-06
242 81566 CSRNP2 -1.2118124 3.519716e-04 -1.0831552 1.874409e-03
243 9802 DAZAP2 -0.4733097 9.632950e-03 -0.4904441 1.294316e-02
244 160622 TAMALIN 1.1670602 5.849039e-03 1.1129331 4.059283e-02
245 2647 BLOC1S1 -0.9361823 1.063945e-02 -1.2069707 5.308265e-03
246 84324 SARNP 1.9850861 3.392792e-05 1.2924817 2.014432e-02
247 1606 DGKA -1.3416105 6.889470e-03 -1.2672936 1.706826e-02
248 4637 MYL6 -0.6208233 1.054238e-06 -0.4216945 4.501027e-03
249 10728 PTGES3 -0.7317474 3.951503e-05 -0.8735440 1.688367e-06
250 4666 NACA -0.9402961 1.195302e-09 -0.8107363 1.007170e-06
251 6472 SHMT2 1.1374543 7.009110e-03 1.4197326 1.260041e-04
252 22864 R3HDM2 1.0575085 1.864084e-03 0.9101495 3.574395e-02
253 10106 CTDSP2 -0.5228011 1.697879e-02 -0.6071262 9.827096e-03
254 4193 MDM2 0.5162521 1.420183e-03 0.5722706 9.204256e-06
255 4673 NAP1L1 -0.6268512 9.779490e-05 -0.5091138 2.586268e-03
256 1466 CSRP2 -0.8656306 2.940261e-06 -0.5731308 4.681778e-03
257 8411 EEA1 1.1609643 2.052218e-04 1.2419375 2.770534e-04
258 57458 TMCC3 2.4466383 3.053042e-02 2.7869660 1.660474e-02
259 6636 SNRPF -0.6886123 9.067862e-03 -0.8460276 1.302775e-03
260 23074 UHRF1BP1L 1.9891039 1.292456e-02 2.0868688 2.747768e-03
261 79158 GNPTAB 1.0095934 5.262357e-04 1.0638101 1.487775e-03
262 7184 HSP90B1 -0.8297707 2.472046e-10 -1.0026424 5.506803e-15
263 10970 CKAP4 -0.5231204 1.963472e-04 -0.6250150 5.957845e-06
264 121642 ALKBH2 1.1881260 1.508488e-03 1.0742132 9.059472e-03
265 10094 ARPC3 -0.7523080 1.326844e-06 -0.8765033 2.160986e-07
266 84329 HVCN1 4.0387920 2.008063e-04 4.4157216 8.959148e-05
267 10961 ERP29 -0.5296490 1.171193e-03 -0.4733213 1.011875e-02
268 643246 MAP1LC3B2 -1.1693202 1.726802e-04 -1.1514770 5.587250e-04
269 6175 RPLP0 -0.7427281 3.438281e-20 -0.2784224 3.519763e-03
270 4440 MSI1 1.3726026 3.957070e-04 1.0955685 7.351875e-03
271 8655 DYNLL1 -0.4910178 1.727812e-04 -0.6008993 1.239605e-05
272 9921 RNF10 0.7004251 7.923407e-04 0.6981440 9.754433e-04
273 9761 MLEC 0.4683059 1.188779e-03 0.5653529 4.661108e-05
274 55596 ZCCHC8 -1.7482099 1.961020e-02 -2.4142500 9.188144e-04
275 79720 VPS37B 0.9026088 1.485030e-03 1.1126039 1.197114e-06
276 51329 ARL6IP4 0.5401940 1.790684e-02 0.6683972 3.609831e-03
277 8099 CDK2AP1 -0.4985766 1.066706e-05 -0.4413100 2.049964e-04
278 9612 NCOR2 -0.7234303 5.381304e-04 -0.8248144 2.936539e-07
279 7316 UBC 0.3627002 2.787712e-03 0.3310509 1.899220e-03
280 2054 STX2 0.8726497 3.914194e-02 1.1685108 8.049816e-03
281 54737 MPHOSPH8 -0.6093420 7.666844e-03 -0.5502569 1.491265e-03
282 26278 SACS 1.0417896 1.649009e-03 1.0018200 3.940864e-03
283 221178 SPATA13 -1.2239684 8.945893e-09 -0.9779087 8.192199e-05
284 219287 AMER2 0.8334604 3.063447e-13 0.7072583 6.087483e-08
285 675 BRCA2 4.8437293 6.303308e-05 4.4783132 5.153121e-03
286 9201 DCLK1 1.0552536 2.276876e-14 0.9505832 6.874839e-10
287 341640 FREM2 0.9575750 3.226430e-03 0.8133285 1.858271e-02
288 10186 LHFPL6 -0.4650645 1.790684e-02 -0.8595817 7.458090e-05
289 11193 WBP4 -1.0962585 4.413549e-06 -0.9162024 3.088599e-04
290 11215 AKAP11 0.8422400 7.932182e-04 1.2606830 3.607048e-09
291 55068 ENOX1 -2.4177415 1.540034e-02 -3.8431654 2.452882e-04
292 7178 TPT1 -1.0430667 9.296532e-39 -0.7052410 1.074257e-16
293 9445 ITM2B -0.5852653 4.418694e-11 -0.6239563 6.611768e-12
294 51131 PHF11 1.5021135 7.180181e-06 1.8957506 6.093754e-08
295 8847 DLEU2 2.0522810 6.337342e-03 1.7427843 4.830400e-02
296 27253 PCDH17 -0.9566323 2.100556e-05 -1.1748425 5.231539e-08
297 122060 SLAIN1 -0.8106943 2.416954e-02 -1.1421408 2.583238e-03
298 5611 DNAJC3 1.1874172 1.434827e-09 0.7536076 4.266996e-03
299 5095 PCCA 1.5895316 3.052919e-04 2.4264321 1.685252e-13
300 55608 ANKRD10 -0.8445098 3.226430e-03 -0.9948470 1.119566e-03
301 55002 TMCO3 -0.7261552 2.866052e-02 -0.7889202 1.811970e-02
302 2621 GAS6 1.6850483 6.409206e-12 0.8078906 1.974866e-02
303 6038 RNASE4 -1.9302768 2.011118e-06 -1.2025272 8.033371e-04
304 57680 CHD8 0.9395286 4.839307e-05 0.8730603 2.538096e-03
305 4323 MMP14 1.0612673 4.393978e-11 1.3284949 1.962593e-17
306 10278 EFS 1.9268720 1.554770e-05 1.6053783 3.176664e-03
307 85446 ZFHX2 -1.5696793 1.028774e-06 -1.6434051 3.928918e-07
308 5720 PSME1 0.5950205 6.116031e-03 0.5471449 2.532466e-02
309 9985 REC8 0.8750887 2.357235e-03 0.8016210 8.410037e-03
310 26277 TINF2 0.7204108 3.873351e-03 0.6246591 2.328111e-02
311 29966 STRN3 1.3153498 1.658088e-07 1.5434901 5.395941e-11
312 25831 HECTD1 0.7356891 1.590851e-04 0.8104926 7.598210e-05
313 394 ARHGAP5 0.7443182 8.323117e-08 0.6647278 1.711393e-05
314 55012 PPP2R3C 0.5379489 3.657829e-02 0.5484802 4.693184e-02
315 5411 PNN -0.6463694 4.180690e-04 -0.7190232 4.968118e-04
316 23116 TOGARAM1 0.7574602 3.998225e-02 0.9200662 3.263452e-02
317 161357 MDGA2 1.1942387 1.678550e-04 0.9083236 1.928000e-02
318 6235 RPS29 0.4490748 2.362414e-06 0.5278008 1.321150e-07
319 6166 RPL36AL -0.9125391 8.257954e-11 -0.7907283 3.761478e-07
320 378706 RN7SL2 2.6170035 2.258347e-08 2.9161589 7.399495e-10
321 81542 TMX1 -0.9419960 1.845171e-05 -0.9141248 4.101185e-04
322 3895 KTN1 0.2886748 4.103657e-02 0.4045997 8.290912e-04
323 5684 PSMA3 -0.7017538 1.859337e-03 -0.8006992 1.806997e-04
324 51528 JKAMP -1.3726262 6.028115e-06 -1.2066665 1.475236e-06
325 6252 RTN1 -0.2886628 2.349734e-03 -0.4964596 4.923798e-08
326 51635 DHRS7 -0.8234558 1.673959e-04 -0.8150266 1.470560e-05
327 3091 HIF1A 1.8493151 2.503885e-17 1.8257181 3.576167e-15
328 23224 SYNE2 1.8616176 7.117427e-27 1.3688272 3.734839e-10
329 87 ACTN1 0.4284562 2.187020e-03 0.4684115 6.632582e-04
330 64093 SMOC1 0.9866785 6.718799e-19 0.6051735 2.779479e-05
331 8110 DPF3 -0.9789436 2.551990e-06 -0.7434020 6.008153e-03
332 8650 NUMB -0.9293603 6.133586e-03 -1.0166026 1.684982e-02
333 9240 PNMA1 -0.8285234 4.396808e-07 -0.5001593 4.612193e-02
334 4329 ALDH6A1 2.3638605 2.653510e-21 2.0569067 1.121320e-14
335 10972 TMED10 -0.9266083 7.998204e-17 -0.7999917 3.772776e-15
336 9517 SPTLC2 1.2379555 1.118082e-04 1.0955649 2.737931e-03
337 9369 NRXN3 -2.0815225 2.496293e-04 -2.9810474 1.170221e-06
338 5700 PSMC1 0.8246297 1.257916e-02 1.0463330 7.027737e-05
339 145567 TTC7B -0.9885643 2.732516e-02 -1.3407013 2.076992e-03
340 4707 NDUFB1 0.4369686 1.360353e-03 0.4696018 4.131010e-04
341 53981 CPSF2 0.7762509 1.909529e-02 0.9830912 1.315135e-03
342 5641 LGMN -0.6970986 2.561799e-03 -0.8213816 6.702576e-04
343 51466 EVL 0.6641817 1.624341e-02 0.6069795 4.979809e-02
344 8788 DLK1 -0.7610714 2.285698e-05 -1.7891293 4.347742e-23
345 3320 HSP90AA1 -0.9351361 7.328821e-18 -0.6908205 9.028993e-10
346 1983 EIF5 -0.6241797 5.686856e-03 -0.5320810 1.339059e-02
347 1152 CKB 1.0646996 7.958010e-24 0.7029645 1.555062e-09
348 1397 CRIP2 1.1480773 6.021030e-23 1.0006637 5.950226e-18
349 646214 <NA> 0.9896756 2.960410e-02 1.0235084 1.859654e-02
350 347746 <NA> 1.0173491 3.294376e-02 1.0088941 4.306992e-02
351 440248 HERC2P9 -2.0141815 3.196005e-04 -1.9771477 1.353172e-03
352 55505 NOP10 0.5100915 2.345297e-02 0.5693931 1.279535e-02
353 57082 KNL1 4.3518578 1.138427e-03 3.9533849 1.300403e-02
354 51332 SPTBN5 -1.5194173 9.394863e-03 -1.6763140 1.201892e-03
355 30844 EHD4 -0.5592482 3.523082e-02 -0.6276293 9.653887e-03
356 25963 TMEM87A -0.5712014 1.596924e-02 -0.4683078 3.551897e-02
357 64397 ZNF106 0.5888948 5.531800e-04 0.5229948 3.609831e-03
358 2628 GATM 1.0641065 8.803533e-06 0.8997106 3.609831e-03
359 2200 FBN1 0.8228623 4.586825e-02 0.9472631 6.130884e-05
360 9728 SECISBP2L 0.9054933 6.477263e-03 0.7180537 5.226021e-03
361 55930 MYO5C 1.6161840 4.872646e-03 1.9094068 8.189179e-04
362 4644 MYO5A 0.7821074 2.849359e-03 1.0527000 1.007170e-06
363 51187 RSL24D1 -0.7582322 4.833167e-02 -0.7211120 3.538759e-02
364 6938 TCF12 -0.7119689 1.361048e-02 -0.8529075 4.335729e-03
365 102 ADAM10 -1.0435933 2.176227e-07 -0.9847376 2.563821e-06
366 79811 SLTM -0.5261474 2.957613e-02 -0.7266043 3.961070e-04
367 2958 GTF2A2 -1.1390753 2.667342e-08 -1.1163038 2.828873e-04
368 302 ANXA2 -0.6174623 7.459776e-12 -0.6791950 4.316901e-13
369 54832 VPS13C 0.9913565 4.323899e-04 0.9832413 3.418495e-04
370 83660 TLN2 0.7075094 5.504391e-06 0.5277677 1.053720e-02
371 8925 HERC1 1.0538969 5.231586e-03 1.0321122 1.520674e-02
372 51324 SPG21 -0.7068337 5.191695e-04 -0.8068551 1.282304e-03
373 8766 RAB11A -0.6927286 1.137117e-04 -0.8830035 3.602168e-04
374 84465 MEGF11 -1.3726201 2.327044e-05 -1.5206484 1.603060e-03
375 6124 RPL4 -0.5214030 6.734381e-04 -0.4077637 1.088155e-02
376 10391 CORO2B 1.2558827 3.283149e-21 1.0136424 8.558249e-14
377 5315 PKM -0.7939105 3.670433e-11 -0.3837185 2.702039e-02
378 4756 NEO1 0.5201654 1.160066e-03 0.7084842 2.854245e-06
379 27020 NPTN -0.7695636 1.767261e-06 -0.7797756 1.423627e-07
380 3671 ISLR -0.2833417 2.028597e-02 -0.3222841 3.332679e-02
381 9377 COX5A -0.6967445 3.494099e-05 -0.5349109 1.390013e-02
382 5780 PTPN9 -0.8448890 1.322620e-03 -0.6038163 2.040272e-02
383 5955 RCN2 -0.8584015 1.643613e-05 -0.6520988 5.948056e-03
384 55466 DNAJA4 5.2930987 1.018488e-02 5.3991296 1.109825e-03
385 10933 MORF4L1 -0.5568219 6.649373e-05 -0.6284132 1.108807e-03
386 1512 CTSH 2.2502971 2.188462e-31 1.1993025 9.204256e-06
387 23423 TMED3 -2.5221986 2.083008e-04 -1.5214805 4.883821e-04
388 2184 FAH 1.3692678 4.251650e-02 1.4510803 3.151168e-02
389 100996492 CTXND1 -1.2594438 2.747066e-09 -0.6366117 1.639764e-02
390 58489 ABHD17C -0.7203873 6.935918e-03 -1.0637108 5.587250e-04
391 57214 CEMIP -3.9315748 1.063531e-02 -2.0436591 3.779308e-07
392 83640 RAMAC -2.5731740 4.573590e-02 -4.6556532 1.466011e-04
393 388165 UBE2Q2P1 2.1997492 1.586437e-03 2.0978713 3.694621e-02
394 4828 NMB 1.2409236 1.168253e-03 1.4003827 2.182028e-04
395 11057 ABHD2 1.0991177 1.173058e-11 1.0141111 1.555218e-09
396 3418 IDH2 1.0091847 7.629644e-03 0.9807063 1.950107e-02
397 8826 IQGAP1 0.6676281 2.298051e-04 0.5221466 4.544405e-03
398 5045 FURIN 0.7669524 6.354729e-03 0.8715731 3.469704e-03
399 100507217 <NA> -0.8697019 7.994831e-10 -0.9408703 1.569851e-09
400 56963 RGMA 0.6604419 6.084450e-04 0.4291084 2.922212e-02
401 80213 TM2D3 -1.0519095 3.625704e-04 -1.6898388 3.096144e-06
402 10573 MRPL28 1.1499369 3.029710e-02 1.2957882 1.485419e-02
403 58986 PGAP6 -0.8998415 1.804999e-03 -0.8592389 1.048363e-03
404 146330 FBXL16 -0.7899244 2.654058e-02 -1.2690415 4.662999e-04
405 79006 METRN 0.6003464 7.760361e-06 0.5046881 4.699858e-04
406 65990 ANTKMT 1.8619041 2.452679e-05 1.7352076 3.035851e-04
407 4832 NME3 0.9375875 2.140022e-04 0.6623158 3.996775e-02
408 735301 <NA> 1.0597505 8.099778e-04 0.9979261 8.293104e-03
409 5310 PKD1 -1.0304686 3.192947e-02 -1.1070155 2.521897e-02
410 527 ATP6V0C 0.4370069 3.907192e-04 0.4542608 8.966766e-04
411 54442 KCTD5 -1.4562156 2.964474e-03 -0.9402968 1.021544e-02
412 54985 HCFC1R1 -0.6079132 3.991626e-02 -0.6490186 2.634717e-02
413 54700 RRN3 -1.2351659 4.128261e-03 -0.8604663 3.409937e-02
414 6210 RPS15A -0.5960953 1.211274e-05 -0.4428597 1.003147e-03
415 23204 ARL6IP1 0.9383252 6.006087e-11 0.9058792 1.158777e-10
416 162073 ITPRIPL2 1.1726156 7.658727e-05 1.5954294 7.109072e-13
417 124152 IQCK -0.5657486 5.628584e-05 -0.5589493 1.117374e-04
418 100271836 <NA> 3.0737938 9.292262e-05 2.4881162 7.305543e-03
419 440345 NPIPB4 -1.5582785 2.743922e-04 -1.6215592 1.854642e-04
420 100132247 NPIPB5 -1.6525869 2.696048e-03 -1.5490723 8.293104e-03
421 4706 NDUFAB1 -0.5472785 6.751972e-04 -0.4580337 4.470866e-03
422 84516 DCTN5 0.8826744 2.374119e-02 1.2467702 1.967691e-03
423 5930 RBBP6 -1.2887842 3.735406e-08 -1.4071110 1.200944e-09
424 84901 NFATC2IP 1.0847510 1.773855e-02 1.1231429 2.177698e-02
425 83985 SPNS1 1.2340362 2.104477e-03 1.5747545 1.257186e-05
426 728888 NPIPB11 -2.8252509 3.901370e-08 -2.1850084 5.952707e-07
427 9961 MVP 0.8920615 7.547243e-05 1.0620417 2.463593e-06
428 283899 INO80E 2.1379343 1.465428e-03 2.0649537 4.561370e-03
429 226 ALDOA -1.5444400 1.280511e-36 -1.0558203 4.194413e-14
430 9274 BCL7C 1.0513226 5.261210e-04 1.4388208 1.866388e-09
431 6810 STX4 0.6977938 2.856031e-02 1.1719340 3.262791e-07
432 79001 VKORC1 -0.8027366 4.541522e-04 -0.6130450 9.319786e-03
433 2521 FUS 0.7632304 7.252086e-10 0.5075587 3.861127e-05
434 583 BBS2 -0.6261172 8.986188e-03 -0.7058018 3.188413e-03
435 4502 MT2A -1.0055816 3.944840e-16 -0.7554787 9.519839e-13
436 9289 ADGRG1 0.3976620 4.775778e-05 0.2441522 3.486594e-02
437 27183 VPS4A 0.7513295 8.744913e-03 0.6347523 4.998338e-02
438 91862 MARVELD3 2.9430332 3.746597e-03 2.4531545 2.922212e-02
439 5713 PSMD7 -0.6205772 1.408600e-02 -0.7739885 7.044908e-04
440 124491 TMEM170A 0.6723400 4.502382e-03 0.5489694 3.677470e-02
441 4166 CHST6 2.6962446 3.960340e-02 2.9333458 2.154713e-02
442 54386 TERF2IP -0.4463460 1.197770e-02 -0.5627876 6.426842e-04
443 100130958 SYCE1L 2.5517604 3.309420e-08 2.0546872 3.600374e-04
444 4094 MAF 1.0118798 1.150650e-10 0.8890634 1.552017e-07
445 10200 MPHOSPH6 0.8730754 4.180690e-04 0.7648047 6.037178e-03
446 3281 HSBP1 -0.5428740 1.600119e-02 -0.4276417 3.484602e-02
447 23406 COTL1 -0.6228931 1.202637e-09 -0.5049880 1.484791e-05
448 81631 MAP1LC3B -0.7188656 8.473933e-06 -0.6431186 6.301319e-05
449 29123 ANKRD11 -0.6278631 1.274030e-07 -0.8518794 3.709899e-09
450 10381 TUBB3 -1.6371122 8.191888e-09 -1.3555122 2.687430e-06
451 7531 YWHAE -0.4972274 3.319772e-04 -0.6790844 4.976348e-07
452 5306 PITPNA 0.8511018 5.672427e-06 0.8483277 1.945406e-05
453 124935 SLC43A2 0.5879152 6.469172e-04 0.4245842 3.069666e-02
454 6117 RPA1 -1.2230346 4.086653e-03 -1.1241705 4.712945e-02
455 23293 SMG6 1.3085509 1.983173e-06 0.8856096 8.608194e-03
456 83460 EMC6 7.3783605 1.556652e-04 6.3921739 2.837770e-02
457 101559451 <NA> -3.6325402 2.419142e-02 -3.4300353 3.630983e-02
458 23302 WSCD1 1.2867431 3.495667e-21 0.9934216 1.143742e-09
459 54478 PIMREG 1.8914490 8.193218e-03 2.0731304 7.415395e-03
460 1742 DLG4 0.6449161 2.187844e-03 0.6425151 1.379859e-02
461 37 ACADVL 0.9264694 3.956736e-07 0.7891664 3.943013e-06
462 23399 CTDNEP1 0.6252976 6.386210e-04 0.5288386 8.925890e-03
463 1984 EIF5A 1.0315814 4.543233e-06 1.3259060 1.274520e-12
464 6154 RPL26 -1.2272616 2.821646e-21 -1.1028759 1.559946e-20
465 9611 NCOR1 -0.8297948 5.964385e-04 -0.7314405 1.533090e-03
466 125144 SNHG29 -0.8703269 1.045102e-07 -0.5452850 5.894301e-03
467 3996 LLGL1 1.1900278 4.993151e-08 0.8556594 3.675840e-04
468 284047 CCDC144B 1.8884786 7.111301e-05 1.5906406 5.151420e-03
469 22905 EPN2 1.4370574 6.184815e-16 1.5810549 3.356685e-26
470 224 ALDH3A2 0.8853191 1.103245e-05 0.8671828 3.435749e-06
471 218 ALDH3A1 2.3556449 2.035509e-03 2.0678832 9.973890e-03
472 100462977 MTRNR2L1 0.7958907 1.369794e-11 0.5234227 1.051784e-04
473 26118 WSB1 -1.1530284 4.282675e-18 -1.2895732 6.796359e-18
474 6147 RPL23A -0.9519818 4.237693e-12 -0.8341970 1.106815e-09
475 147015 DHRS13 -1.2698348 2.472879e-02 -1.4027750 1.384453e-02
476 6347 CCL2 -0.8309797 1.080186e-11 -0.5559667 2.811113e-06
477 163 AP2B1 0.8419641 1.329770e-10 0.5182979 1.468526e-03
478 91608 RASL10B 1.1936587 5.115343e-03 0.9893958 2.742697e-02
479 9326 ZNHIT3 -0.8371984 3.465783e-02 -1.5988886 3.679887e-03
480 9349 RPL23 -0.8601711 1.368029e-11 -0.7530755 1.834738e-10
481 6143 RPL19 -0.5838960 2.960158e-07 -0.4368548 2.773448e-04
482 10948 STARD3 1.0312622 1.372149e-03 0.7799050 4.037384e-02
483 10209 EIF1 -0.5815818 6.679365e-05 -0.4465559 5.651855e-04
484 60681 FKBP10 0.9927652 4.868650e-09 0.7324452 5.532716e-04
485 2118 ETV4 1.1266639 7.095266e-03 1.0881048 2.325569e-02
486 7343 UBTF 0.6423764 4.736278e-03 0.5637409 2.799931e-02
487 51629 SLC25A39 0.7355032 2.081793e-04 0.5493490 1.216379e-02
488 2670 GFAP -0.9725394 8.074219e-04 -0.8263723 2.111793e-02
489 124790 HEXIM2 -2.1718223 1.020913e-03 -2.5862550 1.359943e-03
490 90507 SCRN2 1.2076429 5.834244e-04 0.9343968 3.683940e-02
491 4804 NGFR -1.8648504 3.212246e-04 -3.1054087 1.054488e-06
492 1277 COL1A1 -2.1977388 1.004864e-28 -1.8782416 1.355766e-15
493 51747 LUC7L3 -0.7556232 5.249112e-07 -0.8744854 1.787546e-07
494 404093 CUEDC1 1.0085939 3.429940e-06 0.9298476 2.985881e-04
495 6426 SRSF1 -0.7835381 1.563324e-03 -0.5706565 1.011060e-02
496 6827 SUPT4H1 0.6457652 2.576390e-02 0.5739720 1.820339e-02
497 653653 <NA> 1.3619291 1.746363e-16 1.3746073 1.757163e-16
498 8493 PPM1D -1.5052961 2.032412e-02 -1.1217445 2.987023e-02
499 342538 NACA2 -0.9918503 7.987224e-06 -0.9597353 1.813232e-06
500 9902 MRC2 0.8169026 4.846276e-12 0.8201005 3.549890e-12
501 1534 CYB561 3.0422758 3.438905e-08 2.1727194 4.956277e-03
502 5573 PRKAR1A -1.1025272 2.731797e-19 -1.1435375 1.047407e-19
503 388419 BTBD17 1.3016105 1.738123e-11 1.1857468 7.405348e-08
504 23510 KCTD2 0.8289403 3.560670e-03 0.6640987 4.150298e-02
505 10476 ATP5PD -0.9717998 5.852795e-06 -0.9420880 4.104210e-06
506 30833 NT5C 1.2280223 3.866066e-02 1.3086616 2.684832e-02
507 6613 SUMO2 -0.5930108 2.705062e-02 -0.7286626 1.625612e-02
508 2584 GALK1 1.7254135 1.310249e-02 2.0021461 3.579051e-03
509 3021 H3-3B -0.3994214 1.863027e-03 -0.4230520 1.282304e-03
510 201292 TRIM65 1.2293615 1.751758e-03 1.0188096 3.123313e-02
511 57690 TNRC6C -1.1507167 9.976401e-04 -0.9694068 5.387006e-03
512 332 BIRC5 2.0906223 6.319246e-06 1.4536843 4.356118e-02
513 9021 SOCS3 -2.0791411 8.463804e-13 -1.0958583 2.703121e-03
514 3959 LGALS3BP 0.6904852 1.327004e-05 0.5355953 8.451631e-04
515 114897 C1QTNF1 1.4696470 2.454798e-18 0.9856446 3.435749e-06
516 284184 NDUFAF8 0.5911756 2.083037e-03 0.6861791 2.647084e-05
517 71 ACTG1 -0.2961316 1.159036e-03 -0.2218373 2.331023e-02
518 2873 GPS1 0.6823021 3.766068e-02 0.7508669 2.494401e-02
519 9123 SLC16A3 -4.1330190 7.226284e-07 -3.3561812 4.548231e-05
520 7525 YES1 -1.2615927 3.266399e-04 -1.0557013 5.607378e-03
521 23347 SMCHD1 0.8597124 9.011347e-03 0.8732188 1.003663e-02
522 10627 MYL12A -0.7901486 3.179507e-06 -0.8546644 3.579980e-07
523 103910 MYL12B -1.0486207 4.662796e-15 -0.8754780 5.158171e-09
524 284217 LAMA1 -1.9117689 6.827497e-03 -2.7721247 3.188413e-03
525 201475 RAB12 1.2942048 3.444771e-05 1.1303184 1.006118e-03
526 23253 ANKRD12 -0.9347668 1.231226e-08 -1.0979806 2.631009e-12
527 11031 RAB31 0.5840879 9.078035e-06 0.7492132 4.453646e-09
528 57534 MIB1 1.0253310 1.369637e-05 0.8547497 1.325508e-03
529 114876 OSBPL1A 0.7727328 5.467397e-04 0.6463417 1.359824e-02
530 361 AQP4 1.3046907 4.415749e-12 1.4466123 3.593129e-19
531 498 ATP5F1A -0.6930482 1.508889e-06 -0.6093631 1.945666e-05
532 497661 C18orf32 2.3368170 8.243963e-03 2.0041399 2.645110e-02
533 10449 ACAA2 -1.1252042 9.418471e-06 -0.9019449 1.560490e-04
534 4677 NARS1 0.5722238 2.091157e-03 0.5704313 6.378848e-03
535 6209 RPS15 -1.0001926 1.043696e-08 -0.7964683 4.814394e-06
536 55643 BTBD2 0.8551346 3.004880e-04 0.7291902 1.318394e-03
537 8943 AP3D1 -0.4757093 9.636398e-03 -0.5547152 2.365682e-03
538 4946 OAZ1 -0.5678812 1.593618e-05 -0.5684510 9.197482e-05
539 51690 LSM7 0.8629005 4.461942e-05 0.7662276 1.043661e-04
540 10362 HMG20B 0.8689997 1.251490e-04 0.7084466 8.678934e-03
541 51341 ZBTB7A -0.7362040 3.299776e-05 -0.9163785 1.887914e-07
542 10226 PLIN3 0.6525927 6.166393e-03 0.6941874 3.886414e-04
543 5802 PTPRS 0.6513059 1.188465e-02 0.5756991 7.909267e-03
544 25873 RPL36 -0.4164091 2.349734e-03 -0.3654459 3.825698e-02
545 126328 NDUFA11 0.5011245 2.876334e-03 0.5154632 9.081134e-03
546 8570 KHSRP 0.5583323 1.269109e-04 0.4700514 8.504777e-03
547 59286 UBL5 -0.5032199 1.910347e-03 -0.3814452 3.069666e-02
548 93145 OLFM2 1.2958196 5.451070e-03 1.2964507 1.633293e-02
549 51073 MRPL4 1.1496204 3.708176e-04 0.8858085 1.234463e-02
550 11140 CDC37 0.5990434 2.052218e-04 0.5739898 1.201889e-04
551 6597 SMARCA4 -0.6024604 4.736583e-03 -0.5722336 8.274450e-03
552 3949 LDLR -1.0692312 9.146430e-05 -0.8628490 4.018303e-03
553 664709 HNRNPA1P10 -0.7790312 1.254641e-03 -0.6843172 2.785025e-02
554 84261 FBXW9 2.0842390 9.239159e-03 2.5722090 2.102751e-04
555 30000 TNPO2 0.9492195 7.131099e-10 0.8814543 2.400691e-09
556 811 CALR 0.7334217 4.393978e-11 0.5382697 1.786768e-06
557 4784 NFIX 1.2616492 8.226083e-09 1.1806997 5.782716e-08
558 22859 ADGRL1 -0.6358973 6.412381e-04 -0.8164053 7.858444e-07
559 4713 NDUFB7 1.3413248 1.327334e-08 1.1192722 6.515834e-06
560 10994 ILVBL 1.7209724 2.451358e-04 1.5464380 3.535904e-03
561 4854 NOTCH3 -0.9657688 5.154303e-09 -0.6352958 2.096314e-04
562 10270 AKAP8 -1.3286091 6.084450e-04 -0.8311861 4.546707e-02
563 58525 WIZ -0.7592523 3.166567e-03 -0.5806022 3.672069e-02
564 4218 RAB8A 1.0376511 2.830296e-03 0.9605041 2.023263e-02
565 79016 DDA1 0.7933349 9.067862e-03 0.9922694 8.085905e-05
566 93343 MVB12A 1.7769065 5.261210e-04 1.3674581 2.398354e-02
567 79709 COLGALT1 0.4124601 4.436015e-02 0.5796921 1.315433e-03
568 170463 SSBP4 1.1732690 3.074895e-02 1.2889058 2.671759e-02
569 55049 REX1BD 1.1068160 3.775347e-04 0.9570863 2.891174e-03
570 9454 HOMER3 1.0207052 2.694411e-07 1.2159963 4.374179e-09
571 1463 NCAN 1.8552424 2.188462e-31 1.6067155 1.535438e-23
572 7562 ZNF708 0.8905314 2.796814e-02 0.8959148 3.408261e-02
573 10775 POP4 -1.2569788 3.964031e-03 -1.2112346 8.921095e-03
574 9141 PDCD5 -0.8202988 2.650478e-03 -1.1732265 9.929970e-07
575 2821 GPI -0.7403914 3.824566e-05 -0.5062771 2.630139e-02
576 57655 GRAMD1A 0.9865818 1.070319e-04 1.1724726 9.852140e-07
577 7392 USF2 0.6781979 3.652474e-04 0.7192832 8.714748e-04
578 81 ACTN4 -1.0975926 7.328821e-18 -1.0113257 2.229865e-14
579 1891 ECH1 -0.8293285 2.034413e-06 -0.9450336 1.075059e-08
580 2091 FBL 0.7555994 3.926679e-04 0.9116386 5.870773e-05
581 208 AKT2 0.6588291 3.737784e-05 0.4835865 9.435243e-03
582 23646 PLD3 0.9610472 3.110679e-05 0.5979353 2.187981e-02
583 57716 PRX 4.6707467 9.114871e-04 3.5917022 4.911900e-02
584 11100 HNRNPUL1 0.3282188 3.652300e-02 0.3857864 7.751267e-03
585 2931 GSK3A 1.3518810 7.885800e-07 1.0514270 9.724454e-04
586 348 APOE 1.4498686 7.075051e-34 1.2934789 3.664330e-25
587 27113 BBC3 0.6373515 2.628145e-05 0.6024491 2.306262e-04
588 6415 SELENOW 0.9909652 2.244993e-13 0.9096428 1.029829e-10
589 9266 CYTH2 0.6943171 3.909534e-03 1.0140591 9.474857e-07
590 587 BCAT2 1.4421405 9.219084e-05 1.1208820 6.235893e-03
591 4924 NUCB1 0.9642368 4.599121e-08 0.6443797 3.636552e-03
592 581 BAX 0.6616982 1.733013e-03 0.6491224 6.961040e-04
593 2997 GYS1 -1.1704013 2.424543e-03 -1.0464762 3.949933e-02
594 6205 RPS11 -0.6835725 3.644532e-10 -0.5347524 2.214286e-06
595 57479 PRR12 -1.4598384 2.028532e-05 -1.1119260 1.034438e-02
596 284361 EMC10 0.6566259 2.508187e-05 0.5678333 1.687299e-03
597 81856 ZNF611 1.3370182 3.068669e-02 1.3784094 2.061382e-02
598 90338 ZNF160 -0.7951403 3.013453e-02 -0.8864334 1.891143e-02
599 22870 PPP6R1 0.7905539 1.541383e-02 1.0882563 2.127000e-05
600 57106 NAT14 1.0606447 2.298690e-06 0.9730329 8.991540e-05
601 11338 U2AF2 0.9576634 4.424857e-11 0.9220234 8.803951e-09
602 10782 ZNF274 -2.7420750 3.225211e-03 -1.5732952 4.183662e-02
603 1 A1BG 1.7764942 1.893902e-07 1.7191093 2.513362e-07
604 27243 CHMP2A -0.5828843 1.790711e-03 -0.5497006 1.227021e-02
605 100506054 RNASEH1-AS1 0.7400574 4.069356e-02 1.0344256 1.935911e-03
606 6664 SOX11 0.4954825 2.411350e-02 0.6476866 2.147638e-03
607 10971 YWHAQ -0.9029050 1.733962e-11 -0.6327886 8.085905e-05
608 23175 LPIN1 -1.0987236 1.704742e-02 -1.4486904 5.378831e-03
609 51594 NBAS 1.0570885 3.172130e-03 1.0400491 7.442351e-04
610 9741 LAPTM4A -0.4276444 9.273345e-03 -0.5209931 2.751332e-04
611 23369 PUM2 -0.8077769 1.395178e-03 -0.8828535 1.338400e-02
612 388 RHOB -0.4902705 7.362897e-03 -0.4944563 1.115636e-02
613 2281 FKBP1B 1.8587152 3.699570e-04 1.5071386 4.030367e-03
614 79172 CENPO 2.6346988 1.997567e-03 2.5050997 9.091497e-03
615 150946 GAREM2 2.2269391 1.410312e-02 2.5053629 2.933181e-03
616 64838 FNDC4 0.7282151 1.101089e-03 0.9049124 2.490206e-05
617 23160 WDR43 1.2714116 2.002280e-03 1.6945405 5.532833e-07
618 57448 BIRC6 1.3074670 2.605890e-03 1.7006418 4.685400e-05
619 4052 LTBP1 -0.9280523 4.631957e-02 -1.0822135 4.577571e-03
620 5610 EIF2AK2 1.3201542 2.865812e-05 1.3663565 6.162688e-06
621 130589 GALM 1.0114772 4.590935e-02 1.2592887 3.058976e-03
622 9581 PREPL 1.0783194 1.875154e-04 1.1955425 5.858133e-06
623 618 BCYRN1 0.9002005 9.506296e-09 0.8671163 1.688549e-06
624 6711 SPTBN1 0.4873272 1.535356e-03 0.4310155 1.241425e-02
625 6233 RPS27A -0.5685306 1.426542e-05 -0.3217539 2.004684e-02
626 2202 EFEMP1 -1.8673761 5.632408e-21 -1.3846348 8.727071e-15
627 53335 BCL11A -3.1478672 1.719544e-02 -3.9258961 3.136373e-03
628 100132215 <NA> 1.1237271 3.231566e-04 0.9652739 1.765376e-03
629 4190 MDH1 -0.8992681 9.385312e-05 -0.9554870 1.642206e-05
630 5861 RAB1A -0.6911741 4.231081e-05 -0.4161447 4.929642e-02
631 200734 SPRED2 -2.1771695 7.274667e-17 -2.3144806 9.369923e-11
632 5093 PCBP1 -0.8339433 1.669351e-07 -1.0072698 8.973847e-09
633 51449 PCYOX1 -0.6178456 9.297444e-03 -0.4927827 3.314734e-02
634 6637 SNRPG -0.7202623 3.978501e-04 -0.4936487 1.798174e-02
635 6697 SPR 6.3043835 2.616049e-02 7.3050653 5.168280e-04
636 94097 SFXN5 0.9450706 2.317729e-09 0.8784552 1.162711e-06
637 3099 HK2 -4.5134193 3.385477e-04 -2.6657547 4.626470e-07
638 9168 TMSB10 -0.5736203 7.823343e-09 -0.4355572 9.581289e-06
639 83439 TCF7L1 -2.2282879 2.068168e-07 -1.0079873 1.235070e-02
640 55818 KDM3A -2.4185131 1.269525e-23 -1.9326630 6.312661e-13
641 56910 STARD7 -1.1795632 1.458482e-07 -1.0762310 2.199631e-05
642 51239 ANKRD39 0.9589030 1.627096e-03 0.9555986 1.768028e-02
643 25972 UNC50 -1.5028819 2.830296e-03 -1.1770171 1.700158e-03
644 9669 EIF5B -1.0579362 2.960876e-09 -1.1704707 1.652664e-13
645 6160 RPL31 -1.0404040 2.146221e-19 -0.7049568 6.596252e-09
646 9448 MAP4K4 0.4832022 7.805133e-07 0.4274676 2.330796e-05
647 100506421 PANTR1 0.9229483 1.773272e-11 0.6850591 1.817861e-05
648 102682016 LINC01159 2.0497373 2.530975e-12 1.0275224 1.398310e-02
649 653489 RGPD3 2.0394914 2.545323e-03 1.9816520 5.670454e-03
650 100288695 LIMS4 -1.3865581 1.818117e-03 -0.9851257 2.064174e-02
651 1622 DBI 0.5536426 3.514880e-05 0.6702063 1.250429e-07
652 5899 RALB 1.0444103 4.665916e-06 1.0003916 3.543981e-05
653 56886 UGGT1 0.6895074 2.846024e-03 0.6133531 2.004684e-02
654 9394 HS6ST1 -1.3221679 1.377281e-12 -0.8731861 2.095159e-07
655 80097 MZT2B 0.9371221 2.801397e-08 0.8164168 8.323667e-08
656 100216479 <NA> 3.3341524 2.877854e-04 2.5693812 4.732672e-02
657 653784 MZT2A 1.0645548 6.488380e-05 0.7527903 2.523920e-02
658 23190 UBXN4 -0.8506191 4.585101e-08 -0.5523627 2.135634e-03
659 390 RND3 0.6240307 5.017165e-05 0.5629198 2.599160e-03
660 375287 RBM43 1.4135384 1.372155e-03 1.4670153 2.579034e-04
661 10254 STAM2 -0.7627544 4.571436e-02 -0.9253563 2.626900e-02
662 4929 NR4A2 -2.4191977 3.070374e-03 -3.0328624 2.034881e-02
663 728066 <NA> -1.4580202 5.873088e-06 -0.8553140 1.162056e-02
664 90 ACVR1 -1.4143322 1.029848e-02 -2.3034422 2.927626e-03
665 85461 TANC1 -1.2011594 2.309556e-06 -1.0267857 1.313677e-04
666 5937 RBMS1 -1.4408726 7.509361e-10 -2.0522384 1.580311e-13
667 5163 PDK1 -2.3289650 3.525734e-04 -1.9930010 1.604289e-02
668 1123 CHN1 0.7179388 6.412381e-04 0.8102291 7.179717e-04
669 518 ATP5MC3 -0.6512415 9.283356e-06 -0.4087624 1.168162e-02
670 10651 MTX2 -1.7298221 5.885057e-05 -1.4966179 2.707084e-03
671 10787 NCKAP1 -0.7908878 1.981423e-03 -1.0718763 3.330677e-08
672 1290 COL5A2 -1.0082829 1.426542e-05 -0.8442413 1.724989e-02
673 57181 SLC39A10 1.0657628 5.129329e-04 1.3850089 1.575471e-07
674 3336 HSPE1 -0.8989412 6.940125e-06 -0.7717259 8.062168e-04
675 8324 FZD7 -2.4628538 1.355483e-03 -1.7968246 4.096832e-03
676 7341 SUMO1 -1.0486226 8.494272e-07 -1.1280136 3.141158e-07
677 8828 NRP2 -0.3111674 2.653930e-02 -0.3753242 3.756314e-03
678 57683 ZDBF2 1.7742951 1.067700e-03 1.7175867 7.228121e-03
679 3417 IDH1 -0.9360679 4.259466e-05 -0.5796108 1.995971e-02
680 4133 MAP2 0.9217919 1.463112e-17 0.8554260 8.747995e-16
681 2335 FN1 -1.0414844 1.863797e-06 -0.5017425 7.137736e-03
682 3488 IGFBP5 -1.3041410 4.974055e-39 -1.1204189 6.556344e-19
683 27013 CNPPD1 1.0722193 3.285990e-06 1.0809768 2.572886e-05
684 10290 SPEG 1.1632199 3.113965e-03 1.1482104 1.893859e-02
685 79586 CHPF 0.5053566 1.080166e-02 0.5071932 1.645624e-02
686 6508 SLC4A3 1.0881830 5.205922e-03 0.9881034 2.703164e-02
687 7857 SCG2 -1.0545084 1.495772e-19 -0.8456456 1.752878e-16
688 81618 ITM2C 1.5341829 1.007894e-05 1.1343081 2.469452e-03
689 26058 GIGYF2 1.1186886 5.326370e-06 1.3335160 4.572632e-10
690 150678 COPS9 0.4398101 8.582452e-04 0.3808745 9.947854e-03
691 547 KIF1A 0.3862738 1.492197e-02 0.4182695 8.618599e-03
692 3069 HDLBP 0.5787054 1.318350e-03 0.4509784 5.380893e-03
693 2280 FKBP1A 0.6321454 2.398389e-04 0.7647272 9.299289e-07
694 55968 NSFL1C 0.7124404 5.639142e-03 0.6688523 1.289891e-02
695 65992 DDRGK1 0.7130558 4.259487e-02 0.9468888 1.581896e-02
696 8455 ATRN -0.8599651 1.733850e-03 -0.7983844 8.100894e-03
697 1059 CENPB 0.8905302 1.348676e-04 0.9085005 2.878473e-04
698 57506 MAVS 1.0247849 1.606832e-05 0.9371398 1.244129e-04
699 9770 RASSF2 0.9046947 9.744347e-03 0.8060801 2.817916e-02
700 92675 DTD1 0.5937663 7.442801e-03 0.5958019 4.935101e-03
701 3642 INSM1 -2.1627318 1.634353e-08 -1.7988030 7.958528e-05
702 1471 CST3 1.2574595 1.228132e-43 1.3989904 1.881513e-43
703 1473 CST5 3.4807533 2.130948e-02 4.4776118 1.137283e-04
704 57136 APMAP -0.4687479 3.452141e-03 -0.5532608 6.636269e-04
705 81502 HM13 0.6103657 4.926889e-02 0.7430691 7.799154e-03
706 6640 SNTA1 0.8609711 4.901495e-05 0.7187834 1.441268e-03
707 83737 ITCH 1.5383474 1.831554e-03 1.7961362 6.301319e-05
708 26133 TRPC4AP 0.6034704 2.640019e-02 0.6360617 2.894149e-02
709 8904 CPNE1 -0.7261921 3.963440e-03 -0.6508457 2.433891e-02
710 140679 SLC32A1 -6.9614078 1.665998e-03 -6.9633237 2.377326e-03
711 7150 TOP1 -0.4334168 2.734083e-02 -0.5474378 1.053712e-04
712 5335 PLCG1 0.9397782 1.294045e-03 0.8981406 1.967691e-03
713 6385 SDC4 1.6033788 1.919486e-03 1.6082534 2.882438e-03
714 51604 PIGT 0.6016027 3.172130e-03 0.6626024 1.048363e-03
715 441951 ZFAS1 -0.4844473 1.465428e-03 -0.5151909 2.065086e-03
716 56937 PMEPA1 -1.1234135 3.486397e-10 -1.1428644 5.947594e-15
717 2778 GNAS -1.1274375 7.936376e-35 -1.0341184 1.907468e-32
718 3911 LAMA5 -0.7958419 1.308276e-03 -0.5909412 3.441671e-02
719 3785 KCNQ2 -1.5208703 2.206510e-07 -2.3512731 1.761040e-10
720 79144 PPDPF -1.0589037 1.557186e-26 -1.1102100 6.796359e-18
721 102724594 U2AF1L5 -0.6142693 2.484599e-02 -1.0716140 5.729579e-06
722 8204 NRIP1 1.8390072 2.593748e-18 1.6222269 1.053896e-11
723 58494 JAM2 -0.8511409 2.458429e-03 -0.7355560 1.485775e-02
724 522 ATP5PF -0.8419146 4.664132e-11 -0.7679662 1.761040e-10
725 6647 SOD1 -0.6465754 9.934063e-06 -0.4027966 8.074615e-03
726 10215 OLIG2 1.4931531 8.338989e-04 1.6938804 3.444987e-04
727 6651 SON -0.7252499 3.708503e-07 -0.5982682 1.977253e-04
728 64968 MRPS6 -0.5600060 7.309418e-03 -0.7456760 8.192199e-05
729 51227 PIGP -1.0151924 6.434849e-05 -1.4169807 8.093641e-04
730 7485 GET1 -0.8782413 5.952885e-04 -0.9844376 3.070395e-03
731 4599 MX1 6.3558573 1.362144e-03 4.2851884 1.592019e-03
732 7307 U2AF1 -0.6778997 1.629854e-03 -0.7079508 1.866647e-03
733 56894 AGPAT3 0.4704983 4.182571e-02 0.4434549 3.450608e-02
734 754 PTTG1IP -0.8988419 1.572866e-09 -0.4989243 3.589519e-05
735 23275 POFUT2 -0.6750628 2.798413e-02 -0.6003035 3.970582e-02
736 3275 PRMT2 0.8618709 6.200504e-14 0.8946230 8.932975e-15
737 7122 CLDN5 8.3883777 1.673883e-07 8.0931000 3.435749e-06
738 84861 KLHL22 1.5055838 2.092838e-04 1.4678917 2.909649e-03
739 24144 TFIP11 0.9653725 2.788975e-02 1.2828603 9.860279e-04
740 84133 ZNRF3 0.9608432 2.313716e-02 0.9603653 3.300728e-02
741 25807 RHBDD3 1.1328601 3.180055e-02 1.1706749 2.703164e-02
742 8508 NIPSNAP1 1.7853732 3.888430e-15 1.7820268 1.803443e-11
743 253143 PRR14L 1.2457609 1.834090e-05 1.1781720 1.482524e-04
744 80830 APOL6 1.4413256 1.671602e-02 1.4310562 2.378136e-02
745 80832 APOL4 2.5210905 4.031680e-10 2.0696845 7.062728e-05
746 25828 TXN2 0.8354706 1.166943e-03 1.1201771 4.557875e-06
747 11078 TRIOBP -0.7775169 1.123170e-04 -0.7080126 3.620766e-03
748 3005 H1-0 1.0858638 9.104073e-05 1.3330747 7.405348e-08
749 10521 DDX17 -0.4657370 7.322971e-04 -0.3207491 2.887454e-02
750 23492 CBX7 -1.5490055 2.001006e-03 -1.9909370 6.265631e-03
751 23112 TNRC6B 0.6110730 1.797362e-04 0.5108770 1.789964e-03
752 158 ADSL -0.9459539 5.056202e-03 -0.8877531 1.911147e-02
753 9978 RBX1 -0.7025602 6.283363e-05 -0.6047769 1.734487e-03
754 27351 DESI1 0.9162164 3.548512e-02 1.0545973 1.730020e-02
755 706 TSPO 0.5150853 3.708176e-04 0.7888045 1.457786e-10
756 25814 ATXN10 -0.8446038 7.293622e-05 -0.7235980 3.696941e-04
757 25817 TAFA5 -1.3326552 2.726045e-03 -0.8881709 4.675505e-02
758 10752 CHL1 -0.4827870 8.236944e-03 -0.5881262 1.121250e-02
759 285362 SUMF1 -1.1779362 3.250033e-04 -1.0124457 2.983479e-03
760 8536 CAMK1 1.2315697 3.066155e-02 1.7299232 4.125938e-04
761 10093 ARPC4 1.0425886 1.572107e-07 0.8647963 1.343671e-04
762 7428 VHL 1.0147178 1.257900e-07 0.7398724 1.863685e-03
763 6396 SEC13 -0.5189447 3.986739e-02 -0.7715083 2.209743e-03
764 9686 VGLL4 0.7273346 3.351188e-02 0.7202849 2.612461e-02
765 6161 RPL32 -0.9977789 9.639138e-19 -0.7711331 4.635884e-12
766 2199 FBLN2 -0.7498440 4.371132e-04 -1.5063973 8.365366e-10
767 79750 ZNF385D 0.6772722 2.654633e-02 0.9190135 3.640681e-04
768 7325 UBE2E2 -1.2106877 1.038667e-02 -1.4987755 2.659635e-03
769 6138 RPL15 -0.7647532 3.373498e-18 -0.8472316 4.347742e-23
770 7048 TGFBR2 -2.6158518 1.354956e-02 -1.8877619 1.626682e-02
771 9045 RPL14 -1.0991655 3.060151e-12 -0.9295706 5.143351e-12
772 55129 ANO10 1.2277481 6.743602e-10 0.6732278 1.223579e-02
773 4134 MAP4 0.5676463 2.457925e-06 0.4497198 4.236870e-04
774 64925 CCDC71 1.2623676 1.081510e-02 1.4606370 4.125938e-04
775 2771 GNAI2 0.4000372 3.721473e-04 0.4367197 9.453246e-04
776 132160 PPM1M 1.3847062 1.284946e-02 1.3472098 2.064174e-02
777 378 ARF4 -0.6787331 4.854183e-04 -1.0599049 1.737575e-06
778 5162 PDHB -0.8998770 4.931384e-04 -0.7050772 1.005182e-02
779 11170 FAM107A 0.9019539 3.595037e-13 0.9156521 2.612074e-11
780 132204 SYNPR -4.5714795 1.342440e-04 -3.1543564 4.305321e-03
781 9861 PSMD6 -1.2462613 2.673589e-05 -1.3719776 1.298088e-03
782 166336 PRICKLE2 -1.2918039 4.676828e-04 -1.5444432 2.659635e-03
783 727936 GXYLT2 2.3185270 2.407880e-03 2.3473233 8.451631e-04
784 285237 C3orf38 -1.1868078 2.630981e-02 -1.6640196 1.964804e-03
785 131544 CRYBG3 1.6878201 2.613220e-02 1.7089412 4.547170e-02
786 55076 TMEM45A -6.3544942 2.237875e-03 -4.0427023 4.576852e-02
787 29114 TAGLN3 -2.0269659 3.682592e-03 -2.4059202 1.464662e-07
788 151887 CCDC80 0.8069456 2.122272e-15 0.7595701 3.271995e-14
789 25871 NEPRO 0.7898265 3.515523e-02 0.8704867 1.744985e-02
790 10063 COX17 -1.0122122 1.229871e-06 -0.9457776 2.720699e-06
791 4710 NDUFB4 0.4495966 7.309418e-03 0.4128587 1.443009e-02
792 2804 GOLGB1 0.5022046 7.909733e-03 0.4755504 9.953376e-03
793 26355 FAM162A -1.6172471 3.813423e-18 -1.3451385 1.041823e-12
794 54625 PARP14 1.2464407 3.350094e-04 1.0046250 2.974436e-02
795 54437 SEMA5B -0.5775444 4.530561e-02 -1.3440046 1.860633e-03
796 10954 PDIA5 -0.7754740 4.570312e-02 -0.7258743 2.742697e-02
797 57493 HEG1 -1.0557142 3.478100e-08 -0.6742118 1.076310e-02
798 84303 CHCHD6 1.6919593 7.496738e-05 1.3962226 4.434165e-03
799 11343 MGLL 1.1144299 9.215220e-17 1.0100009 1.558741e-07
800 29927 SEC61A1 0.4791172 1.790711e-03 0.3892516 2.795976e-02
801 8607 RUVBL1 1.0489119 2.763334e-03 0.9160656 2.363942e-02
802 8971 H1-10 1.4063725 2.340612e-18 1.3063005 1.126179e-14
803 6259 RYK -2.0211616 7.118626e-14 -1.4405850 1.545863e-06
804 22808 MRAS 0.7019507 1.266008e-02 0.8127516 1.315527e-02
805 92370 PXYLP1 -0.9637595 6.215956e-04 -1.1259169 2.790936e-05
806 9616 RNF7 -1.2038336 1.261723e-06 -1.2897244 6.862628e-09
807 483 ATP1B3 -0.6341125 6.438534e-03 -0.8346410 3.796594e-04
808 9435 CHST2 -1.4414572 4.268293e-16 -1.1660266 6.552169e-12
809 205428 DIPK2A -0.9895666 2.078672e-03 -1.2635912 3.914614e-05
810 5352 PLOD2 -1.1564791 8.469171e-06 -1.0093895 7.767172e-05
811 4071 TM4SF1 -1.0480331 6.563097e-10 -1.1388825 7.489678e-09
812 51714 SELENOT -0.8988647 1.330311e-03 -0.7237756 1.255979e-02
813 6747 SSR3 -0.5296982 1.839420e-05 -0.4132969 3.093032e-02
814 25976 TIPARP 1.2298068 1.874552e-05 0.9784203 3.242270e-03
815 647033 <NA> 1.4506093 9.219084e-05 1.8080614 3.645026e-06
816 5806 PTX3 -2.4429172 1.761816e-09 -1.8866608 2.550278e-05
817 101243545 LINC02067 -1.2758056 6.856263e-05 -1.2680884 9.724454e-04
818 7095 SEC62 -0.5057600 3.652376e-04 -0.6414447 3.540592e-06
819 64778 FNDC3B -0.7124311 8.757998e-04 -0.7662147 1.237268e-04
820 64393 ZMAT3 0.5898881 3.161822e-04 0.7586235 9.426139e-08
821 59345 GNB4 0.5375369 1.846323e-02 0.4834116 2.634587e-02
822 4711 NDUFB5 -0.6678206 7.309418e-03 -1.0444914 9.929970e-07
823 5708 PSMD2 0.8175908 6.570138e-06 0.9086990 1.218329e-06
824 1981 EIF4G1 0.6148957 1.149979e-03 0.6750565 6.235094e-04
825 23355 VPS8 0.9302267 1.671602e-02 1.4890532 4.486472e-05
826 10644 IGF2BP2 -1.8910339 2.716598e-13 -1.0584528 1.101850e-05
827 2119 ETV5 0.6231281 5.147271e-06 0.4834801 7.078013e-03
828 1427 CRYGS 1.0250111 6.286110e-04 1.0003041 7.732515e-03
829 1974 EIF4A2 -0.5422310 1.979869e-03 -0.7003313 1.027394e-03
830 3280 HES1 1.3067640 5.177006e-17 1.0026634 1.165196e-14
831 152002 XXYLT1 0.6107124 2.726715e-02 0.7424757 2.917558e-03
832 5504 PPP1R2 -0.8542790 1.198774e-02 -1.3598579 2.999403e-04
833 7037 TFRC -1.8902219 1.051211e-10 -1.3824688 7.618815e-06
834 22916 NCBP2 0.4690908 3.574626e-02 0.5596570 2.567591e-02
835 6165 RPL35A -0.9143664 1.463252e-16 -0.9048525 7.518873e-17
836 521 ATP5ME -0.3755903 4.960564e-02 -0.6288114 1.109825e-03
837 2580 GAK 0.7949277 3.912914e-03 0.8002064 3.260131e-03
838 10460 TACC3 2.0448673 3.311675e-08 1.3201499 1.334292e-02
839 677770 SCARNA22 3.5640783 4.500075e-24 3.5273401 9.813043e-20
840 401115 C4orf48 1.4948861 3.255711e-10 0.9191376 5.660188e-03
841 339983 NAT8L 1.1542053 2.673589e-05 0.9319789 4.935101e-03
842 10608 MXD4 1.1572425 6.551740e-18 0.7724441 3.540592e-06
843 118 ADD1 0.4879196 5.157894e-04 0.4971619 3.656670e-05
844 6002 RGS12 1.2826448 2.112503e-04 1.4270219 3.773619e-05
845 85013 TMEM128 -1.1757276 2.173370e-02 -1.1556747 3.313285e-02
846 114932 MRFAP1L1 1.0002344 3.512925e-08 0.6430647 8.824011e-03
847 259282 BOD1L1 -0.4510582 1.266008e-02 -0.5817596 1.280140e-03
848 5860 QDPR -0.6227368 1.189567e-03 -0.4796809 2.649954e-02
849 57620 STIM2 0.4937752 1.150648e-02 0.3581694 2.972976e-02
850 5099 PCDH7 -1.1263769 9.919625e-03 -1.2945977 1.285023e-03
851 55728 N4BP2 1.6450103 1.143343e-03 1.4412843 3.562897e-03
852 65997 RASL11B -6.6651138 1.125966e-02 -5.7044272 3.639798e-02
853 5156 PDGFRA -1.7558863 1.515392e-17 -1.8639525 2.069884e-30
854 3490 IGFBP7 0.6820844 4.251649e-03 1.0385101 4.750404e-07
855 258 AMBN -6.1985571 1.220498e-04 -4.1219349 2.647842e-03
856 25849 PARM1 -0.4986369 1.909574e-06 -1.0396695 1.014559e-17
857 950 SCARB2 -0.3059094 1.250141e-02 -0.3697860 2.749261e-02
858 10983 CCNI -0.6816002 6.122848e-08 -0.6780022 1.665411e-09
859 65008 MRPL1 0.8607050 8.027712e-03 0.8818691 3.535904e-03
860 9987 HNRNPDL -0.3992914 1.069576e-02 -0.6819008 1.255247e-05
861 79966 SCD5 -0.6425003 1.621696e-05 -0.3401131 1.057945e-02
862 6696 SPP1 0.7750330 9.473182e-05 0.6493998 1.390013e-02
863 10611 PDLIM5 -0.7791109 3.303880e-05 -0.8104113 2.829357e-05
864 8633 UNC5C -1.2619957 1.437038e-02 -1.1217370 3.346579e-02
865 3015 H2AZ1 -0.4375541 4.262233e-02 -0.6286706 8.081783e-03
866 7323 UBE2D3 -0.5800032 3.291082e-02 -0.4983115 1.412559e-02
867 6164 RPL34 -1.2316059 2.718076e-31 -1.1214041 1.559515e-35
868 58505 OSTC -0.9127847 2.491635e-05 -1.1003852 6.222865e-07
869 79071 ELOVL6 1.0002636 2.293579e-02 1.3548378 1.253234e-03
870 287 ANK2 0.8508230 1.318390e-05 0.9854018 9.838779e-08
871 401152 C4orf3 -0.7399140 3.738033e-06 -0.6491520 4.171132e-05
872 10252 SPRY1 1.3496250 1.608686e-29 1.0878301 2.718616e-22
873 10424 PGRMC2 -0.7313297 2.492626e-03 -0.7653054 2.841173e-03
874 57575 PCDH10 -0.5576917 7.778962e-04 -0.8800318 7.517228e-08
875 55294 FBXW7 0.8304382 3.218092e-02 0.9279142 9.319937e-04
876 79884 MAP9 -0.7048196 2.155945e-02 -0.7641540 4.737882e-03
877 6307 MSMO1 -1.2232146 7.766704e-11 -0.5305763 9.201490e-04
878 91351 DDX60L 1.7888210 3.214107e-02 1.7988656 3.483148e-02
879 9848 MFAP3L -1.1368037 1.119360e-03 -1.3853712 1.935911e-03
880 11341 SCRG1 -0.6441951 3.408611e-02 -1.2278129 2.102751e-04
881 2180 ACSL1 -3.0422754 2.757001e-02 -6.1202059 3.440427e-04
882 291 SLC25A4 -1.0196267 1.774482e-03 -1.2727577 1.421572e-05
883 65980 BRD9 0.7319604 7.404146e-03 0.7007806 1.168245e-02
884 4726 NDUFS6 -0.4293533 2.798413e-02 -0.7182884 3.700270e-04
885 170690 ADAMTS16 2.1418325 1.181011e-05 2.2530015 1.613799e-05
886 23379 ICE1 1.1141457 2.527353e-03 1.2641374 3.386557e-04
887 10299 MARCHF6 -0.5055872 4.142033e-02 -0.5933650 8.625888e-03
888 1008 CDH10 -1.8310709 3.009173e-07 -1.3356292 2.062147e-06
889 6897 TARS1 0.5449755 7.651393e-03 0.5618440 2.483078e-02
890 114899 C1QTNF3 -1.8710080 8.201995e-06 -1.5951577 1.451104e-02
891 92255 LMBRD2 1.2907673 3.843427e-02 1.2612212 2.782013e-02
892 202151 RANBP3L 5.9947575 4.769557e-02 7.3259727 2.960946e-04
893 6507 SLC1A3 1.2261073 2.073054e-27 1.0474464 9.826939e-22
894 3977 LIFR 0.5075304 2.438437e-02 0.5055484 4.009305e-02
895 9180 OSMR -1.6806252 2.166379e-17 -1.3079736 1.404824e-08
896 3157 HMGCS1 -1.2977528 5.202469e-28 -0.4698210 5.720666e-04
897 5144 PDE4D -1.8255781 2.438437e-02 -1.7623041 1.744985e-02
898 3796 KIF2A 0.7588020 1.641977e-02 0.6608915 2.634601e-02
899 285671 RNF180 1.1000820 2.106799e-05 1.1443162 7.176229e-06
900 285672 SREK1IP1 -1.2487584 7.253432e-08 -0.8534174 3.636552e-03
901 11039 <NA> 2.9008860 4.571436e-02 2.6864421 1.835619e-02
902 3842 TNPO1 1.0534232 1.098834e-08 1.1684308 3.641483e-11
903 689 BTF3 -0.6640619 1.440408e-04 -0.6391783 1.323864e-03
904 3156 HMGCR -1.0292318 1.317987e-08 -0.7945030 3.292241e-05
905 10087 CERT1 1.2562065 2.461916e-08 0.5547309 4.091248e-02
906 51426 POLK 0.9117751 3.534386e-02 0.9887011 2.568562e-02
907 6902 TBCA -0.5198963 8.391923e-05 -0.4901010 1.117374e-04
908 105379045 <NA> 5.5359017 7.264987e-05 4.8129384 2.490820e-03
909 256987 SERINC5 -0.8856079 2.007828e-09 -0.7677267 4.814394e-06
910 100462981 MTRNR2L12 2.3728233 4.412485e-121 2.0821714 9.216426e-90
911 5924 RASGRF2 0.6281567 1.306408e-02 0.8531180 7.074303e-04
912 6228 RPS23 -0.7586035 1.158385e-14 -0.4561300 2.072916e-05
913 1462 VCAN 2.1385062 2.385483e-34 2.0203203 4.347742e-23
914 9652 TTC37 0.8667440 2.934680e-04 0.7973857 3.535904e-03
915 285704 RGMB -2.2793041 2.506751e-02 -1.5081480 2.450929e-02
916 5066 PAM -0.5339104 4.312686e-03 -0.6884944 6.150246e-04
917 90355 MACIR -1.2077593 3.333911e-02 -1.6540499 1.093099e-03
918 2241 FER 1.8287641 1.670853e-04 1.9395679 4.256741e-06
919 4124 MAN2A1 -1.4805865 1.685329e-04 -1.2347478 1.275351e-02
920 324 APC 1.2938950 1.246320e-19 1.1667567 8.551660e-16
921 7905 REEP5 -0.8599144 7.253432e-08 -0.4905003 5.003620e-03
922 9140 ATG12 0.6628566 2.882654e-02 0.7136343 1.659067e-02
923 57556 SEMA6A -0.8584427 1.507903e-14 -0.8119492 3.459618e-14
924 153443 SRFBP1 1.7492238 7.651393e-03 1.5027332 8.100894e-03
925 4015 LOX -3.4492726 1.534331e-02 -5.5702533 2.751332e-04
926 4001 LMNB1 1.0735518 3.918699e-02 1.2470807 1.052093e-02
927 3094 HINT1 -0.9597675 1.443601e-13 -0.8270266 4.886536e-11
928 56951 C5orf15 -1.2436538 6.155303e-09 -1.0393249 2.422391e-07
929 6500 SKP1 -0.7388214 6.672718e-10 -0.6068449 2.981052e-04
930 23338 JADE2 1.6415751 3.538368e-03 1.5306703 2.562736e-02
931 9879 DDX46 -1.3232377 1.228772e-09 -1.3897567 5.601777e-10
932 6695 SPOCK1 -0.3992412 1.909529e-02 -0.9485331 3.482655e-09
933 51308 REEP2 0.5177892 1.398287e-02 0.8098869 2.218699e-05
934 1495 CTNNA1 -0.3223623 4.384920e-02 -0.3620190 5.612742e-03
935 5813 PURA -0.4739584 2.495881e-02 -0.8561705 9.168914e-06
936 56139 PCDHA10 1.6594768 1.243936e-02 2.0103726 4.414930e-04
937 1729 DIAPH1 1.0095936 1.129233e-02 0.9517830 7.517506e-03
938 9812 DELE1 0.9966876 3.618391e-03 0.9875318 2.873087e-03
939 10007 GNPDA1 0.7444086 4.772613e-06 0.8028246 3.387729e-07
940 81555 YIPF5 -0.7107069 3.262287e-02 -0.6276118 2.276521e-02
941 1836 SLC26A2 -0.7002361 3.667461e-02 -0.7535285 3.819847e-02
942 6949 TCOF1 -1.3559200 9.919625e-03 -1.1530379 9.727384e-03
943 972 CD74 2.6668660 2.020915e-19 1.8788221 6.903108e-07
944 309 ANXA6 1.1994955 8.360836e-16 0.6720061 1.064444e-04
945 2760 GM2A 0.9908944 1.062736e-07 0.6623566 3.097188e-03
946 57451 TENM2 -1.5403147 1.463252e-16 -1.2374595 2.430985e-13
947 79646 PANK3 1.3983193 6.510940e-03 1.3158478 1.827212e-02
948 4869 NPM1 -0.6629394 3.120819e-02 -0.8830174 1.857708e-04
949 91272 BOD1 -0.9615587 3.273182e-03 -0.9526690 4.429697e-02
950 1212 CLTB 0.7480007 8.434080e-03 0.7894512 6.304220e-03
951 64324 NSD1 1.7693606 1.346075e-12 1.5941898 4.279366e-09
952 80758 PRR7 0.5590812 2.596234e-02 0.5954623 2.232803e-02
953 91522 COL23A1 1.5331617 1.003958e-04 1.1047430 8.405361e-03
954 821 CANX -0.4401075 8.078890e-05 -0.2923362 8.504777e-03
955 8878 SQSTM1 0.3269261 6.827497e-03 0.2845370 2.733297e-02
956 55819 RNF130 -1.0273074 5.037306e-05 -1.1695436 4.841817e-05
957 10399 RACK1 -0.5853888 9.380366e-07 -0.3534830 5.979495e-03
958 7280 TUBB2A -0.6523625 6.820400e-10 -0.4223057 2.536242e-02
959 347733 TUBB2B -0.4068452 3.092731e-05 -0.3121213 2.065086e-03
960 221749 PXDC1 0.9963329 1.487422e-03 1.0337919 1.924487e-04
961 8899 PRPF4B -0.6382914 6.066757e-04 -0.6727835 2.568866e-03
962 54898 ELOVL2 0.8309062 3.086342e-12 0.6013948 1.990421e-05
963 10048 RANBP9 -0.8719225 1.763338e-02 -0.9313987 8.115302e-03
964 10486 CAP2 -1.2199630 2.316106e-03 -0.9460051 2.655741e-02
965 3400 ID4 -1.1729122 3.536546e-05 -1.4701369 4.163988e-08
966 55856 ACOT13 -1.0767539 3.581976e-03 -1.2781208 1.201889e-04
967 9750 RIPOR2 -4.3828824 7.814646e-03 -4.8433891 4.851746e-03
968 55604 CARMIL1 1.4839269 3.405275e-03 1.8063191 8.938578e-04
969 10590 SCGN -2.3919563 1.044409e-05 -3.9601061 4.182359e-23
970 8364 H4C3 0.9451051 1.366833e-05 0.7174858 2.036132e-03
971 493812 HCG11 4.7796185 2.029789e-03 4.3485079 3.707406e-02
972 3137 <NA> 1.3140214 8.496514e-09 1.3031711 1.009809e-07
973 3107 HLA-C 1.1193240 2.938337e-19 1.0818260 4.847682e-15
974 3106 HLA-B 1.1287090 1.325624e-06 1.2305854 8.705199e-08
975 534 ATP6V1G2 1.8892072 1.705161e-02 1.9257573 2.463332e-02
976 4758 NEU1 0.9330691 8.174253e-03 1.4729430 1.928330e-04
977 7922 SLC39A7 1.1109136 5.258606e-04 0.8742493 1.166589e-02
978 6222 RPS18 -0.8177342 4.819272e-03 -0.8081587 9.380303e-03
979 6892 TAPBP 0.6831594 3.319996e-03 0.5612667 1.213298e-02
980 221491 SMIM29 0.9451797 9.219084e-05 1.2516034 5.325344e-06
981 1026 CDKN1A 0.3671832 2.120348e-04 0.5293086 4.230156e-08
982 57699 CPNE5 1.7044231 2.456650e-43 1.4739600 2.887406e-20
983 9025 RNF8 1.1573508 1.384884e-03 1.3092432 2.102751e-04
984 2739 GLO1 0.6264107 1.973620e-03 0.7763592 6.301319e-05
985 6722 SRF -0.8589408 2.513043e-02 -0.7375109 1.937077e-02
986 7422 VEGFA -3.5771151 8.006230e-39 -1.8740998 7.189818e-14
987 55362 TMEM63B 0.9507098 9.349905e-03 1.1685571 1.792530e-05
988 9697 TRAM2 -1.3151451 3.507218e-10 -1.0203589 2.081117e-06
989 730101 <NA> -0.8255339 3.223422e-02 -1.5221937 1.105712e-05
990 2941 GSTA4 -0.6254280 2.752608e-03 -0.5224627 2.732302e-02
991 667 DST 1.0260073 8.346718e-11 1.1947347 7.062728e-05
992 577 ADGRB3 1.1970290 1.941937e-03 0.9884202 4.436115e-02
993 79627 OGFRL1 1.1446520 1.880664e-08 0.4622340 4.657382e-02
994 79940 LINC00472 3.0193372 1.401517e-08 2.9805289 1.577472e-08
995 1915 EEF1A1 -0.5659628 9.077925e-07 -0.4132856 5.424443e-04
996 55754 TMEM30A 1.4721523 3.562862e-02 2.1280078 3.197776e-05
997 55023 PHIP -0.8736034 2.098786e-03 -1.0001512 7.837069e-04
998 387066 <NA> -1.1806565 1.434827e-09 -0.7796893 6.761550e-05
999 26799 <NA> 4.2969273 5.619315e-15 3.1919402 8.062652e-05
1000 1268 CNR1 0.8407997 2.962184e-03 0.8385144 2.666680e-03
1001 10690 FUT9 1.6137422 2.910943e-10 1.0974774 3.088599e-04
1002 25957 PNISR -0.8351896 4.188804e-07 -0.7329497 1.859918e-06
1003 892 CCNC -1.3283579 6.107508e-03 -1.0828915 2.086549e-02
1004 10973 ASCC3 0.9740322 1.398450e-02 1.3374888 2.371890e-04
1005 100133941 CD24 -4.3815306 1.404673e-02 -5.6309490 5.191700e-03
1006 55084 SOBP -0.4245339 9.760040e-03 -0.6266803 2.779028e-04
1007 2309 FOXO3 0.7411300 1.225323e-02 0.7568960 9.478544e-03
1008 8763 CD164 -0.6601841 4.613712e-05 -0.5391174 2.143089e-03
1009 10758 TRAF3IP2 0.6459487 1.929006e-02 0.7564423 9.455946e-03
1010 2534 FYN -0.3430576 1.472462e-02 -0.4551027 2.967679e-03
1011 3910 LAMA4 1.2757771 6.167079e-05 1.4702063 2.159632e-06
1012 7259 TSPYL1 -0.6590721 1.554525e-02 -0.6814849 7.732515e-03
1013 57515 SERINC1 -0.5948738 2.187020e-03 -0.9072815 1.819267e-06
1014 2173 FABP7 -1.0895523 1.468732e-18 -0.8173959 3.235664e-02
1015 51020 HDDC2 -0.6087856 3.339516e-02 -0.7685111 1.599050e-03
1016 135114 HINT3 0.6125591 4.324743e-02 0.7963661 5.016529e-03
1017 1490 CCN2 -3.4233347 9.244045e-07 -3.4623379 9.118969e-27
1018 6206 RPS12 -1.0102756 3.852799e-13 -0.6113954 6.954987e-05
1019 81706 PPP1R14C 1.2884750 1.861711e-02 1.6802229 7.939616e-04
1020 56995 TULP4 1.4635305 1.210761e-06 0.7874619 4.409724e-02
1021 3482 IGF2R -0.4982640 7.559460e-03 -0.4628997 2.823296e-02
1022 51660 MPC1 -0.6362673 2.034413e-06 -0.4037930 1.466118e-02
1023 6196 RPS6KA2 0.4482844 1.645518e-02 0.7026317 3.622400e-07
1024 5689 PSMB1 -1.4306699 1.709341e-14 -1.3353015 1.844748e-10
1025 60 ACTB 0.4316069 1.156729e-04 0.3813709 1.549594e-03
1026 6624 FSCN1 -1.0650741 3.295316e-21 -0.8177755 5.345990e-12
1027 79034 C7orf26 1.3754879 9.808167e-03 1.3930069 4.397246e-03
1028 4697 NDUFA4 -0.5565546 3.034047e-08 -0.4021756 2.647842e-03
1029 9771 RAPGEF5 1.6813472 1.588777e-07 1.1190181 1.639858e-02
1030 55975 KLHL7 -1.3929368 4.169786e-06 -1.1058372 1.027960e-03
1031 10643 IGF2BP3 0.8121885 7.308784e-04 1.1770296 1.648070e-09
1032 11335 CBX3 0.6725664 2.937034e-05 0.6021006 1.255247e-05
1033 9865 TRIL -0.5413231 2.373205e-06 -0.4316549 1.174174e-03
1034 23333 DPY19L1 -1.9756419 1.870823e-07 -1.3396201 1.441338e-05
1035 83930 STARD3NL -1.4000936 4.106381e-07 -1.3635678 1.394166e-08
1036 27072 VPS41 0.9637214 3.367563e-04 0.7366929 9.455946e-03
1037 5683 PSMA2 -1.2694849 4.083299e-09 -1.2379262 4.584934e-05
1038 23386 NUDCD3 1.1975808 1.083489e-05 1.0873010 3.773619e-05
1039 83605 CCM2 0.9187804 2.916465e-03 0.8723152 1.442882e-02
1040 3486 IGFBP3 -2.1268987 3.475055e-02 -3.3522683 5.434873e-06
1041 23480 SEC61G -1.2225534 2.300721e-02 -1.0217223 2.102751e-04
1042 1956 EGFR 1.2505734 3.807672e-04 1.4236782 8.811623e-05
1043 908 CCT6A -0.8025697 1.260260e-05 -0.5358095 7.769446e-03
1044 51142 CHCHD2 0.4914996 2.099724e-04 0.5238814 3.391164e-04
1045 285908 LINC00174 -2.6778128 3.247166e-02 -3.0969462 1.190762e-03
1046 55069 TMEM248 0.5109028 4.264221e-02 0.5584811 1.641871e-02
1047 51119 SBDS -0.9086152 2.861771e-03 -1.0980977 4.180930e-03
1048 2969 GTF2I 1.8741678 2.115792e-08 1.4704149 3.949890e-04
1049 2970 GTF2IP1 0.4957421 9.760040e-03 0.3458507 4.197736e-02
1050 5447 POR 1.2552945 5.719273e-06 0.8218520 1.600230e-02
1051 3315 HSPB1 -0.5108580 2.458787e-05 -0.4151774 1.012390e-03
1052 222194 RSBN1L -1.1127770 6.827497e-03 -1.2398893 1.855899e-03
1053 3082 HGF -6.1562404 3.626441e-02 -6.1579361 4.498105e-02
1054 5244 ABCB4 -6.1965700 3.675018e-02 -6.1991912 4.528461e-02
1055 6717 SRI -0.7268927 4.375343e-09 -0.6253537 3.047018e-07
1056 5218 CDK14 0.9575605 6.388307e-04 0.7238509 3.593873e-02
1057 54467 ANKIB1 0.9857906 5.437996e-05 0.6429197 2.703164e-02
1058 1021 CDK6 0.8255013 1.909068e-04 0.6914380 1.934690e-03
1059 1278 COL1A2 -1.7032506 3.730046e-35 -3.0662598 4.949363e-58
1060 8910 SGCE -0.9947101 4.297143e-03 -1.1717772 2.244372e-06
1061 7979 SEM1 -0.8872191 4.444586e-10 -0.6656241 3.769006e-05
1062 1749 DLX5 -2.4091798 3.538169e-05 -2.4808466 3.053985e-05
1063 10552 ARPC1A -1.5505765 1.132553e-06 -1.4014472 3.374089e-05
1064 9551 ATP5MF -0.9122261 1.046184e-12 -1.0013636 2.320850e-12
1065 441272 SPDYE3 3.2323583 2.483159e-06 2.3129106 1.878336e-02
1066 81628 TSC22D4 0.7218744 2.534931e-02 0.6623944 4.866324e-02
1067 100316904 SAP25 -6.5211249 7.075835e-03 -6.5232547 9.746457e-03
1068 7205 TRIP6 0.5184782 6.242458e-03 0.7052049 4.814394e-06
1069 5054 SERPINE1 -0.8147019 3.306630e-04 -0.7419385 6.179144e-06
1070 51024 FIS1 0.6621925 9.567496e-04 0.7320772 2.610772e-03
1071 5439 POLR2J -0.8340540 5.136801e-03 -0.6312595 4.167769e-02
1072 5701 PSMC2 -0.8227119 6.566488e-04 -0.8105875 2.164361e-04
1073 3912 LAMB1 -1.7129157 7.869335e-07 -1.6398376 3.792587e-07
1074 5803 PTPRZ1 0.8499531 8.857353e-16 0.7828030 2.986159e-13
1075 2861 GPR37 -1.0058424 1.062736e-07 -0.9841472 6.116840e-07
1076 29923 HILPDA -0.8644915 2.690730e-03 -1.3336372 3.192238e-06
1077 813 CALU -0.5642215 1.098449e-03 -0.6757290 1.711393e-05
1078 9296 ATP6V1F 0.5605802 1.204329e-03 0.4319463 2.040272e-02
1079 23534 TNPO3 0.5267186 3.753410e-03 0.4674936 8.772606e-03
1080 800 CALD1 -1.0604498 3.095809e-25 -0.9969709 1.525995e-19
1081 5764 PTN -0.5561775 1.263635e-05 -0.5236909 2.155123e-05
1082 9747 TCAF1 -0.6596205 1.331632e-02 -0.7793796 3.302720e-04
1083 26047 CNTNAP2 1.0529656 8.191008e-03 1.3018181 1.239605e-05
1084 9601 PDIA4 0.5400641 3.166494e-03 0.4304019 2.485455e-02
1085 155066 ATP6V0E2 0.8836044 1.188315e-09 0.7137228 1.087412e-03
1086 10922 FASTK 0.6739543 2.956378e-02 1.0148587 8.069758e-04
1087 6009 RHEB -0.6596723 7.255424e-04 -0.8501332 2.907693e-06
1088 58508 KMT2C 1.2837004 1.511755e-07 0.6270360 3.737328e-02
1089 3638 INSIG1 -1.5311896 1.530070e-09 -1.2334013 5.062690e-05
1090 9690 UBE3C 0.7247088 1.094544e-02 1.1348315 9.544714e-06
1091 55326 AGPAT5 0.6809654 1.034671e-02 0.6855259 1.045075e-02
1092 9258 MFHAS1 1.8839473 1.540980e-04 1.8457996 2.305208e-03
1093 2222 FDFT1 -0.9574911 6.468122e-07 -0.4416615 2.561598e-02
1094 7991 TUSC3 -0.6248532 1.410312e-02 -0.8541539 1.322641e-02
1095 51201 ZDHHC2 -1.1095686 1.298308e-02 -1.3326518 3.590577e-02
1096 4023 LPL -0.8077300 2.695365e-07 -1.7464661 1.149501e-25
1097 4747 NEFL -1.5177214 2.056881e-19 -1.5656654 1.525995e-19
1098 665 BNIP3L -1.1564470 3.336063e-11 -0.9224700 4.196975e-13
1099 1808 DPYSL2 0.6517512 6.182593e-05 0.6439877 8.411273e-07
1100 148 ADRA1A 1.1247519 1.180486e-09 1.0022627 3.841822e-07
1101 1191 CLU 0.4500957 2.038659e-05 0.3534327 2.737931e-03
1102 51435 SCARA3 1.0436263 7.111232e-03 0.9383369 2.483078e-02
1103 5368 PNOC -2.4193744 5.896725e-06 -3.1203224 7.834159e-08
1104 55893 ZNF395 -1.1092006 1.141548e-04 -1.2240649 2.687430e-06
1105 7976 FZD3 0.4565468 3.899663e-06 0.3478755 6.458641e-03
1106 2137 EXTL3 -0.8286334 1.063351e-11 -0.9122561 7.306328e-13
1107 51669 SARAF -1.1054450 2.685201e-23 -0.8435553 2.861997e-12
1108 10671 DCTN6 -0.7865972 1.060526e-02 -0.9294487 1.026461e-02
1109 692084 SNORD13 3.5814883 1.084694e-14 3.1406624 2.981701e-09
1110 83877 TM2D2 -0.6954581 3.989551e-02 -0.6575888 4.432710e-02
1111 51125 GOLGA7 -0.8253894 1.184741e-03 -0.7949723 6.108184e-04
1112 1052 CEBPD -1.3986854 2.748017e-06 -1.6086805 1.498142e-05
1113 5591 PRKDC 1.0564994 6.098003e-07 0.7960897 1.725305e-03
1114 6224 RPS20 -0.4287188 7.568176e-04 -0.3019994 2.604493e-02
1115 54928 BPNT2 -0.8045056 6.665623e-06 -0.6206243 1.523335e-02
1116 6386 SDCBP -0.7543932 4.594914e-05 -0.5516403 2.873087e-03
1117 9760 TOX 1.0267727 2.116667e-05 0.7767222 1.072121e-02
1118 641638 <NA> -1.1172364 6.670521e-13 -0.9594642 8.276891e-09
1119 80243 PREX2 2.0993992 1.109976e-03 1.9029162 3.136373e-03
1120 23213 SULF1 -2.2849884 1.666922e-11 -2.8757807 4.827200e-17
1121 27067 STAU2 1.5194868 3.060151e-12 1.5477622 5.051800e-15
1122 6921 ELOC -0.5749804 4.189718e-03 -0.6347296 1.215240e-03
1123 83690 CRISPLD1 -0.8573380 1.880054e-03 -0.6742713 4.791183e-02
1124 793 CALB1 -3.3433224 3.608602e-08 -1.6612826 3.262349e-03
1125 169200 TMEM64 -1.3885216 6.328290e-06 -1.0534055 5.380893e-03
1126 157657 CFAP418 2.1406114 2.826441e-03 2.3907474 1.858846e-04
1127 7381 UQCRB -0.8441729 2.247430e-08 -0.7093605 9.355824e-06
1128 6383 SDC2 -1.3612925 9.876046e-18 -0.7310451 2.871879e-05
1129 10404 CPQ 1.4685766 2.247100e-06 1.5448830 8.279331e-08
1130 6156 RPL30 -0.7385175 4.846276e-12 -0.6084917 5.564470e-09
1131 157680 VPS13B 1.7788432 1.983173e-06 1.2807797 1.300299e-02
1132 1345 COX6C -0.4642074 1.578547e-04 -0.3599264 4.485192e-03
1133 26986 PABPC1 1.0219107 4.500075e-24 1.1563470 2.443693e-32
1134 7534 YWHAZ -0.5247511 5.664507e-03 -0.7528931 2.603378e-05
1135 51123 ZNF706 -0.5884937 3.214430e-02 -0.8084932 3.126144e-03
1136 83988 NCALD 1.6421306 1.483546e-02 1.8446474 6.913283e-03
1137 51582 AZIN1 -0.8535790 2.801529e-04 -1.0227270 1.346778e-06
1138 3646 EIF3E -1.4448954 2.003885e-17 -1.2243319 4.831108e-17
1139 7227 TRPS1 0.7751844 1.354956e-02 0.7603250 2.567591e-02
1140 8667 EIF3H -0.7123231 9.434711e-07 -0.5797577 1.247850e-03
1141 5168 ENPP2 -1.4693316 1.122237e-07 -1.1867265 3.192238e-06
1142 157378 TMEM65 1.2862627 1.568367e-04 1.2341949 2.760661e-04
1143 6713 SQLE -1.2353531 5.249112e-07 -1.1082942 5.359539e-04
1144 4062 LY6H 1.8013510 9.983239e-05 2.2937684 1.653706e-09
1145 1936 EEF1D -0.8904676 2.286553e-02 -0.9067862 4.098628e-02
1146 2907 GRINA 1.5349975 5.482041e-53 1.3910913 5.752684e-41
1147 8733 GPAA1 0.5220514 1.721679e-02 0.5497770 2.954568e-02
1148 414919 C8orf82 1.1133290 2.775911e-03 1.1195292 1.022057e-02
1149 65265 C8orf33 1.5395053 3.492828e-06 1.7829171 4.361312e-10
1150 23189 KANK1 1.3522040 9.534509e-10 1.0487020 4.857602e-08
1151 7436 VLDLR -1.4084607 5.876598e-03 -1.3625483 8.221977e-03
1152 4781 NFIB 1.0576175 4.980551e-11 1.2948008 3.376685e-14
1153 158326 FREM1 -1.8314618 6.374590e-03 -2.0223534 2.784290e-03
1154 10670 RRAGA -0.6663678 2.029789e-03 -0.5921200 7.947954e-03
1155 1029 CDKN2A 1.2077224 3.173660e-08 0.9230954 1.122198e-03
1156 100129250 SMIM27 0.5825178 3.645523e-02 0.8522364 6.301319e-05
1157 10488 CREB3 1.2460254 2.015862e-04 1.2922152 1.513145e-03
1158 347252 IGFBPL1 2.2282164 3.374804e-11 1.1530911 4.282239e-02
1159 23670 CEMIP2 -1.1221064 6.404097e-07 -0.9477786 2.324785e-04
1160 7763 ZFAND5 -1.0843667 1.588232e-04 -0.7649882 1.691653e-02
1161 301 ANXA1 -1.3431326 2.241250e-20 -1.2152902 7.856257e-11
1162 5125 PCSK5 0.8934213 8.467466e-03 1.0360546 3.047012e-02
1163 7091 TLE4 0.6382555 7.758070e-09 0.4169314 7.094943e-03
1164 7088 TLE1 -1.8155925 1.716142e-04 -1.0141598 3.662671e-02
1165 2619 GAS1 -1.4648877 3.038473e-04 -2.2040747 8.323667e-08
1166 53358 SHC3 0.9262683 9.956158e-04 0.9269721 1.283522e-03
1167 84270 CARD19 -1.0415437 7.583025e-04 -0.6751315 1.294730e-02
1168 23196 FAM120A -0.4236324 1.512396e-02 -0.6795777 4.824212e-04
1169 10541 ANP32B -0.6589726 8.645788e-05 -0.8931879 3.350677e-05
1170 9568 GABBR2 1.0262131 4.391028e-02 1.8380988 4.032745e-07
1171 10952 SEC61B -0.6166122 1.576844e-05 -0.5613319 9.947854e-03
1172 23732 FRRS1L 2.8744991 3.542662e-04 2.7652934 1.314673e-03
1173 158399 ZNF483 2.8536433 2.203106e-08 2.5895244 2.209743e-03
1174 9550 ATP6V1G1 -0.4754534 2.910711e-03 -0.4181778 1.424583e-02
1175 7099 TLR4 -1.0528558 1.790711e-03 -0.8600661 4.274876e-02
1176 1620 BRINP1 -0.7489547 2.710170e-02 -1.4410807 2.107563e-03
1177 55755 CDK5RAP2 0.5912534 1.092101e-02 0.6132454 1.205363e-02
1178 169611 OLFML2A -2.3305029 4.853510e-02 -6.4601904 4.314329e-05
1179 11224 RPL35 -0.7050636 3.874540e-06 -0.7387057 4.147536e-05
1180 3309 HSPA5 -0.3808976 4.279457e-03 -0.7013340 9.275859e-10
1181 2801 GOLGA2 0.7559263 3.485763e-05 0.5452990 2.941887e-02
1182 81605 URM1 0.6158857 3.723992e-02 0.7681568 6.155077e-03
1183 89891 DYNC2I2 1.4614778 3.925263e-03 1.8047762 1.491239e-04
1184 883 KYAT1 2.4885843 1.199615e-04 1.8104104 3.632698e-02
1185 23048 FNBP1 0.6397174 6.488380e-05 0.6757149 1.367674e-07
1186 23064 SETX 0.7723261 4.244227e-03 0.9832935 1.506867e-03
1187 266655 BRD3OS 0.8046130 1.111845e-02 0.8628447 6.304220e-03
1188 8019 BRD3 0.8545019 9.394896e-05 0.7572487 1.306473e-04
1189 10422 UBAC1 1.1458949 3.309420e-08 0.9976798 6.705950e-06
1190 138151 NACC2 -0.9237412 2.595748e-08 -0.5638195 2.186773e-02
1191 4851 NOTCH1 -0.4646589 3.078629e-02 -0.5488352 3.300728e-02
1192 29085 PHPT1 0.5660772 1.850625e-05 0.5193602 1.091906e-04
1193 8721 EDF1 -1.0902562 1.172236e-08 -1.2199517 5.335663e-12
1194 26012 NSMF 0.9098442 5.205922e-03 0.8318681 1.451284e-02
1195 64975 MRPL41 0.7681481 4.830750e-05 0.4915816 2.435590e-02
1196 4549 <NA> 1.2454552 1.138345e-07 0.6615865 3.076121e-07
1197 4577 <NA> 1.4925311 1.377281e-12 1.0180558 4.740407e-06
1198 4550 <NA> 0.9482599 6.394072e-19 0.7538563 3.384186e-13
1199 4535 MT-ND1 -0.8328308 4.935918e-17 -0.9112035 1.030044e-20
1200 4565 <NA> 1.6392351 1.082964e-02 2.0354395 3.830498e-03
1201 4572 <NA> 1.2552975 1.252343e-15 1.3358005 6.181298e-06
1202 4569 <NA> 2.6387640 1.781356e-10 2.2340554 1.635875e-06
1203 4536 MT-ND2 0.5553390 5.106459e-11 0.5067176 1.082195e-08
1204 4578 <NA> 1.9672975 3.056260e-05 1.3723878 3.326214e-02
1205 4570 <NA> 0.9449237 6.122967e-13 0.9874331 6.552169e-12
1206 4579 <NA> 0.9604742 1.704628e-07 0.8534016 3.024507e-05
1207 4513 MT-CO2 -0.5329465 2.494799e-06 -0.6268429 1.895303e-09
1208 4509 MT-ATP8 1.1981271 1.295503e-21 1.0473691 6.355908e-06
1209 4508 MT-ATP6 -0.6794116 9.314834e-13 -0.9285691 2.426533e-34
1210 4514 MT-CO3 -0.2902918 3.011073e-03 -0.4383352 4.361843e-07
1211 4538 MT-ND4 -0.7403678 1.312136e-14 -0.8838916 1.368263e-25
1212 4564 <NA> 2.5719804 1.628081e-05 2.8232814 8.323667e-08
1213 4575 <NA> 3.0493965 3.521144e-07 2.1281057 1.157273e-02
1214 4540 MT-ND5 1.1911849 2.126822e-31 0.8676954 7.463550e-19
1215 4541 MT-ND6 0.8500680 1.826693e-13 0.4351731 4.429108e-04
1216 4519 MT-CYB -0.5003529 3.080074e-10 -0.6889478 4.827200e-17
1217 4571 <NA> 3.4044633 2.362771e-119 2.8563893 1.746726e-69
1218 8905 AP1S2 -0.9664051 6.101350e-23 -0.7749899 4.260762e-21
1219 94056 SYAP1 0.6064412 5.684941e-03 0.7330270 1.867686e-04
1220 10549 PRDX4 -1.6675877 3.694873e-10 -0.9225504 6.156778e-04
1221 10159 ATP6AP2 -0.8275559 4.426843e-07 -0.6952396 3.103277e-05
1222 54539 NDUFB11 -0.7516247 1.103419e-02 -1.1640156 1.678749e-04
1223 56850 GRIPAP1 0.6015785 4.095064e-02 0.6798442 1.516274e-02
1224 57477 SHROOM4 1.0039269 5.299002e-03 1.0496827 5.380893e-03
1225 728239 MAGED4 1.4320558 1.426777e-02 1.2798849 4.379649e-02
1226 3028 HSD17B10 0.8381355 1.739762e-03 1.0876016 1.345276e-06
1227 54552 GNL3L 1.2637831 6.868196e-07 1.0683116 3.149558e-04
1228 550643 NBDY -0.7225578 3.803228e-03 -0.6603237 3.214588e-03
1229 442454 <NA> -0.6373378 3.749090e-03 -0.4452347 4.347245e-02
1230 158586 ZXDB -3.1663152 1.104407e-03 -1.4865472 3.632698e-02
1231 9843 HEPH -1.7205327 1.415837e-04 -3.0352356 9.922827e-06
1232 1947 EFNB1 0.9924894 2.290356e-04 0.8597194 1.249707e-02
1233 340527 NHSL2 2.3301845 4.622585e-05 2.1087034 2.424107e-04
1234 5303 PIN4 -0.8835492 3.820335e-03 -0.8437007 3.188040e-03
1235 6191 RPS4X -0.5281537 1.614387e-05 -0.4433029 2.976157e-03
1236 441531 PGAM4 -0.7227182 1.497859e-02 -0.6859448 3.628419e-02
1237 5230 PGK1 -2.2418518 1.719764e-80 -1.2305879 2.661201e-26
1238 2846 LPAR4 1.4091085 8.177171e-08 1.2141436 5.276508e-05
1239 79366 HMGN5 -1.6773764 2.458787e-05 -2.1269753 1.565924e-07
1240 7105 TSPAN6 -0.4770235 2.708350e-02 -0.6324670 1.385789e-03
1241 27286 SRPX2 0.9507795 5.249112e-07 0.7486537 6.254085e-04
1242 94121 SYTL4 -2.1392611 2.369016e-12 -1.2710173 2.146449e-05
1243 51566 ARMCX3 0.5644596 3.988277e-02 0.9271075 2.139683e-04
1244 9823 ARMCX2 -0.9830875 1.782986e-04 -0.9581115 3.435068e-03
1245 84460 ZMAT1 -0.8542285 3.925541e-02 -1.3734403 2.677183e-03
1246 340543 TCEAL5 1.1268906 3.934522e-07 1.0011318 2.095923e-05
1247 9643 MORF4L2 -0.6747360 5.247299e-03 -0.4717278 3.263452e-02
1248 1641 DCX -0.8457536 7.306344e-03 -0.9610581 5.303766e-03
1249 5358 PLS3 -1.5233899 4.816454e-06 -1.0025877 4.267737e-03
1250 10857 PGRMC1 -0.7314699 2.612498e-04 -0.6340352 7.388822e-03
1251 4694 NDUFA1 -0.5530361 2.258081e-05 -0.5041327 5.871543e-04
1252 55026 TMEM255A -1.1946326 4.352120e-03 -1.1077157 1.121250e-02
1253 2239 GPC4 -2.1473273 5.147271e-06 -1.2110122 1.201094e-02
1254 2719 GPC3 -0.5884722 2.270755e-03 -2.9646777 6.067464e-67
1255 27316 RBMX 1.1630289 9.116097e-16 0.6873829 4.661108e-05
1256 1038 CDR1 3.7692197 4.289889e-59 3.9196558 7.957925e-73
1257 83692 CD99L2 0.8195141 5.631666e-04 0.7089770 1.177798e-03
1258 29944 PNMA3 5.4634513 2.323953e-04 4.9629362 1.922443e-02
1259 84968 PNMA6A 2.4873948 4.238186e-08 2.3903937 1.589204e-06
1260 4204 MECP2 0.8163152 1.867538e-02 0.7692576 3.750467e-02
1261 2316 FLNA 0.4895471 2.194210e-04 0.3709100 1.352675e-02
1262 2010 EMD 0.8932399 9.310564e-07 0.8302233 8.241662e-06
1263 7411 VBP1 -0.7364146 6.114222e-03 -0.4752162 4.356118e-02
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 1.2004215 0.9049203 1.570216 1.908726e-01
02_TSC2_KO_Grabole_2016 1.4255145 1.2645679 1.606005 5.064721e-09
03_TSC2_Grabole-2016 1.4160309 1.2575323 1.595280 5.493296e-09
04_TSC2-tuber-Martin2017 2.1323041 1.2404072 3.500877 4.664193e-03
05_TSC2-SEN_SEGA-Martin2017 1.2105824 1.0290531 1.419102 1.969641e-02
06_all_EpilepsyGene 1.2232596 0.8608799 1.699740 2.425478e-01
07_high_conf_EpilepsyGene 1.1406076 0.5870818 2.039154 6.405796e-01
08_ASD_Epilepsy_EpilepsyGene 1.4498686 0.7801469 2.516390 1.964988e-01
09_Epi25_dataset 1.0663946 0.4427013 2.220974 8.472133e-01
10_SFARI_all 1.3711794 0.8919403 2.039237 1.140568e-01
11_SFARI_score4plus 1.5564891 0.9633182 2.416097 4.943506e-02
12_DeRubeis_RDNV 2.3692151 1.2478920 4.230333 5.024359e-03
13_Iossifov_RDNV 1.3502214 1.0090736 1.780511 3.517499e-02
14_FMRP_Darnell 1.9356981 1.5642182 2.380164 2.958261e-09
15_Voineagu_M12 0.6363092 0.3869344 0.994238 4.643397e-02
16_Voineagu_M16 2.7503442 2.0789844 3.601668 9.031342e-12
17_ID_genes_Neel 1.0676875 0.7134921 1.549303 6.990195e-01
18_ID_genes_pinto2014 1.2911033 0.8341784 1.930107 2.167127e-01
19_Fromer_SCZ_FunDN 1.2638669 0.9332924 1.684041 1.133299e-01
20_Cocchi_Pruning 1.9566540 1.0403460 3.449224 2.649349e-02
Beta SE Padj
01_Swaminathan2018_DEPDC5KO 0.18267273 0.14417404 1.000000e+00
02_TSC2_KO_Grabole_2016 0.35453283 0.06112364 1.012944e-07
03_TSC2_Grabole-2016 0.34785780 0.06056455 1.098659e-07
04_TSC2-tuber-Martin2017 0.75720312 0.27640988 9.328387e-02
05_TSC2-SEN_SEGA-Martin2017 0.19110154 0.08288902 3.939282e-01
06_all_EpilepsyGene 0.20151907 0.17924455 1.000000e+00
07_high_conf_EpilepsyGene 0.13156107 0.33885319 1.000000e+00
08_ASD_Epilepsy_EpilepsyGene 0.37147292 0.31619692 1.000000e+00
09_Epi25_dataset 0.06428339 0.44854259 1.000000e+00
10_SFARI_all 0.31567124 0.21940169 1.000000e+00
11_SFARI_score4plus 0.44243273 0.24479809 9.887012e-01
12_DeRubeis_RDNV 0.86255871 0.32709335 1.004872e-01
13_Iossifov_RDNV 0.30026858 0.14858972 7.034999e-01
14_FMRP_Darnell 0.66046802 0.10871525 5.916522e-08
15_Voineagu_M12 -0.45207062 0.25379061 9.286794e-01
16_Voineagu_M16 1.01172608 0.14277887 1.806268e-10
17_ID_genes_Neel 0.06549505 0.20565255 1.000000e+00
18_ID_genes_pinto2014 0.25549714 0.22285977 1.000000e+00
19_Fromer_SCZ_FunDN 0.23417599 0.15470039 1.000000e+00
20_Cocchi_Pruning 0.67123588 0.32228701 5.298698e-01
ReN
getlinmodoutput(targetline = "ReN",targetdiff = "noDIFF",targetrapa = "noRAPA") entrezgene genname log2FC_2.1 fdr_2.1 log2FC_2.2 fdr_2.2
1 55920 RCC2 -0.7709626 4.129780e-05 -0.2645249 3.812275e-02
2 2152 F3 -1.6052562 4.812020e-05 -1.1057348 6.860234e-03
3 116496 NIBAN1 -0.8567869 2.608034e-02 -0.9061142 1.725769e-07
4 10625 IVNS1ABP 1.0111945 1.290996e-02 0.8932301 1.349441e-03
5 1316 KLF6 0.6226359 6.285458e-03 0.4374648 2.393860e-03
6 27063 ANKRD1 0.7284664 8.767738e-03 0.6484243 1.845423e-03
7 10410 IFITM3 0.8639180 1.900099e-04 0.8986399 1.358229e-15
8 9415 FADS2 -0.5463766 1.048817e-02 -0.4041426 7.790489e-04
9 6876 TAGLN 0.5665027 3.412600e-03 0.3089471 3.634781e-05
10 8788 DLK1 1.3271225 2.339702e-06 1.0858472 4.185648e-07
11 55384 MEG3 0.6186050 6.986237e-03 0.3983264 1.395902e-02
12 7168 TPM1 0.6153430 9.929395e-04 0.7254517 9.832148e-29
13 8482 SEMA7A -1.1493099 2.996955e-02 -1.3520616 1.078898e-04
14 9289 ADGRG1 0.5742315 1.781405e-02 0.4019053 1.383476e-02
15 6560 SLC12A4 1.3887778 5.524029e-03 1.0250149 9.911553e-03
16 2670 GFAP 0.7380134 2.981670e-02 0.3964766 1.934040e-04
17 1277 COL1A1 1.1694356 3.505403e-08 0.7581812 3.017104e-08
18 114897 C1QTNF1 -1.6933139 4.743532e-04 -1.0442519 2.674684e-06
19 6597 SMARCA4 0.9510221 8.633707e-08 0.3447233 4.739736e-02
20 3589 IL11 1.0942977 7.595885e-10 0.7528246 5.200636e-17
21 7837 PXDN 1.2479747 7.686976e-10 0.8975230 3.194388e-13
22 6664 SOX11 0.5491863 2.902291e-02 0.4725256 3.590150e-03
23 64838 FNDC4 1.0766732 3.651082e-02 0.7477309 3.004000e-02
24 57142 RTN4 0.6548997 3.022107e-02 0.5092739 6.213421e-04
25 72 ACTG2 1.5107705 4.003181e-04 1.6657161 1.910836e-09
26 1622 DBI 0.6069698 9.572129e-03 0.2668891 5.430482e-03
27 8324 FZD7 -0.9560900 2.981670e-02 -0.9506187 3.864097e-04
28 3485 IGFBP2 0.4572250 8.559464e-03 0.2640600 1.483333e-02
29 547 KIF1A 1.0191769 3.837016e-03 0.8084061 1.349441e-03
30 1299 COL9A3 0.6652539 7.257546e-03 0.5082300 8.421927e-09
31 1291 COL6A1 -0.7239440 2.337870e-05 -1.3280713 2.904372e-67
32 1292 COL6A2 -0.9028436 6.275974e-03 -1.8399877 1.015325e-15
33 6285 S100B 1.0618307 2.499636e-04 1.1014556 4.978164e-11
34 151887 CCDC80 1.3269840 1.910378e-09 0.5349808 2.674684e-06
35 4071 TM4SF1 0.7983308 7.460130e-03 0.5525958 2.134321e-02
36 55752 SEPTIN11 0.5614741 2.309992e-02 0.6041739 5.856423e-06
37 10769 PLK2 -1.0628661 2.897441e-02 -0.9051113 1.805202e-02
38 2297 FOXD1 -1.1949549 3.907876e-02 -1.1498402 3.107899e-02
39 1839 HBEGF 0.7418055 3.092105e-03 0.7139983 4.059826e-08
40 8728 ADAM19 1.3682698 4.303558e-05 1.4944132 5.024004e-12
41 64065 PERP -0.9466032 5.083185e-05 -0.6466159 3.712832e-03
42 6624 FSCN1 0.6434701 1.733283e-06 0.3170077 5.802062e-05
43 800 CALD1 0.7665582 1.166677e-04 0.8241889 3.424143e-30
44 5764 PTN 0.5227649 2.820302e-02 0.7267524 3.128694e-23
45 1052 CEBPD 0.6269253 4.612829e-02 0.5429092 1.433602e-02
46 641638 <NA> 0.6140200 1.963879e-02 0.3201642 1.862983e-02
47 793 CALB1 -1.1418089 6.542001e-09 -1.3893524 3.320383e-23
48 28998 MRPL13 -0.9837532 2.905522e-04 -0.4863646 2.251966e-02
49 1515 CTSV -1.3687163 3.534266e-06 -2.5548099 1.628854e-55
50 9568 GABBR2 0.8591791 1.299630e-04 0.7804877 1.030234e-16
51 3371 TNC -1.0395490 1.382104e-06 -0.3561205 4.590609e-02
52 1289 COL5A1 -1.5101448 7.312207e-03 -1.1785048 4.211205e-07
53 4539 MT-ND4L 0.4547687 1.940962e-02 0.2676648 4.270763e-03
54 92745 SLC38A5 1.3495871 6.273324e-07 0.8102770 4.087766e-06
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 0.8487259 0.09989353 3.237908 1.0000000000
02_TSC2_KO_Grabole_2016 1.3967597 0.77680995 2.477698 0.2518780221
03_TSC2_Grabole-2016 1.4536366 0.81785072 2.628758 0.2194194589
04_TSC2-tuber-Martin2017 7.2212983 1.41995499 22.889012 0.0100471083
05_TSC2-SEN_SEGA-Martin2017 2.1290741 1.06776822 4.006525 0.0185447289
06_all_EpilepsyGene 1.3418222 0.15775609 5.130774 0.6634089148
07_high_conf_EpilepsyGene 2.0509246 0.05057317 12.147996 0.3919490878
08_ASD_Epilepsy_EpilepsyGene 2.1950289 0.05409370 13.015784 0.3720290812
09_Epi25_dataset 0.0000000 0.00000000 11.970736 1.0000000000
10_SFARI_all 0.0000000 0.00000000 4.002205 1.0000000000
11_SFARI_score4plus 0.0000000 0.00000000 5.436925 1.0000000000
12_DeRubeis_RDNV 0.0000000 0.00000000 12.602077 1.0000000000
13_Iossifov_RDNV 0.4853168 0.01204121 2.836155 0.7236633027
14_FMRP_Darnell 1.7411550 0.53979560 4.364462 0.2245150282
15_Voineagu_M12 0.0000000 0.00000000 2.758299 0.6468121238
16_Voineagu_M16 5.8663885 2.22056745 13.187271 0.0003854323
17_ID_genes_Neel 0.7693916 0.01906445 4.506239 1.0000000000
18_ID_genes_pinto2014 3.2898328 0.65218159 10.289161 0.0704745817
19_Fromer_SCZ_FunDN 1.5676565 0.31188937 4.874852 0.4470978815
20_Cocchi_Pruning 0.0000000 0.00000000 10.741481 1.0000000000
Beta SE Padj
01_Swaminathan2018_DEPDC5KO -0.1640190 1.0916487 1.000000000
02_TSC2_KO_Grabole_2016 0.3341551 0.2993442 1.000000000
03_TSC2_Grabole-2016 0.3740684 0.2934408 1.000000000
04_TSC2-tuber-Martin2017 1.9770348 0.8298008 0.200942165
05_TSC2-SEN_SEGA-Martin2017 0.7556872 0.3521003 0.370894578
06_all_EpilepsyGene 0.2940285 1.0922111 1.000000000
07_high_conf_EpilepsyGene 0.7182907 1.8890943 1.000000000
08_ASD_Epilepsy_EpilepsyGene 0.7861952 1.8894045 1.000000000
09_Epi25_dataset -Inf NaN 1.000000000
10_SFARI_all -Inf NaN 1.000000000
11_SFARI_score4plus -Inf NaN 1.000000000
12_DeRubeis_RDNV -Inf NaN 1.000000000
13_Iossifov_RDNV -0.7229534 1.8859525 1.000000000
14_FMRP_Darnell 0.5545487 0.5975068 1.000000000
15_Voineagu_M12 -Inf NaN 1.000000000
16_Voineagu_M16 1.7692392 0.4956512 0.007708647
17_ID_genes_Neel -0.2621552 1.8866199 1.000000000
18_ID_genes_pinto2014 1.1908367 0.8256474 1.000000000
19_Fromer_SCZ_FunDN 0.4495818 0.8238207 1.000000000
20_Cocchi_Pruning -Inf NaN 1.000000000
KO effect in DIFF noRAPA
D62
getlinmodoutput(targetline = "D62",targetdiff = "DIFF",targetrapa = "noRAPA") entrezgene genname log2FC_2.1 fdr_2.1 log2FC_2.2 fdr_2.2
1 51150 SDF4 -0.4955025 2.579359e-03 -0.5953468 1.781040e-04
2 64856 VWA1 -0.5621746 3.771578e-03 -1.4107532 1.828404e-14
3 1953 MEGF6 -1.0425165 1.794545e-02 -2.6466407 8.328495e-05
4 26038 CHD5 -1.2094340 9.476205e-03 -1.2741363 2.815505e-02
5 9249 DHRS3 -1.3097280 2.111936e-15 -1.2296776 2.617139e-18
6 2048 EPHB2 -0.8641387 3.887602e-09 -1.0985671 1.035345e-12
7 3925 STMN1 0.7944170 3.016039e-07 1.4274906 1.254741e-25
8 2537 IFI6 -0.8433904 4.332154e-06 -0.8189382 2.284061e-04
9 10657 KHDRBS1 0.4700116 6.464077e-03 0.4598147 2.286086e-02
10 65108 MARCKSL1 0.5000844 3.804763e-02 0.9989000 1.168573e-06
11 6421 SFPQ 0.4515981 1.693582e-02 0.5128704 1.572492e-02
12 63967 CLSPN 1.5137939 2.851279e-02 1.6319799 4.375498e-02
13 84879 MFSD2A 0.9763791 9.131033e-06 1.8248040 1.138677e-20
14 6513 SLC2A1 -0.5300470 2.822089e-02 -0.7679623 2.811444e-03
15 1996 ELAVL4 3.2608311 4.962903e-06 4.0652987 4.144930e-09
16 5865 RAB3B 3.5894843 1.843733e-05 4.3813828 3.762860e-08
17 3725 JUN 0.7298672 1.942181e-08 0.5537306 4.001398e-03
18 4774 NFIA 0.5175837 7.823789e-04 0.7298703 1.415834e-05
19 91624 NEXN 1.0028329 9.119499e-04 1.2187668 3.222356e-05
20 3491 CCN1 1.1287146 4.877936e-14 1.2278310 2.873031e-13
21 9411 ARHGAP29 1.7634825 1.769450e-02 1.8714486 3.230913e-02
22 84722 PSRC1 -0.3789217 2.535810e-02 -0.5226016 9.529778e-03
23 3752 KCND3 4.4704034 1.059294e-02 4.7438914 1.505603e-02
24 7482 WNT2B -1.4543823 3.547978e-03 -3.1408787 3.528764e-02
25 54879 ST7L -1.1880679 3.140635e-03 -2.0706668 1.253519e-07
26 389 RHOC -0.7041464 5.115743e-04 -0.7909251 2.023271e-04
27 476 ATP1A1 -1.0997358 6.225788e-09 -0.6174432 9.665606e-03
28 10628 TXNIP -1.0151132 8.325040e-03 -1.5573992 9.558770e-04
29 25832 NBPF14 -0.5872187 1.314383e-02 -0.6992549 9.981604e-03
30 4170 MCL1 0.5884118 8.485303e-03 0.5492956 3.046150e-02
31 10962 MLLT11 0.6808427 3.689879e-03 0.9870859 3.654889e-04
32 6282 S100A11 -0.6620088 2.674714e-04 -1.4333294 1.723954e-08
33 112770 GLMP -1.1545239 1.783433e-04 -0.8114086 1.604436e-02
34 10485 MIR9-1HG 0.3922581 1.894780e-03 0.4052353 2.092622e-02
35 93183 PIGM -0.8527513 2.001797e-03 -0.9327189 2.348428e-03
36 477 ATP1A2 1.4390816 4.482580e-05 2.0217080 1.246246e-09
37 5999 RGS4 1.4843432 1.246320e-02 1.8144199 4.411380e-03
38 387597 ILDR2 -0.7472582 3.654285e-04 -0.8916310 1.466669e-04
39 481 ATP1B1 1.0621640 5.828589e-03 1.2966800 1.205500e-03
40 23057 NMNAT2 3.4158547 8.593309e-04 3.5208565 3.846423e-03
41 23127 COLGALT2 -0.6453155 4.170684e-03 -1.0025729 2.990741e-06
42 5997 RGS2 2.3549801 2.908959e-03 2.4140555 1.135038e-02
43 23046 KIF21B 1.4025501 4.017314e-02 2.9011030 2.747197e-10
44 23612 PHLDA3 -0.9978168 8.918304e-08 -0.5631703 2.399817e-02
45 89796 NAV1 0.9189098 7.922638e-05 1.2236795 1.733921e-08
46 55220 KLHDC8A 0.4315198 3.954693e-02 1.1871507 1.409696e-12
47 254428 SLC41A1 -0.6641172 1.320366e-02 -1.0159950 5.463962e-04
48 50486 G0S2 -1.2769869 3.776809e-02 -3.7478581 2.744552e-36
49 1063 CENPF 0.9674909 1.276505e-04 0.6984687 1.927045e-02
50 3930 LBR 1.1691924 2.189956e-04 1.1824021 1.402408e-03
51 7044 LEFTY2 -1.8967514 2.076460e-02 -5.4919034 1.299317e-06
52 56776 FMN2 1.8223429 1.818342e-05 1.4585189 1.179215e-02
53 5214 PFKP -0.7085246 4.103217e-03 -0.9698443 1.182711e-03
54 1316 KLF6 0.4591444 4.092246e-02 0.9649889 2.229439e-06
55 5209 PFKFB3 0.9025962 1.244501e-06 0.6596269 5.396264e-03
56 56243 KIAA1217 -1.0092171 1.487638e-02 -1.6358087 4.374010e-04
57 57512 GPR158 6.2531163 1.041083e-02 6.1967773 4.088838e-02
58 3185 HNRNPF 0.4924999 1.043753e-02 0.5434778 3.751870e-02
59 118738 ZNF488 -1.3591800 1.781176e-05 -1.5052581 3.235236e-05
60 100507008 <NA> -1.0683994 1.666217e-02 -1.1833009 2.512927e-02
61 84159 ARID5B 1.1067873 7.036831e-10 0.7182760 8.550844e-04
62 55680 RUFY2 1.4665537 2.349213e-02 1.7921536 1.081271e-02
63 140766 ADAMTS14 -1.0590339 2.629807e-02 -1.9314582 1.261456e-04
64 5660 PSAP -0.5893935 1.614984e-09 -0.6307739 1.718370e-08
65 9806 SPOCK2 -0.7006081 1.000618e-06 -0.9393863 2.122881e-09
66 5328 PLAU -0.7107724 2.041878e-02 -1.7229682 1.575495e-11
67 132 ADK 0.8457418 3.776809e-02 1.2331920 3.288831e-03
68 23522 KAT6B 0.7195214 1.092992e-02 1.1942312 9.256950e-05
69 311 ANXA11 -0.8715186 9.406076e-05 -1.0391239 7.087740e-04
70 27063 ANKRD1 -1.4181691 1.258581e-03 -2.0199847 4.082433e-04
71 9124 PDLIM1 -0.4570125 4.949466e-03 -1.8256331 1.310934e-20
72 10580 SORBS1 0.7949338 2.625106e-02 1.2342037 5.463962e-04
73 83742 MARVELD1 -1.0196936 7.773859e-03 -3.0128114 1.626479e-05
74 84171 LOXL4 -1.0820720 5.359873e-03 -2.0032920 3.739933e-05
75 25911 DPCD 1.1158041 1.179168e-03 0.9881699 3.230913e-02
76 9118 INA 2.3042902 1.740790e-09 3.0690799 1.090343e-18
77 63877 FAM204A 1.2483183 4.111141e-03 1.1495418 3.713935e-02
78 9531 BAG3 -0.6141248 2.872818e-02 -0.8006766 2.551578e-03
79 64787 EPS8L2 -1.8841773 2.413899e-02 -2.5508625 2.033169e-03
80 6181 RPLP2 -0.7084403 7.711357e-12 -0.4562317 7.819783e-05
81 977 CD151 -0.8589280 1.329522e-07 -0.7195245 1.046971e-03
82 54472 TOLLIP -0.4889611 4.074004e-02 -0.6314934 4.081618e-03
83 1509 CTSD -1.3844459 6.042722e-11 -1.1546733 1.485188e-11
84 975 CD81 -0.6898415 3.572604e-10 -0.5108469 3.696366e-05
85 1200 TPP1 -0.8395789 5.673328e-09 -0.6679043 4.991740e-06
86 283298 OLFML1 -2.5901081 3.728262e-04 -4.3858271 1.744180e-11
87 8495 PPFIBP2 -1.9365285 4.201254e-03 -2.6640963 2.508021e-02
88 6157 RPL27A -0.4484639 2.172998e-05 -0.5557320 1.299543e-07
89 56672 AKIP1 -0.8593692 2.797337e-04 -1.0236992 1.320957e-02
90 100463486 MTRNR2L8 -0.5578237 2.828289e-05 -0.7469176 7.922861e-11
91 10335 IRAG1 2.7773162 1.257846e-03 3.4613748 2.067171e-05
92 10418 SPON1 2.3371384 1.821001e-25 2.8657805 2.055482e-37
93 100126784 <NA> -1.0947445 3.748100e-02 -2.0601972 5.716200e-04
94 90139 TSPAN18 -1.2350599 9.075399e-03 -3.1872211 1.471856e-07
95 4192 MDK -0.7403873 6.530164e-10 -1.2928391 2.363787e-22
96 54972 TMEM132A -1.5686110 2.263621e-06 -1.2014332 1.988352e-02
97 1937 EEF1G -0.6993356 3.122941e-08 -0.3454940 3.230913e-02
98 6094 ROM1 -0.7216586 7.087820e-03 -0.7315965 2.598470e-02
99 51035 UBXN1 -0.6519263 5.898459e-03 -0.6014790 1.409058e-02
100 6520 SLC3A2 -0.9796559 3.111335e-12 -0.9942900 3.719212e-09
101 5920 PLAAT4 -0.8592724 7.548369e-07 -0.6612061 1.541733e-05
102 402 ARL2 -1.0917134 1.144262e-06 -0.7172434 5.602278e-03
103 4054 LTBP3 -0.8975351 1.180630e-04 -1.4336403 4.685666e-09
104 29984 RHOD -2.1359526 1.651096e-02 -3.5853260 6.808726e-03
105 54961 SSH3 -0.9106481 1.023444e-02 -1.2660190 2.632959e-03
106 80194 TMEM134 -0.8017841 5.114206e-04 -0.7902311 3.070781e-02
107 1374 CPT1A -0.5505969 4.013752e-02 -0.7928566 1.142001e-03
108 55191 NADSYN1 -1.2535007 4.782090e-04 -1.0527382 3.797532e-02
109 6188 RPS3 -0.5129980 1.255454e-06 -0.4465642 7.555908e-05
110 2893 GRIA4 1.1796260 2.790154e-02 1.3712466 1.521117e-02
111 23086 EXPH5 5.5069765 1.744228e-02 7.1085098 1.182043e-04
112 1410 CRYAB -0.9064181 2.412081e-06 -1.0487832 5.878247e-09
113 23705 CADM1 0.2874183 4.487948e-02 0.4231700 2.510206e-02
114 50937 CDON -1.2766445 1.525007e-02 -2.0779999 1.173198e-04
115 334 APLP2 -0.6772377 1.015275e-06 -0.5802617 7.651342e-08
116 84318 CCDC77 1.9658368 1.749660e-02 2.1758950 3.412593e-02
117 2597 GAPDH -0.6653002 1.981316e-10 -0.3687779 1.983706e-03
118 2 A2M 1.3571253 3.286528e-04 1.3799321 3.349517e-03
119 53919 SLCO1C1 2.1983350 3.924279e-03 3.5345281 7.474492e-10
120 51474 LIMA1 1.3709008 4.390829e-26 0.9187943 3.001160e-08
121 3164 NR4A1 1.9392213 7.720419e-03 2.9236343 1.977458e-06
122 84926 SPRYD3 -0.8912767 1.242525e-03 -1.0968278 3.581571e-04
123 3489 IGFBP6 -1.6066792 3.470231e-09 -2.8097426 3.037210e-19
124 4327 MMP19 -1.0206521 3.718852e-02 -2.3634379 1.791381e-03
125 1606 DGKA -0.8334538 8.538833e-03 -1.6919856 1.766773e-07
126 10956 OS9 -0.5352587 1.315690e-03 -0.3777409 3.741461e-02
127 4193 MDM2 -0.8774030 1.265300e-06 -0.7506638 1.422245e-05
128 10576 CCT2 0.6548356 1.818342e-05 0.5180339 2.065548e-02
129 6857 SYT1 1.6645278 3.586655e-16 1.7366885 7.554068e-12
130 1848 DUSP6 0.9472608 1.507218e-05 0.8270646 4.384776e-03
131 694 BTG1 0.8678603 2.142367e-04 1.5305075 9.496891e-11
132 7112 TMPO 1.1775440 8.630785e-03 1.2966858 9.083012e-03
133 429 ASCL1 -2.4634672 7.050646e-09 -1.5122563 1.529090e-03
134 51559 NT5DC3 -1.6497901 1.121657e-04 -2.5550160 6.192312e-07
135 7296 TXNRD1 0.5299716 2.765136e-02 0.6784375 4.983759e-02
136 5992 RFX4 0.8119488 3.438064e-02 1.1235226 4.497281e-03
137 9921 RNF10 -0.8848528 4.794095e-10 -0.5315531 3.288831e-03
138 100293704 <NA> 4.1652044 2.637579e-05 3.4557775 2.613152e-02
139 9612 NCOR2 -0.7511655 1.501871e-05 -0.5527530 1.783153e-03
140 100507206 LINC00943 6.2760701 1.017513e-02 7.3674812 9.033309e-04
141 219287 AMER2 2.3065591 5.995112e-03 2.6089411 3.298906e-03
142 2963 GTF2F2 -0.5957940 1.811377e-02 -0.8237930 4.213769e-03
143 1948 EFNB2 0.7194535 8.451578e-05 0.9336074 2.764288e-05
144 1284 COL4A2 -0.8395538 1.828348e-08 -0.8404414 1.655976e-08
145 4323 MMP14 -1.5188045 3.672983e-05 -0.9287367 3.491573e-02
146 26020 LRP10 -0.7033103 1.818342e-05 -0.5537884 1.546205e-03
147 5720 PSME1 -0.5382084 1.867755e-03 -0.5772061 4.373057e-03
148 9472 AKAP6 1.7389756 6.851832e-03 1.8568791 4.070817e-02
149 64067 NPAS3 -0.4163694 2.398464e-02 -0.5080488 1.384654e-02
150 6235 RPS29 -0.7327891 3.199018e-11 -0.3803609 6.761011e-03
151 54331 GNG2 1.7462712 1.438339e-06 2.3850711 1.281297e-12
152 10979 FERMT2 0.4541759 1.001712e-02 0.6317041 3.403977e-04
153 652 BMP4 3.4322241 2.358141e-02 3.9413514 1.737453e-02
154 1033 CDKN3 1.4212585 1.657082e-02 1.5963138 1.861682e-02
155 5015 OTX2 -3.8471754 1.568726e-04 -8.7646450 5.096832e-08
156 23002 DAAM1 0.5756500 1.144014e-02 0.6480771 1.098956e-02
157 6252 RTN1 1.2138304 8.122873e-11 2.0253347 5.279550e-25
158 57570 TRMT5 0.5475171 1.728621e-02 0.7457291 1.358172e-03
159 3306 HSPA2 1.0124703 9.266707e-03 1.4676988 3.998716e-04
160 87 ACTN1 -0.4948545 3.613831e-05 -0.6160727 8.692213e-06
161 10577 NPC2 -0.5255423 3.558149e-03 -0.6101615 3.882748e-04
162 83694 RPS6KL1 3.8278595 2.284983e-02 4.3859902 7.594668e-03
163 7043 TGFB3 -1.7661103 7.289027e-05 -1.5817604 8.359027e-04
164 9369 NRXN3 1.2169767 2.413395e-02 2.4311314 2.659111e-08
165 145508 CEP128 7.1384851 3.603826e-04 6.8877576 3.834139e-03
166 10516 FBLN5 1.3856734 8.048815e-09 2.7589733 5.797998e-30
167 90050 FAM181A 0.6710977 1.314873e-02 0.8880721 1.142563e-03
168 83982 IFI27L2 -0.7111727 1.971316e-04 -0.8337053 6.760721e-04
169 283596 SNHG10 -0.9834750 4.264469e-02 -1.3534864 3.597421e-02
170 1778 DYNC1H1 -0.5395047 3.662869e-04 -0.6729980 1.119043e-03
171 7127 TNFAIP2 -1.2376403 1.806957e-07 -1.8796597 9.493629e-13
172 26153 KIF26A 1.5457261 1.467521e-03 2.5721679 2.241496e-12
173 7057 THBS1 1.1410705 4.491190e-02 2.3285348 1.071863e-07
174 388115 CCDC9B -0.9614209 1.019494e-02 -0.9618937 3.587554e-02
175 825 CAPN3 -2.4966123 7.173925e-03 -2.6874120 1.027918e-02
176 10169 SERF2 -0.5003563 5.689073e-04 -0.4259759 1.565503e-02
177 2628 GATM 1.0133473 1.046865e-04 2.1557044 4.223549e-22
178 9768 PCLAF 1.0640307 3.781109e-02 1.4935236 6.760721e-04
179 6176 RPLP1 -0.6093418 3.166160e-07 -0.4406568 7.279779e-05
180 5315 PKM -0.9369895 3.555936e-13 -1.1770603 2.540533e-20
181 3073 HEXA -0.6652942 5.121717e-04 -0.9594898 7.852808e-06
182 80381 CD276 -1.1989176 1.371933e-11 -0.7033776 6.626380e-04
183 4016 LOXL1 -1.1530879 1.557437e-11 -2.2150069 1.393321e-19
184 57611 ISLR2 -1.5523167 1.047715e-04 -1.4906241 1.194952e-03
185 1512 CTSH -0.9493288 6.993697e-03 -2.4987702 7.651342e-08
186 9055 PRC1 0.8509816 1.334434e-02 1.1448669 4.181127e-04
187 6627 SNRPA1 0.9370428 1.515239e-02 0.9710838 1.530019e-02
188 146330 FBXL16 1.2609745 6.780349e-03 1.1989549 3.072066e-02
189 1186 CLCN7 -0.9821757 1.938327e-04 -0.9597895 2.136651e-03
190 9235 IL32 -0.6723417 2.063015e-02 -1.5711091 1.688161e-07
191 84662 GLIS2 -0.8156735 2.638713e-03 -0.7750988 2.533532e-02
192 2903 GRIN2A 2.2116964 1.102525e-03 2.3194333 2.811444e-03
193 8303 SNN 0.4548868 4.175567e-02 0.5396832 3.066528e-02
194 51704 GPRC5B -0.4588105 1.525190e-02 -0.5810413 4.486396e-03
195 388228 SBK1 0.6975649 3.087182e-02 1.3383912 1.252054e-05
196 4502 MT2A -0.8592943 5.139522e-13 -0.7215908 6.547722e-07
197 6236 RRAD -1.2863347 6.482764e-08 -1.6024059 3.329564e-10
198 8824 CES2 -0.6507556 2.915376e-04 -0.6322111 3.907452e-03
199 5699 PSMB10 -0.9345479 1.674125e-03 -0.8847187 1.605926e-02
200 6560 SLC12A4 -1.2011669 1.168969e-04 -1.1745485 2.658996e-05
201 794 CALB2 1.4654634 1.245084e-14 2.7505470 3.771214e-49
202 497190 CLEC18B -1.7376001 1.636610e-05 -2.3390890 1.813716e-09
203 57687 VAT1L 1.0555940 3.343727e-10 1.3598243 2.662264e-15
204 55839 CENPN 1.9185524 4.318828e-04 1.9128202 2.755764e-03
205 80790 CMIP 0.6352677 1.065092e-02 1.0207875 4.669550e-05
206 23199 GSE1 0.6591221 2.943672e-03 0.9168692 7.672086e-04
207 8140 SLC7A5 -1.0733358 3.036524e-21 -2.2277424 1.646229e-54
208 10381 TUBB3 0.5102387 1.912244e-03 1.0074982 5.187304e-11
209 79007 DBNDD1 -1.2036565 5.626879e-04 -1.3212792 2.580847e-04
210 5187 PER1 0.7742327 2.911848e-02 1.7299740 3.482076e-10
211 4628 MYH10 0.4704751 1.176551e-02 0.4854399 3.784166e-02
212 9423 NTN1 -0.8038572 1.879074e-05 -0.5145178 1.565503e-02
213 5376 PMP22 0.5913604 3.709520e-03 0.5934196 1.042772e-02
214 201161 CENPV 1.2216823 1.590302e-07 2.0786215 1.601383e-23
215 51655 RASD1 0.9291624 3.037219e-03 1.6067946 1.018530e-08
216 146691 TOM1L2 -0.5988929 8.648250e-04 -0.5822012 4.891828e-03
217 8851 CDK5R1 0.7281006 2.902766e-02 1.4368297 1.688161e-07
218 124842 TMEM132E -1.1128654 5.631934e-05 -0.9711416 4.506951e-03
219 7153 TOP2A 0.6603221 1.020516e-02 1.2133368 1.522068e-08
220 60681 FKBP10 -0.4693712 1.111818e-02 -0.8194118 1.663741e-05
221 4669 NAGLU -1.1758444 2.360348e-05 -0.7471729 2.925943e-02
222 10493 VAT1 -0.4738040 2.095758e-02 -0.6318269 1.729325e-03
223 8153 RND2 -0.9296475 8.389526e-04 -0.6963927 4.627494e-02
224 10900 RUNDC3A 3.4327764 9.617462e-04 4.2369216 2.005898e-06
225 51629 SLC25A39 -0.7622986 6.773908e-04 -0.6448171 2.065242e-02
226 2896 GRN -0.8639623 1.193912e-09 -1.0190800 4.723064e-10
227 23131 GPATCH8 0.9948362 8.268025e-03 1.0406734 2.169798e-02
228 2535 FZD2 -0.8518293 6.488938e-03 -0.7678688 2.815505e-02
229 2670 GFAP -0.8788076 8.688770e-14 -0.6135068 7.450698e-12
230 4836 NMT1 -1.1632887 2.217884e-14 -0.6361625 5.493712e-04
231 113026 PLCD3 -0.6464323 1.203694e-03 -1.0225654 4.338592e-07
232 10951 CBX1 0.3944676 4.649747e-02 0.5992823 1.055582e-02
233 4804 NGFR -1.8961919 1.638191e-04 -2.0647461 7.699124e-05
234 9902 MRC2 -0.4674889 3.502325e-04 -0.7894924 7.125825e-08
235 10351 ABCA8 7.1845356 2.807586e-04 6.5117911 2.349140e-02
236 2232 FDXR -1.0998184 2.512139e-04 -0.8961472 9.375928e-03
237 3021 H3-3B 0.4481503 1.388105e-02 0.5709138 1.727819e-03
238 91107 TRIM47 -0.5521811 4.337940e-02 -1.0892316 3.109138e-04
239 6427 SRSF2 0.6570711 8.949572e-04 0.7749439 8.856202e-04
240 57690 TNRC6C 0.9318899 1.811934e-03 1.2590142 3.536824e-05
241 7077 TIMP2 -0.5451779 1.909010e-05 -0.5143953 4.559581e-03
242 3959 LGALS3BP -1.0807887 1.016548e-10 -0.9944939 1.156218e-09
243 2548 GAA -1.1008862 3.334932e-04 -1.1046775 2.438171e-03
244 57674 RNF213 -0.8289028 1.166942e-03 -0.8022541 1.096290e-02
245 284184 NDUFAF8 -0.7803367 4.361201e-07 -0.3851560 2.844284e-02
246 124565 SLC38A10 -0.9196737 1.967783e-06 -0.7500777 9.981604e-03
247 5034 P4HB -0.4811759 6.537472e-04 -0.4358903 1.725798e-02
248 23136 EPB41L3 0.8043025 1.809110e-02 1.2410497 4.155530e-05
249 361 AQP4 1.9832329 1.458331e-21 2.4813295 4.518687e-20
250 8715 NOL4 2.5687040 4.710820e-05 2.3750310 3.748654e-03
251 56853 CELF4 2.8308665 1.337532e-02 3.6788376 1.542505e-04
252 5596 MAPK4 2.1620912 1.378009e-05 3.1944381 4.168558e-15
253 51320 MEX3C 0.7216292 1.368868e-03 0.7288804 1.327124e-02
254 6925 TCF4 0.5224426 8.286071e-03 0.6992144 2.433102e-03
255 51046 ST8SIA3 1.7236224 5.223639e-03 2.0225337 1.231036e-03
256 115701 ALPK2 -0.3642425 1.318485e-02 -0.9000492 4.287961e-06
257 90701 SEC11C 0.6393863 9.080238e-03 0.7131786 1.199206e-02
258 22850 ADNP2 0.9382335 2.980606e-02 1.0730372 3.364371e-02
259 10272 FSTL3 -1.9141863 1.507138e-08 -2.4098435 1.145709e-08
260 2879 GPX4 -0.7943588 1.117022e-04 -0.5399049 1.042772e-02
261 4616 GADD45B 0.6442761 4.617392e-02 0.8482295 1.711765e-02
262 60680 CELF5 1.6397514 9.718171e-05 2.8299477 9.724418e-19
263 10362 HMG20B -0.5705072 2.482387e-02 -0.6321276 4.569560e-02
264 1938 EEF2 -0.7389372 1.785278e-10 -0.6395235 1.845226e-06
265 80700 UBXN6 -1.3315384 3.883207e-07 -0.5436964 4.416257e-02
266 25873 RPL36 -1.1881207 3.462815e-23 -0.4791971 1.583682e-03
267 3383 ICAM1 -0.5382711 3.466183e-02 -0.9588536 7.172713e-03
268 7297 TYK2 -0.8352119 3.919247e-03 -0.8395900 1.042772e-02
269 1995 ELAVL3 1.6008247 2.454648e-14 2.9572941 4.249882e-64
270 51398 WDR83OS -0.6621618 7.344926e-06 -0.4834366 1.179665e-02
271 4784 NFIX -0.5776782 1.388105e-02 -0.6800133 1.051906e-02
272 9592 IER2 0.7907178 1.128910e-03 0.8540200 7.832869e-03
273 23025 UNC13A 1.9799400 3.834358e-02 2.9789190 4.894679e-04
274 54858 PGPEP1 -1.1812771 4.796700e-11 -1.1865815 1.170981e-08
275 1463 NCAN 0.5462462 4.655457e-04 1.3779361 2.286572e-20
276 57616 TSHZ3 2.2062795 8.996888e-04 2.7318589 2.240349e-05
277 1054 CEBPG 2.4944429 5.594227e-11 1.9096803 2.498586e-04
278 9710 GARRE1 -0.6462264 1.658445e-02 -0.8139986 7.634639e-03
279 826 CAPNS1 -0.9150501 1.243570e-09 -0.6479115 2.443150e-04
280 7538 ZFP36 2.1059243 6.969675e-05 2.1236973 1.194859e-03
281 645 BLVRB -1.0333420 1.228879e-03 -1.0952873 5.846189e-04
282 602 BCL3 -0.6322777 1.674787e-02 -1.4886064 9.936794e-09
283 27113 BBC3 -1.3305512 2.285361e-14 -1.1325714 3.830730e-09
284 8605 PLA2G4C -1.3554795 3.958831e-02 -1.6706418 4.784355e-02
285 10945 KDELR1 -0.3167301 4.213416e-02 -0.5231799 5.564150e-03
286 6141 RPL18 -0.3924189 1.383462e-03 -0.3167985 2.360646e-02
287 51171 HSD17B14 -2.4382627 8.095397e-06 -3.0486255 9.880131e-07
288 4924 NUCB1 -0.8808132 6.334853e-08 -0.5112236 9.375928e-03
289 581 BAX -1.4924872 2.618953e-13 -0.7377792 1.239803e-05
290 2512 FTL -0.4942241 2.712866e-03 -0.6672808 2.482689e-08
291 2217 FCGRT -0.8782572 7.301084e-04 -1.0374652 2.021297e-03
292 6237 RRAS -1.0491362 2.177220e-05 -1.7450213 2.652380e-06
293 2109 ETFB -0.9079624 1.045505e-05 -0.5234932 3.723936e-02
294 101060391 <NA> 2.4792585 1.390130e-02 3.7223004 2.194727e-06
295 6664 SOX11 0.6401704 2.796227e-05 1.8647460 3.791295e-32
296 57498 KIDINS220 0.6170120 3.915208e-03 0.6849782 5.593621e-03
297 6382 SDC1 -1.3289872 4.026500e-03 -1.7592725 3.278351e-03
298 5500 PPP1CB -0.3473838 2.187066e-02 -0.9982070 1.894902e-10
299 6432 SRSF7 0.9228610 3.402040e-04 0.9014630 1.710025e-03
300 9378 NRXN1 3.2548950 1.117022e-04 4.3738759 2.987959e-10
301 55704 CCDC88A 1.3880390 1.399888e-20 1.1390501 1.632985e-08
302 51255 RNF181 -0.6008622 1.419132e-03 -0.7086328 1.174351e-03
303 51652 CHMP3 -1.0607526 2.116479e-05 -0.8821282 1.791381e-03
304 400986 ANKRD36C 1.0527632 9.243063e-04 0.9333155 2.028577e-02
305 57730 ANKRD36B 1.0015210 2.195924e-04 0.8999155 1.711765e-02
306 9486 CHST10 -0.8993879 2.266197e-07 -0.9206192 7.125825e-08
307 84417 ECRG4 1.0248005 2.217257e-03 1.1840566 8.394612e-04
308 3625 INHBB -1.1471836 1.615238e-05 -1.6018996 1.446473e-04
309 2863 GPR39 -1.6489253 2.178554e-03 -2.2435522 2.325506e-04
310 4249 MGAT5 0.7442919 9.599486e-03 0.9842356 9.405533e-04
311 3800 KIF5C 0.4649209 1.525190e-02 0.7388030 2.977731e-04
312 114793 FMNL2 -0.7898825 1.705881e-05 -0.8536632 4.788315e-05
313 56475 RPRM 2.6483233 2.564757e-02 3.7565992 3.335295e-04
314 90 ACVR1 1.2507968 1.781456e-02 1.6051601 2.597708e-03
315 220988 HNRNPA3 0.6482484 4.706088e-04 0.6659135 1.978731e-03
316 91404 SESTD1 1.6691029 9.604536e-05 1.5514432 7.832869e-03
317 51602 NOP58 1.2115301 2.267611e-06 1.0686516 8.546641e-04
318 8828 NRP2 -0.5226133 3.204906e-03 -0.9573256 1.599583e-08
319 8609 KLF7 1.0025878 1.033785e-06 1.0033664 3.078591e-04
320 2066 ERBB4 2.2485676 3.804598e-04 2.9170132 8.735657e-08
321 79582 SPAG16 0.6284534 3.959769e-03 0.7885585 1.342963e-03
322 6168 RPL37A -0.9303554 3.042872e-18 -0.3655451 8.019089e-03
323 3488 IGFBP5 -1.4806287 1.305233e-12 -2.6276423 1.373751e-26
324 5798 PTPRN 6.8817517 8.593309e-04 7.8030319 3.307515e-05
325 7857 SCG2 2.6113161 6.033672e-10 3.7349230 1.200548e-25
326 5270 SERPINE2 -0.9926334 1.123782e-07 -1.4256796 1.036254e-07
327 151473 SLC16A14 6.8979289 8.572895e-04 7.2070774 1.558555e-03
328 5757 PTMA 0.7519147 1.387138e-04 0.7887292 8.998932e-05
329 3635 INPP5D -2.2579553 5.424084e-03 -2.8167141 7.994280e-04
330 2637 GBX2 -2.7009859 4.364859e-03 -6.2925642 1.466669e-04
331 2817 GPC1 -0.7017691 1.769125e-03 -0.6905752 3.943678e-03
332 57506 MAVS -0.9250269 4.940842e-05 -0.8589591 2.809631e-04
333 6238 RRBP1 -0.8686983 2.637579e-05 -0.9009048 3.285356e-04
334 2937 GSS -0.7443337 9.556314e-03 -1.0706544 1.119043e-03
335 4826 NNAT 3.1680251 7.373864e-17 5.3451431 5.973672e-20
336 84969 TOX2 -1.1459953 7.190124e-04 -1.3343938 1.161155e-03
337 51604 PIGT -0.4991703 3.478910e-02 -0.6856040 8.774860e-03
338 11065 UBE2C 1.3363669 3.139684e-03 1.8034193 2.587335e-04
339 5740 PTGIS -2.7612814 1.938607e-02 -7.0602674 1.050621e-04
340 655 BMP7 0.4510380 4.264469e-02 0.5359877 4.798275e-02
341 100462983 MTRNR2L3 -0.9819699 4.010125e-03 -1.1648154 2.074899e-03
342 56937 PMEPA1 -0.5230080 3.898929e-03 -0.9284119 2.782505e-07
343 3911 LAMA5 -0.6052878 9.972372e-03 -1.2493616 1.833221e-08
344 6227 RPS21 -0.5594318 2.996471e-06 -0.4096432 2.941618e-03
345 79144 PPDPF -0.6670751 4.327228e-06 -0.3941644 2.634767e-02
346 140578 CHODL 0.8632802 1.949047e-02 1.2636075 1.565239e-03
347 10600 USP16 1.2901756 4.427731e-09 0.8025704 1.271791e-02
348 56245 C21orf62 0.8932085 5.886905e-04 1.0088722 1.367254e-04
349 1827 RCAN1 1.6169413 1.891122e-32 1.8123293 2.115084e-33
350 54102 CLIC6 -2.1222556 1.120768e-02 -2.6977421 1.231036e-03
351 5211 PFKL -0.9994257 6.710778e-06 -0.7925855 2.421756e-03
352 80781 COL18A1 -0.6429705 4.185984e-03 -1.4012123 9.118276e-11
353 1291 COL6A1 -0.7334164 4.184865e-07 -0.6569213 4.337822e-05
354 1292 COL6A2 -1.3165699 8.946508e-04 -1.4529057 1.727819e-03
355 114044 MCM3AP-AS1 4.8433420 2.054490e-02 5.1556030 2.798496e-02
356 9993 DGCR2 -0.7393578 1.071439e-06 -0.4582500 2.169798e-02
357 652968 CASTOR1 -0.8958563 1.023060e-02 -1.0533783 7.355072e-03
358 6948 TCN2 -1.3719700 4.070087e-04 -1.2418938 6.518635e-03
359 8542 APOL1 -2.4345061 3.621806e-03 -2.7056263 4.636375e-04
360 4627 MYH9 -0.3688866 5.764094e-03 -0.6803203 6.846859e-05
361 29775 CARD10 -0.9401422 7.212982e-03 -1.2970562 2.494423e-02
362 27350 APOBEC3C -1.9626154 5.457109e-06 -2.5872219 1.910522e-06
363 6122 RPL3 -0.3961649 5.118954e-04 -0.4590053 4.374010e-04
364 468 ATF4 0.7341126 2.253227e-04 0.6362050 1.221214e-03
365 55964 SEPTIN3 0.6535855 1.198266e-04 0.9633868 2.581520e-08
366 112885 PHF21B 1.5549008 4.011849e-03 2.2449725 6.620180e-06
367 55007 FAM118A -1.0297339 1.087497e-02 -1.3182219 4.685516e-02
368 7508 XPC -0.7104169 8.209563e-03 -0.7223291 3.410553e-02
369 9975 NR1D2 -1.2910971 5.627615e-03 -1.1626472 3.409973e-02
370 7068 THRB 5.0150341 2.159653e-03 6.1027810 1.198285e-05
371 116135 LRRC3B 1.1558432 8.772857e-04 1.5001648 1.478949e-04
372 27303 RBMS3 -2.0662574 7.993136e-03 -1.9706185 4.640489e-02
373 91392 ZNF502 2.1416244 4.197156e-02 2.7973671 3.055488e-03
374 10675 CSPG5 0.8446787 1.466453e-02 1.5989512 8.664247e-07
375 2771 GNAI2 -0.4543327 1.350202e-04 -0.4763113 4.896779e-05
376 7869 SEMA3B -1.6475938 4.752961e-08 -1.4351780 2.091144e-04
377 440957 SMIM4 -0.5866022 6.939397e-04 -0.5266405 3.709768e-03
378 7086 TKT -0.8925533 9.251601e-12 -1.1219402 9.581386e-15
379 2317 FLNB -0.6756728 4.312458e-02 -1.1666722 3.634648e-03
380 11170 FAM107A 1.1104834 2.350922e-03 2.4518419 3.100573e-17
381 8618 CADPS 6.9087162 1.192958e-03 8.3390362 6.297620e-07
382 132204 SYNPR 3.1769801 5.309386e-13 3.1533266 5.348598e-12
383 9223 MAGI1 0.4978709 1.427483e-02 0.7145249 1.937158e-02
384 56650 CLDND1 1.0804913 1.666380e-04 0.8996633 3.238264e-02
385 961 CD47 0.8328868 1.615238e-05 0.8365725 9.139134e-05
386 55081 IFT57 1.0963751 3.073686e-05 1.0014533 7.706317e-03
387 29114 TAGLN3 0.8305021 3.258099e-03 1.9453827 4.168558e-15
388 79858 NEK11 1.3419328 1.850060e-02 1.4663334 3.003395e-02
389 7018 TF -3.3138202 4.725046e-35 -2.6201244 4.161319e-27
390 5217 PFN2 0.3523718 4.478066e-02 0.7112425 1.747127e-05
391 5806 PTX3 1.8589852 1.367837e-11 1.4264436 2.064758e-03
392 6657 SOX2 -0.5130097 8.535894e-05 -0.4483034 3.190897e-02
393 84002 B3GNT5 3.1771060 9.492418e-05 2.9853757 3.924664e-03
394 6480 ST6GAL1 5.2895695 3.498778e-02 6.4189671 2.152638e-03
395 53834 FGFRL1 -0.8519278 5.105178e-04 -1.0492044 1.422827e-04
396 10417 SPON2 -2.3091363 1.712572e-08 -4.2748445 1.430988e-13
397 285489 DOK7 -1.6758347 2.855885e-02 -3.3022258 2.754133e-03
398 4043 LRPAP1 -0.4685760 2.442153e-03 -0.6023743 4.082433e-04
399 27065 NSG1 1.4644396 1.376922e-03 2.5808441 2.241496e-12
400 57537 SORCS2 -0.7871403 4.529303e-02 -1.6736831 1.240910e-04
401 8532 CPZ -0.7725561 6.978706e-04 -1.1278406 7.929514e-06
402 79730 NSUN7 3.2018938 7.750809e-03 3.7341067 1.069240e-03
403 9662 CEP135 2.3818682 3.676748e-03 2.3832982 1.944258e-02
404 57482 CRACD 1.4143169 1.376922e-03 1.3546269 3.076361e-02
405 84525 HOPX 0.8006811 1.307252e-05 0.4927356 4.720265e-02
406 2926 GRSF1 0.6256449 3.584136e-02 0.7764957 1.534185e-02
407 9508 ADAMTS3 1.2581974 3.040421e-02 1.8256163 4.890966e-03
408 9987 HNRNPDL 0.7667476 8.001259e-10 0.8633976 2.346389e-11
409 8404 SPARCL1 3.4518746 1.810240e-02 5.7065746 1.283212e-09
410 6164 RPL34 -0.2726410 1.335382e-02 -0.4045876 1.809947e-03
411 5188 GATB -0.6342599 1.003106e-02 -1.0566535 4.213824e-04
412 84057 MND1 6.3689687 7.985926e-04 5.7875478 2.157803e-02
413 3148 HMGB2 1.5575692 3.399080e-07 1.8107787 1.042069e-06
414 79682 CENPU 1.7572873 2.248609e-02 2.0161924 1.497425e-02
415 134121 C5orf49 1.2891972 2.152868e-02 1.6567350 1.318342e-03
416 100505738 MIR4458HG -0.6736466 4.960015e-04 -0.9792733 3.598272e-07
417 56172 ANKH 1.9013191 4.952983e-02 2.3061208 2.360646e-02
418 3157 HMGCS1 0.8251998 1.308333e-04 1.2064166 3.304990e-09
419 5144 PDE4D 3.0265041 1.233264e-02 3.9901682 7.651789e-05
420 3796 KIF2A 0.7211634 2.075211e-02 0.9707886 7.986975e-03
421 4131 MAP1B 0.6501884 1.009581e-11 0.4458657 4.760952e-03
422 8507 ENC1 0.7194827 7.482311e-03 1.0252607 2.551228e-05
423 3156 HMGCR 1.1990674 1.438339e-06 1.0978114 2.295227e-04
424 7060 THBS4 1.6714202 3.470063e-03 1.9361751 1.656621e-03
425 7025 NR2F1 -0.5239516 5.301621e-03 -0.7285153 1.757675e-02
426 1946 EFNA5 1.8063297 3.037219e-03 2.3255291 1.182043e-04
427 324 APC 0.8329661 1.828265e-03 0.9625218 7.604579e-04
428 4001 LMNB1 0.9899708 4.791469e-02 1.3387424 5.396264e-03
429 441108 <NA> -0.7398561 3.240773e-02 -1.0710016 3.001819e-02
430 23338 JADE2 -2.1443131 1.923788e-03 -1.8656289 1.839096e-02
431 9879 DDX46 0.4407792 3.343420e-02 0.7063848 2.434675e-03
432 9547 CXCL14 -1.1500571 5.710320e-15 -2.3721417 1.503380e-08
433 6695 SPOCK1 -1.4233259 3.516658e-06 -1.7590654 2.210035e-08
434 51306 FAM13B 1.3277345 2.263273e-02 1.4046261 4.749983e-02
435 1958 EGR1 2.2672437 3.856617e-04 2.4980545 1.028471e-03
436 1839 HBEGF 0.7151459 2.979990e-02 1.3006599 1.528098e-04
437 2246 FGF1 0.6235654 2.880638e-02 1.0320918 1.282450e-03
438 11346 SYNPO -1.1973194 6.008782e-09 -1.1898142 1.055427e-05
439 10318 TNIP1 -1.1302281 4.470897e-08 -1.1870840 2.381835e-05
440 345630 FBLL1 1.0250079 3.462894e-02 1.4713806 1.983706e-03
441 64901 RANBP17 7.3286999 9.675490e-05 6.1899962 4.070817e-02
442 1843 DUSP1 2.3389517 1.273281e-03 2.5638656 2.811444e-03
443 8992 ATP6V0E1 -0.3377393 3.655155e-02 -0.6097685 4.551850e-04
444 51617 NSG2 1.8040947 9.266707e-03 4.1218627 7.584436e-19
445 10814 CPLX2 1.6274692 9.392387e-04 3.5137687 2.236009e-29
446 11282 MGAT4B -0.7511967 1.707978e-05 -0.7693371 1.528098e-04
447 54898 ELOVL2 0.7979453 5.119268e-03 1.1282748 2.853354e-04
448 84062 DTNBP1 -1.1375751 3.084289e-05 -0.7077513 4.978160e-02
449 3400 ID4 1.3234321 2.454648e-14 0.9597098 5.245563e-06
450 10590 SCGN 2.4339359 3.784284e-26 3.1883757 3.436960e-49
451 100129195 ZSCAN16-AS1 -0.9824939 2.547771e-03 -0.9671895 2.925943e-02
452 3105 HLA-A -0.7630050 2.536753e-02 -1.1830565 7.298879e-04
453 3106 HLA-B -0.6920167 4.768717e-04 -0.9450936 4.991740e-06
454 6892 TAPBP -1.0925660 2.103301e-09 -0.8757743 3.598272e-07
455 221491 SMIM29 -0.9126123 3.265619e-04 -0.7966399 2.300862e-02
456 6428 SRSF3 0.5907227 1.544322e-03 0.5518872 2.655440e-02
457 1026 CDKN1A -0.7352948 5.673328e-09 -1.0205134 3.102091e-12
458 221477 C6orf89 -0.4290711 3.655155e-02 -0.5997872 4.176082e-03
459 4188 MDFI -1.6946787 4.396140e-07 -1.3989779 7.206897e-03
460 6722 SRF 0.5035098 3.518799e-02 0.6710501 1.775345e-02
461 5429 POLH -0.8482561 5.598261e-03 -0.8333806 3.838590e-02
462 441151 TMEM151B 2.4813514 2.136663e-02 3.8733208 1.307363e-06
463 10492 SYNCRIP 0.6547845 9.106134e-05 0.6851036 3.292267e-04
464 10690 FUT9 1.6228542 4.295188e-02 2.0538863 1.353922e-02
465 100133941 CD24 0.7826658 3.352518e-04 1.0520556 2.959499e-06
466 2534 FYN 0.5754398 2.001797e-03 0.5222057 2.420192e-02
467 2697 GJA1 0.7860628 1.505593e-09 0.6923602 6.978354e-08
468 1490 CCN2 1.7669666 1.270529e-38 1.5007085 1.529090e-03
469 51696 HECA 2.2305072 7.866600e-03 2.0715526 4.712701e-02
470 168090 C6orf118 6.5459019 9.453808e-06 7.1323223 6.583826e-07
471 51660 MPC1 1.3861836 7.373864e-17 0.9075743 1.915919e-03
472 392617 ELFN1 -0.7633663 1.535848e-02 -0.9114103 1.418670e-02
473 29886 SNX8 -0.8103420 1.203993e-03 -0.7810089 7.506111e-03
474 2115 ETV1 1.6971077 2.762389e-28 1.7069240 2.317050e-16
475 8701 DNAH11 6.6153200 3.513273e-03 7.3569130 9.558770e-04
476 4852 NPY 1.3154757 1.750895e-06 2.3498901 2.565768e-28
477 79017 GGCT 1.2098831 3.979532e-06 1.0129868 1.365792e-02
478 64759 TNS3 -0.6654305 1.769450e-02 -1.2746450 1.839349e-05
479 7378 UPP1 -0.6755395 6.065297e-03 -0.9264188 1.027423e-03
480 64409 GALNT17 -1.0238278 7.558802e-06 -1.9099800 7.365375e-03
481 11257 <NA> -0.8753233 3.386687e-02 -1.2223439 1.452713e-02
482 5244 ABCB4 -0.7938959 1.121641e-02 -1.7461164 2.042689e-08
483 1750 DLX6 1.6967820 9.798325e-04 2.9795474 1.176582e-16
484 1749 DLX5 2.1487545 2.964895e-05 3.6472396 1.961173e-22
485 25798 BRI3 -0.5605655 3.962710e-05 -0.4798202 1.983706e-03
486 245812 CNPY4 -0.6789715 3.975321e-02 -1.0137840 1.705933e-02
487 7205 TRIP6 -0.5516844 1.432870e-03 -0.4696307 2.079177e-02
488 5054 SERPINE1 2.8513450 2.722428e-19 2.6376578 1.989264e-14
489 2861 GPR37 1.9616350 2.142435e-04 2.6412375 1.626127e-09
490 9296 ATP6V1F -0.6208547 4.185984e-03 -0.4916495 3.190897e-02
491 4232 MEST 1.1090253 7.948981e-06 1.8407917 6.282989e-16
492 26958 COPG2 2.0371199 2.372957e-08 2.3938799 4.276165e-09
493 155066 ATP6V0E2 -0.9295884 9.408256e-10 -0.5163034 8.652071e-04
494 54480 CHPF2 -0.6725414 3.776809e-02 -0.8143411 2.613487e-02
495 349136 WDR86 -1.1356266 2.235311e-09 -1.1158594 1.933368e-04
496 79660 PPP1R3B 1.4609627 1.402176e-03 1.8644080 4.269170e-05
497 10395 DLC1 1.8760039 1.172214e-16 1.7331700 2.605612e-11
498 4747 NEFL -1.9411917 8.790184e-07 -2.8226773 6.525063e-10
499 1808 DPYSL2 0.8030127 2.557717e-10 0.9879686 4.168558e-15
500 1191 CLU -0.3444037 1.107307e-02 -0.6555587 8.068107e-07
501 80223 RAB11FIP1 -1.7160464 1.990906e-05 -2.8548878 3.690210e-05
502 286183 NKAIN3 -0.9005197 2.312742e-06 -1.0762978 3.536824e-05
503 5569 PKIA 1.2397113 4.103217e-03 1.2258164 2.598470e-02
504 11075 STMN2 5.0289645 3.982030e-03 6.2206112 3.882748e-04
505 862 RUNX1T1 2.3617343 8.043349e-06 3.3261306 7.110959e-14
506 79870 BAALC 0.5247210 1.942507e-04 0.4522719 1.094306e-03
507 23237 ARC 2.3259726 4.013752e-02 2.5449994 4.898564e-02
508 4062 LY6H 2.3379504 8.390999e-04 3.5422444 1.865305e-10
509 1936 EEF1D -1.1027922 3.167177e-05 -0.6419713 1.207905e-02
510 6132 RPL8 -0.6916893 2.510775e-12 -0.5291093 8.363642e-06
511 6595 SMARCA2 -0.4913439 2.490699e-02 -0.6977376 2.043116e-03
512 11168 PSIP1 1.0403464 5.601800e-10 0.5164943 3.233658e-02
513 92949 ADAMTSL1 -1.5663012 1.242368e-02 -2.3008362 6.016343e-03
514 10210 TOPORS 0.8707731 2.075211e-02 0.9013817 4.070817e-02
515 2683 B4GALT1 -0.7018422 3.693915e-03 -1.5182056 1.759899e-05
516 7094 TLN1 -0.5504165 1.272024e-02 -0.6671978 2.021297e-03
517 389765 <NA> 5.4260040 2.076460e-02 5.9222574 1.505603e-02
518 8013 NR4A3 1.7014179 5.244930e-03 1.7403012 1.588166e-02
519 5998 RGS3 -0.4113436 4.968924e-02 -0.7189488 2.225797e-03
520 3371 TNC 1.4982035 2.413395e-02 2.0004229 2.211218e-03
521 5069 PAPPA -2.2700106 9.962078e-03 -3.7710131 3.117838e-03
522 1620 BRINP1 2.2574012 1.286098e-07 3.0310203 1.402464e-15
523 6136 RPL12 -0.3890133 4.301363e-03 -0.5832159 1.061134e-05
524 64855 NIBAN2 -0.5600645 3.062325e-02 -0.7750492 9.711585e-03
525 10044 SH2D3C 2.6970967 2.599771e-02 3.4350539 1.777636e-03
526 114789 SLC25A25 0.9656242 6.642499e-04 1.0071855 1.250459e-03
527 5524 PTPA -0.6425695 3.513537e-03 -0.7954230 1.068443e-03
528 100506119 LINC01503 -1.1175070 1.441011e-02 -1.7491243 5.914940e-04
529 1289 COL5A1 -1.2018514 4.170684e-03 -2.0049030 7.289041e-07
530 4851 NOTCH1 -0.5344426 3.411729e-02 -0.7501386 8.179276e-03
531 4558 <NA> -0.4298432 1.610129e-03 -0.3656401 1.571732e-02
532 4577 <NA> -1.3295590 1.169416e-14 -1.2308466 1.478113e-10
533 4567 <NA> -1.4148488 9.051147e-27 -0.5195176 2.424442e-03
534 4578 <NA> -0.6747855 3.804763e-02 -1.0236360 1.254247e-03
535 1654 DDX3X 1.1505064 8.327307e-07 0.8401308 5.341800e-03
536 4129 MAOB 0.9150234 1.210106e-04 1.4785002 8.754387e-13
537 57477 SHROOM4 -1.3830074 4.845572e-02 -1.9919367 2.274220e-02
538 170685 NUDT10 1.4147710 2.818500e-02 2.0014879 1.025794e-03
539 28986 MAGEH1 1.2649014 4.241764e-03 1.7982424 3.382692e-05
540 4675 NAP1L3 1.7743412 3.889017e-04 1.9082968 2.021297e-03
541 6173 RPL36A -0.7016506 8.268025e-03 -0.7838113 1.120698e-02
542 11013 TMSB15A 1.5374152 2.912308e-05 2.7447767 3.849016e-24
543 55859 BEX1 0.3872331 1.470021e-02 0.4061960 2.133427e-02
544 51186 TCEAL9 -0.3800982 5.096525e-03 -0.3282262 1.872563e-02
545 5063 PAK3 1.4667139 3.497466e-03 1.5683615 9.420164e-03
546 1641 DCX 1.7466251 1.152596e-19 3.0922910 3.506445e-68
547 3597 IL13RA1 -0.6760142 4.444139e-02 -1.0945962 2.155298e-02
548 6170 RPL39 -0.4799398 5.522891e-05 -0.4551620 2.043707e-03
549 3897 L1CAM 0.9404392 4.222256e-02 1.3354601 4.174608e-03
550 2316 FLNA -0.6232515 9.169656e-07 -0.5112294 1.768206e-03
551 8270 LAGE3 -0.5859079 2.326138e-02 -0.8720007 3.940762e-03
552 2539 G6PD -0.5578078 4.406929e-02 -0.8467634 9.657304e-03
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 0.9583742 0.59708289 1.468663 1.000000e+00
02_TSC2_KO_Grabole_2016 1.8770766 1.57627048 2.235015 7.533614e-13
03_TSC2_Grabole-2016 1.9358721 1.61429855 2.327220 1.382478e-13
04_TSC2-tuber-Martin2017 3.4242840 1.79363318 6.073134 1.793370e-04
05_TSC2-SEN_SEGA-Martin2017 2.9945499 2.47096771 3.618615 4.881108e-27
06_all_EpilepsyGene 1.1121355 0.63584989 1.823161 6.910190e-01
07_high_conf_EpilepsyGene 1.4137717 0.55347557 3.026237 3.559290e-01
08_ASD_Epilepsy_EpilepsyGene 0.8396849 0.22405456 2.222993 1.000000e+00
09_Epi25_dataset 0.5945811 0.07059024 2.230521 7.744278e-01
10_SFARI_all 1.3814218 0.71934599 2.431774 2.442488e-01
11_SFARI_score4plus 1.4346896 0.67149147 2.726517 2.473882e-01
12_DeRubeis_RDNV 2.3715118 0.91541260 5.181357 3.707211e-02
13_Iossifov_RDNV 1.2888500 0.82533800 1.934140 2.076402e-01
14_FMRP_Darnell 1.3862891 0.97415992 1.926965 5.696057e-02
15_Voineagu_M12 1.0924633 0.60010072 1.845716 6.768491e-01
16_Voineagu_M16 3.2944950 2.28004905 4.654416 1.600300e-09
17_ID_genes_Neel 1.2296736 0.68894616 2.048181 3.933697e-01
18_ID_genes_pinto2014 1.1335593 0.55459533 2.083469 6.212855e-01
19_Fromer_SCZ_FunDN 0.8924430 0.52017976 1.440140 7.276071e-01
20_Cocchi_Pruning 4.0459242 2.04832572 7.391796 6.835179e-05
Beta SE Padj
01_Swaminathan2018_DEPDC5KO -0.04251700 0.24141955 1.000000e+00
02_TSC2_KO_Grabole_2016 0.62971558 0.08910917 1.506723e-11
03_TSC2_Grabole-2016 0.66055790 0.09268233 2.764957e-12
04_TSC2-tuber-Martin2017 1.23089240 0.32992302 3.586739e-03
05_TSC2-SEN_SEGA-Martin2017 1.09679392 0.09805309 9.762216e-26
06_all_EpilepsyGene 0.10628204 0.28524225 1.000000e+00
07_high_conf_EpilepsyGene 0.34626111 0.47846876 1.000000e+00
08_ASD_Epilepsy_EpilepsyGene -0.17472858 0.67404955 1.000000e+00
09_Epi25_dataset -0.51989815 1.08722718 1.000000e+00
10_SFARI_all 0.32311327 0.33292148 1.000000e+00
11_SFARI_score4plus 0.36094855 0.38734822 1.000000e+00
12_DeRubeis_RDNV 0.86352762 0.48566735 7.414422e-01
13_Iossifov_RDNV 0.25375031 0.22740438 1.000000e+00
14_FMRP_Darnell 0.32663043 0.18000522 1.000000e+00
15_Voineagu_M12 0.08843506 0.30565960 1.000000e+00
16_Voineagu_M16 1.19225290 0.18778364 3.200601e-08
17_ID_genes_Neel 0.20674874 0.29558209 1.000000e+00
18_ID_genes_pinto2014 0.12536248 0.36473421 1.000000e+00
19_Fromer_SCZ_FunDN -0.11379263 0.27540215 1.000000e+00
20_Cocchi_Pruning 1.39771001 0.34728943 1.367036e-03
D244
getlinmodoutput(targetline = "D244",targetdiff = "DIFF",targetrapa = "noRAPA") entrezgene genname log2FC_2.1 fdr_2.1 log2FC_2.2 fdr_2.2
1 4237 MFAP2 -1.1043692 7.672135e-03 -1.2811560 2.995447e-02
2 57134 MAN1C1 0.5990502 7.965530e-03 0.9212493 1.543752e-03
3 6272 SORT1 0.4443084 1.768453e-02 0.5998305 4.210823e-02
4 5738 PTGFRN 0.9467220 3.518917e-04 1.0025640 9.050373e-03
5 6282 S100A11 0.6023700 2.653885e-05 0.5859466 4.404445e-02
6 10485 MIR9-1HG -0.8272271 9.664047e-04 -1.2643130 3.121650e-05
7 10763 NES -0.7704375 2.248345e-08 -0.7919072 4.336417e-04
8 3766 KCNJ10 -1.7938894 1.629161e-06 -1.4794653 4.628547e-03
9 477 ATP1A2 -1.0395969 8.462466e-08 -0.9120463 1.282985e-03
10 8490 RGS5 1.5556701 3.267739e-23 1.2211234 1.551601e-06
11 9019 MPZL1 0.7188379 3.194134e-04 0.6881345 4.555882e-02
12 25874 MPC2 1.1139096 6.543961e-06 1.0688515 1.180660e-03
13 116496 NIBAN1 0.7374131 4.703459e-03 1.0554679 1.282985e-03
14 25802 LMOD1 1.3562336 2.303687e-05 1.8496848 1.084917e-07
15 50486 G0S2 -1.4492217 3.370529e-32 -1.7927431 4.532054e-17
16 5629 PROX1 -1.5178846 1.675095e-02 -2.4556355 7.280961e-03
17 7044 LEFTY2 -1.6863840 1.444934e-19 -2.6934841 1.215175e-28
18 84886 C1orf198 1.2166944 7.326387e-13 0.9990460 1.949588e-05
19 84457 PHYHIPL -0.8575537 1.374903e-03 -0.9576670 2.428566e-02
20 9124 PDLIM1 0.6695783 7.704916e-06 0.9157777 6.404187e-05
21 6319 SCD 1.0653410 1.558967e-14 1.1186607 1.839053e-07
22 2674 GFRA1 -0.6523985 8.183490e-05 -0.8093946 1.203216e-03
23 8519 IFITM1 3.2595909 6.024803e-05 1.8815573 2.234507e-02
24 283298 OLFML1 1.7085130 3.680616e-24 1.8640153 5.795595e-17
25 9537 TP53I11 -1.7242136 7.206134e-08 -1.1792320 1.245941e-02
26 11098 PRSS23 1.0913154 9.842498e-20 0.8635884 5.530015e-06
27 4684 NCAM1 -0.5494706 1.026677e-03 -0.6331499 2.256772e-02
28 4837 NNMT 0.7842202 7.898614e-03 1.1464285 5.758824e-04
29 6876 TAGLN 0.4123892 9.665626e-03 0.7132672 4.250429e-03
30 53826 FXYD6 -1.7162372 1.433325e-34 -1.8416866 1.901516e-15
31 63876 PKNOX2 -1.7482105 1.168670e-04 -1.4982166 5.459458e-04
32 8076 MFAP5 2.3168338 8.651461e-20 2.3448004 2.273254e-14
33 347902 AMIGO2 -1.3842915 2.128170e-04 -2.1109406 1.299218e-06
34 1280 COL2A1 -2.1371974 3.797828e-07 -3.0302746 2.533087e-07
35 3875 KRT18 1.6064905 8.644783e-09 1.3205650 3.053862e-03
36 22877 MLXIP -0.9638468 5.810816e-05 -0.9796499 6.372486e-03
37 114795 TMEM132B -2.6346648 5.304330e-07 -2.3794077 2.797473e-04
38 1910 EDNRB -0.8195503 7.898614e-03 -1.1644740 4.006173e-03
39 1638 DCT -1.4330439 2.648927e-11 -1.7502418 9.909285e-10
40 2621 GAS6 0.5265338 3.923218e-02 0.7026356 1.951712e-02
41 652 BMP4 1.4247389 3.501929e-09 1.1752283 3.095265e-03
42 9369 NRXN3 -1.6621007 6.672684e-07 -2.4424245 1.695466e-04
43 3429 IFI27 4.2542529 6.279178e-06 3.6278061 1.376217e-09
44 12 SERPINA3 -1.6236056 2.521750e-24 -0.8631301 4.289578e-02
45 8788 DLK1 -0.9248486 4.651918e-04 -0.9471378 1.212670e-02
46 567 B2M 1.2077170 3.778239e-11 0.7984159 5.870878e-03
47 79875 THSD4 -2.6664291 6.734017e-08 -2.7334640 1.768468e-05
48 64220 STRA6 -1.0928913 3.537829e-05 -1.2826098 3.114309e-05
49 1512 CTSH 0.5571709 2.552339e-02 0.9196970 3.210155e-02
50 57214 CEMIP 1.8401544 5.074532e-32 1.3640633 2.369816e-10
51 30812 SOX8 -0.9468840 3.369214e-03 -1.2444795 1.103060e-03
52 6236 RRAD 0.8607933 9.125466e-03 1.3528494 4.718324e-04
53 55175 KLHL11 -1.1881721 1.259171e-02 -1.6699572 3.293354e-03
54 284119 CAVIN1 0.6081325 6.279660e-05 0.8970985 3.090207e-03
55 4804 NGFR -2.1767618 3.267739e-23 -2.3203327 2.270876e-09
56 81558 FAM117A 1.1920123 8.271636e-03 1.4175407 5.933378e-03
57 1277 COL1A1 -0.7832460 3.421826e-10 -0.5292790 4.809935e-02
58 114897 C1QTNF1 -2.0950386 5.044701e-12 -2.3070277 7.443622e-11
59 115701 ALPK2 1.0228813 4.356290e-11 1.0947289 4.170082e-07
60 1264 CNN1 0.8030666 7.729680e-05 0.8792943 7.015280e-03
61 10653 SPINT2 1.9402401 1.454866e-05 2.3186908 1.836859e-05
62 81606 LBH 1.5450729 7.986236e-08 1.1938272 1.245941e-02
63 4052 LTBP1 -0.6502580 3.452794e-02 -0.8744678 2.459597e-02
64 7039 TGFA -1.5478130 9.355259e-16 -1.8785682 5.052243e-14
65 2995 GYPC -2.4294636 1.874496e-11 -1.9199833 7.112116e-04
66 2487 FRZB -2.7856065 1.455250e-06 -4.1134175 3.895502e-09
67 23671 TMEFF2 -1.4201643 3.113925e-02 -2.1181155 1.599333e-02
68 8324 FZD7 -1.1339644 4.538585e-03 -1.7225282 3.199580e-04
69 2335 FN1 1.3432977 1.275635e-12 0.9941101 4.294325e-04
70 3485 IGFBP2 0.5823047 8.244139e-07 0.7080885 1.695466e-04
71 80303 EFHD1 -2.2240001 1.869882e-06 -1.6178733 1.377763e-03
72 10123 ARL4C -0.8157205 2.068082e-08 -0.6598818 1.004240e-02
73 3397 ID1 1.0968681 3.778573e-09 0.9615010 1.377763e-03
74 4826 NNAT -1.7863625 3.938824e-09 -1.0454326 2.778496e-02
75 7052 TGM2 1.0996047 1.172199e-04 1.1008156 7.015280e-03
76 56937 PMEPA1 -1.1739691 1.378185e-19 -1.1140883 6.627336e-09
77 1917 EEF1A2 -1.5125821 8.827770e-04 -1.6940719 3.053862e-03
78 6453 ITSN1 1.0065733 4.303701e-05 0.9960276 8.619861e-03
79 5121 PCP4 0.4446898 4.951707e-02 0.9254292 8.667160e-05
80 80781 COL18A1 -1.0190535 1.418955e-07 -1.0103524 6.341399e-05
81 7078 TIMP3 -0.6399207 2.209381e-07 -1.0523639 3.895502e-09
82 2847 MCHR1 -1.7383604 2.719626e-06 -1.7412994 9.279880e-04
83 2192 FBLN1 -1.6448627 1.282796e-08 -1.3138823 4.588621e-03
84 10752 CHL1 -0.6451113 4.538585e-03 -1.3138271 5.459458e-04
85 2199 FBLN2 -1.4094832 3.184372e-04 -1.7087813 1.467409e-03
86 7869 SEMA3B -1.3403981 3.060962e-05 -1.2301226 4.896891e-03
87 1295 COL8A1 -2.5537145 3.437208e-60 -2.5283334 5.898885e-25
88 100506621 <NA> 2.5230669 1.416933e-09 2.2736690 1.346570e-05
89 151887 CCDC80 0.9438908 9.829811e-11 1.2905848 3.240083e-10
90 84561 SLC12A8 -1.1198579 4.852200e-02 -1.6935275 2.118427e-02
91 7018 TF -1.7913566 9.804860e-08 -2.1881714 5.243374e-07
92 5947 RBP1 -1.0715058 1.418681e-15 -0.9284459 1.055017e-04
93 4071 TM4SF1 1.3518166 5.022271e-05 1.1842675 1.873053e-02
94 5010 CLDN11 1.8993934 1.201573e-29 1.8494500 3.978462e-13
95 1427 CRYGS 0.9755418 2.259854e-06 1.3402048 3.659429e-06
96 27065 NSG1 -1.3129250 1.061877e-02 -1.6624600 2.991588e-02
97 54360 CYTL1 -2.6337714 7.090266e-11 -2.1502290 1.855011e-05
98 55351 STK32B -1.5441350 2.153720e-03 -1.4961851 4.689396e-02
99 57537 SORCS2 -1.1432855 4.392572e-07 -1.3209447 1.875633e-06
100 8532 CPZ 0.7750727 1.514441e-03 1.2363550 1.434080e-06
101 9948 WDR1 0.4325543 5.175629e-03 0.7742839 1.377763e-03
102 83888 FGFBP2 -2.1483914 1.344610e-05 -4.2223052 7.674223e-15
103 201780 SLC10A4 0.7930787 1.766552e-03 0.7960404 4.902966e-02
104 65997 RASL11B -1.6303068 9.658775e-12 -2.0074814 1.152095e-05
105 25849 PARM1 -1.1715404 4.787249e-03 -1.9035644 2.824212e-03
106 1363 CPE 1.4185324 4.697313e-13 1.3283372 2.306290e-07
107 11341 SCRG1 0.9125289 8.199232e-15 0.6878051 1.216796e-03
108 100505738 MIR4458HG -0.9544000 2.870460e-05 -0.9170490 1.585138e-02
109 9037 SEMA5A -0.6428037 3.036736e-03 -0.8826364 2.219060e-02
110 1601 DAB2 0.7968959 1.540781e-03 0.7951780 3.414656e-02
111 5144 PDE4D -1.8089323 3.060405e-06 -1.3519833 2.899278e-02
112 645323 LINC00461 -0.8089834 7.729680e-05 -0.8159426 1.771747e-03
113 57556 SEMA6A -0.5829327 3.804354e-03 -0.8454463 3.402279e-02
114 972 CD74 1.0486764 4.082443e-05 1.9810723 8.203233e-12
115 11346 SYNPO -1.0320585 3.175806e-06 -0.8511356 7.015280e-03
116 2878 GPX3 -0.8307352 1.502602e-04 -1.4336932 4.108185e-06
117 23286 WWC1 1.5309623 5.957962e-03 1.9357560 1.936223e-03
118 1843 DUSP1 1.8428072 9.089214e-06 1.7754384 2.802331e-03
119 51617 NSG2 -2.0990520 1.175722e-03 -1.9440049 3.947452e-02
120 3107 HLA-C 0.7460155 1.928539e-03 1.1407880 3.121650e-05
121 3106 HLA-B 0.7080853 1.098278e-02 1.3086746 1.677737e-06
122 2697 GJA1 0.9786886 1.006861e-11 0.7103970 2.802331e-03
123 9053 MAP7 -0.9335155 3.404203e-03 -1.5664711 7.689786e-05
124 6648 SOD2 1.0135486 2.010532e-06 0.8424062 1.599333e-02
125 5154 PDGFA -1.3793439 1.064486e-02 -1.6068819 1.591965e-02
126 10457 GPNMB 1.1582452 3.810058e-08 1.3785261 4.578081e-08
127 358 AQP1 -1.8170423 2.468838e-04 -2.0168612 4.718324e-04
128 5244 ABCB4 -1.3752686 2.416092e-05 -2.2432327 1.296467e-05
129 5243 ABCB1 -1.1713101 3.427240e-05 -1.5823229 2.269751e-06
130 1278 COL1A2 -1.5956895 1.872763e-37 -2.2370695 1.682870e-38
131 1749 DLX5 -1.7044278 3.207583e-06 -2.6514489 9.565218e-07
132 51200 CPA4 3.3228930 6.365409e-05 3.1103410 8.470072e-03
133 28996 HIPK2 -0.8391336 1.550376e-09 -0.8387070 2.797473e-04
134 3084 NRG1 2.5200046 1.733589e-35 2.4862133 5.843487e-25
135 286 ANK1 1.8151747 1.147763e-03 1.7245348 3.953019e-02
136 4147 MATN2 2.1408080 8.995671e-10 1.9035397 1.636967e-04
137 114907 FBXO32 1.1939560 2.430979e-17 1.0565700 2.030369e-06
138 1030 CDKN2B 1.2067611 7.993677e-14 0.7141965 1.737711e-02
139 7169 TPM2 0.5224004 2.201374e-02 0.8922799 1.910044e-04
140 1164 CKS2 1.4049983 2.986016e-02 1.8050482 2.392489e-02
141 23446 SLC44A1 -0.6399794 5.854605e-03 -0.8460054 4.555882e-02
142 3371 TNC 1.4093005 5.957962e-03 1.4983126 4.016110e-02
143 1620 BRINP1 -0.8174476 3.918294e-02 -1.5059106 3.298460e-03
144 100506119 LINC01503 1.1047022 5.760934e-09 1.3491184 7.419941e-07
145 4577 <NA> 0.6482089 5.697536e-04 0.7339766 3.261869e-02
146 4564 <NA> 1.3438030 1.618919e-02 1.5611560 2.675819e-02
147 7102 TSPAN7 -0.7991686 3.697190e-02 -0.9151580 3.414206e-02
148 51186 TCEAL9 0.4947480 4.954149e-03 0.6425542 3.022561e-02
149 5354 PLP1 -1.7840245 1.631697e-04 -2.3895645 3.266449e-05
150 10857 PGRMC1 1.5465723 1.470735e-25 1.0576200 2.522925e-06
151 633 BGN -2.7382586 5.058178e-19 -1.7534538 9.522607e-05
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 1.4056031 0.62654217 2.763592 3.109960e-01
02_TSC2_KO_Grabole_2016 1.9200002 1.37412094 2.683343 9.572006e-05
03_TSC2_Grabole-2016 1.7026951 1.20895133 2.417617 1.781611e-03
04_TSC2-tuber-Martin2017 4.2525902 1.33352593 10.463156 8.314656e-03
05_TSC2-SEN_SEGA-Martin2017 3.0531135 2.12290029 4.342801 2.595086e-09
06_all_EpilepsyGene 1.1957650 0.38028788 2.880076 6.162926e-01
07_high_conf_EpilepsyGene 2.2237529 0.44720014 6.782833 1.606467e-01
08_ASD_Epilepsy_EpilepsyGene 0.0000000 0.00000000 2.876627 6.426428e-01
09_Epi25_dataset 1.1097402 0.02757239 6.456619 5.977032e-01
10_SFARI_all 1.5440119 0.41169653 4.091552 3.387752e-01
11_SFARI_score4plus 2.1044631 0.55951964 5.602390 1.317950e-01
12_DeRubeis_RDNV 0.0000000 0.00000000 4.381144 1.000000e+00
13_Iossifov_RDNV 1.0672994 0.38346881 2.396791 8.276203e-01
14_FMRP_Darnell 1.6134753 0.83382001 2.868981 1.055826e-01
15_Voineagu_M12 0.5202004 0.06216787 1.927224 5.942408e-01
16_Voineagu_M16 3.7530167 1.92830724 6.721290 1.141028e-04
17_ID_genes_Neel 0.5450579 0.06511959 2.020046 5.900912e-01
18_ID_genes_pinto2014 1.1255446 0.22785602 3.394610 7.513912e-01
19_Fromer_SCZ_FunDN 1.1016149 0.39573027 2.474213 8.245434e-01
20_Cocchi_Pruning 0.9968485 0.02479799 5.784120 1.000000e+00
Beta SE Padj
01_Swaminathan2018_DEPDC5KO 0.340466493 0.4122478 1.000000e+00
02_TSC2_KO_Grabole_2016 0.652325309 0.1706689 1.914401e-03
03_TSC2_Grabole-2016 0.532212368 0.1747240 3.563223e-02
04_TSC2-tuber-Martin2017 1.447528257 0.5916846 1.662931e-01
05_TSC2-SEN_SEGA-Martin2017 1.116161892 0.1853973 5.190172e-08
06_all_EpilepsyGene 0.178786188 0.5844964 1.000000e+00
07_high_conf_EpilepsyGene 0.799196280 0.8183395 1.000000e+00
08_ASD_Epilepsy_EpilepsyGene -Inf NaN 1.000000e+00
09_Epi25_dataset 0.104125912 1.8852379 1.000000e+00
10_SFARI_all 0.434384148 0.6744148 1.000000e+00
11_SFARI_score4plus 0.744060353 0.6758862 1.000000e+00
12_DeRubeis_RDNV -Inf NaN 1.000000e+00
13_Iossifov_RDNV 0.065131557 0.5222595 1.000000e+00
14_FMRP_Darnell 0.478390416 0.3368001 1.000000e+00
15_Voineagu_M12 -0.653541225 1.0838652 1.000000e+00
16_Voineagu_M16 1.322559963 0.3397538 2.282057e-03
17_ID_genes_Neel -0.606863178 1.0840136 1.000000e+00
18_ID_genes_pinto2014 0.118266970 0.8149532 1.000000e+00
19_Fromer_SCZ_FunDN 0.096777155 0.5223467 1.000000e+00
20_Cocchi_Pruning -0.003156519 1.8846102 1.000000e+00
ReN
getlinmodoutput(targetline = "ReN",targetdiff = "DIFF",targetrapa = "noRAPA") entrezgene genname log2FC_2.1 fdr_2.1 log2FC_2.2 fdr_2.2
1 473 RERE -0.5118111 2.837468e-04 -0.5727503 1.267634e-02
2 56998 CTNNBIP1 -0.9224672 6.378644e-06 -0.6898244 2.600186e-02
3 57190 SELENON 0.7388231 2.242220e-03 0.9922930 3.648510e-03
4 93974 ATP5IF1 0.3750303 5.529278e-03 0.5328467 2.086976e-02
5 9672 SDC3 0.4200234 1.905774e-02 0.7255504 5.656066e-04
6 1296 COL8A2 -2.7649200 3.725687e-21 -1.0785453 6.224653e-03
7 8613 PLPP3 0.7599778 1.011492e-05 0.8241804 7.275014e-03
8 205 AK4 1.6580222 1.649947e-07 1.1798881 3.090197e-02
9 1266 CNN3 0.9730737 1.784179e-08 0.6234705 1.091323e-02
10 4853 NOTCH2 1.0229204 1.107394e-05 0.7966362 3.963774e-02
11 8991 SELENBP1 1.1278639 5.274970e-05 1.5364305 3.403004e-05
12 140576 S100A16 0.7930354 3.473825e-04 1.2748916 7.501518e-06
13 6284 S100A13 0.9651031 9.736536e-06 0.9486517 1.232686e-02
14 57863 CADM3 2.3186406 1.779588e-04 2.6663276 4.723515e-04
15 4921 DDR2 1.0420514 3.473825e-04 1.0152726 2.777144e-02
16 5087 PBX1 -1.0593261 4.907081e-28 -0.9601448 5.162137e-12
17 5396 PRRX1 -2.3101820 1.828671e-07 -1.5755696 3.261094e-03
18 23215 PRRC2C -0.4414583 1.981079e-02 -0.8365786 2.889939e-04
19 9588 PRDX6 0.8015208 2.449107e-13 0.6735934 7.244009e-05
20 93273 LEMD1 2.2784598 9.693402e-05 2.3308687 2.147669e-02
21 5629 PROX1 -1.7582585 2.840679e-10 -1.0251478 2.334237e-02
22 25782 RAB3GAP2 0.7103025 1.015203e-03 0.7609884 1.556170e-02
23 3142 HLX 7.3913395 4.742238e-05 7.9051559 2.131872e-04
24 375057 STUM -2.2381342 3.124981e-18 -1.5076900 7.360385e-04
25 183 AGT 1.4135071 7.255331e-03 1.8485512 3.789527e-03
26 5209 PFKFB3 1.2101232 4.928500e-06 0.9912340 1.573111e-02
27 7431 VIM 0.4836743 3.835456e-10 0.3223265 3.380892e-02
28 783 CACNB2 2.0236730 2.357647e-03 2.1401503 3.174840e-02
29 22852 ANKRD26 -0.6982284 3.945250e-02 -1.0848550 2.376198e-02
30 23522 KAT6B -1.1820263 7.110670e-08 -1.0116676 1.091323e-02
31 9124 PDLIM1 0.7066029 4.700066e-02 1.0994174 1.838462e-02
32 6319 SCD 0.5841642 2.539450e-07 0.5131367 3.524913e-02
33 57698 SHTN1 -2.2194186 2.081371e-15 -1.7826326 3.088823e-04
34 55366 LGR4 1.5362244 6.859844e-03 1.9709420 9.843683e-03
35 4192 MDK -1.5148613 3.682824e-06 -1.1201928 3.019314e-02
36 2785 GNG3 5.3650269 2.831130e-02 6.0132720 3.918578e-02
37 4718 NDUFC2 0.6489253 1.037384e-03 0.6959760 4.090037e-02
38 143686 SESN3 1.0484072 6.807509e-10 1.0902203 5.753519e-06
39 4684 NCAM1 -1.4661757 2.548571e-24 -0.9214890 1.984333e-06
40 4837 NNMT 1.7157895 7.167236e-04 1.5991146 2.853278e-02
41 6876 TAGLN -1.7986553 1.499050e-88 -0.4903330 9.931289e-03
42 220323 OAF 0.9612079 3.540122e-02 1.4388907 8.546162e-03
43 7132 TNFRSF1A 0.5667423 2.095919e-02 1.1179910 9.320462e-05
44 55885 LMO3 -1.9086464 1.936685e-05 -1.8756365 2.358171e-02
45 117177 RAB3IP -1.5583580 2.161168e-09 -0.8447957 3.317232e-02
46 1466 CSRP2 1.2824167 1.883552e-11 0.9813446 3.789527e-03
47 160335 TMTC2 0.9851093 1.735493e-10 0.7707206 7.161402e-03
48 283431 GAS2L3 -1.3843243 1.897922e-04 -1.3911010 6.647306e-03
49 51559 NT5DC3 -1.1395309 4.985118e-02 -1.5142001 3.111249e-02
50 84915 FAM222A -1.0703628 1.112791e-03 -1.1000597 2.376198e-02
51 54997 TESC 2.5229672 3.326932e-08 2.5729805 1.492068e-05
52 10186 LHFPL6 -0.9005337 1.673936e-10 -0.7186683 2.029774e-03
53 115207 KCTD12 -1.6539535 1.905866e-13 -1.2472397 9.558302e-03
54 10253 SPRY2 1.5622436 3.437285e-04 1.9049387 1.352112e-03
55 8660 IRS2 0.4989190 2.572734e-05 0.8149257 4.824424e-07
56 64067 NPAS3 0.8316952 2.113359e-03 0.9998032 8.258381e-03
57 3958 LGALS3 0.8192631 1.949086e-09 0.8413821 2.301044e-05
58 23002 DAAM1 -0.5669808 4.089591e-02 -0.8735874 1.988219e-02
59 6252 RTN1 0.7675965 1.783937e-03 1.0132506 1.990635e-03
60 123096 SLC25A29 -0.8758338 3.887469e-05 -0.8259506 4.038827e-02
61 113146 AHNAK2 -2.3453203 3.470782e-11 -1.9232024 1.388677e-02
62 4212 MEIS2 -0.4937972 1.523294e-02 -0.9262050 1.305772e-02
63 10099 TSPAN3 0.5119911 2.591050e-04 0.5529489 1.457608e-02
64 1512 CTSH 1.3023557 1.374873e-19 1.3941737 4.135188e-13
65 4828 NMB 1.1404205 5.594195e-07 1.8295736 1.045468e-15
66 56963 RGMA 0.5208479 6.670103e-05 0.9645057 7.845403e-10
67 80205 CHD9 -0.7636277 4.103199e-03 -0.7078110 4.253471e-02
68 643911 <NA> 1.9003473 1.146616e-08 1.4860851 1.919426e-02
69 221184 CPNE2 -1.5607056 1.524401e-15 -1.1346859 6.430378e-06
70 124491 TMEM170A 1.0445542 6.886734e-04 1.0648140 2.600186e-02
71 11345 GABARAPL2 0.6720920 2.394815e-05 0.6132839 2.309342e-02
72 57687 VAT1L 2.2804660 6.488897e-08 2.4309094 1.086892e-05
73 23199 GSE1 -1.1414934 1.486258e-09 -1.2333610 1.398099e-04
74 10381 TUBB3 -0.4585011 1.850568e-03 -0.6061171 4.102580e-03
75 9955 HS3ST3A1 2.2476161 1.085830e-04 2.3078288 9.843683e-03
76 6347 CCL2 1.0556954 8.383866e-09 1.5714356 4.135188e-13
77 91608 RASL10B 1.4627291 2.359389e-02 1.7165464 3.418162e-02
78 379 ARL4D -1.8159221 1.921646e-14 -1.5481257 1.602870e-08
79 11248 NXPH3 1.8474520 3.270374e-08 1.4162731 1.780658e-02
80 2186 BPTF -1.0095078 3.253859e-07 -1.0020383 2.484974e-04
81 23580 CDC42EP4 -1.2767945 3.626884e-11 -0.8325367 2.517962e-02
82 3021 H3-3B -0.6624998 3.241902e-12 -0.4133346 3.174840e-02
83 2302 FOXJ1 -1.1561841 2.045266e-09 -1.3793825 6.313723e-07
84 7077 TIMP2 -0.8077256 4.431683e-19 -0.3788819 2.148951e-02
85 1630 DCC -4.1789687 8.420107e-17 -2.9175898 3.789527e-03
86 23327 NEDD4L -0.5187851 8.363735e-05 -0.4976309 3.174840e-02
87 684 BST2 2.4194952 9.536273e-05 3.1164598 8.611552e-06
88 2014 EMP3 0.8953559 2.597256e-02 1.2974901 2.232260e-02
89 59284 CACNG7 1.7802245 3.679574e-08 1.7985133 2.937358e-05
90 59283 CACNG8 1.6369424 8.089671e-03 2.2351074 5.299233e-04
91 79042 TSEN34 6.6587376 7.209516e-03 7.6916724 5.188673e-04
92 10971 YWHAQ 0.6807554 5.214634e-09 0.5325181 2.358171e-02
93 55133 SRBD1 -0.9173926 2.311308e-02 -1.3623015 3.206683e-02
94 618 BCYRN1 0.8717516 1.901245e-06 1.3821674 6.620114e-09
95 6233 RPS27A 0.3229373 5.493640e-04 0.5275396 3.229242e-02
96 55704 CCDC88A -0.8204642 7.053404e-09 -1.2429623 6.536418e-11
97 53335 BCL11A -3.2405034 6.503446e-18 -2.0257391 9.931289e-03
98 7360 UGP2 1.0474353 1.016636e-02 1.3589884 8.860302e-03
99 72 ACTG2 -3.4080129 5.081336e-20 -1.3283225 3.174840e-02
100 200424 TET3 -1.0569728 4.651943e-02 -2.0848612 4.943602e-02
101 100506421 PANTR1 1.2313685 5.518367e-20 0.6304971 3.090197e-02
102 1622 DBI 0.4411729 1.371119e-04 0.6440859 2.541290e-02
103 56475 RPRM -4.6001121 1.157342e-02 -1.8142592 4.348741e-03
104 5937 RBMS1 -2.2493687 3.019080e-25 -1.3362943 2.341052e-04
105 1745 DLX1 -0.3424517 4.932440e-02 -0.5749909 7.304694e-03
106 165215 FAM171B 1.5448241 6.810704e-17 1.0039986 5.357695e-03
107 7855 FZD5 -2.2991055 1.419217e-04 -1.4463537 4.693355e-03
108 5270 SERPINE2 1.9587881 1.447870e-09 1.5305883 1.826175e-02
109 55502 HES6 1.7230597 2.643337e-38 0.8571782 3.531982e-03
110 1471 CST3 0.9847587 6.810704e-17 1.3108306 1.272181e-16
111 84532 ACSS1 -2.5583536 4.406397e-28 -0.8517395 4.475405e-02
112 128866 CHMP4B 0.6179510 2.898966e-03 0.7581324 1.702666e-02
113 4826 NNAT 0.6753798 1.008659e-06 0.5850898 1.246781e-03
114 23613 ZMYND8 -0.8587809 3.047943e-10 -0.5467463 3.165370e-02
115 1002 CDH4 2.2383921 1.002118e-05 1.9181880 3.151841e-02
116 3785 KCNQ2 -1.5671610 3.913126e-11 -1.5567066 1.229957e-05
117 7074 TIAM1 -1.6456508 8.638312e-07 -1.2257337 1.024657e-02
118 7267 TTC3 -0.4009573 1.301827e-02 -0.5714940 2.770684e-02
119 6285 S100B 0.4361850 3.958528e-03 0.6894344 3.418162e-02
120 23331 TTC28 -1.0914580 1.030457e-05 -1.0705977 8.621707e-04
121 29796 UQCR10 0.3755899 2.747706e-02 0.8975934 2.112227e-03
122 25817 TAFA5 -0.9044653 6.293602e-13 -0.6826780 3.380537e-03
123 23209 MLC1 0.4954270 1.746139e-03 1.0375064 1.001671e-10
124 10752 CHL1 -2.1227676 2.355915e-12 -1.3424921 9.843683e-03
125 79750 ZNF385D -1.4213989 1.596019e-19 -0.9925602 1.112720e-06
126 25907 TMEM158 0.7663621 8.892543e-04 1.0440572 2.484905e-04
127 10675 CSPG5 1.5547282 1.826144e-13 0.9684691 7.181364e-03
128 51246 SHISA5 0.6384714 2.468608e-05 0.9898423 4.570837e-03
129 11170 FAM107A 0.5347181 5.241972e-03 0.8459335 2.821248e-03
130 55079 FEZF2 2.7931010 3.433714e-21 1.7649628 3.084119e-02
131 132204 SYNPR -0.8516845 4.980919e-03 -1.3095218 1.100699e-03
132 23150 FRMD4B -2.1460348 9.954241e-19 -1.2760995 1.703790e-04
133 23024 PDZRN3 -0.6014417 2.158857e-03 -0.6640674 4.371370e-02
134 29114 TAGLN3 -1.5145174 4.800362e-12 -1.1764531 4.821974e-06
135 4638 MYLK -1.5925555 4.154974e-04 -1.4218626 3.100057e-02
136 3693 ITGB5 0.3997963 2.784764e-03 0.5681016 4.846183e-03
137 11343 MGLL 2.0283318 7.323354e-11 1.8218835 9.284187e-05
138 200916 RPL22L1 0.4708538 2.102961e-04 0.6575604 2.179467e-03
139 347689 SOX2-OT -1.0390614 2.900255e-04 -1.3448406 3.732726e-02
140 1974 EIF4A2 -0.5051331 2.784764e-03 -0.6192012 2.836337e-02
141 79572 ATP13A3 1.2381986 1.198998e-02 1.6383107 7.161402e-03
142 677770 SCARNA22 -0.5387333 1.540525e-02 -1.6310283 6.147798e-06
143 23231 SEL1L3 1.2038795 7.231155e-06 1.7878558 9.350406e-09
144 5156 PDGFRA 1.9689443 3.275954e-30 0.9211449 1.457608e-02
145 258 AMBN -3.6043640 1.144179e-10 -1.8675956 1.001671e-10
146 118429 ANTXR2 1.0746021 4.448427e-02 1.5519526 1.091323e-02
147 658 BMPR1B 1.4281673 1.988417e-03 1.5495631 1.457608e-02
148 5530 PPP3CA -0.4987347 2.427693e-02 -0.9842317 1.808248e-03
149 10252 SPRY1 1.4416377 9.053302e-03 2.0074464 7.624287e-04
150 166614 DCLK2 -0.7800887 1.516474e-13 -0.5514906 2.114357e-02
151 2891 GRIA2 -2.2004887 4.832502e-12 -1.0694494 4.719826e-02
152 1363 CPE 0.9929161 2.365879e-03 1.0805984 3.317232e-02
153 9037 SEMA5A -2.6665055 2.967264e-25 -1.1499589 1.078532e-03
154 10299 MARCHF6 -0.7717050 2.540553e-05 -0.5823373 4.572559e-02
155 10923 SUB1 0.6526205 1.541839e-05 0.6116682 3.418162e-02
156 6507 SLC1A3 2.0719378 2.013311e-90 1.2793758 2.431251e-13
157 6414 SELENOP 6.7692914 2.114500e-04 6.1650224 2.584376e-02
158 10769 PLK2 -1.8043835 1.077426e-04 -2.4574249 8.425086e-04
159 10788 IQGAP2 2.6721549 1.370323e-14 1.8300775 1.287786e-02
160 100462981 MTRNR2L12 -0.3435337 2.265463e-02 -0.4969972 4.023352e-02
161 5921 RASA1 -1.6779072 2.295906e-02 -3.0779635 3.019314e-02
162 4163 MCC -3.8365044 4.151600e-15 -1.9041806 2.744752e-03
163 1036 CDO1 1.1866761 6.076264e-06 1.2078375 4.161845e-03
164 57507 ZNF608 -1.3340790 2.232613e-06 -1.3623876 5.937990e-03
165 5307 PITX1 1.6884320 4.836088e-42 1.5022916 3.201550e-10
166 5097 PCDH1 5.5796435 2.755055e-03 6.3389812 3.095204e-03
167 6678 SPARC 0.3579895 5.944844e-04 0.6168653 1.435890e-05
168 55568 GALNT10 -1.9193496 4.431683e-19 -0.9553827 7.181364e-03
169 9750 RIPOR2 -1.7337824 3.508525e-13 -1.5673649 3.351622e-06
170 5754 PTK7 0.7098335 1.792818e-02 1.1872815 5.640193e-04
171 26799 <NA> -0.8880015 2.345857e-02 -1.0266831 4.356326e-02
172 6885 MAP3K7 -0.9445473 1.789151e-05 -0.8711201 4.177692e-02
173 2045 EPHA7 -9.0198174 2.012381e-09 -8.6471063 1.172572e-06
174 3910 LAMA4 1.4638053 1.185379e-05 1.4358070 1.306777e-02
175 7259 TSPYL1 0.9712468 3.991679e-04 1.0974665 4.472515e-03
176 2697 GJA1 -1.6674753 4.020441e-43 -1.0510888 2.784052e-08
177 2173 FABP7 1.2469020 4.198713e-03 0.7216714 4.472515e-03
178 221833 SP8 -1.9615685 1.132884e-16 -1.1588439 6.155514e-04
179 55536 CDCA7L -0.8393205 9.432644e-04 -1.1181122 2.137559e-04
180 5137 PDE1C -1.8102877 9.402767e-05 -1.5885147 1.710431e-02
181 6424 SFRP4 -1.8003394 1.038493e-04 -1.9072638 1.091323e-02
182 3315 HSPB1 0.6929614 2.545328e-08 0.5423033 2.541290e-02
183 6717 SRI 0.7564112 3.830091e-10 0.7037221 1.799961e-04
184 23089 PEG10 -0.7643596 1.273863e-19 -1.1453607 2.231584e-08
185 285987 <NA> -1.4335392 1.123079e-02 -1.7625131 2.597827e-02
186 1750 DLX6 -1.2595335 1.852040e-04 -1.3383312 7.275014e-03
187 1749 DLX5 -1.3065394 1.490941e-10 -1.1039911 1.569167e-05
188 5054 SERPINE1 0.7709491 4.408783e-02 1.3463896 1.255029e-03
189 692084 SNORD13 -0.8359273 1.105342e-02 -1.5020719 3.353433e-02
190 6422 SFRP1 1.3198774 6.856865e-05 1.2920121 4.008169e-02
191 11075 STMN2 -4.2789314 1.317360e-13 -2.1678468 4.038827e-02
192 79870 BAALC 1.5045546 1.133068e-24 1.0464921 5.683475e-07
193 4062 LY6H 0.9079039 2.116643e-02 1.3479402 1.070719e-02
194 4781 NFIB -0.4954804 9.717873e-06 -0.5378088 2.086595e-03
195 4915 NTRK2 1.7149831 1.179490e-17 1.4233780 1.129255e-04
196 1620 BRINP1 -1.7881517 2.753966e-27 -1.2716438 4.444840e-07
197 6418 SET -0.5442739 1.272150e-07 -0.5171314 1.966472e-02
198 4508 MT-ATP6 0.4249397 9.305886e-07 0.4145912 1.071062e-02
199 7114 TMSB4X 0.3710941 2.878931e-02 0.9514107 2.842344e-05
200 7102 TSPAN7 -2.3083989 1.147391e-16 -1.9063349 8.611552e-06
201 442454 <NA> 0.4602658 5.514531e-03 0.6320617 9.931289e-03
202 4435 CITED1 1.3956687 1.145260e-04 1.4024685 1.388677e-02
203 55859 BEX1 -0.5562600 7.400299e-08 -0.4944181 4.493398e-02
204 1641 DCX -0.9825873 1.428037e-16 -0.8743527 2.709261e-07
205 5358 PLS3 -1.4726799 1.578490e-24 -0.8123603 4.874364e-04
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 1.1345923 0.53266776 2.146972 6.061621e-01
02_TSC2_KO_Grabole_2016 1.9962929 1.49978294 2.658380 1.234092e-06
03_TSC2_Grabole-2016 1.9866254 1.47318893 2.699791 2.819082e-06
04_TSC2-tuber-Martin2017 3.0920126 0.97339012 7.563659 2.758485e-02
05_TSC2-SEN_SEGA-Martin2017 3.0120559 2.20576576 4.079449 1.050135e-11
06_all_EpilepsyGene 0.8693106 0.27755694 2.081081 1.000000e+00
07_high_conf_EpilepsyGene 2.1927566 0.58223629 5.849217 1.189359e-01
08_ASD_Epilepsy_EpilepsyGene 1.7387099 0.35036131 5.285237 2.566187e-01
09_Epi25_dataset 1.6540845 0.19554612 6.253977 3.474641e-01
10_SFARI_all 2.3356746 0.98254283 4.771893 2.729035e-02
11_SFARI_score4plus 2.3500704 0.84032329 5.313111 5.010660e-02
12_DeRubeis_RDNV 2.6626359 0.53244917 8.202205 1.111669e-01
13_Iossifov_RDNV 1.7647131 0.91614998 3.118571 6.005727e-02
14_FMRP_Darnell 1.4500183 0.80773723 2.433146 1.640624e-01
15_Voineagu_M12 0.3802491 0.04555281 1.402262 2.523069e-01
16_Voineagu_M16 4.9075984 2.95929549 7.786880 1.022341e-08
17_ID_genes_Neel 0.8098984 0.21720370 2.126622 1.000000e+00
18_ID_genes_pinto2014 1.1052273 0.29576687 2.912102 7.861544e-01
19_Fromer_SCZ_FunDN 0.9392830 0.37074278 1.986818 1.000000e+00
20_Cocchi_Pruning 3.0671837 0.80939785 8.262557 4.758133e-02
Beta SE Padj
01_Swaminathan2018_DEPDC5KO 0.12627335 0.3857810 1.000000e+00
02_TSC2_KO_Grabole_2016 0.69129191 0.1459038 2.468184e-05
03_TSC2_Grabole-2016 0.68643744 0.1525551 5.638163e-05
04_TSC2-tuber-Martin2017 1.12882222 0.5896901 5.516971e-01
05_TSC2-SEN_SEGA-Martin2017 1.10262286 0.1589531 2.100271e-10
06_all_EpilepsyGene -0.14005479 0.5824869 1.000000e+00
07_high_conf_EpilepsyGene 0.78515948 0.6765502 1.000000e+00
08_ASD_Epilepsy_EpilepsyGene 0.55314337 0.8173131 1.000000e+00
09_Epi25_dataset 0.50324766 1.0893912 1.000000e+00
10_SFARI_all 0.84830074 0.4417919 5.458070e-01
11_SFARI_score4plus 0.85444526 0.5247009 1.000000e+00
12_DeRubeis_RDNV 0.97931656 0.8212165 1.000000e+00
13_Iossifov_RDNV 0.56798810 0.3344711 1.000000e+00
14_FMRP_Darnell 0.37157619 0.2985177 1.000000e+00
15_Voineagu_M12 -0.96692876 1.0826296 1.000000e+00
16_Voineagu_M16 1.59078471 0.2580783 2.044683e-07
17_ID_genes_Neel -0.21084642 0.6714659 1.000000e+00
18_ID_genes_pinto2014 0.10005101 0.6725687 1.000000e+00
19_Fromer_SCZ_FunDN -0.06263842 0.4742900 1.000000e+00
20_Cocchi_Pruning 1.12075978 0.6797064 9.516267e-01
KO effect in noDIFF RAPA
D62
getlinmodoutput(targetline = "D62",targetdiff = "noDIFF",targetrapa = "RAPA") entrezgene genname log2FC_2.1 fdr_2.1 log2FC_2.2 fdr_2.2
1 64856 VWA1 0.7961187 1.591361e-02 0.8468392 2.620357e-02
2 3925 STMN1 -0.5685577 5.368831e-03 -0.6224295 1.905328e-02
3 9077 DIRAS3 1.9775503 6.473752e-17 1.5404231 2.797022e-07
4 64123 ADGRL4 1.8538504 7.722135e-05 1.6497307 3.911791e-03
5 6004 RGS16 1.1197917 1.317082e-06 1.0596972 2.861369e-03
6 29089 UBE2T -1.1211661 1.817676e-02 -1.2182221 4.945532e-02
7 149111 CNIH3 1.5083815 4.669966e-05 1.3495441 3.911791e-03
8 642938 INSYN2A 0.8617151 8.516245e-03 1.0006299 3.911791e-03
9 10581 IFITM2 -1.3249897 6.006754e-04 -1.5999599 8.700211e-05
10 4004 LMO1 -2.2672120 8.536899e-05 -2.2934700 8.213942e-09
11 960 CD44 1.4720618 1.480635e-07 1.3079443 6.140437e-05
12 1410 CRYAB 0.6463602 8.516245e-03 0.6999128 3.911791e-03
13 3709 ITPR2 1.4682329 7.883463e-05 1.4707635 7.064746e-04
14 84790 TUBA1C 0.8289466 1.522844e-05 0.7701332 1.404306e-02
15 160335 TMTC2 -0.9849648 8.069505e-03 -1.2868846 3.851921e-03
16 28526 <NA> 1.7946615 3.389494e-05 1.7259641 2.481597e-04
17 771 CA12 -0.8261845 2.555665e-04 -0.8015783 2.684880e-03
18 57611 ISLR2 -1.4138448 2.195926e-02 -1.3579845 3.754547e-02
19 56963 RGMA 1.1669346 1.509525e-08 1.0344198 3.851921e-03
20 2013 EMP2 -1.0920225 1.088237e-05 -0.7586095 3.222339e-02
21 643911 <NA> 2.7408935 2.461214e-02 2.9639647 4.974950e-03
22 2775 GNAO1 -1.1596849 6.876785e-06 -0.9286509 3.851921e-03
23 11031 RAB31 0.4783287 1.893394e-02 0.5147462 2.436953e-02
24 361 AQP4 0.7543128 2.751680e-03 0.8155313 5.746483e-03
25 1995 ELAVL3 -0.7800473 5.335671e-03 -0.7905853 2.436953e-02
26 348 APOE 1.0971097 6.637560e-05 1.0393426 2.965233e-03
27 79784 MYH14 -3.8557202 2.709801e-07 -2.3165157 2.436953e-02
28 151354 LRATD1 0.9410834 2.909158e-05 0.9934844 1.512676e-05
29 10267 RAMP1 1.2135869 1.056177e-06 1.0155836 3.681457e-04
30 1827 RCAN1 0.6625347 1.075336e-02 0.7270640 1.100868e-02
31 1826 DSCAM 1.3402666 8.069505e-03 1.7780242 6.401270e-06
32 2596 GAP43 1.3179970 1.456465e-22 0.9193596 2.388836e-08
33 5947 RBP1 -0.6459721 3.514077e-02 -0.8069445 9.568643e-03
34 4071 TM4SF1 1.8373599 6.909949e-07 1.4492589 3.890591e-03
35 3280 HES1 -0.7541376 8.973097e-04 -0.7161149 1.212638e-02
36 3490 IGFBP7 2.0277479 7.733560e-30 2.1251337 8.495963e-29
37 79966 SCD5 0.5668715 1.837778e-03 0.6470040 3.082466e-03
38 8404 SPARCL1 2.6711596 3.366738e-08 1.6962771 5.746483e-03
39 401207 C5orf63 0.6732523 3.217736e-02 0.8698764 1.422380e-03
40 85027 SMIM3 0.9707553 2.751680e-03 0.7790661 2.907467e-02
41 1026 CDKN1A 1.0793028 2.660019e-14 0.8376862 1.782308e-06
42 4188 MDFI -0.9944602 4.224909e-02 -1.2025531 2.447782e-02
43 4852 NPY -1.9241887 7.017330e-08 -1.5819410 2.956766e-06
44 23089 PEG10 0.7098065 2.053550e-03 0.7282390 8.417096e-03
45 1749 DLX5 -2.2913973 7.064968e-05 -1.8533389 8.417096e-03
46 25798 BRI3 -0.4962410 8.093883e-03 -0.5961950 3.911791e-03
47 5054 SERPINE1 1.9244309 3.434909e-05 2.1022473 1.782308e-06
48 4747 NEFL 1.1956686 1.505759e-05 1.2813013 1.832464e-05
49 2185 PTK2B 1.6672078 4.711653e-11 1.3930835 1.273791e-05
50 5327 PLAT 0.5886363 7.283803e-03 0.5708704 2.436953e-02
51 11075 STMN2 -6.0400119 7.422811e-03 -7.7180162 1.422380e-03
52 2171 FABP5 1.5435853 2.826377e-06 1.0667232 4.910801e-02
53 9568 GABBR2 1.7674445 1.682968e-16 1.6003234 2.740366e-09
54 56548 CHST7 1.0768094 4.713142e-04 1.1190497 2.965233e-03
55 5358 PLS3 1.0340243 6.595231e-04 1.2931225 1.535983e-06
56 10178 TENM1 -1.3363992 8.536899e-05 -1.3832123 7.013857e-03
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 0.4004526 0.00994547 2.335242 5.191550e-01
02_TSC2_KO_Grabole_2016 2.3400242 1.33533983 4.138755 1.748419e-03
03_TSC2_Grabole-2016 2.2968387 1.26764835 4.334256 4.480912e-03
04_TSC2-tuber-Martin2017 6.9457439 1.36782496 21.963147 1.109565e-02
05_TSC2-SEN_SEGA-Martin2017 4.2623212 2.38392107 7.499436 7.408461e-07
06_all_EpilepsyGene 1.9797878 0.39393523 6.152519 2.051171e-01
07_high_conf_EpilepsyGene 1.9760607 0.04875929 11.678747 4.030732e-01
08_ASD_Epilepsy_EpilepsyGene 4.3453375 0.50713556 16.830829 8.305153e-02
09_Epi25_dataset 0.0000000 0.00000000 11.527050 1.000000e+00
10_SFARI_all 3.2205256 0.63913194 10.052591 7.383975e-02
11_SFARI_score4plus 2.8510008 0.33406010 10.963980 1.631103e-01
12_DeRubeis_RDNV 0.0000000 0.00000000 12.144245 1.000000e+00
13_Iossifov_RDNV 0.9544417 0.11240197 3.636546 1.000000e+00
14_FMRP_Darnell 2.0501461 0.71597593 4.804695 1.294979e-01
15_Voineagu_M12 0.0000000 0.00000000 2.656146 4.058569e-01
16_Voineagu_M16 4.7118897 1.63944077 11.100343 2.738157e-03
17_ID_genes_Neel 0.0000000 0.00000000 2.782932 6.457777e-01
18_ID_genes_pinto2014 0.0000000 0.00000000 3.788141 6.280384e-01
19_Fromer_SCZ_FunDN 2.0540941 0.53733918 5.614999 1.445296e-01
20_Cocchi_Pruning 2.7376465 0.06735287 16.287285 3.120327e-01
Beta SE Padj
01_Swaminathan2018_DEPDC5KO -0.91515984 1.8854481 1.000000e+00
02_TSC2_KO_Grabole_2016 0.85016126 0.2862120 3.496839e-02
03_TSC2_Grabole-2016 0.83153370 0.3032501 8.961824e-02
04_TSC2-tuber-Martin2017 1.93812908 0.8290343 2.219131e-01
05_TSC2-SEN_SEGA-Martin2017 1.44981388 0.2964629 1.481692e-05
06_all_EpilepsyGene 0.68298965 0.8237543 1.000000e+00
07_high_conf_EpilepsyGene 0.68110533 1.8887576 1.000000e+00
08_ASD_Epilepsy_EpilepsyGene 1.46910342 1.0959594 1.000000e+00
09_Epi25_dataset -Inf NaN 1.000000e+00
10_SFARI_all 1.16954459 0.8250964 1.000000e+00
11_SFARI_score4plus 1.04767008 1.0939308 1.000000e+00
12_DeRubeis_RDNV -Inf NaN 1.000000e+00
13_Iossifov_RDNV -0.04662876 1.0913495 1.000000e+00
14_FMRP_Darnell 0.71791106 0.5367448 1.000000e+00
15_Voineagu_M12 -Inf NaN 1.000000e+00
16_Voineagu_M16 1.55008903 0.5386397 5.476314e-02
17_ID_genes_Neel -Inf NaN 1.000000e+00
18_ID_genes_pinto2014 -Inf NaN 1.000000e+00
19_Fromer_SCZ_FunDN 0.71983494 0.6841636 1.000000e+00
20_Cocchi_Pruning 1.00709860 1.8902594 1.000000e+00
D244
getlinmodoutput(targetline = "D244",targetdiff = "noDIFF",targetrapa = "RAPA") entrezgene genname log2FC_2.1 fdr_2.1 log2FC_2.2 fdr_2.2
1 9636 ISG15 1.5824388 1.484743e-04 1.2829492 4.189665e-04
2 51150 SDF4 0.3756765 5.723901e-03 0.7747854 3.597778e-08
3 54587 MXRA8 0.5977314 1.411991e-03 0.7833115 7.754367e-07
4 440556 PRDM16-DT 1.1315687 1.249709e-04 0.8742095 7.287652e-03
5 63976 PRDM16 0.9034465 7.477217e-04 0.8046191 6.154955e-03
6 6146 RPL22 -0.4927361 7.363852e-04 -0.4927466 1.338800e-02
7 57449 PLEKHG5 1.6363155 3.230095e-04 1.3618997 2.095723e-02
8 23261 CAMTA1 -0.4277936 1.060105e-02 -1.0349325 2.432229e-08
9 54206 ERRFI1 -1.3165602 1.037519e-03 -1.4906598 7.650727e-04
10 5351 PLOD1 -1.1569610 1.240324e-06 -0.6079571 1.094670e-02
11 9927 MFN2 0.6205604 4.280046e-02 0.7025316 4.881864e-02
12 23254 KAZN 1.2345212 1.378131e-08 1.2945358 1.004445e-07
13 79180 EFHD2 0.5980518 6.568616e-03 0.6662879 5.180092e-03
14 440567 UQCRHL -1.2803222 8.776551e-04 -1.2369868 2.383955e-03
15 1969 EPHA2 -1.3444040 3.011003e-08 -1.1198203 6.815015e-08
16 51154 MRTO4 0.9001111 1.208548e-03 1.1304167 1.356098e-04
17 5322 PLA2G5 0.9577801 1.663496e-08 0.4856486 4.417485e-02
18 80818 ZNF436 -1.0371306 1.553439e-06 -1.1762577 9.841589e-08
19 3399 ID3 2.4835164 1.184258e-15 2.5010389 3.965480e-11
20 6135 RPL11 -0.9034285 1.834218e-07 -0.8115438 6.156107e-05
21 400746 NCMAP 2.9840207 1.064511e-04 2.3852290 1.763911e-02
22 10250 SRRM1 -0.3822801 3.181680e-02 -0.5304198 1.346275e-02
23 2537 IFI6 0.9741889 1.206228e-05 1.0236378 4.385758e-05
24 93974 ATP5IF1 -0.6261414 8.695858e-04 -0.6908658 2.192988e-03
25 9672 SDC3 0.3948315 1.958294e-02 0.4098725 3.427626e-02
26 3065 HDAC1 1.8390637 9.482389e-10 1.5314298 6.411181e-06
27 65108 MARCKSL1 -0.7073388 7.484675e-06 -0.6872964 9.988034e-05
28 79830 ZMYM1 1.8973526 1.712152e-02 2.0510684 9.972732e-03
29 9202 ZMYM4 0.8477035 1.770631e-03 0.8880819 1.951939e-03
30 54936 ADPRS 0.8709287 1.891722e-03 1.0841879 4.286178e-05
31 79647 AKIRIN1 -0.5293416 3.522515e-02 -0.6261662 3.241008e-02
32 4725 NDUFS5 -0.5830952 5.870251e-03 -0.6891822 8.998613e-03
33 643314 <NA> 2.1725309 4.898647e-07 2.3577943 1.002124e-07
34 4904 YBX1 -1.3904264 2.311743e-10 -1.2975221 2.323167e-09
35 6513 SLC2A1 -1.0617617 3.714706e-05 -0.7877181 3.154895e-04
36 26828 RNU5F-1 2.0302911 6.371631e-06 1.8065787 2.648764e-03
37 6202 RPS8 -0.5414825 1.190284e-06 -0.5575464 6.898967e-04
38 7388 UQCRH -0.6603621 1.640027e-04 -0.6892499 5.170060e-04
39 9528 TMEM59 -1.2316079 1.093312e-08 -0.6547585 1.963470e-02
40 205 AK4 -2.7310177 5.732523e-20 -3.0611435 4.595910e-13
41 54741 LEPROT -0.9389114 4.145418e-04 -1.6739560 3.367794e-11
42 1647 GADD45A -1.3406168 3.563966e-13 -1.2007802 1.082157e-10
43 9295 SRSF11 -0.4772421 3.689493e-03 -0.4496266 3.255072e-02
44 127254 ERICH3 4.1004930 2.151140e-02 4.3238701 2.009553e-02
45 5876 RABGGTB -1.4739387 2.272381e-02 -1.5220374 8.241496e-03
46 26289 AK5 -6.6003590 5.316610e-03 -6.4077026 9.311821e-03
47 2787 GNG5 -0.9030735 1.215658e-06 -0.7521400 1.000459e-04
48 3491 CCN1 -2.6405793 3.221564e-03 -2.0468527 4.443236e-04
49 9403 SELENOF -0.9302475 3.030301e-05 -1.1807101 1.279069e-06
50 2959 GTF2B -1.4583494 5.286202e-03 -1.1262157 2.822474e-02
51 6125 RPL5 -0.6367997 1.399423e-07 -0.5317626 5.771616e-04
52 9411 ARHGAP29 1.1653946 4.932031e-04 1.1596250 1.250806e-03
53 199857 ALG14 -2.0099368 1.930902e-05 -1.2869056 4.066935e-02
54 55119 PRPF38B -1.0050981 1.969653e-04 -0.7558508 7.029130e-03
55 6884 TAF13 3.1432810 4.391786e-16 2.6409385 1.938146e-09
56 84722 PSRC1 0.6166813 3.679775e-04 0.5774528 4.135456e-03
57 10542 LAMTOR5 -0.6859886 1.315846e-03 -0.7935888 8.983314e-05
58 10390 CEPT1 1.7325630 5.842110e-07 1.1284440 2.812949e-02
59 9939 RBM8A 0.8053453 1.599023e-09 0.6485053 1.615114e-04
60 200030 NBPF11 -0.5821200 2.713890e-02 -0.6515514 2.316868e-02
61 8337 H2AC18 -1.2977402 9.473626e-04 -1.3058019 9.580993e-04
62 51177 PLEKHO1 1.1133671 1.758600e-03 1.0186346 1.308626e-02
63 51107 APH1A 0.9963791 2.961773e-09 0.8144306 1.691489e-05
64 2029 ENSA -0.7210669 5.069302e-04 -0.7396818 3.820409e-03
65 29956 CERS2 -1.0922118 1.102436e-04 -1.2926428 2.963420e-05
66 10962 MLLT11 -1.5728076 4.391871e-12 -1.2923854 4.545775e-09
67 6281 S100A10 -1.5542314 2.194388e-05 -0.9993398 2.000028e-02
68 5872 RAB13 -0.9625542 1.498239e-07 -0.7637741 6.898967e-04
69 3782 KCNN3 0.8972991 1.779152e-02 1.2051483 4.906984e-04
70 55974 SLC50A1 1.1288291 1.406689e-03 1.0502843 8.855696e-03
71 54344 DPM3 0.7244787 1.674644e-02 0.8202974 1.898751e-02
72 55870 ASH1L 1.0599562 1.035521e-07 0.9928743 4.238631e-06
73 10485 MIR9-1HG 0.8086786 4.139934e-05 1.6709057 4.208470e-15
74 63827 BCAN 1.5532471 1.982801e-02 1.6892838 1.090152e-02
75 10763 NES 0.4079433 5.273539e-03 0.5694218 6.267806e-05
76 79590 MRPL24 0.9905111 5.694319e-03 1.1756719 9.838201e-04
77 25874 MPC2 -0.7726272 1.249143e-02 -0.9510370 2.192665e-02
78 481 ATP1B1 0.6534559 4.259089e-04 0.6993252 4.454316e-05
79 149041 RC3H1 1.0483608 3.350527e-02 1.1865388 5.598056e-03
80 9910 RABGAP1L 1.2266867 1.835811e-03 1.0466286 1.689752e-02
81 27101 CACYBP -0.8082859 8.814786e-03 -1.2054734 5.533371e-03
82 9917 FAM20B -1.0196979 5.220750e-03 -0.7592172 4.727448e-02
83 2752 GLUL -0.6833173 6.529329e-08 -0.8773989 4.292386e-08
84 81563 C1orf21 -0.6054954 6.615147e-03 -0.7207867 2.987392e-03
85 116496 NIBAN1 1.7929732 2.822698e-24 2.2280988 2.531885e-45
86 259266 ASPM 3.1818923 2.066537e-07 2.2533168 4.184859e-02
87 149345 SHISA4 0.7005681 4.574101e-02 0.8535469 1.245922e-02
88 6635 SNRPE -0.9221128 1.895528e-03 -0.9144657 3.896508e-03
89 55224 ETNK2 2.5831462 1.576230e-05 1.8539789 2.111881e-02
90 64710 NUCKS1 1.1967881 3.459305e-32 0.5989236 9.262941e-03
91 574036 <NA> -7.4593516 9.291791e-05 -7.2666958 2.165543e-04
92 127018 LYPLAL1 -1.6393321 1.663246e-07 -1.3579740 1.579159e-03
93 6726 SRP9 -1.2122287 4.135278e-07 -1.1517048 8.324859e-05
94 2052 EPHX1 1.2047806 2.671130e-03 1.0828554 9.705714e-03
95 3020 H3-3A -0.7006252 4.155287e-03 -0.6832695 8.007593e-03
96 388753 COA6 -0.8285424 3.154998e-02 -0.8040808 4.987914e-02
97 116228 COX20 -1.3698346 8.983419e-04 -1.7037172 2.264260e-06
98 51097 SCCPDH -1.0334920 6.477480e-05 -0.7709995 1.454060e-02
99 5209 PFKFB3 -0.9669253 2.240351e-04 -0.6608066 1.170651e-02
100 10659 CELF2 0.8972197 2.674221e-06 0.8151819 1.695273e-05
101 7431 VIM -0.6208164 2.762412e-06 -0.4048857 1.686708e-02
102 2572 GAD2 -5.6271621 6.625798e-09 -2.6726735 5.108571e-03
103 8829 NRP1 -0.9261206 5.007966e-07 -1.9809501 3.375055e-22
104 219749 ZNF25 -1.8097228 3.504311e-03 -1.1713950 4.546404e-02
105 8031 NCOA4 -0.8523913 8.727930e-05 -0.5980325 1.589383e-02
106 642826 <NA> 4.1420140 2.105696e-14 2.7679408 1.440485e-03
107 220963 SLC16A9 1.1803065 1.506299e-02 1.2230316 2.271632e-02
108 288 ANK3 1.3402628 3.229147e-03 1.2772510 1.614208e-02
109 3189 HNRNPH3 -0.8461245 7.945592e-07 -1.1500266 2.162598e-05
110 55680 RUFY2 1.3700833 1.408189e-03 1.4173596 3.519114e-03
111 80312 TET1 2.1154125 4.306909e-11 1.8346565 2.448617e-07
112 55749 CCAR1 -1.1702983 1.426437e-12 -0.5809230 5.498438e-03
113 219699 UNC5B 0.7114188 1.259044e-03 0.5167184 3.691250e-02
114 9806 SPOCK2 1.3285234 5.251144e-07 1.5233192 7.626200e-09
115 5033 P4HA1 -1.3247173 1.261018e-08 -1.5640109 2.099629e-05
116 729096 <NA> 4.5350368 2.036222e-06 3.4345158 2.574665e-02
117 142891 SAMD8 -1.2187331 7.389393e-03 -1.5312218 5.448833e-03
118 7417 VDAC2 -0.7118831 1.329084e-03 -0.5028832 3.987163e-02
119 6229 RPS24 -0.7305259 1.947391e-10 -0.5999155 5.163469e-06
120 57178 ZMIZ1 -0.5721452 1.152404e-03 -0.5240230 1.023035e-02
121 5995 RGR -1.1575992 1.435723e-02 -1.3838349 1.260681e-02
122 2894 GRID1 -0.9744374 1.443265e-02 -1.1174950 3.348652e-02
123 80351 TNKS2 1.0660217 1.026909e-06 0.7203107 1.142187e-02
124 83742 MARVELD1 1.0373666 3.352741e-08 0.7662849 1.344835e-03
125 81894 SLC25A28 1.5280121 3.234247e-03 1.5473076 5.637033e-03
126 282991 BLOC1S2 -0.7557446 2.011331e-03 -0.6518919 1.571734e-02
127 55719 SLF2 1.1337798 1.374251e-14 0.9604407 3.685936e-08
128 84833 ATP5MK -0.6046461 1.922291e-03 -0.7493619 6.201621e-04
129 85450 ITPRIP -1.5196831 1.985031e-02 -1.5912083 2.716982e-02
130 114815 SORCS1 -2.3375328 4.094130e-02 -3.5886849 1.429855e-03
131 8036 SHOC2 0.7463604 2.604400e-02 0.7716231 4.803865e-02
132 6934 TCF7L2 -0.5296395 4.536440e-02 -0.6965345 1.356053e-02
133 404636 DENND10 -0.8040247 2.075991e-03 -0.8048053 4.809852e-03
134 10935 PRDX3 -0.4712721 1.126754e-02 -0.6925035 3.584173e-04
135 2869 GRK5 -0.6878115 3.951226e-05 -0.5107161 5.310234e-03
136 9531 BAG3 -1.1004282 1.702147e-07 -1.0401403 1.381167e-04
137 22876 INPP5F -1.1029570 5.729009e-04 -1.1945523 4.220962e-04
138 10579 TACC2 1.5234636 5.789860e-08 1.5309721 9.740075e-06
139 5654 HTRA1 1.2019532 1.108631e-36 0.9903916 2.522760e-15
140 56647 BCCIP 0.8417131 3.873630e-04 0.8018413 2.264114e-03
141 664 BNIP3 -2.8319867 5.823775e-35 -2.2786315 1.137152e-20
142 10581 IFITM2 1.5109988 6.549627e-07 1.3074970 1.169641e-03
143 283232 TMEM80 -1.3327746 1.403477e-02 -1.2226829 8.515564e-03
144 975 CD81 0.2942571 4.408413e-02 0.3556005 3.099488e-02
145 4004 LMO1 1.4433843 6.220350e-11 1.3258866 3.649893e-10
146 133 ADM -1.1558237 1.797575e-14 -0.6475969 2.839770e-04
147 100463486 MTRNR2L8 2.0318202 4.235834e-62 2.0634858 5.935490e-05
148 1982 EIF4G2 0.3458726 3.094287e-02 0.5788820 1.346036e-03
149 5682 PSMA1 -1.0615781 9.014012e-06 -1.1012916 2.171462e-05
150 6207 RPS13 -0.6355080 2.211871e-05 -0.5301279 1.175016e-03
151 3939 LDHA -3.4450725 3.555975e-57 -3.2270563 4.818517e-50
152 89797 NAV2 -1.2715516 1.672697e-03 -1.3518098 1.553398e-03
153 55366 LGR4 -0.4596623 1.389123e-02 -0.6599830 1.297946e-03
154 79832 QSER1 1.2732257 5.842110e-07 0.9493788 5.798319e-03
155 966 CD59 -0.4470639 1.942333e-03 -0.4298558 2.265781e-02
156 4005 LMO2 -0.9439280 9.795680e-09 -1.0353899 1.362535e-09
157 25841 ABTB2 -1.9023949 1.148220e-08 -2.1948899 1.217194e-12
158 24147 FJX1 -1.2795283 1.485935e-06 -1.3571886 6.311075e-08
159 392 ARHGAP1 0.5524057 4.696285e-03 0.7313479 1.196175e-03
160 9793 CKAP5 1.3498049 1.190752e-10 0.9206405 3.693917e-04
161 5795 PTPRJ -1.4944567 4.669593e-09 -0.7948589 7.489466e-03
162 710 SERPING1 1.5477979 7.141345e-06 1.5806734 1.367010e-07
163 5007 OSBP -0.7514993 1.969092e-02 -0.8450710 1.734554e-02
164 219988 PATL1 -1.0861330 4.750628e-02 -1.1569902 5.180092e-03
165 9415 FADS2 0.7626196 1.026452e-06 0.7990381 1.071382e-05
166 2495 FTH1 -1.1447389 2.122669e-18 -1.0032806 2.806385e-11
167 7423 VEGFB -1.4590412 9.749048e-10 -1.2675706 9.435057e-07
168 5331 PLCB3 1.3387600 3.379337e-04 1.3823730 9.252685e-03
169 9379 NRXN2 1.3666355 2.553474e-09 1.3997911 2.401544e-09
170 10263 CDK2AP2 0.6093632 1.868947e-03 0.5886891 2.627495e-02
171 1374 CPT1A 1.0164792 3.092289e-20 0.7679831 1.375191e-08
172 219927 MRPL21 -0.8550106 4.875423e-02 -0.8281652 2.943702e-02
173 1717 DHCR7 -0.9898568 1.991312e-02 -0.7107950 2.855912e-02
174 23201 FAM168A -0.7923228 1.514209e-02 -0.9133797 2.001961e-02
175 254225 RNF169 2.2320646 1.382485e-02 1.9892575 3.990335e-02
176 143570 XRRA1 2.6346674 8.162851e-04 2.3630977 4.325461e-03
177 408 ARRB1 2.2685181 5.698223e-05 1.6957982 5.741357e-03
178 6188 RPS3 0.6455032 2.996139e-05 0.8239249 4.454634e-07
179 4135 MAP6 0.6653568 1.655575e-04 0.5934970 3.255681e-03
180 5547 PRCP -1.4113064 3.924570e-25 -1.2391368 1.972074e-10
181 1740 DLG2 1.4715011 2.963450e-15 0.9855713 2.342898e-04
182 11098 PRSS23 -0.5314697 2.316156e-02 -0.6340091 1.669958e-02
183 619383 SCARNA9 4.8265782 1.045932e-45 3.6141656 1.013795e-13
184 79101 TAF1D -0.8279775 3.410271e-02 -1.1685785 4.576136e-03
185 4361 MRE11 2.2080192 1.123628e-02 2.1289689 1.864014e-02
186 51503 CWC15 -0.6569116 2.854221e-04 -0.5998060 4.108747e-03
187 143686 SESN3 1.5208110 3.365994e-24 0.6697407 1.018237e-03
188 26521 TIMM8B -0.7276418 2.773393e-05 -0.5900655 1.967217e-03
189 5805 PTS -0.8421404 1.796029e-02 -0.9672717 1.497561e-02
190 23705 CADM1 -1.2893882 2.186411e-27 -1.1917463 2.734871e-11
191 6330 SCN4B 1.2799326 2.515569e-03 1.5017509 1.895289e-04
192 372 ARCN1 -0.6163297 1.131600e-02 -1.0063294 8.744126e-06
193 6230 RPS25 -1.1879930 1.087308e-10 -1.1487088 1.142438e-06
194 10525 HYOU1 0.4801722 1.991312e-02 0.5439716 1.002803e-02
195 867 CBL 0.9862442 7.630371e-04 1.1159437 5.209139e-04
196 23365 ARHGEF12 0.7708840 4.472279e-03 0.6039591 4.546651e-02
197 6309 SC5D -1.2578982 1.703773e-06 -0.6704416 1.613515e-02
198 6653 SORL1 0.9160623 4.693998e-03 1.2360072 4.872692e-05
199 84959 UBASH3B 0.9669846 5.205697e-04 0.7461784 5.877956e-03
200 3312 HSPA8 -0.8107801 3.612595e-13 -0.5565886 3.026526e-04
201 50863 NTM 1.6180618 2.150137e-08 1.0551223 7.257588e-03
202 27087 B3GAT1 0.8320166 3.689493e-03 0.7956606 1.030918e-02
203 81029 WNT5B -5.4734885 4.353497e-03 -5.3365568 7.838853e-03
204 928 CD9 -1.4360451 3.469720e-19 -1.6913935 8.625945e-17
205 51258 MRPL51 -0.6967226 2.937988e-03 -0.6955322 7.820459e-03
206 7167 TPI1 -1.0327660 2.121892e-06 -0.7844075 9.813256e-04
207 2026 ENO2 -1.3155183 7.505891e-13 -0.6506850 3.896812e-03
208 1822 ATN1 -1.7528870 1.805554e-14 -1.2290057 6.425936e-07
209 51279 C1RL -1.8665671 2.192402e-03 -1.5744124 3.264559e-02
210 8531 YBX3 -0.7382606 7.061527e-03 -0.6371255 4.546566e-02
211 2012 EMP1 -1.3494119 1.068472e-02 -1.8602544 1.890182e-05
212 55729 ATF7IP 0.8866408 2.954535e-03 1.2658836 1.146903e-05
213 3945 LDHB -0.6605578 1.633804e-05 -0.5790951 1.177618e-03
214 3709 ITPR2 1.0144843 3.199205e-03 1.0716091 1.786538e-03
215 441631 TSPAN11 0.9463665 6.891792e-03 1.0200880 8.443121e-03
216 440093 H3-5 -0.9320423 7.719732e-03 -1.2309948 1.305595e-04
217 636 BICD1 1.0501165 2.724718e-06 0.7343712 4.282353e-02
218 83448 PUS7L 3.5264050 2.710122e-08 3.0685051 5.825696e-05
219 9416 DDX23 1.1615000 2.153836e-07 0.8378215 9.345609e-03
220 7009 TMBIM6 0.7060460 1.363229e-09 0.6572957 2.324081e-06
221 57609 DIP2B 0.9470451 4.047441e-05 0.6473065 3.660628e-02
222 9802 DAZAP2 -0.9437682 4.271968e-08 -0.6995231 6.898967e-04
223 5204 PFDN5 -0.8609163 3.095867e-04 -0.5454512 2.821849e-02
224 140465 MYL6B -0.8054253 4.745960e-03 -0.8814983 2.903229e-03
225 4637 MYL6 -0.6163122 5.981035e-05 -0.6635701 6.276546e-04
226 506 ATP5F1B -0.4563243 3.048455e-04 -0.5400958 3.254161e-04
227 10728 PTGES3 -0.6156502 8.630233e-03 -0.9159722 9.753096e-05
228 4666 NACA -1.1459737 2.315934e-12 -1.3366001 6.239144e-15
229 6472 SHMT2 0.8459188 1.973739e-02 1.2364375 6.898967e-04
230 3798 KIF5A 3.6143608 2.034501e-03 3.4889098 6.053031e-03
231 10106 CTDSP2 -0.9923990 1.305389e-05 -0.5869442 2.513168e-02
232 4673 NAP1L1 -0.7120084 1.324329e-05 -0.4246846 1.740220e-02
233 1466 CSRP2 -0.6920638 9.505580e-06 -0.4917198 4.008592e-02
234 490 ATP2B1 0.9012531 2.614983e-05 1.0374740 1.108626e-06
235 6636 SNRPF -1.1324493 2.453012e-06 -1.0860560 3.082267e-06
236 79158 GNPTAB 1.1463324 2.173083e-05 0.6720679 4.565400e-02
237 7184 HSP90B1 -0.8634184 1.265523e-04 -0.7841444 2.164383e-03
238 728568 C12orf73 -1.5512684 3.242068e-03 -1.2469048 8.241496e-03
239 7296 TXNRD1 -0.6776423 3.615251e-02 -0.7882707 3.264559e-02
240 10970 CKAP4 -0.7690259 3.015689e-06 -0.9838818 1.017166e-08
241 51228 GLTP -0.4821875 4.618272e-02 -0.7599732 4.884879e-03
242 10094 ARPC3 -0.6102782 2.972650e-03 -0.9412420 6.729471e-06
243 84329 HVCN1 3.3747724 4.295913e-02 3.3686669 3.811470e-02
244 5501 PPP1CC -0.8128626 1.220379e-02 -0.8080460 1.116728e-02
245 643246 MAP1LC3B2 -1.4663643 1.267301e-04 -1.2280103 1.113274e-03
246 8655 DYNLL1 -0.5477195 3.986710e-04 -0.6919491 7.018900e-05
247 9761 MLEC 0.6722115 9.546733e-07 0.6169386 1.050568e-04
248 605 BCL7A 1.1315003 1.560655e-03 1.1728135 7.523336e-03
249 8099 CDK2AP1 -0.4694600 3.904163e-03 -0.4886292 1.635987e-02
250 7316 UBC 0.4997596 4.954409e-06 0.4822442 2.174564e-03
251 5901 RAN -0.3936993 3.107234e-02 -0.5350856 2.365134e-03
252 80324 PUS1 1.0286966 4.280046e-02 1.1286737 3.099488e-02
253 26278 SACS 1.5636743 7.664811e-07 1.1165926 6.584897e-03
254 221178 SPATA13 -0.8902048 6.035418e-04 -1.1657566 6.508979e-06
255 219287 AMER2 0.8461887 7.236179e-11 0.5680272 1.033381e-03
256 432369 <NA> -0.3692138 3.504351e-02 -0.4453423 2.397161e-02
257 51371 POMP -0.4804148 2.331793e-03 -0.6964847 2.260392e-05
258 9201 DCLK1 1.3179092 6.796682e-19 0.9142153 2.072691e-06
259 341640 FREM2 1.6954165 8.713935e-11 0.8982423 1.337545e-02
260 10186 LHFPL6 -0.6086307 1.863760e-02 -0.7115927 1.872176e-03
261 11193 WBP4 -0.6874295 2.487734e-02 -0.7996704 3.492492e-03
262 11215 AKAP11 1.4253930 3.820775e-11 1.1710854 7.201902e-06
263 387923 SERP2 2.4517691 3.534834e-03 2.6807674 3.979238e-04
264 2963 GTF2F2 -0.8249755 2.772878e-05 -0.5434308 2.988918e-02
265 7178 TPT1 -1.0059231 2.061131e-30 -0.8601923 2.276152e-11
266 23091 ZC3H13 -0.5529994 4.665459e-04 -0.5310758 5.180092e-03
267 9445 ITM2B -0.5220673 1.929989e-04 -0.6285540 4.805853e-05
268 51131 PHF11 1.4321384 1.437404e-03 1.5329898 1.737613e-03
269 27253 PCDH17 -0.9751132 2.876048e-06 -1.4640379 1.303741e-09
270 23077 MYCBP2 0.6255073 5.145461e-03 0.5997358 2.598748e-02
271 1638 DCT 1.0870598 1.498000e-02 0.9205481 4.979406e-02
272 5095 PCCA 2.0733463 3.953563e-08 1.2003783 3.959115e-02
273 1284 COL4A2 0.3695904 3.615251e-02 0.8082727 4.638740e-05
274 55002 TMCO3 -1.0332278 3.342980e-03 -1.0746997 3.079478e-03
275 6038 RNASE4 -0.9164290 2.077805e-02 -1.2163044 2.873368e-02
276 57680 CHD8 0.8968184 3.372939e-05 0.6991214 1.329218e-02
277 4323 MMP14 0.9850565 5.177454e-06 1.2786677 2.131713e-09
278 599 BCL2L2 -1.5865893 4.665920e-04 -1.7070956 3.857687e-04
279 51310 SLC22A17 0.5154397 1.814580e-04 0.4934902 1.966518e-03
280 10278 EFS 2.4883883 2.147077e-12 1.8752328 1.809868e-05
281 85446 ZFHX2 -1.6625580 9.933235e-08 -1.5340958 2.013072e-06
282 9985 REC8 0.7033157 1.748692e-04 0.5771245 2.657893e-02
283 26277 TINF2 0.7029526 1.197424e-02 0.7484572 2.706049e-02
284 29966 STRN3 1.5508301 8.057865e-08 1.2769628 9.613083e-04
285 25831 HECTD1 0.5459785 3.746719e-02 0.6708643 9.880774e-03
286 55012 PPP2R3C 0.5799324 4.782572e-02 0.6691687 1.549309e-02
287 5411 PNN -0.4168608 2.540171e-02 -0.7135687 1.201599e-02
288 23116 TOGARAM1 0.9600572 7.941597e-03 0.9851191 2.652754e-02
289 161357 MDGA2 1.6513023 8.923562e-11 0.9655134 3.225967e-03
290 6235 RPS29 0.4807624 3.455008e-04 0.6510355 2.116004e-05
291 6166 RPL36AL -0.9957680 9.082824e-08 -1.1016991 3.672404e-08
292 378706 RN7SL2 2.4805335 1.418235e-11 1.9179568 5.840687e-05
293 11183 MAP4K5 0.8785682 2.286557e-03 0.7507975 3.524523e-02
294 5684 PSMA3 -0.6584165 1.539840e-03 -0.8476550 1.354044e-03
295 9786 KIAA0586 1.6993680 2.599433e-04 1.4071980 1.440329e-02
296 51528 JKAMP -1.2023218 6.385736e-05 -1.3111579 3.396557e-06
297 6252 RTN1 -0.3639800 3.557987e-03 -0.6884447 1.770971e-08
298 51635 DHRS7 -0.6796524 5.647213e-04 -0.8371637 2.696340e-04
299 3091 HIF1A 2.1229447 3.487554e-16 1.6336410 3.065415e-07
300 23224 SYNE2 2.0670181 8.869231e-30 1.5662832 3.749292e-13
301 51109 RDH11 -0.5499171 2.484270e-03 -0.4760457 1.829743e-02
302 6430 SRSF5 0.5674659 2.224111e-03 0.5336157 1.077263e-02
303 64093 SMOC1 0.7132338 4.260506e-06 0.7084819 9.149357e-04
304 10965 ACOT2 0.6848311 1.900536e-02 0.7047440 3.214083e-02
305 4329 ALDH6A1 2.2418365 7.217714e-20 1.6061019 3.065415e-07
306 97 ACYP1 -1.3084894 4.216796e-03 -1.5900128 1.743211e-03
307 10972 TMED10 -0.8560095 8.713935e-11 -0.8328233 5.181240e-10
308 2353 FOS -1.6064915 1.243978e-03 -1.1608242 2.646130e-02
309 85457 CIPC -0.9313047 9.447552e-03 -0.8095020 1.789535e-02
310 9517 SPTLC2 1.1221050 7.990316e-06 1.1312278 2.118018e-05
311 9369 NRXN3 -1.6065716 3.449313e-02 -1.5887835 1.184699e-02
312 123016 TTC8 0.7142490 2.737574e-02 1.0099592 8.055467e-05
313 5700 PSMC1 0.7331662 2.158759e-02 0.8375600 8.052262e-03
314 9321 TRIP11 1.0443074 3.744096e-04 1.0147238 2.281472e-03
315 5641 LGMN -0.9730725 1.597545e-04 -0.7925332 6.240399e-03
316 23405 DICER1 0.8257131 2.331994e-02 1.1559007 5.170060e-04
317 8788 DLK1 -0.5609641 1.304295e-03 -1.7510012 1.281397e-17
318 3320 HSP90AA1 -1.1753867 9.781107e-29 -0.7131140 5.324325e-08
319 1983 EIF5 -0.6169436 1.244378e-02 -0.8321811 3.210971e-05
320 1152 CKB 1.1521331 1.734651e-16 0.7991025 1.815224e-04
321 9529 BAG5 0.8386522 7.607621e-04 0.6817342 2.821559e-02
322 64423 INF2 1.6891678 1.533649e-02 1.8987812 1.308795e-03
323 1397 CRIP2 1.1201174 9.734029e-09 0.9635236 8.096318e-06
324 646214 <NA> 1.2321069 9.224010e-04 0.9434233 1.500102e-02
325 400322 <NA> -1.5977707 1.410845e-02 -2.8006606 6.470850e-07
326 338429 SNORD109B 2.0097776 2.540171e-02 2.0919884 1.207255e-02
327 100505573 INAFM2 -1.4749615 1.319847e-02 -1.0051999 4.400500e-02
328 30844 EHD4 -0.6083114 2.158759e-02 -0.5089841 3.241008e-02
329 25963 TMEM87A -0.7257593 9.565968e-03 -0.6191638 1.354313e-02
330 10169 SERF2 0.4404454 2.170030e-03 0.6736692 6.526499e-05
331 2628 GATM 1.5643737 1.048643e-10 0.9616877 3.703696e-03
332 2200 FBN1 0.8607575 5.772459e-03 1.1847374 4.450604e-06
333 9728 SECISBP2L 1.0816217 1.255468e-03 0.8018022 4.377840e-02
334 55930 MYO5C 2.3785961 4.455859e-09 1.8100040 5.326105e-04
335 102 ADAM10 -1.0933933 6.246805e-06 -1.2182947 7.086852e-07
336 2958 GTF2A2 -0.8484710 2.716828e-03 -0.9048391 1.156914e-03
337 302 ANXA2 -0.5537088 1.866956e-04 -0.7113861 7.371241e-08
338 54832 VPS13C 1.1836564 4.451909e-06 0.8341882 1.007868e-02
339 4947 OAZ2 -0.4928508 4.484629e-03 -0.4782622 2.061321e-02
340 8766 RAB11A -0.9549842 1.054123e-06 -1.0568213 2.000083e-07
341 84465 MEGF11 -1.7186404 8.209982e-06 -1.1408627 4.145113e-03
342 6124 RPL4 -0.8771004 6.381839e-08 -0.5179205 2.001062e-02
343 10391 CORO2B 0.8589018 6.312711e-09 0.9243462 1.482286e-10
344 7090 TLE3 -6.7603617 2.978198e-03 -6.5677032 5.555131e-03
345 4756 NEO1 0.7737262 2.999006e-06 1.0788257 8.593413e-12
346 27020 NPTN -0.8818356 1.082249e-07 -0.6839712 1.133234e-02
347 9377 COX5A -0.6773013 9.758073e-05 -0.4486781 3.667230e-02
348 5780 PTPN9 -0.7547634 1.835840e-03 -1.2022981 3.903492e-07
349 257364 SNX33 1.6109347 1.408189e-03 1.8906458 1.031601e-04
350 5955 RCN2 -0.5281499 9.254131e-03 -0.9946384 2.552655e-04
351 10518 CIB2 1.5171911 4.633562e-04 1.4908279 1.120339e-03
352 1512 CTSH 2.0223758 3.355758e-19 1.2880767 2.118018e-05
353 54469 ZFAND6 -0.7238855 7.714215e-05 -0.6354142 2.675745e-04
354 100996492 CTXND1 -1.4610311 1.207149e-11 -1.0458236 3.462791e-06
355 57214 CEMIP -1.7258045 5.144530e-04 -1.2654567 1.334918e-02
356 9455 HOMER2 0.7921360 2.206341e-03 1.2020124 2.308369e-03
357 4828 NMB 1.3904482 1.209186e-03 1.7651951 4.082702e-05
358 23478 SEC11A -0.5071683 1.143399e-02 -0.7215752 1.530893e-03
359 11057 ABHD2 0.9867256 1.055214e-09 0.7448633 1.979386e-04
360 8826 IQGAP1 0.6887089 6.225407e-04 0.6857426 3.996255e-03
361 5045 FURIN 0.7288971 4.369405e-02 0.8065481 1.022489e-02
362 100507217 <NA> -0.6709382 1.434922e-05 -1.0526726 8.705861e-10
363 56963 RGMA 0.7056909 6.604404e-06 0.4876214 1.364992e-02
364 220 ALDH1A3 -3.6617546 2.321927e-02 -3.2939555 4.998178e-02
365 6627 SNRPA1 -1.4735138 6.025296e-06 -1.2717078 9.436098e-04
366 89941 RHOT2 0.6412986 2.211189e-02 0.6603700 2.526053e-02
367 146330 FBXL16 -1.3336109 1.052039e-03 -1.4302758 4.823952e-03
368 79006 METRN 0.5937960 2.511496e-04 0.5155136 1.360463e-02
369 4832 NME3 1.0266186 2.123065e-03 0.7703233 4.378514e-02
370 54442 KCTD5 -0.7554263 3.146392e-02 -0.9369020 2.344794e-02
371 23295 MGRN1 0.7979232 2.434262e-03 0.8281164 2.879230e-03
372 9665 MARF1 2.8542798 4.896935e-03 2.7023822 1.622654e-02
373 6210 RPS15A -0.7541864 9.596458e-06 -0.6651631 4.927704e-04
374 162073 ITPRIPL2 1.1724059 4.362093e-05 1.2406781 1.181085e-04
375 124152 IQCK -0.5529377 1.994773e-03 -0.8890497 2.921859e-06
376 51704 GPRC5B -0.5055507 1.513117e-03 -0.6900454 1.081939e-04
377 100132247 NPIPB5 -2.3215555 3.056852e-05 -1.8754768 1.802764e-02
378 4706 NDUFAB1 -0.5630920 8.843514e-04 -0.4566382 1.285059e-02
379 5930 RBBP6 -1.0066197 1.200452e-04 -0.7095351 2.843181e-02
380 728888 NPIPB11 -2.6355541 1.603400e-08 -1.9490314 8.570030e-05
381 283899 INO80E 2.9471199 9.759911e-07 2.1134615 9.468187e-03
382 226 ALDOA -1.3606083 2.798711e-17 -0.9728360 7.286096e-09
383 5595 MAPK3 0.6513239 3.661915e-02 0.7057474 3.446340e-02
384 11151 CORO1A 2.2349179 1.619569e-02 2.2342981 4.006712e-02
385 79077 DCTPP1 0.7113736 3.417531e-03 0.8565531 5.078489e-04
386 9274 BCL7C 1.5065615 1.943921e-08 1.1091868 6.498955e-04
387 6810 STX4 1.1925147 2.042837e-05 1.2388882 2.251825e-05
388 79001 VKORC1 -0.9601554 7.422678e-05 -0.6185071 1.877226e-02
389 2521 FUS 0.7410369 3.181030e-05 0.6204779 4.494913e-04
390 583 BBS2 -0.7482505 2.173867e-02 -0.8087094 6.589888e-03
391 4502 MT2A -1.2282267 1.664401e-22 -0.8229889 7.013897e-09
392 4493 MT1E 0.9300064 3.004138e-02 1.0751455 4.915824e-02
393 1783 DYNC1LI2 0.4974782 5.772459e-03 0.4532773 2.176852e-02
394 197258 FCSK 2.3984890 3.167946e-04 1.8808315 1.520342e-02
395 92154 MTSS2 0.5294757 1.914562e-02 1.0163654 3.065415e-07
396 5713 PSMD7 -1.0050699 2.112658e-04 -0.8860564 4.278111e-04
397 4166 CHST6 3.0645768 7.308068e-04 2.6810800 1.508054e-02
398 11345 GABARAPL2 -0.5831238 1.739853e-04 -0.5337674 8.088136e-03
399 54386 TERF2IP -0.6599059 6.545003e-06 -0.4920765 8.713752e-03
400 100130958 SYCE1L 1.8513710 6.371125e-05 1.9520282 5.917311e-05
401 4094 MAF 0.6601958 3.970478e-03 0.8544728 1.552264e-04
402 10200 MPHOSPH6 0.7186914 7.527866e-04 0.7569288 7.557718e-04
403 3281 HSBP1 -0.9791065 5.977306e-05 -0.8763515 2.071921e-05
404 23406 COTL1 -1.0468653 3.578360e-21 -0.7607910 6.151220e-07
405 81631 MAP1LC3B -0.7608972 1.625938e-04 -0.8909154 1.289561e-04
406 29123 ANKRD11 -0.6415374 5.192073e-07 -0.7459759 8.624795e-07
407 10381 TUBB3 -1.8799015 2.553474e-09 -1.5529605 8.242803e-08
408 7531 YWHAE -0.3729903 3.290109e-03 -0.3212018 2.610818e-02
409 5306 PITPNA 0.7210321 2.431354e-05 0.7542352 1.000956e-04
410 23302 WSCD1 1.0269661 2.545646e-09 0.8341752 3.197617e-05
411 1742 DLG4 1.0168062 1.241528e-06 1.0112762 5.170060e-04
412 37 ACADVL 0.6216676 3.701643e-03 0.6442395 5.809633e-03
413 11337 GABARAP -0.7586896 1.964721e-05 -0.5466087 1.233636e-02
414 23399 CTDNEP1 0.6708036 6.173454e-05 0.7816274 3.026526e-04
415 1984 EIF5A 1.1134736 3.154101e-08 1.3122690 6.205293e-09
416 8742 TNFSF12 1.0187220 1.459895e-02 1.1437520 6.790872e-03
417 6154 RPL26 -1.0460345 2.509745e-19 -0.8622822 2.463887e-11
418 4213 <NA> 1.5820650 6.035758e-03 1.6092586 1.622654e-02
419 9611 NCOR1 -0.6081892 1.695747e-02 -0.5495149 1.707968e-02
420 7314 UBB -0.4691251 1.061397e-04 -0.3483102 2.610818e-02
421 3996 LLGL1 1.4897518 7.828128e-12 1.1759520 6.767713e-06
422 22905 EPN2 1.4997465 4.376134e-20 1.2335509 1.938146e-09
423 5598 MAPK7 -1.7273884 1.782831e-02 -1.8507405 7.045468e-03
424 224 ALDH3A2 1.0707664 4.848732e-06 0.8587628 4.958752e-04
425 218 ALDH3A1 4.7649674 6.798268e-11 4.2115605 1.559989e-05
426 100462977 MTRNR2L1 0.5390923 4.998631e-04 0.4795306 3.597145e-02
427 26118 WSB1 -0.6667744 5.838890e-04 -1.0155676 3.164552e-06
428 6147 RPL23A -1.2495909 3.507351e-10 -1.4730771 3.905016e-14
429 147015 DHRS13 -1.5904096 4.436896e-03 -1.3580087 2.036057e-02
430 163 AP2B1 0.9170481 4.391871e-12 0.5561412 1.686939e-03
431 9349 RPL23 -0.9609142 1.448658e-14 -0.7499664 1.973976e-06
432 6143 RPL19 -0.6496690 7.202380e-07 -0.4333177 7.007300e-03
433 5709 PSMD3 0.4486873 3.803015e-02 0.4953493 4.337170e-02
434 10209 EIF1 -0.8655077 1.218459e-11 -0.7102267 1.207773e-05
435 60681 FKBP10 0.8066666 5.091359e-05 0.6908554 4.406530e-03
436 6155 RPL27 -0.5392102 4.821528e-04 -0.5422350 4.327176e-04
437 7343 UBTF 0.6029705 9.174393e-03 0.8177925 2.046263e-04
438 5164 PDK2 1.2152361 1.904797e-04 1.1907447 4.563305e-05
439 1277 COL1A1 -2.8471299 2.995600e-39 -1.8285507 2.040815e-13
440 51747 LUC7L3 -0.6610476 3.857106e-06 -0.9295326 1.304088e-07
441 400604 TOB1-AS1 -6.1036766 3.873388e-03 -6.8727609 1.644381e-03
442 404093 CUEDC1 1.0923463 2.369303e-09 1.2435518 2.771823e-09
443 6426 SRSF1 -0.5865971 9.832837e-03 -0.7513147 3.903825e-02
444 51651 PTRH2 -1.1640318 3.574377e-02 -1.5787622 5.267260e-03
445 653653 <NA> 1.4239438 3.467382e-09 1.7399199 6.011646e-18
446 342538 NACA2 -0.9300780 3.015689e-06 -1.1975437 1.017166e-08
447 9902 MRC2 1.1038193 1.638472e-20 1.1162576 8.625945e-17
448 1534 CYB561 2.4158674 1.680369e-05 1.6040817 4.933118e-02
449 57003 CCDC47 0.7906737 9.598831e-04 0.8245096 2.090641e-03
450 5705 PSMC5 -0.4908692 2.234183e-02 -0.5234272 2.177510e-02
451 5573 PRKAR1A -1.0014435 1.197939e-07 -0.8420927 6.534938e-05
452 388419 BTBD17 1.3664531 3.650656e-13 1.1790808 1.784528e-08
453 54868 TMEM104 1.3112915 6.952907e-03 1.3391409 4.117834e-03
454 23510 KCTD2 0.9061594 2.145458e-04 0.5868645 3.890927e-02
455 10476 ATP5PD -1.0698931 2.195591e-09 -1.1032170 1.084478e-08
456 3021 H3-3B -0.5430925 1.086129e-04 -0.7777642 2.435996e-08
457 91107 TRIM47 1.6792228 7.217060e-03 1.8933073 8.918467e-04
458 201292 TRIM65 1.1240151 2.665472e-02 1.4725577 8.160852e-04
459 51 ACOX1 1.1598918 1.702593e-13 0.5881737 9.993501e-03
460 10801 SEPTIN9 0.4981700 1.926090e-05 0.3542610 1.262411e-02
461 9021 SOCS3 -2.0406971 7.667438e-07 -0.9303624 2.637179e-02
462 3959 LGALS3BP 0.4278459 4.764323e-02 0.5390982 2.085401e-02
463 114897 C1QTNF1 1.1314203 1.006811e-07 0.7203363 1.501335e-02
464 284184 NDUFAF8 0.6478430 8.413831e-06 0.6534928 1.456353e-03
465 71 ACTG1 -0.4680908 2.715692e-06 -0.4227503 1.250806e-03
466 201254 CENPX 0.9654809 8.055192e-04 0.6960919 3.037249e-02
467 5881 RAC3 1.4383392 1.309392e-03 1.3111040 2.163096e-02
468 9123 SLC16A3 -7.4951724 1.577182e-08 -4.6801469 6.413758e-08
469 23347 SMCHD1 1.4355319 1.582610e-03 1.2198838 1.376472e-03
470 10627 MYL12A -0.8038030 5.724630e-05 -0.6752340 2.496280e-03
471 103910 MYL12B -0.8575369 1.621226e-10 -0.8117296 5.233679e-08
472 284217 LAMA1 -2.2257179 6.361789e-03 -2.0289047 7.975250e-03
473 201475 RAB12 1.3339036 5.817152e-07 1.1245542 1.084291e-04
474 23253 ANKRD12 -0.8681116 2.601905e-07 -0.9152023 3.065415e-07
475 114876 OSBPL1A 1.0766236 7.366692e-06 0.9044615 1.100923e-03
476 361 AQP4 1.5656176 1.853286e-21 1.4074809 5.825739e-17
477 498 ATP5F1A -0.6416771 4.356958e-06 -0.5865395 1.462442e-04
478 84064 HDHD2 -1.1724552 3.871622e-05 -0.8265877 3.960607e-02
479 6139 RPL17 -0.8860713 3.459308e-04 -0.8203003 5.170060e-04
480 10449 ACAA2 -0.9835198 1.748729e-04 -0.8956480 1.526013e-03
481 220164 DOK6 1.1034941 3.803015e-02 1.4893884 7.937452e-03
482 9306 SOCS6 0.6771815 1.511831e-03 0.6649241 1.376269e-02
483 9658 ZNF516 -1.3949158 6.602410e-03 -1.2481438 4.683662e-02
484 10907 TXNL4A -0.8554553 3.464622e-03 -0.8401470 3.249287e-03
485 57418 WDR18 0.9082210 1.322176e-02 0.8619321 2.884778e-02
486 6209 RPS15 -1.1655410 9.427873e-13 -0.7401840 8.264494e-04
487 4946 OAZ1 -0.9144420 1.035688e-06 -0.8295024 5.396696e-07
488 51690 LSM7 0.6851350 1.625938e-04 0.6592302 2.082811e-03
489 7064 THOP1 1.5633735 7.422678e-05 1.2915626 1.982972e-02
490 4782 NFIC -0.4955306 1.019937e-02 -0.6084822 2.238075e-03
491 10362 HMG20B 0.9104760 7.168929e-04 0.9698949 8.701801e-05
492 1613 DAPK3 1.1210634 8.583011e-03 1.4670027 5.149358e-05
493 51341 ZBTB7A -0.5329792 2.174952e-02 -0.6014640 1.680627e-02
494 10226 PLIN3 0.7468669 1.731812e-04 0.6718949 2.987392e-03
495 5802 PTPRS 0.5814723 3.792843e-02 0.5671801 4.497410e-02
496 9667 SAFB2 -0.6302106 1.991312e-02 -0.7619429 2.644829e-03
497 25873 RPL36 -0.5978185 3.267858e-03 -0.5381396 2.431132e-02
498 126328 NDUFA11 0.5444187 3.504072e-03 0.5460042 5.670675e-03
499 8570 KHSRP 0.4531844 3.890512e-03 0.6730349 1.215965e-04
500 5609 MAP2K7 0.8145074 2.515161e-02 1.0251983 6.875258e-03
501 59286 UBL5 -0.6634272 1.135321e-04 -0.5617379 5.769987e-03
502 11140 CDC37 0.6525490 2.916640e-04 0.9248559 1.478986e-08
503 6597 SMARCA4 -0.6388741 2.116413e-04 -0.4370694 3.788967e-02
504 664709 HNRNPA1P10 -0.8202349 1.319885e-03 -1.1368359 3.046410e-06
505 30000 TNPO2 0.9871910 2.879390e-12 1.0137554 1.123235e-10
506 811 CALR 0.5171798 1.055917e-04 0.5652609 2.200134e-04
507 4784 NFIX 1.3494924 3.877122e-10 1.1380430 5.245494e-06
508 4854 NOTCH3 -0.7984197 1.107035e-04 -0.5367607 3.290530e-02
509 23309 SIN3B 0.5376397 1.786169e-02 1.1559082 2.557046e-09
510 29086 BABAM1 0.5444527 3.192491e-02 0.5725905 4.870170e-02
511 684 BST2 4.1044688 2.448898e-07 2.4245661 4.133457e-02
512 23025 UNC13A -1.4931368 1.626257e-03 -1.2487069 2.646238e-02
513 6142 RPL18A -1.1924036 4.972920e-05 -0.8330070 2.756954e-02
514 54858 PGPEP1 0.5743370 2.946539e-02 0.6945012 5.880719e-03
515 9454 HOMER3 0.6580178 2.728967e-02 1.1169763 1.394607e-05
516 126382 NR2C2AP 1.7684018 6.227875e-03 2.0415365 1.297946e-03
517 1463 NCAN 2.0063903 2.093700e-39 1.5848372 1.802605e-19
518 199777 ZNF626 1.2503435 2.324914e-02 1.2250439 3.137160e-02
519 9141 PDCD5 -1.1924111 3.352741e-08 -1.5108428 1.043035e-10
520 2821 GPI -0.8182675 7.141345e-06 -0.6441403 9.803840e-03
521 57655 GRAMD1A 0.6170433 3.368466e-02 1.2095016 2.797167e-07
522 7392 USF2 0.8150802 7.818162e-04 0.8852666 2.003848e-03
523 55851 PSENEN 0.6441546 2.705447e-02 0.8293852 1.338893e-03
524 390927 ZNF793 1.1624545 5.507474e-03 1.1992339 7.007300e-03
525 81 ACTN4 -0.9711769 9.383044e-11 -0.8946542 1.902623e-04
526 1891 ECH1 -0.8841565 1.188934e-06 -0.7721249 7.751143e-06
527 2091 FBL 0.8150981 5.297385e-05 0.7676569 9.436098e-04
528 208 AKT2 0.6374496 6.928342e-05 0.5051990 1.813853e-02
529 6223 RPS19 -0.6876310 1.035756e-05 -0.6189867 2.820892e-03
530 348 APOE 1.1522867 2.550867e-12 1.1986122 8.038100e-11
531 27113 BBC3 0.7761841 5.367863e-05 0.7609061 5.485502e-05
532 6415 SELENOW 0.7770321 9.579005e-08 0.6348706 2.338289e-04
533 9266 CYTH2 0.6058005 2.732904e-02 0.7927179 1.934439e-03
534 114783 LMTK3 0.9480215 3.949142e-02 1.2953316 2.109213e-03
535 587 BCAT2 1.5592921 8.160051e-07 1.0495492 2.269406e-02
536 4924 NUCB1 0.7887961 1.329084e-03 0.9847285 2.839770e-04
537 2512 FTL -0.3556224 2.866145e-03 -0.4019268 5.246853e-03
538 23521 RPL13A -0.4194443 1.506299e-02 -0.4215042 2.365199e-02
539 6205 RPS11 -0.6614844 1.204615e-04 -0.4856142 1.551758e-02
540 284361 EMC10 0.6624030 4.771072e-04 0.5769863 1.183788e-02
541 94030 LRRC4B 0.4740838 2.088254e-02 0.6435874 1.955646e-03
542 22870 PPP6R1 1.2045892 2.694076e-05 1.2526980 2.118018e-05
543 3589 IL11 -2.3886842 2.449178e-02 -3.4881869 2.358497e-02
544 57106 NAT14 1.0891691 1.904718e-04 1.1249846 3.828627e-04
545 11338 U2AF2 1.0205563 2.423170e-08 1.2225093 1.970862e-11
546 10782 ZNF274 -2.3087036 2.034501e-03 -2.5598429 7.478455e-04
547 1 A1BG 1.0668549 1.135968e-02 1.0326944 4.966984e-02
548 27243 CHMP2A -0.9064416 7.832469e-07 -0.6666526 6.246455e-03
549 52 ACP1 -1.1377447 3.462058e-04 -0.8916591 2.090641e-03
550 7837 PXDN -0.3290889 3.408553e-02 -0.4502360 1.257367e-02
551 55256 ADI1 0.9224474 1.666662e-04 0.6410400 4.013384e-02
552 6664 SOX11 0.6912783 1.701194e-03 0.7174623 1.703667e-02
553 10971 YWHAQ -0.8210504 1.000003e-06 -0.6755020 1.226452e-04
554 9475 ROCK2 0.8346411 1.136763e-02 0.8095556 1.131041e-02
555 100506474 <NA> -1.5982889 2.440088e-02 -2.2156404 1.393295e-02
556 23369 PUM2 -0.8245376 1.197424e-02 -0.9152835 9.252685e-03
557 1788 DNMT3A 0.9579356 1.796029e-02 1.2639074 7.176007e-04
558 2498 <NA> -0.9087544 1.435723e-02 -1.1999027 1.444109e-03
559 29959 NRBP1 0.9624157 1.830496e-06 0.8847736 3.893351e-04
560 64838 FNDC4 0.9644681 8.342670e-04 0.9341919 4.833162e-03
561 23160 WDR43 1.2590444 2.095399e-03 1.2698739 5.741357e-03
562 57448 BIRC6 1.1606625 2.511496e-04 1.0147184 6.686043e-03
563 4052 LTBP1 -1.3724028 1.778799e-03 -1.7960557 3.974205e-08
564 5610 EIF2AK2 1.5877796 6.858212e-09 1.0966518 1.072710e-03
565 9167 COX7A2L -0.7887471 6.017926e-03 -0.9864544 3.965731e-03
566 9581 PREPL 1.4106356 1.490691e-08 1.1669508 6.670263e-05
567 90411 MCFD2 -0.8534024 6.212943e-04 -0.7653025 2.320449e-02
568 618 BCYRN1 1.1481897 4.687568e-11 0.7904782 1.743211e-03
569 6233 RPS27A -0.5869447 4.180878e-07 -0.4716746 2.436719e-03
570 2202 EFEMP1 -1.5040760 2.610553e-10 -1.4541560 4.618032e-10
571 150962 PUS10 -1.6267832 1.809134e-04 -1.1783226 1.738090e-02
572 9736 USP34 0.6629489 2.118902e-02 0.6043363 4.928176e-02
573 4190 MDH1 -1.3014972 3.011003e-08 -1.2366448 2.140939e-07
574 200734 SPRED2 -1.4266956 2.030167e-05 -1.6172656 3.995397e-06
575 27247 NFU1 -0.8449345 4.144806e-02 -1.2119069 2.533826e-04
576 22848 AAK1 0.5601755 2.011326e-02 0.7988644 6.392189e-04
577 5093 PCBP1 -0.8498054 2.218219e-06 -0.5342829 5.183356e-03
578 6637 SNRPG -0.8997136 3.242095e-09 -0.9151109 2.855369e-07
579 94097 SFXN5 0.9463019 1.681136e-05 0.9579809 4.220126e-05
580 116540 MRPL53 -1.0324314 5.395323e-05 -0.6913691 1.262411e-02
581 3099 HK2 -3.3309343 1.594738e-16 -4.2459586 1.346036e-03
582 9168 TMSB10 -0.8474615 2.767975e-10 -0.5227594 2.016952e-03
583 83439 TCF7L1 -2.0526037 4.683382e-03 -1.9991394 1.305595e-04
584 84913 ATOH8 1.1852155 5.269336e-09 1.0431946 8.096318e-06
585 55818 KDM3A -2.0335439 6.702358e-07 -2.0759424 1.607238e-06
586 729857 RGPD2 3.5272906 3.171255e-04 3.5276271 1.397300e-03
587 56910 STARD7 -1.0227191 1.006811e-07 -1.1204582 2.171022e-08
588 25972 UNC50 -0.8665031 3.410271e-02 -1.5261007 1.845494e-03
589 51263 MRPL30 0.8703242 5.947905e-03 0.8017773 2.918484e-02
590 9669 EIF5B -1.0963573 8.362389e-19 -0.8541908 5.292832e-08
591 4862 NPAS2 -5.7368942 3.130281e-03 -4.5240348 1.096030e-02
592 6160 RPL31 -0.9658469 2.797911e-17 -0.7099248 5.184623e-07
593 9448 MAP4K4 0.4100621 2.284218e-03 0.4202157 2.125937e-02
594 100506421 PANTR1 0.9780882 4.942034e-08 0.6353487 6.010093e-03
595 102682016 LINC01159 1.7227936 1.207016e-05 1.4002439 2.631022e-03
596 100288695 LIMS4 -1.6780865 1.324682e-06 -1.3833020 6.586686e-04
597 6574 SLC20A1 -0.6693197 2.565649e-03 -0.6163021 2.489354e-02
598 55240 STEAP3 -1.4419739 1.899507e-02 -1.8258206 1.253088e-03
599 5899 RALB 0.7628939 4.805134e-03 0.9772579 1.809868e-05
600 9394 HS6ST1 -0.9357036 1.382177e-04 -0.9316714 5.797352e-06
601 80097 MZT2B 0.6017073 3.355527e-03 0.6834076 3.508558e-03
602 653784 MZT2A 0.9549674 9.727316e-04 0.8347819 1.034728e-02
603 116372 LYPD1 -6.2885116 1.774920e-02 -6.0958524 2.657893e-02
604 23190 UBXN4 -0.7151932 7.489185e-05 -0.5442665 1.592498e-02
605 1615 DARS1 -0.4502497 4.357571e-02 -0.6777391 1.095256e-03
606 55777 MBD5 1.5335735 1.533649e-02 1.5209488 8.913731e-03
607 27249 MMADHC -1.0656269 1.362946e-02 -0.8307710 3.312198e-02
608 90 ACVR1 -2.0416431 5.843736e-03 -1.7937962 9.494858e-03
609 5937 RBMS1 -1.2392401 6.887964e-07 -2.4280154 2.528686e-18
610 9360 PPIG -0.6234780 9.426565e-04 -0.4444366 1.463157e-02
611 29081 METTL5 -1.4305197 2.031223e-03 -2.0690238 7.930938e-05
612 1745 DLX1 -0.7904554 4.379604e-02 -0.8927985 4.910555e-02
613 5163 PDK1 -2.1285998 2.115807e-02 -1.7678435 1.079832e-03
614 440926 <NA> -0.9154993 3.278871e-02 -1.0285757 3.559935e-02
615 518 ATP5MC3 -0.5910226 1.241528e-06 -0.4956253 6.875258e-03
616 10651 MTX2 -1.4065501 4.954487e-04 -1.4724389 5.725756e-03
617 220988 HNRNPA3 -0.7180730 2.563000e-03 -0.6992930 4.523637e-03
618 10787 NCKAP1 -0.9419657 5.004447e-04 -0.8625636 6.042247e-03
619 94101 ORMDL1 -0.9117302 2.497988e-03 -0.6406131 3.290530e-02
620 23671 TMEFF2 -6.9412488 9.263510e-10 -1.6671606 1.252755e-02
621 3336 HSPE1 -0.9361015 1.620163e-07 -0.5738337 2.943702e-02
622 4709 NDUFB3 -0.8599914 2.195084e-02 -1.5430307 1.972074e-10
623 66008 TRAK2 1.1469229 3.828445e-05 0.7988402 1.665171e-02
624 7341 SUMO1 -1.1692703 1.498417e-06 -1.0808101 3.724102e-06
625 4133 MAP2 0.9717932 3.904716e-15 0.8135220 6.413758e-08
626 2335 FN1 -0.6180557 7.870373e-03 -0.5129073 4.209339e-02
627 3488 IGFBP5 -1.0704516 8.624182e-21 -1.0255359 2.373062e-12
628 6508 SLC4A3 1.6170398 5.997335e-07 1.4806608 1.305595e-04
629 7857 SCG2 -0.9795131 8.076526e-13 -0.8821592 7.286096e-09
630 5757 PTMA -0.7980282 2.664439e-04 -0.5411530 2.348092e-02
631 26058 GIGYF2 0.7938093 7.465367e-05 0.6147934 9.513596e-03
632 2637 GBX2 -7.6628226 2.593849e-05 -7.4701666 6.396227e-05
633 547 KIF1A 0.5294785 1.624405e-03 0.4920022 1.093023e-02
634 55968 NSFL1C 0.5829945 3.826949e-02 0.7680300 2.534991e-03
635 6628 SNRPB 0.6229986 2.951031e-02 0.6490339 4.727499e-02
636 1059 CENPB 0.6440433 3.224106e-02 1.1292443 6.104656e-06
637 57506 MAVS 0.7851711 8.503194e-04 0.9669530 3.026305e-05
638 9770 RASSF2 0.7663205 1.857666e-03 0.7638085 5.221604e-03
639 29058 TMEM230 -0.6237705 4.614585e-03 -0.5474712 1.957347e-02
640 3642 INSM1 -1.9971556 2.843388e-05 -1.3653666 4.385264e-03
641 57186 RALGAPA2 1.0177461 4.768293e-03 1.1086594 1.949396e-03
642 55857 KIZ -3.2996821 9.426565e-04 -2.1092718 4.156827e-02
643 1471 CST3 1.2086087 3.743043e-26 1.3795657 6.923384e-27
644 57136 APMAP -0.6698550 1.185051e-03 -0.6812122 3.405905e-04
645 3397 ID1 2.3793819 8.169067e-03 2.7721296 1.739855e-04
646 9777 TM9SF4 -1.0423368 6.192435e-04 -1.4224951 4.563305e-05
647 84557 MAP1LC3A 1.2840689 2.218219e-06 0.8092823 2.802262e-02
648 58476 TP53INP2 -0.4969754 1.994346e-02 -0.8549743 6.390434e-04
649 26133 TRPC4AP 0.7202326 1.177626e-02 0.7369166 1.788840e-02
650 6185 RPN2 -0.4945573 5.046971e-03 -0.4877500 8.318659e-03
651 7150 TOP1 -0.4546108 8.589350e-04 -0.3807670 4.001298e-02
652 6385 SDC4 2.5582812 6.366611e-04 2.9459696 1.633773e-05
653 441951 ZFAS1 -0.7642309 3.630008e-05 -0.7115971 3.738045e-04
654 8813 DPM1 -1.3770244 5.706391e-03 -1.4120845 1.354480e-03
655 56937 PMEPA1 -1.3599819 1.250678e-09 -1.2412038 5.233679e-08
656 2778 GNAS -0.9110424 1.234079e-14 -0.9728377 2.043935e-15
657 3785 KCNQ2 -1.7287824 1.964923e-08 -2.0442425 8.570030e-05
658 1917 EEF1A2 -1.3102373 2.013576e-02 -1.5331370 5.277554e-04
659 79144 PPDPF -1.0455302 1.803030e-13 -1.0205089 1.391263e-11
660 6919 TCEA2 0.9970302 5.239650e-05 0.8564869 2.124406e-03
661 8204 NRIP1 1.5223402 9.760142e-13 1.2837321 2.001283e-07
662 54148 MRPL39 -1.2028438 1.651603e-02 -2.0249979 6.498955e-04
663 58494 JAM2 -1.2866157 3.075335e-05 -0.8060453 4.242012e-03
664 522 ATP5PF -1.1047917 2.067912e-16 -1.1207650 5.651067e-13
665 6647 SOD1 -0.6594340 9.505580e-06 -0.6400151 5.498998e-04
666 6651 SON -0.7380577 3.450537e-06 -0.8452348 3.347372e-06
667 539 ATP5PO -0.5510416 1.963777e-03 -0.5600488 3.519114e-03
668 64968 MRPS6 -0.6109838 2.284218e-03 -0.9016343 1.234605e-03
669 53820 RIPPLY3 1.8166987 4.033829e-02 2.3301752 2.972342e-03
670 51227 PIGP -1.0641385 7.642985e-04 -1.5559019 1.207749e-07
671 7485 GET1 -0.9670272 4.485725e-04 -1.0659018 7.469235e-05
672 4599 MX1 6.5129709 1.178985e-13 4.7489981 2.307235e-05
673 7307 U2AF1 -0.8753253 5.273963e-05 -0.5883751 1.725673e-02
674 150094 SIK1 -1.9449168 3.276602e-03 -2.5082565 8.172906e-06
675 754 PTTG1IP -0.7092259 4.694368e-05 -0.5106379 6.385133e-03
676 3275 PRMT2 0.9041244 1.447797e-13 0.7347605 1.607238e-06
677 23783 <NA> -2.0535666 1.064511e-04 -1.2660121 3.922499e-02
678 7122 CLDN5 7.6882552 1.507084e-06 7.5326013 5.245494e-06
679 9127 P2RX6 -6.9475368 1.411991e-03 -4.9495952 2.596403e-02
680 100037417 DDTL;DDT -4.1173363 4.351619e-02 -5.8350477 9.564642e-03
681 2130 EWSR1 -0.5497894 5.182409e-03 -0.6566420 2.652517e-03
682 8508 NIPSNAP1 2.0854791 1.117597e-17 1.7238679 1.342090e-09
683 253143 PRR14L 1.0061306 4.480015e-03 0.9355993 3.828982e-03
684 25828 TXN2 0.6309463 2.122480e-02 0.7837703 1.951939e-03
685 11078 TRIOBP -0.6890856 3.496671e-03 -0.8728017 8.957536e-05
686 3005 H1-0 0.9685330 9.727316e-04 1.3186945 1.014313e-05
687 25776 CBY1 0.8826165 1.291386e-02 1.2055688 5.978783e-05
688 4248 MGAT3 -1.3154641 1.331357e-03 -1.2968380 6.327923e-05
689 23112 TNRC6B 1.0234879 3.449208e-11 0.5734776 1.811473e-03
690 158 ADSL -0.8027735 1.002866e-02 -1.1597245 2.212467e-02
691 9978 RBX1 -0.7886203 4.661877e-04 -0.9068143 7.699282e-05
692 84844 PHF5A 1.1243600 3.196933e-04 1.4350685 3.087719e-05
693 27351 DESI1 0.9025063 2.198545e-02 1.0721990 2.589638e-03
694 706 TSPO 0.6557583 1.507084e-06 0.8486172 9.770725e-09
695 25814 ATXN10 -1.0353980 5.925748e-07 -0.6120749 3.824003e-02
696 10752 CHL1 -0.7303162 1.437404e-03 -0.9860194 6.170626e-05
697 57633 LRRN1 -1.8102115 2.183632e-06 -1.6260312 8.324859e-05
698 285362 SUMF1 -1.1070522 6.235271e-04 -1.0245436 1.631457e-03
699 7428 VHL 0.7257850 1.331805e-03 0.7279293 1.220129e-02
700 9797 TATDN2 1.0210697 3.189095e-02 1.2458058 6.390434e-04
701 6396 SEC13 -0.9579656 1.118838e-04 -0.6826414 9.044477e-03
702 5894 RAF1 -2.5997129 5.820569e-04 -2.0650136 2.646130e-02
703 6161 RPL32 -1.0806325 1.189903e-21 -0.7779658 1.989364e-08
704 2199 FBLN2 -0.8459523 7.881683e-04 -1.8077219 5.456321e-12
705 27258 LSM3 -1.0773957 1.068273e-06 -1.2368542 4.450604e-06
706 85403 EAF1 -1.4396254 4.664552e-04 -1.5459180 8.797670e-05
707 79750 ZNF385D 0.6342609 1.659110e-02 0.8168542 9.222303e-03
708 6138 RPL15 -0.7440450 9.290416e-12 -0.5354022 6.923078e-05
709 9045 RPL14 -0.9462397 2.834396e-11 -0.7659313 4.106732e-05
710 55129 ANO10 1.5672085 1.557156e-13 1.3859490 7.572853e-11
711 29072 SETD2 1.3332470 1.014466e-05 0.7952285 4.783854e-02
712 4134 MAP4 0.5866986 4.791304e-06 0.4371847 9.399814e-03
713 51372 TMA7 -0.4770049 3.816624e-02 -0.5930463 1.973507e-02
714 51447 IP6K2 0.6464313 1.626257e-03 0.8612760 4.869847e-05
715 64925 CCDC71 2.0654711 2.039079e-06 1.4270082 1.763911e-02
716 2771 GNAI2 0.4746637 1.711679e-04 0.4473208 8.711497e-03
717 9136 RRP9 1.6565451 3.603634e-02 1.5104446 3.241008e-02
718 80335 WDR82 0.4126762 3.940433e-02 0.4139527 4.612069e-02
719 28972 SPCS1 -1.2087611 1.507814e-05 -1.2522218 8.015505e-07
720 378 ARF4 -0.9342524 1.236015e-06 -0.7150834 1.177618e-03
721 5162 PDHB -0.8891871 6.426932e-04 -0.7744018 1.104922e-02
722 11170 FAM107A 0.7108706 4.564289e-07 0.8438374 8.634626e-09
723 9861 PSMD6 -1.2606773 5.977117e-06 -0.6906518 4.287478e-02
724 26018 LRIG1 -0.9823859 7.287051e-04 -1.2744312 3.203586e-03
725 131544 CRYBG3 1.9507274 4.119533e-02 1.8024199 3.578587e-02
726 1295 COL8A1 -2.0689175 2.320414e-02 -1.8307207 2.177510e-02
727 11259 FILIP1L -2.4415449 1.312190e-04 -5.6215128 3.702945e-09
728 55076 TMEM45A -3.5116566 5.214947e-03 -2.7410971 1.990733e-02
729 6152 RPL24 -0.4054846 4.885973e-03 -0.6037308 6.751807e-05
730 29114 TAGLN3 -1.5838847 6.961514e-03 -1.5878162 5.935201e-03
731 151887 CCDC80 0.6139833 2.964007e-05 0.5925393 9.847078e-04
732 10063 COX17 -0.6716026 4.485725e-04 -0.8393306 3.859001e-05
733 26355 FAM162A -1.9328801 3.288821e-22 -1.7126726 3.905016e-14
734 11343 MGLL 0.7436404 1.131736e-05 0.7988030 1.146903e-05
735 7555 CNBP -0.8977343 1.331197e-03 -0.8510197 6.236408e-03
736 8971 H1-10 1.0615496 4.847150e-07 0.8496144 6.375121e-04
737 6259 RYK -1.2134416 2.967454e-04 -1.1672802 3.665206e-03
738 80723 SLC35G2 -1.5472348 3.091483e-02 -2.4589313 2.526053e-02
739 92370 PXYLP1 -1.3140189 1.802276e-06 -0.8730358 4.523637e-03
740 9616 RNF7 -0.9841381 2.569506e-04 -1.3306717 1.375191e-08
741 483 ATP1B3 -0.7743038 6.459443e-03 -0.6626562 1.455525e-02
742 7029 TFDP2 0.8795826 1.665012e-02 0.8136336 2.710507e-02
743 9435 CHST2 -1.5760160 8.357784e-14 -1.8614337 1.631966e-22
744 4071 TM4SF1 -1.1531120 3.455921e-09 -1.0081670 5.173272e-07
745 51714 SELENOT -0.8079909 5.387139e-03 -0.6699049 1.260624e-02
746 6747 SSR3 -0.6347800 7.354903e-05 -0.7382513 1.225101e-06
747 25976 TIPARP 1.5621679 9.482389e-10 1.1563866 8.934141e-05
748 647033 <NA> 1.7055114 4.981620e-04 1.2759773 3.241008e-02
749 5806 PTX3 -1.4627165 2.682797e-03 -1.5351188 1.338800e-02
750 101243545 LINC02067 -2.2377320 7.530395e-16 -2.6491210 9.324337e-19
751 7095 SEC62 -0.7644827 9.650125e-07 -0.8421825 2.019764e-05
752 64778 FNDC3B -0.6494456 2.697896e-03 -0.7890739 1.471416e-03
753 79718 TBL1XR1 -0.7898441 3.911199e-02 -0.9407823 2.369589e-02
754 5708 PSMD2 0.6876897 6.829008e-05 0.6827839 4.826572e-03
755 64110 MAGEF1 -0.8812192 1.065961e-03 -0.8000918 2.555704e-03
756 10644 IGF2BP2 -2.0440181 8.734998e-18 -1.3019720 3.763786e-10
757 1427 CRYGS 1.1346179 6.562101e-05 1.1290719 9.777012e-05
758 2257 FGF12 1.9695269 7.906879e-05 2.0731871 2.039721e-05
759 3280 HES1 1.0207300 1.426437e-12 0.8214888 1.819415e-06
760 7037 TFRC -1.0562573 6.582075e-06 -1.8171049 5.988919e-13
761 1739 DLG1 0.8252637 6.755750e-03 1.0083381 2.819406e-04
762 6165 RPL35A -1.2229325 3.109067e-21 -1.0521400 6.485709e-13
763 521 ATP5ME -0.5657451 9.194512e-03 -0.5906954 7.838853e-03
764 2580 GAK 0.7219336 1.932494e-02 1.1020172 7.888319e-04
765 677770 SCARNA22 3.5414447 7.851343e-25 2.8760672 2.264676e-09
766 401115 C4orf48 1.0552561 6.545003e-06 1.2896350 1.768084e-05
767 6002 RGS12 1.4972339 6.355291e-08 1.1265948 4.678387e-04
768 114932 MRFAP1L1 1.1541753 9.482389e-10 1.0281080 3.491332e-06
769 23216 TBC1D1 1.1957982 8.857641e-03 1.1346256 1.299349e-02
770 6133 RPL9 -0.6058636 6.173691e-04 -0.5020652 2.212467e-02
771 81608 FIP1L1 -0.7217850 1.221124e-02 -1.2176557 1.226960e-05
772 5156 PDGFRA -1.5433008 1.666080e-09 -1.8040781 1.141369e-08
773 10606 PAICS -1.0034386 3.063956e-07 -0.6216646 1.456774e-02
774 258 AMBN -4.9822265 5.424457e-05 -8.2440786 4.237262e-07
775 25849 PARM1 -0.6114839 6.769801e-05 -1.3062333 3.326232e-14
776 10983 CCNI -0.6852370 1.904664e-10 -0.7118929 9.927156e-09
777 79966 SCD5 -0.5322866 1.230578e-04 -0.4569213 1.393295e-02
778 55008 HERC6 7.0791383 1.617490e-03 6.9486918 1.031036e-02
779 10611 PDLIM5 -0.6004503 1.507507e-02 -0.8534016 2.701263e-03
780 4547 MTTP -1.0906775 8.703424e-04 -0.8974650 3.606036e-03
781 4126 MANBA -0.7938814 3.283708e-02 -1.1831670 1.252402e-02
782 6164 RPL34 -1.3921977 1.380424e-30 -1.0834473 1.567134e-13
783 58505 OSTC -0.9279881 2.719888e-04 -1.2227041 1.725856e-05
784 79071 ELOVL6 0.9133948 8.399396e-03 0.8068751 3.241008e-02
785 401152 C4orf3 -1.1621356 2.825190e-09 -1.0761642 1.658403e-07
786 84162 KIAA1109 1.2338722 6.525714e-04 0.9774658 1.284853e-02
787 10252 SPRY1 1.0429198 4.128846e-12 0.9471736 2.323167e-09
788 27152 INTU 1.5599481 2.136125e-04 1.1175906 2.638770e-02
789 4717 NDUFC1 -0.7003878 9.709341e-04 -0.9021109 3.350605e-04
790 80155 NAA15 1.0183967 3.245051e-02 1.0491582 4.289425e-02
791 80854 SETD7 -0.8750229 1.105187e-02 -1.2817550 3.224189e-05
792 166614 DCLK2 0.6223728 6.876281e-04 0.5551005 7.506696e-03
793 2891 GRIA2 0.8500305 1.527124e-05 0.9016344 6.278649e-05
794 6307 MSMO1 -1.2139955 5.296230e-12 -0.7628001 1.877933e-03
795 1363 CPE 1.0386038 1.014466e-05 0.7934292 3.263649e-03
796 9848 MFAP3L -1.1793134 4.523090e-03 -1.1844621 8.500805e-03
797 291 SLC25A4 -1.2086954 4.107730e-05 -1.1735844 1.543444e-05
798 57587 CFAP97 0.7427990 3.950588e-02 0.8450499 1.622654e-02
799 170690 ADAMTS16 1.6694763 6.490208e-03 2.9001721 5.193755e-09
800 23379 ICE1 1.3175326 5.299632e-04 1.0401525 3.350546e-03
801 100505738 MIR4458HG -0.5665383 1.955629e-02 -0.5996206 2.801906e-02
802 1008 CDH10 -1.9505643 3.648729e-08 -1.5448575 1.119362e-04
803 6507 SLC1A3 1.1820878 5.080933e-34 0.8743854 3.552351e-12
804 25836 NIPBL 1.0564073 3.948792e-04 0.9007622 2.177334e-03
805 9180 OSMR -1.9049220 2.152111e-11 -1.4239353 1.686645e-08
806 100506548 <NA> -0.9277715 1.114229e-02 -1.3409343 1.334918e-02
807 3157 HMGCS1 -1.1957172 2.234338e-17 -0.6594077 6.647511e-05
808 10605 PAIP1 -0.8532986 2.411425e-02 -1.0505537 1.124294e-02
809 4338 MOCS2 -0.7519809 3.491021e-02 -0.7886653 2.489895e-02
810 4724 NDUFS4 -0.6970723 6.520793e-04 -0.7350511 2.682046e-03
811 285671 RNF180 1.0996899 2.037693e-05 1.0858061 6.668474e-05
812 285672 SREK1IP1 -0.9533591 1.662485e-04 -0.9230718 1.718029e-02
813 5295 PIK3R1 0.9872231 7.594497e-04 0.9326371 2.879230e-03
814 55814 BDP1 1.5183886 2.224452e-02 1.5600369 2.883354e-02
815 3842 TNPO1 1.2807072 5.574322e-14 0.9004943 1.779785e-05
816 3074 HEXB -1.3173354 9.564588e-04 -0.6483662 4.378514e-02
817 3156 HMGCR -1.0292358 3.587951e-07 -0.9936596 6.977203e-05
818 10087 CERT1 1.4438973 9.558491e-16 1.0091891 5.797352e-06
819 6902 TBCA -0.4512944 9.215731e-04 -0.5152711 2.836696e-03
820 202333 CMYA5 4.8864830 7.520028e-05 4.7441964 1.871909e-04
821 256987 SERINC5 -0.6496750 1.073260e-03 -1.1003432 4.929951e-08
822 100462981 MTRNR2L12 2.3607249 1.166815e-166 2.0421868 2.970385e-27
823 5924 RASGRF2 0.7056930 9.553566e-03 0.9703039 5.552133e-05
824 6228 RPS23 -0.8739794 9.387213e-18 -0.7366332 9.357521e-08
825 1462 VCAN 2.1957441 1.976976e-34 1.7224678 2.043935e-15
826 5921 RASA1 2.5061754 1.390634e-04 3.1646447 9.526825e-10
827 1070 CETN3 0.5774513 6.476386e-03 0.4861433 3.987163e-02
828 345757 FAM174A -1.6038075 3.055840e-02 -2.0149687 4.405284e-03
829 2241 FER 2.6067226 1.337098e-10 2.3302244 6.075290e-07
830 114915 <NA> -1.6808780 2.080361e-05 -0.9968276 2.213953e-02
831 324 APC 1.1150494 1.820257e-14 0.6892972 1.134053e-04
832 6728 SRP19 -1.0821472 1.024343e-04 -0.8080873 2.669405e-02
833 7905 REEP5 -0.6127878 2.211377e-03 -0.8389722 1.262360e-04
834 51014 TMED7 -1.0144508 1.223899e-03 -0.8793472 9.861464e-03
835 57556 SEMA6A -0.7987993 5.679116e-09 -0.8176305 3.724102e-06
836 153443 SRFBP1 2.1337669 7.873206e-06 1.5922350 8.858092e-03
837 57507 ZNF608 1.5250971 2.519027e-07 1.0416429 2.934910e-03
838 3094 HINT1 -0.9455195 5.671458e-14 -0.8364669 6.174445e-10
839 56951 C5orf15 -1.2535332 4.102697e-09 -1.0819668 5.070085e-07
840 6500 SKP1 -0.6264521 4.485725e-04 -0.5715314 1.346036e-03
841 23338 JADE2 1.7238473 4.448263e-02 1.9515703 7.862124e-03
842 9879 DDX46 -0.9901795 4.951180e-04 -1.0515823 7.445233e-05
843 9555 MACROH2A1 -0.5119695 1.561228e-02 -0.4970320 3.290530e-02
844 7045 TGFBI -1.7922980 4.119533e-02 -2.2067195 3.033021e-04
845 6695 SPOCK1 -0.4388064 2.561841e-02 -0.8318303 6.363547e-06
846 995 CDC25C 4.3163710 2.345874e-02 4.1862802 3.248617e-02
847 56662 VTRNA1-3 6.4490102 3.630008e-05 5.7757103 2.021229e-03
848 26167 PCDHB5 -0.6978699 1.013941e-02 -0.9148200 3.617950e-03
849 56106 PCDHGA10 2.5049006 8.315254e-03 2.4517359 2.358497e-02
850 1729 DIAPH1 0.8882793 5.145461e-03 0.9129698 3.249669e-02
851 10007 GNPDA1 0.9408571 5.054616e-09 0.7923198 4.220126e-05
852 815 CAMK2A 1.6792011 2.479306e-03 1.8405059 3.560700e-04
853 972 CD74 2.1906950 3.072670e-11 1.7478005 5.877562e-05
854 3340 NDST1 0.5832947 8.169067e-03 0.6146485 6.541794e-03
855 309 ANXA6 0.8098381 7.506017e-06 0.5304214 2.943702e-02
856 57451 TENM2 -1.1494814 3.857776e-10 -1.2878565 3.717116e-13
857 8992 ATP6V0E1 -0.6906722 1.282110e-04 -0.4490359 2.313609e-02
858 662 BNIP1 1.2812599 8.169067e-03 1.0978521 2.089476e-02
859 1212 CLTB 0.8729299 3.053562e-03 0.9015231 3.307371e-03
860 64324 NSD1 1.7515088 2.505110e-14 1.2402096 6.363547e-06
861 80758 PRR7 0.6315226 4.665216e-02 0.9166882 1.222449e-03
862 54732 TMED9 0.5645326 7.783222e-06 0.4013908 2.188471e-02
863 91522 COL23A1 2.3112797 2.544098e-11 2.1266171 5.256011e-09
864 55819 RNF130 -1.0077006 1.605162e-02 -1.7980915 5.245494e-06
865 10399 RACK1 -0.5254117 6.385736e-05 -0.3793132 1.650399e-02
866 56897 WRNIP1 -1.5471129 3.628200e-05 -1.7437219 1.607238e-06
867 1992 SERPINB1 4.9146404 2.926616e-04 5.2335655 2.204739e-05
868 7280 TUBB2A -0.7089601 6.267252e-07 -0.6708941 1.635422e-05
869 347733 TUBB2B -0.7067559 1.888823e-07 -0.4985577 4.462794e-03
870 81853 TMEM14B -0.9179555 2.742442e-02 -0.9018269 7.723997e-03
871 54898 ELOVL2 0.9428945 7.828128e-12 0.6285030 4.018058e-04
872 51406 NOL7 -1.0009519 4.066968e-04 -0.8148895 2.946177e-03
873 3400 ID4 -0.9120412 2.154370e-03 -1.1700889 2.372486e-04
874 51473 DCDC2 1.2443843 7.564192e-03 1.3195920 9.513596e-03
875 55856 ACOT13 -0.9022622 2.324914e-02 -1.4228438 2.518596e-07
876 9750 RIPOR2 -5.8034728 1.393580e-02 -6.5726093 7.286063e-03
877 10590 SCGN -1.3158239 2.928310e-03 -2.8434388 3.120874e-08
878 11120 BTN2A1 -1.4164333 2.808964e-04 -1.8137714 2.571776e-05
879 3137 <NA> 1.0127683 1.204615e-04 0.9826226 4.770550e-04
880 3107 HLA-C 1.2931591 7.351098e-18 1.0994190 6.540541e-11
881 7922 SLC39A7 1.4996572 1.875790e-07 1.1195832 6.582692e-03
882 57699 CPNE5 1.3108553 2.016435e-20 1.3795464 8.625945e-17
883 2739 GLO1 0.5911196 1.437404e-03 0.4748510 3.290530e-02
884 285855 RPL7L1 -0.5822925 1.867945e-02 -0.5495086 3.792659e-02
885 116138 KLHDC3 0.7039657 9.291893e-04 1.0077716 3.176501e-06
886 10591 DNPH1 0.5807379 8.537075e-03 0.8159909 6.468157e-05
887 25844 YIPF3 0.5531543 3.105704e-02 0.7077815 5.262326e-03
888 7422 VEGFA -2.3750017 9.132820e-12 -2.1017346 1.970862e-11
889 9697 TRAM2 -1.1687443 8.035919e-05 -0.7628945 9.987876e-03
890 667 DST 1.3066882 3.953791e-17 1.3636002 5.344141e-15
891 55788 LMBRD1 -1.0727743 1.004953e-04 -1.0754706 1.631457e-03
892 79627 OGFRL1 1.1393962 1.275092e-07 0.7481483 6.820254e-03
893 79940 LINC00472 1.9153970 9.865105e-04 2.1763861 3.356981e-04
894 1915 EEF1A1 -0.8015550 5.133405e-09 -0.6658325 1.563890e-03
895 9324 HMGN3 -0.5533836 1.318382e-02 -1.0783521 3.858040e-07
896 7162 TPBG -1.0432333 9.671356e-03 -1.6963659 5.982751e-09
897 387066 <NA> -1.3933526 7.309480e-12 -1.0545530 3.066793e-05
898 26799 <NA> 4.4480807 3.645600e-10 3.3109946 2.124406e-03
899 154313 CFAP206 -6.4873816 1.231225e-02 -6.2947208 1.916278e-02
900 1268 CNR1 0.6703656 2.747521e-02 0.7638065 1.993997e-02
901 10690 FUT9 1.6760412 5.693455e-08 1.0993674 2.726542e-03
902 25957 PNISR -0.6338491 2.610510e-04 -0.5849137 4.378086e-03
903 10973 ASCC3 1.3190847 1.630044e-04 0.8665382 1.962129e-02
904 5550 PREP -1.5078120 1.985515e-02 -1.3018358 1.763911e-02
905 100133941 CD24 -7.8393997 8.144601e-06 -5.7783913 5.659621e-04
906 8763 CD164 -0.9132365 2.242736e-04 -1.0199432 3.970221e-05
907 10758 TRAF3IP2 0.6105654 3.831231e-02 0.7831279 2.244861e-02
908 2534 FYN -0.4887334 1.857858e-03 -0.6654093 3.210971e-05
909 3910 LAMA4 0.9816690 1.796029e-02 1.3614822 2.822612e-06
910 7259 TSPYL1 -1.0066554 2.030167e-05 -0.8455353 1.966518e-03
911 25842 ASF1A -1.0844678 1.108836e-02 -1.6052613 7.714980e-05
912 57515 SERINC1 -0.6740563 4.823290e-04 -0.7793831 2.108357e-05
913 2173 FABP7 -1.5750241 1.992080e-07 -1.6703756 3.164172e-06
914 7164 TPD52L1 -1.0054001 1.661418e-02 -1.1429760 5.809267e-03
915 51020 HDDC2 -0.6481942 1.011438e-02 -0.6375036 4.250877e-02
916 23493 HEY2 -3.8037514 5.106707e-03 -3.2360874 2.559698e-02
917 93663 ARHGAP18 0.8694748 1.256783e-02 0.8629630 1.494738e-02
918 1490 CCN2 -3.1554085 3.418038e-16 -4.2814332 1.976875e-28
919 6206 RPS12 -1.1491929 1.332521e-13 -0.7474210 7.475852e-05
920 7430 EZR 0.9648313 8.092332e-03 0.9838192 1.228025e-02
921 3482 IGF2R -0.5881522 6.885354e-03 -0.8972238 1.596718e-03
922 6196 RPS6KA2 0.3810064 3.340861e-02 0.7111698 7.352437e-05
923 101929523 <NA> 3.6390108 1.793939e-02 4.4095356 8.844827e-03
924 5689 PSMB1 -1.3603850 3.785619e-09 -1.3308572 6.759562e-11
925 23353 SUN1 -0.9938442 3.021516e-02 -0.9336274 4.249711e-02
926 29886 SNX8 0.5523896 2.770815e-02 0.7926513 1.291166e-03
927 6624 FSCN1 -1.0713334 9.331388e-21 -0.8325498 9.905933e-07
928 4697 NDUFA4 -0.6857134 4.144021e-08 -0.5453823 5.154806e-03
929 8701 DNAH11 2.6990566 7.281788e-04 2.4321317 7.862124e-03
930 10643 IGF2BP3 0.8694833 3.339777e-03 1.0047908 6.621297e-05
931 4852 NPY -2.5012943 4.831459e-03 -4.1586786 6.690797e-06
932 11335 CBX3 0.5547655 6.426932e-04 0.4707137 2.361762e-02
933 9865 TRIL -0.6869435 1.858073e-08 -0.6966268 4.731214e-06
934 54504 CPVL -0.9011170 9.629234e-03 -1.1181150 2.631022e-03
935 23658 LSM5 -0.9948036 5.824816e-04 -1.3722624 5.060173e-05
936 23333 DPY19L1 -2.0667730 4.509647e-07 -1.4044842 3.706986e-03
937 83930 STARD3NL -1.3486632 6.786786e-06 -0.7768161 2.883354e-02
938 2737 GLI3 0.9593370 2.258820e-02 0.9499567 3.450329e-02
939 5683 PSMA2 -1.1084040 7.267595e-08 -1.2717362 2.899835e-08
940 23386 NUDCD3 0.7902751 2.744749e-03 0.9103817 1.743062e-03
941 4967 OGDH 1.2931752 1.419791e-05 0.8833557 2.269406e-02
942 83605 CCM2 0.8886044 1.070896e-02 0.9034776 1.313529e-02
943 3486 IGFBP3 -2.2835324 1.617490e-03 -3.0909521 8.105970e-04
944 23480 SEC61G -1.7027271 1.904718e-04 -1.7535890 7.572853e-11
945 51142 CHCHD2 0.5992320 3.754695e-07 0.7204071 3.903492e-07
946 51119 SBDS -1.1144088 2.370369e-03 -1.9388407 7.013897e-09
947 2969 GTF2I 1.8731674 3.857776e-10 1.0795996 7.489466e-03
948 5447 POR 0.9526933 8.936179e-04 0.7024575 2.395150e-02
949 100505854 APTR -1.6188872 4.195847e-02 -3.1489749 4.284771e-05
950 222194 RSBN1L -1.0346992 2.210049e-02 -1.4653252 2.226998e-02
951 6717 SRI -0.7315985 5.258914e-08 -0.7194124 1.258595e-05
952 1595 CYP51A1 -0.7679455 5.040980e-05 -0.6896136 1.344835e-03
953 54467 ANKIB1 0.8988626 6.611509e-03 0.8496291 1.589383e-02
954 1278 COL1A2 -1.8044267 2.774879e-17 -2.6985465 2.861990e-51
955 8910 SGCE -1.1595413 1.284825e-03 -1.3681407 7.241593e-05
956 23089 PEG10 1.2813683 2.586992e-39 0.3492587 1.840892e-02
957 7979 SEM1 -1.0150038 3.106345e-10 -1.0726954 9.106799e-07
958 1749 DLX5 -1.8207920 5.149658e-03 -9.1287072 6.304782e-10
959 10552 ARPC1A -1.5581714 1.434742e-06 -1.6037044 1.099400e-08
960 9551 ATP5MF -0.9977073 3.079767e-11 -0.9526787 1.718309e-07
961 7205 TRIP6 0.5688503 1.582610e-03 0.8974429 9.949827e-07
962 51024 FIS1 0.7062099 2.013576e-02 0.9859722 1.949396e-03
963 3912 LAMB1 -1.6430576 1.897841e-07 -0.7314453 3.937134e-02
964 401397 SMIM30 -1.1314569 3.784807e-03 -0.9816881 1.332957e-02
965 5803 PTPRZ1 1.1501936 1.405664e-13 0.9114296 4.464529e-06
966 2861 GPR37 -1.2991912 3.622386e-06 -1.1075672 1.968864e-08
967 64101 LRRC4 2.0242364 2.548109e-10 1.1252903 2.194272e-02
968 813 CALU -0.7317704 2.585546e-06 -0.6162849 4.690217e-04
969 64753 CCDC136 1.5435761 8.370267e-03 1.4607115 1.455525e-02
970 800 CALD1 -0.9200718 6.811766e-16 -0.9520463 4.679431e-14
971 5764 PTN -0.6769084 8.651978e-15 -0.7300167 2.117855e-10
972 51650 MRPS33 -0.8949939 1.758600e-03 -1.0986688 5.699268e-04
973 26047 CNTNAP2 1.7279244 1.659437e-06 1.4111858 4.493978e-04
974 155066 ATP6V0E2 0.9072461 4.474290e-06 0.7210372 1.950412e-03
975 10922 FASTK 0.7641096 1.787291e-02 0.9882660 6.245499e-04
976 6009 RHEB -0.6150900 2.937988e-03 -1.1056928 7.864066e-08
977 3638 INSIG1 -1.4066187 7.994214e-06 -1.1205356 7.557718e-04
978 79660 PPP1R3B -1.1395033 8.720267e-05 -0.5734475 1.002911e-02
979 2222 FDFT1 -0.7811303 3.323915e-05 -0.5716171 9.705714e-03
980 4023 LPL -1.3515968 8.879865e-16 -1.9391683 4.328081e-30
981 64236 PDLIM2 0.4546158 2.540171e-02 0.4772553 3.141640e-02
982 4747 NEFL -1.4123499 4.378022e-14 -1.9807071 1.008475e-18
983 665 BNIP3L -1.4808545 4.451508e-21 -1.7334117 3.282031e-26
984 148 ADRA1A 1.2223872 3.928010e-11 0.9041357 8.957536e-05
985 1191 CLU 0.5675630 9.570125e-08 0.3585553 1.221455e-02
986 2137 EXTL3 -0.6455879 7.664811e-07 -0.7128163 3.065415e-07
987 51669 SARAF -0.9491485 2.131984e-09 -0.8062936 1.698814e-05
988 692084 SNORD13 3.5705896 9.558819e-15 2.1180819 4.256124e-02
989 1052 CEBPD -0.9768778 7.951942e-03 -1.3845761 6.276546e-04
990 5591 PRKDC 0.9434372 1.262898e-04 0.8360927 2.249249e-03
991 641638 <NA> -1.3612659 4.237594e-12 -1.2802754 6.933904e-10
992 80243 PREX2 3.3335727 6.465637e-08 2.6851231 2.844817e-04
993 23213 SULF1 -1.9847588 7.581180e-08 -2.9676716 1.348690e-15
994 6129 RPL7 -0.8711653 1.847115e-05 -0.4738742 4.495736e-02
995 27067 STAU2 1.8946808 1.263630e-25 1.3784939 1.750258e-08
996 6921 ELOC -0.6828490 3.310423e-03 -1.1015451 2.091900e-07
997 54968 TMEM70 -1.4282037 1.505530e-04 -0.9587612 3.372442e-02
998 83690 CRISPLD1 -0.8076399 5.694319e-03 -0.6913367 3.266529e-02
999 401466 RBIS -0.6109441 2.282347e-02 -1.1290735 4.758366e-05
1000 169200 TMEM64 -0.8474270 3.615251e-02 -1.0096307 3.489786e-02
1001 7381 UQCRB -0.9882168 2.208474e-12 -0.8163836 3.724102e-06
1002 6383 SDC2 -1.2380643 6.236589e-09 -0.7518041 2.365134e-03
1003 10404 CPQ 1.4222343 9.653782e-06 1.1597588 4.165623e-03
1004 6156 RPL30 -0.7376391 1.013553e-10 -0.7108959 7.449348e-06
1005 1345 COX6C -0.5777179 5.474002e-05 -0.5623486 6.308417e-04
1006 5440 POLR2K -0.5044544 3.651419e-02 -0.7176969 7.967493e-03
1007 26986 PABPC1 1.0519808 6.214647e-14 0.9567969 3.060342e-06
1008 83988 NCALD 1.6890694 2.529989e-03 1.9039998 3.089672e-03
1009 50484 RRM2B 1.0343173 3.689493e-03 0.7836091 4.091967e-02
1010 51582 AZIN1 -0.5209480 4.680108e-02 -0.7501651 1.048791e-02
1011 3646 EIF3E -1.2967221 3.621184e-11 -1.7926835 4.692596e-19
1012 8667 EIF3H -0.8789134 2.277908e-07 -0.7488252 3.343362e-04
1013 5168 ENPP2 -1.3575140 8.795334e-06 -1.4292122 1.180285e-04
1014 28998 MRPL13 -0.7511183 2.502752e-02 -0.6989666 3.516548e-02
1015 157378 TMEM65 1.5657262 7.365527e-09 1.1724731 1.668589e-02
1016 6713 SQLE -0.8748781 3.452117e-03 -0.9996655 1.479596e-04
1017 4062 LY6H 2.0404450 3.587951e-07 1.8806104 2.075791e-05
1018 5339 PLEC 0.5398222 4.635828e-02 0.7203850 7.044621e-03
1019 2907 GRINA 0.9810473 6.768665e-15 0.9564501 3.474366e-11
1020 8733 GPAA1 0.8408190 1.166590e-03 0.7240015 1.626651e-02
1021 84232 MAF1 1.0458379 6.859720e-03 1.1526630 1.331088e-03
1022 65265 C8orf33 1.2926181 8.743396e-08 1.0108476 7.888319e-04
1023 23189 KANK1 0.7144651 7.895217e-03 0.8721550 8.060539e-03
1024 4781 NFIB 0.8854179 7.913729e-09 0.9374237 1.854601e-08
1025 6194 RPS6 -0.4156980 1.249709e-04 -0.4208246 4.123543e-03
1026 55958 KLHL9 -1.0329553 1.095726e-03 -0.7951135 2.601431e-02
1027 1029 CDKN2A 1.1355662 8.895738e-07 0.8740444 1.569308e-03
1028 4712 NDUFB6 -0.8906200 7.354903e-05 -1.0624409 3.517011e-05
1029 7415 VCP -0.4336137 4.673478e-03 -0.5964534 1.219025e-03
1030 26267 FBXO10 0.8254536 1.904018e-03 0.7197069 3.307371e-03
1031 347252 IGFBPL1 1.4842951 6.600389e-06 0.7910572 4.881864e-02
1032 23137 SMC5 0.8298430 4.069353e-02 1.0222075 1.277603e-02
1033 23670 CEMIP2 -0.7164397 4.263387e-04 -0.6846670 2.310065e-03
1034 301 ANXA1 -1.2241328 9.482389e-10 -1.0624764 5.946754e-06
1035 2619 GAS1 -1.6908161 1.035109e-02 -2.1164596 7.888319e-04
1036 53358 SHC3 0.9146960 9.227041e-05 0.7323579 8.160467e-03
1037 10952 SEC61B -0.6878836 6.312036e-06 -0.8087133 5.059413e-07
1038 19 ABCA1 1.3942846 1.002036e-16 0.8831721 2.555704e-03
1039 7295 TXN -0.9919738 2.440240e-09 -0.9387855 3.226627e-06
1040 3371 TNC -0.9351474 1.384094e-06 -1.0540684 4.937183e-07
1041 7099 TLR4 -1.4742665 2.792422e-05 -1.5358692 2.356454e-03
1042 11224 RPL35 -0.7140837 5.328804e-04 -0.5636122 2.370230e-02
1043 3309 HSPA5 -0.3475594 2.052126e-02 -0.6009229 4.952359e-04
1044 6136 RPL12 -0.7408997 2.799860e-05 -0.5080363 1.740316e-02
1045 2801 GOLGA2 0.9408435 8.648658e-07 0.8556162 7.906252e-05
1046 81605 URM1 0.5044218 3.868969e-02 0.6566555 2.631022e-03
1047 51490 SPOUT1 0.8880710 2.170030e-03 0.9268879 3.644784e-03
1048 23048 FNBP1 0.8670697 7.171580e-10 0.4497187 2.716982e-02
1049 23064 SETX 1.2082170 2.852961e-06 0.7463572 2.726974e-02
1050 10422 UBAC1 1.3077029 3.031354e-09 1.0328132 2.266897e-04
1051 8721 EDF1 -1.2571777 1.808271e-11 -1.1580497 5.795139e-07
1052 26012 NSMF 0.7596866 3.070386e-02 0.9300300 1.767130e-03
1053 64975 MRPL41 0.4664101 3.570204e-02 0.5562549 2.244861e-02
1054 4549 <NA> 1.6331191 3.857776e-10 1.3996902 1.510058e-02
1055 4577 <NA> 1.5219784 2.037433e-12 1.2943451 2.151536e-09
1056 4550 <NA> 1.0065265 6.789721e-36 0.8732613 2.053751e-02
1057 4535 MT-ND1 -0.9737351 1.140679e-32 -0.8329473 2.488051e-10
1058 4572 <NA> 1.3321582 2.895981e-17 1.5378374 5.611052e-18
1059 4569 <NA> 2.3208192 4.721665e-12 1.7409576 1.262360e-04
1060 4536 MT-ND2 0.5406437 8.802362e-07 0.6937946 1.795972e-04
1061 4570 <NA> 0.4694520 3.107778e-02 0.6724287 5.809267e-03
1062 4579 <NA> 0.9286471 4.908604e-08 0.9849385 1.159320e-07
1063 4513 MT-CO2 -0.9285861 7.322731e-11 -0.8475787 7.042812e-07
1064 4509 MT-ATP8 1.5395524 1.276534e-06 1.7137389 6.507206e-04
1065 4508 MT-ATP6 -0.8548935 5.067631e-20 -0.9766476 4.574961e-18
1066 4514 MT-CO3 -0.5001743 9.867495e-09 -0.6062588 3.065415e-07
1067 4539 MT-ND4L 0.4098798 7.860423e-03 0.7061768 4.445112e-03
1068 4538 MT-ND4 -0.9778092 2.474374e-28 -0.8874018 8.200323e-13
1069 4564 <NA> 2.8968952 2.657613e-09 2.1367216 5.236779e-04
1070 4540 MT-ND5 1.2589533 5.499656e-43 1.3017628 3.543200e-03
1071 4519 MT-CYB -0.8936775 1.210009e-18 -0.9136131 3.552351e-12
1072 4571 <NA> 2.8741663 3.964011e-60 2.7148072 6.076172e-47
1073 9189 ZBED1 0.8756657 1.626257e-03 0.6715765 4.443677e-02
1074 1183 CLCN4 1.1987875 7.477217e-04 1.0632694 3.777914e-02
1075 8905 AP1S2 -1.0197074 2.045773e-23 -0.7491404 7.673449e-07
1076 94056 SYAP1 0.6401036 3.195817e-03 0.5801140 1.362446e-02
1077 30011 SH3KBP1 0.5176608 2.284218e-03 0.4838495 1.217034e-02
1078 256643 BCLAF3 1.4383765 3.978266e-03 1.1011397 3.824003e-02
1079 10549 PRDX4 -0.9963902 6.235271e-04 -0.8931776 1.921452e-02
1080 10159 ATP6AP2 -0.6904247 3.074659e-03 -0.6512225 5.161862e-03
1081 54539 NDUFB11 -1.0911680 4.618734e-05 -0.6999433 1.573848e-02
1082 56850 GRIPAP1 1.1956108 8.144601e-06 1.1150998 3.350605e-04
1083 57477 SHROOM4 1.1972732 1.141820e-02 1.1100956 3.290530e-02
1084 9500 MAGED1 -0.5999945 1.024625e-06 -0.6306059 5.400590e-05
1085 54552 GNL3L 1.1412892 1.913864e-04 1.0420340 4.939225e-03
1086 550643 NBDY -0.5743538 7.468132e-03 -0.8051838 4.776423e-04
1087 442454 <NA> -0.5148396 1.333396e-02 -0.5696300 9.315952e-03
1088 9843 HEPH -1.1594244 7.268861e-03 -1.9647934 2.024163e-06
1089 1947 EFNB1 0.8758498 9.956070e-04 0.8150692 1.174269e-02
1090 340527 NHSL2 2.6372096 1.669647e-15 2.4046029 3.809264e-10
1091 392490 NHSL2 -1.2470683 3.225254e-03 -1.1971654 2.782563e-02
1092 5303 PIN4 -0.8235796 7.974793e-03 -1.2192356 1.284309e-05
1093 6191 RPS4X -0.6470555 9.270311e-09 -0.5282855 3.102246e-04
1094 1349 COX7B -0.6093206 5.357676e-04 -0.6052488 3.134155e-03
1095 5230 PGK1 -1.8136626 4.994565e-57 -1.0856060 1.184684e-15
1096 2846 LPAR4 1.5527621 2.624884e-11 1.3030488 2.365932e-07
1097 79366 HMGN5 -0.9809284 6.168525e-03 -0.9729236 1.118223e-02
1098 90843 TCEAL8 0.7450006 6.752355e-05 0.4504685 4.112077e-02
1099 340543 TCEAL5 1.3703889 1.571670e-14 1.2069287 7.371241e-08
1100 51186 TCEAL9 0.3238067 4.584347e-02 0.5488991 2.252696e-04
1101 7319 UBE2A -0.8935808 3.098489e-03 -0.8697075 8.308968e-03
1102 6170 RPL39 -0.4626669 1.100917e-02 -0.6139391 4.103190e-03
1103 4694 NDUFA1 -1.0161937 1.277991e-09 -0.8558358 2.205322e-05
1104 55026 TMEM255A -1.4802818 1.484960e-02 -0.9209734 4.378176e-02
1105 63035 BCORL1 1.2572034 2.282347e-02 1.2992716 2.420042e-02
1106 159090 PABIR2 -1.2347532 2.705447e-02 -1.0495457 4.915824e-02
1107 27316 RBMX 1.4104813 5.734145e-20 0.8287942 5.485502e-05
1108 1038 CDR1 4.1675101 2.089264e-70 3.9732007 7.747275e-33
1109 2334 AFF2 1.8926920 3.325676e-03 2.3471570 1.588911e-05
1110 1069 CETN2 0.4761454 3.698264e-02 0.5823596 4.184859e-02
1111 84968 PNMA6A 1.4555371 1.348505e-02 1.7028966 2.170595e-04
1112 2010 EMD 0.6855411 4.443434e-03 0.7763575 6.254644e-03
1113 537 ATP6AP1 -0.6037523 4.768119e-03 -0.6004954 1.650399e-02
1114 6192 RPS4Y1 -6.3220505 1.983734e-02 -6.1293881 2.943702e-02
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 1.3368424 1.0028228 1.756475 3.802884e-02
02_TSC2_KO_Grabole_2016 1.3245406 1.1660937 1.503782 1.231542e-05
03_TSC2_Grabole-2016 1.3455116 1.1869565 1.525993 2.635266e-06
04_TSC2-tuber-Martin2017 2.1558355 1.2201462 3.612191 5.130354e-03
05_TSC2-SEN_SEGA-Martin2017 1.1765581 0.9891949 1.393715 5.959465e-02
06_all_EpilepsyGene 0.9611605 0.6354413 1.405705 9.243670e-01
07_high_conf_EpilepsyGene 0.7680892 0.3230734 1.570135 6.209493e-01
08_ASD_Epilepsy_EpilepsyGene 1.0534730 0.4895249 2.022132 8.645822e-01
09_Epi25_dataset 1.2247801 0.5083246 2.551856 5.419038e-01
10_SFARI_all 1.7074488 1.1248765 2.514414 8.321251e-03
11_SFARI_score4plus 1.8800000 1.1735809 2.899389 7.675800e-03
12_DeRubeis_RDNV 1.4810923 0.6477934 2.991091 2.926464e-01
13_Iossifov_RDNV 1.1774013 0.8500058 1.599312 2.837695e-01
14_FMRP_Darnell 1.6930496 1.3393722 2.121791 1.112072e-05
15_Voineagu_M12 0.7701221 0.4736596 1.193020 2.708067e-01
16_Voineagu_M16 2.7292144 2.0348510 3.616695 9.824988e-11
17_ID_genes_Neel 1.4083465 0.9615878 2.008817 6.450879e-02
18_ID_genes_pinto2014 1.1289230 0.6900336 1.762534 5.537765e-01
19_Fromer_SCZ_FunDN 1.2187890 0.8795088 1.656348 2.088175e-01
20_Cocchi_Pruning 1.5595925 0.7459834 2.956130 1.743610e-01
Beta SE Padj
01_Swaminathan2018_DEPDC5KO 0.29031043 0.14667942 7.605768e-01
02_TSC2_KO_Grabole_2016 0.28106572 0.06500322 2.463085e-04
03_TSC2_Grabole-2016 0.29677435 0.06397035 5.270531e-05
04_TSC2-tuber-Martin2017 0.76817836 0.29041210 1.026071e-01
05_TSC2-SEN_SEGA-Martin2017 0.16259331 0.08849860 1.000000e+00
06_all_EpilepsyGene -0.03961384 0.21113355 1.000000e+00
07_high_conf_EpilepsyGene -0.26384934 0.44185022 1.000000e+00
08_ASD_Epilepsy_EpilepsyGene 0.05209231 0.39102668 1.000000e+00
09_Epi25_dataset 0.20276133 0.44867162 1.000000e+00
10_SFARI_all 0.53500035 0.21292200 1.664250e-01
11_SFARI_score4plus 0.63127177 0.24041432 1.535160e-01
12_DeRubeis_RDNV 0.39277985 0.42192008 1.000000e+00
13_Iossifov_RDNV 0.16330971 0.16623564 1.000000e+00
14_FMRP_Darnell 0.52653142 0.11955635 2.224144e-04
15_Voineagu_M12 -0.26120615 0.24798990 1.000000e+00
16_Voineagu_M16 1.00401382 0.14979144 1.964998e-09
17_ID_genes_Neel 0.34241635 0.19468660 1.000000e+00
18_ID_genes_pinto2014 0.12126405 0.25116280 1.000000e+00
19_Fromer_SCZ_FunDN 0.19785778 0.16645383 1.000000e+00
20_Cocchi_Pruning 0.44442455 0.37626348 1.000000e+00
ReN
getlinmodoutput(targetline = "ReN",targetdiff = "noDIFF",targetrapa = "RAPA") entrezgene genname log2FC_2.1 fdr_2.1 log2FC_2.2 fdr_2.2
1 477 ATP1A2 1.220208 3.413380e-03 1.4114570 5.720993e-08
2 1116 CHI3L1 -8.526972 6.249375e-06 -3.4445448 3.594290e-04
3 283131 NEAT1 -3.020307 1.549094e-02 -2.6088409 2.202376e-03
4 100996492 CTXND1 2.154011 1.002823e-02 2.0926141 1.808240e-03
5 147495 APCDD1 3.498348 6.176015e-03 3.6529841 6.140606e-05
6 7837 PXDN 1.283920 7.440217e-04 0.8097423 2.805530e-04
7 6335 SCN9A -8.223257 1.521923e-04 -7.4694341 1.809116e-04
8 1292 COL6A2 -1.451055 4.091302e-02 -1.6813575 1.603615e-05
9 3693 ITGB5 1.102633 4.887867e-02 0.9037382 6.302982e-04
10 55752 SEPTIN11 1.161097 1.174152e-02 0.5291060 1.394031e-02
11 64065 PERP -1.162849 1.192027e-02 -0.8848644 8.653585e-03
12 148 ADRA1A 1.225387 2.497271e-02 1.6096956 3.510562e-08
13 793 CALB1 -1.195628 2.325343e-03 -1.4001215 7.414265e-13
14 9568 GABBR2 1.236450 1.521923e-04 0.8179580 5.197383e-05
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 0.000000 0.00000000 6.668883 1.000000000
02_TSC2_KO_Grabole_2016 1.881390 0.56272516 6.289801 0.264620693
03_TSC2_Grabole-2016 1.330939 0.40472473 4.655797 0.790420601
04_TSC2-tuber-Martin2017 0.000000 0.00000000 36.590621 1.000000000
05_TSC2-SEN_SEGA-Martin2017 3.372386 0.88683771 11.219330 0.037502309
06_all_EpilepsyGene 9.565320 1.70653483 36.434078 0.006238071
07_high_conf_EpilepsyGene 18.301000 1.96933619 83.575682 0.007036976
08_ASD_Epilepsy_EpilepsyGene 0.000000 0.00000000 35.336315 1.000000000
09_Epi25_dataset 0.000000 0.00000000 51.036325 1.000000000
10_SFARI_all 0.000000 0.00000000 17.098391 1.000000000
11_SFARI_score4plus 0.000000 0.00000000 23.217073 1.000000000
12_DeRubeis_RDNV 0.000000 0.00000000 53.747406 1.000000000
13_Iossifov_RDNV 1.984480 0.04660814 13.257344 0.413250326
14_FMRP_Darnell 2.840533 0.30822586 12.795519 0.180510915
15_Voineagu_M12 0.000000 0.00000000 11.785713 1.000000000
16_Voineagu_M16 2.984612 0.07003711 19.976342 0.300270008
17_ID_genes_Neel 0.000000 0.00000000 12.348174 1.000000000
18_ID_genes_pinto2014 0.000000 0.00000000 16.806456 1.000000000
19_Fromer_SCZ_FunDN 2.047571 0.04808734 13.680127 0.403726846
20_Cocchi_Pruning 0.000000 0.00000000 45.842037 1.000000000
Beta SE Padj
01_Swaminathan2018_DEPDC5KO -Inf NaN 1.0000000
02_TSC2_KO_Grabole_2016 0.6320107 0.6158034 1.0000000
03_TSC2_Grabole-2016 0.2858845 0.6073636 1.0000000
04_TSC2-tuber-Martin2017 -Inf NaN 1.0000000
05_TSC2-SEN_SEGA-Martin2017 1.2156204 0.6814866 0.7500462
06_all_EpilepsyGene 2.2581440 0.8794281 0.1247614
07_high_conf_EpilepsyGene 2.9069557 1.1373771 0.1407395
08_ASD_Epilepsy_EpilepsyGene -Inf NaN 1.0000000
09_Epi25_dataset -Inf NaN 1.0000000
10_SFARI_all -Inf NaN 1.0000000
11_SFARI_score4plus -Inf NaN 1.0000000
12_DeRubeis_RDNV -Inf NaN 1.0000000
13_Iossifov_RDNV 0.6853570 1.9139475 1.0000000
14_FMRP_Darnell 1.0439918 1.1331195 1.0000000
15_Voineagu_M12 -Inf NaN 1.0000000
16_Voineagu_M16 1.0934696 1.9143876 1.0000000
17_ID_genes_Neel -Inf NaN 1.0000000
18_ID_genes_pinto2014 -Inf NaN 1.0000000
19_Fromer_SCZ_FunDN 0.7166544 1.9139748 1.0000000
20_Cocchi_Pruning -Inf NaN 1.0000000
KO effect in DIFF RAPA
D62
getlinmodoutput(targetline = "D62",targetdiff = "DIFF",targetrapa = "RAPA") entrezgene genname log2FC_2.1 fdr_2.1 log2FC_2.2 fdr_2.2
1 2048 EPHB2 -0.5826101 1.678683e-02 -0.9117379 1.313340e-03
2 2537 IFI6 -0.6988523 7.989899e-03 -0.7770059 3.125215e-02
3 7802 DNALI1 1.1560264 7.989899e-03 1.1151275 2.698021e-02
4 656 BMP8B -4.3683019 9.578298e-05 -4.1372908 5.694587e-04
5 84879 MFSD2A 1.2289963 2.150229e-06 1.7582888 8.298043e-13
6 5865 RAB3B 1.6505809 4.937490e-03 2.4918745 6.877320e-08
7 3491 CCN1 0.9195214 7.581913e-06 0.7819251 2.641835e-02
8 2633 GBP1 1.8909950 1.759866e-03 1.7683986 4.240144e-03
9 127003 C1orf194 1.6879579 3.330240e-04 2.4605882 1.032009e-07
10 26227 PHGDH 0.8707624 5.898199e-03 0.9385243 4.829171e-02
11 10628 TXNIP -1.1214557 3.107157e-03 -1.1801245 6.734027e-03
12 63827 BCAN -1.1448836 9.790123e-07 -0.6860625 4.114286e-02
13 3766 KCNJ10 -1.2030614 1.487223e-04 -1.1249486 2.258695e-03
14 8490 RGS5 0.9423725 2.179796e-03 1.3297066 5.430918e-06
15 55220 KLHDC8A 0.6961260 4.835977e-02 1.0893545 7.903818e-04
16 50486 G0S2 -2.1437954 2.962521e-18 -2.7798517 3.914474e-23
17 7044 LEFTY2 -1.1461461 1.517838e-02 -2.5101270 2.217413e-06
18 2786 GNG4 2.3453579 4.858966e-03 3.1441825 1.403575e-07
19 1959 EGR2 3.8839588 1.874906e-14 3.0338531 5.266483e-05
20 84858 ZNF503 1.8061212 2.018034e-06 1.2808100 2.206113e-02
21 2674 GFRA1 -1.7237479 8.130698e-05 -1.9850405 7.413693e-05
22 5654 HTRA1 0.9285695 1.920731e-05 0.9326186 1.201306e-03
23 10418 SPON1 2.9484113 1.881502e-29 3.3355085 3.371835e-38
24 4038 LRP4 -0.7469557 9.813347e-03 -1.0170181 8.237349e-03
25 374393 FAM111B 3.2862486 3.272494e-02 3.5433728 1.519904e-02
26 79026 AHNAK 0.6672394 4.172050e-02 0.8083736 3.003533e-02
27 254263 CNIH2 1.8795923 1.019547e-04 2.0891824 2.361622e-06
28 2 A2M 1.5219410 1.637477e-12 1.4270188 9.741003e-07
29 79365 BHLHE41 1.2107203 7.466811e-04 1.2350832 4.063916e-03
30 6857 SYT1 1.6677230 1.075725e-05 1.8266367 2.280229e-06
31 101929005 <NA> -6.9715587 4.902298e-04 -4.6002948 9.128832e-03
32 114795 TMEM132B -2.0420745 9.180844e-15 -1.4932069 6.161726e-06
33 688 KLF5 1.6322523 1.076324e-03 1.2452259 4.025393e-02
34 1948 EFNB2 0.9663081 7.296640e-05 1.1138922 2.080333e-04
35 23002 DAAM1 0.7554336 2.883318e-02 0.8353463 2.729476e-02
36 6252 RTN1 1.7650685 1.637477e-12 1.5572796 2.559488e-04
37 89932 PAPLN -1.5716382 4.500273e-02 -1.9661083 1.608497e-02
38 10516 FBLN5 2.0034532 5.633136e-26 2.5520488 2.184210e-21
39 26153 KIF26A 4.9479081 5.215718e-03 5.7609605 3.792368e-05
40 7057 THBS1 1.3681011 2.335652e-03 2.0741402 4.016936e-06
41 4756 NEO1 0.9742518 3.129045e-08 1.1479467 1.474883e-05
42 4916 NTRK3 1.5317619 4.721754e-08 1.3041078 1.647761e-04
43 2903 GRIN2A 2.6808625 3.537752e-05 2.5409853 4.486943e-04
44 729993 SHISA9 -3.8900657 6.124761e-22 -1.3730096 3.597350e-03
45 51704 GPRC5B -0.6943593 1.607767e-02 -0.7158227 4.390799e-02
46 54768 HYDIN 3.1155151 3.786053e-07 3.4412476 6.679975e-10
47 794 CALB2 1.9745979 3.021138e-03 2.4744374 1.492341e-06
48 57687 VAT1L 1.0691442 3.043079e-09 1.1210515 7.707488e-06
49 5187 PER1 1.6211046 2.190498e-03 1.9721847 3.039329e-06
50 201161 CENPV 1.0748005 7.683185e-03 1.3627941 2.911996e-04
51 7153 TOP2A 0.8909203 2.167562e-03 0.9775318 6.734027e-03
52 10882 C1QL1 -1.2462122 5.655205e-06 -1.2834520 1.792262e-03
53 113026 PLCD3 -0.7125454 2.066817e-02 -0.8306542 3.008581e-02
54 4804 NGFR -2.2008093 1.158457e-10 -2.1406331 1.813272e-06
55 2302 FOXJ1 1.2523610 5.640820e-06 1.3486622 1.172300e-03
56 11322 TMC6 -4.5286641 5.215718e-03 -4.0938782 3.270737e-02
57 81035 COLEC12 -1.4481407 2.447676e-02 -2.1538079 1.443187e-04
58 361 AQP4 2.5636450 2.492154e-18 3.3509493 1.099340e-16
59 5596 MAPK4 1.9477813 6.272020e-04 2.2808623 7.694179e-08
60 51046 ST8SIA3 2.3046926 3.116301e-03 2.6061923 1.164931e-03
61 90701 SEC11C -0.6549366 3.435661e-02 -0.7731007 4.443954e-02
62 404217 CTXN1 1.0659448 8.423358e-05 1.0100041 9.810692e-04
63 1995 ELAVL3 1.3869316 2.022244e-05 2.2056761 2.475397e-13
64 9518 GDF15 -0.7403892 4.767716e-02 -1.6894578 3.955062e-05
65 79784 MYH14 -2.3279006 1.986276e-02 -3.3385941 1.061620e-03
66 92749 DRC1 2.1693851 3.021138e-03 2.6759469 3.653718e-06
67 57628 DPP10 -5.2195891 3.952380e-08 -3.4116486 3.792368e-05
68 3625 INHBB -0.9765568 9.918180e-03 -1.6587721 5.064936e-06
69 2995 GYPC -2.3370979 5.640820e-06 -2.1226178 2.620590e-06
70 129881 CCDC173 2.3618858 1.709086e-03 2.4161211 5.153394e-03
71 8324 FZD7 -1.3251978 1.958775e-04 -1.0401722 2.527407e-02
72 8609 KLF7 1.0357609 1.588294e-05 0.8513477 1.101567e-02
73 3488 IGFBP5 -1.2042255 1.457509e-03 -1.2840334 3.354261e-03
74 5270 SERPINE2 -1.3848242 2.877852e-07 -1.2444555 4.917038e-04
75 92737 DNER 1.1961221 4.937490e-03 1.4081602 9.810692e-04
76 3769 KCNJ13 1.7530569 2.673956e-02 2.4403902 3.280473e-05
77 4826 NNAT 3.6894568 3.488356e-26 4.2039042 2.362392e-28
78 55959 SULF2 -1.4277449 1.159590e-02 -1.7758706 2.595059e-02
79 56245 C21orf62 1.0646833 4.488374e-05 0.8807853 2.698021e-02
80 116448 OLIG1 -1.1515256 6.288787e-03 -1.1549137 1.146610e-02
81 1827 RCAN1 0.7193603 2.551274e-03 0.9394508 1.688169e-04
82 3708 ITPR1 1.9492299 8.682648e-03 1.9092677 3.573171e-02
83 116135 LRRC3B 1.9133409 1.961045e-03 1.7450856 1.695501e-02
84 114884 OSBPL10 -1.9426068 5.017110e-03 -1.7311338 3.270737e-02
85 79442 LRRC2 3.4398862 2.502129e-03 3.6516561 2.331951e-04
86 64147 KIF9 1.5020285 1.328423e-04 2.1385875 6.097979e-08
87 11170 FAM107A 1.4030083 3.471441e-02 1.4558105 4.169884e-02
88 132204 SYNPR 6.8513818 2.117888e-04 6.6455378 2.331951e-04
89 1295 COL8A1 -4.5471851 7.161381e-03 -3.7379338 2.815452e-02
90 151887 CCDC80 0.7317143 1.740585e-02 0.8723305 1.319498e-03
91 7018 TF -3.7162415 1.267988e-67 -2.8326531 2.204247e-30
92 5947 RBP1 -1.0910735 4.502025e-07 -0.7994095 4.109501e-02
93 5806 PTX3 1.5680761 1.391425e-04 1.7658383 1.403575e-07
94 10417 SPON2 -2.4640319 1.386561e-02 -2.8331591 2.289093e-03
95 83888 FGFBP2 -1.9562182 9.567416e-03 -2.3549128 2.393688e-04
96 201780 SLC10A4 1.0951238 6.731157e-06 1.0314890 4.917266e-03
97 23284 ADGRL3 -3.3747984 7.547937e-11 -1.7590050 1.454827e-03
98 9508 ADAMTS3 2.2334709 4.424914e-04 2.4774894 2.276936e-04
99 134121 C5orf49 1.9616110 1.942062e-04 2.7374028 1.875367e-10
100 8507 ENC1 0.9047363 2.522638e-02 1.0186176 3.003533e-02
101 1946 EFNA5 1.6677640 1.275805e-06 1.7088384 2.736112e-05
102 9547 CXCL14 -0.8064340 7.756694e-04 -1.5018443 1.611197e-09
103 6695 SPOCK1 -1.1943301 9.157880e-03 -2.2354822 7.206010e-08
104 1958 EGR1 2.4401660 4.817670e-35 2.5287577 7.564100e-19
105 2878 GPX3 -1.3013559 3.780855e-08 -2.0926990 6.557503e-11
106 23286 WWC1 1.0141019 4.480737e-03 1.2974451 1.326571e-04
107 1843 DUSP1 1.9108451 3.135363e-02 1.9266165 2.620078e-02
108 51617 NSG2 6.1426994 3.418688e-03 6.8884048 3.792368e-05
109 10814 CPLX2 5.4606577 4.901378e-04 6.4010760 1.032009e-07
110 221749 PXDC1 0.6438690 5.973334e-03 0.8543232 7.604554e-03
111 84062 DTNBP1 -0.9335939 1.619760e-02 -1.0706331 8.110300e-03
112 3400 ID4 1.0490761 1.704169e-04 1.0639650 3.249851e-03
113 10590 SCGN 3.4205650 6.377511e-11 4.5896530 4.348573e-26
114 285755 PPIL6 1.9279650 1.149142e-02 2.0954784 3.249945e-03
115 1490 CCN2 0.9956475 7.740168e-05 0.7663979 2.527407e-02
116 80129 CCDC170 2.1586226 4.715202e-02 2.8181988 8.319996e-03
117 10457 GPNMB -1.5291994 9.285904e-04 -2.1669377 1.004649e-07
118 4852 NPY 3.1522125 8.913224e-05 4.2222539 1.588167e-14
119 6424 SFRP4 -0.7815462 4.441654e-04 -1.3426635 1.190509e-07
120 81628 TSC22D4 -0.6157171 1.986276e-02 -0.7767061 3.021189e-02
121 5054 SERPINE1 1.6827552 1.689858e-08 1.2590846 3.249945e-03
122 2861 GPR37 1.3670610 2.441806e-03 1.8297795 1.213313e-04
123 10395 DLC1 1.6123746 1.080367e-09 1.4263211 1.924268e-06
124 1808 DPYSL2 1.0114199 5.825476e-08 1.0652386 2.958230e-06
125 23643 LY96 -2.5944597 2.432275e-03 -1.9480631 4.727642e-02
126 11075 STMN2 4.3069575 1.817215e-02 5.8540685 8.750900e-09
127 6383 SDC2 0.8744463 2.437254e-04 0.7889015 1.687242e-02
128 6674 SPAG1 2.0789941 2.964268e-03 2.0054451 1.090224e-02
129 1029 CDKN2A -1.0355011 1.361593e-03 -1.0444652 4.684678e-03
130 687 KLF9 1.4648767 5.328514e-09 1.6563008 6.155819e-08
131 9568 GABBR2 2.3415232 5.056054e-03 2.2372413 3.030523e-03
132 54566 EPB41L4B -1.0936684 2.311572e-03 -1.1537337 5.516218e-04
133 1620 BRINP1 2.9343779 2.911080e-02 3.7325356 2.891086e-05
134 83543 AIF1L -0.9344874 1.208559e-03 -0.9029015 2.547855e-02
135 8021 NUP214 -0.8740175 4.181539e-03 -0.9834048 5.828119e-03
136 5730 PTGDS -2.0109583 5.051669e-20 -1.9008593 7.330218e-09
137 4129 MAOB 1.2838784 2.040953e-05 1.0111052 1.111439e-02
138 1641 DCX 3.7333360 1.413819e-18 5.0056019 2.802915e-51
139 1069 CETN2 0.6735559 1.149142e-02 0.9817983 9.286896e-05
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 1.3531683 0.56940258 2.763972 3.973374e-01
02_TSC2_KO_Grabole_2016 2.1585572 1.52276295 3.066294 8.934558e-06
03_TSC2_Grabole-2016 1.9664117 1.36679606 2.862101 1.562368e-04
04_TSC2-tuber-Martin2017 4.6371159 1.45237548 11.432969 5.904828e-03
05_TSC2-SEN_SEGA-Martin2017 4.3103219 3.00739593 6.140656 6.426553e-15
06_all_EpilepsyGene 1.3040385 0.41418064 3.147179 4.433955e-01
07_high_conf_EpilepsyGene 2.4223469 0.48662600 7.400112 1.349090e-01
08_ASD_Epilepsy_EpilepsyGene 3.5168838 0.92858316 9.468038 3.146620e-02
09_Epi25_dataset 0.0000000 0.00000000 4.526376 1.000000e+00
10_SFARI_all 3.0516538 1.19006981 6.567324 1.091196e-02
11_SFARI_score4plus 3.5334127 1.25625359 8.057352 9.322558e-03
12_DeRubeis_RDNV 0.0000000 0.00000000 4.768739 1.000000e+00
13_Iossifov_RDNV 0.9613635 0.30580209 2.315034 1.000000e+00
14_FMRP_Darnell 2.0797679 1.12407459 3.587280 1.342012e-02
15_Voineagu_M12 0.8582674 0.17392932 2.583640 1.000000e+00
16_Voineagu_M16 1.4517078 0.46080102 3.506997 4.038906e-01
17_ID_genes_Neel 0.5933426 0.07083178 2.202312 7.762594e-01
18_ID_genes_pinto2014 0.8078992 0.09630282 3.006937 1.000000e+00
19_Fromer_SCZ_FunDN 1.4160882 0.55542785 3.023035 3.555920e-01
20_Cocchi_Pruning 5.8469859 1.82193469 14.520006 2.312936e-03
Beta SE Padj
01_Swaminathan2018_DEPDC5KO 0.3024488 0.4416410 1.000000e+00
02_TSC2_KO_Grabole_2016 0.7694400 0.1780171 1.786912e-04
03_TSC2_Grabole-2016 0.6762104 0.1855822 3.124735e-03
04_TSC2-tuber-Martin2017 1.5340926 0.5922919 1.180966e-01
05_TSC2-SEN_SEGA-Martin2017 1.4610126 0.1836418 1.285311e-13
06_all_EpilepsyGene 0.2654660 0.5851628 1.000000e+00
07_high_conf_EpilepsyGene 0.8847369 0.8188757 1.000000e+00
08_ASD_Epilepsy_EpilepsyGene 1.2575753 0.6794238 6.293241e-01
09_Epi25_dataset -Inf NaN 1.000000e+00
10_SFARI_all 1.1156837 0.4804447 2.182393e-01
11_SFARI_score4plus 1.2622642 0.5276175 1.864512e-01
12_DeRubeis_RDNV -Inf NaN 1.000000e+00
13_Iossifov_RDNV -0.0394027 0.5843951 1.000000e+00
14_FMRP_Darnell 0.7322563 0.3139266 2.684024e-01
15_Voineagu_M12 -0.1528395 0.8144218 1.000000e+00
16_Voineagu_M16 0.3727406 0.5854743 1.000000e+00
17_ID_genes_Neel -0.5219834 1.0844205 1.000000e+00
18_ID_genes_pinto2014 -0.2133179 1.0851734 1.000000e+00
19_Fromer_SCZ_FunDN 0.3478983 0.4775076 1.000000e+00
20_Cocchi_Pruning 1.7659263 0.5949119 4.625873e-02
D244
getlinmodoutput(targetline = "D244",targetdiff = "DIFF",targetrapa = "RAPA") entrezgene genname log2FC_2.1 fdr_2.1 log2FC_2.2 fdr_2.2
1 1969 EPHA2 -0.4156436 1.786505e-03 -0.4614548 1.856825e-02
2 4237 MFAP2 -1.8799463 1.408076e-06 -1.3745964 4.624004e-04
3 644068 <NA> -0.3590070 2.869457e-02 -0.4807850 1.104913e-02
4 3399 ID3 0.5061376 7.729593e-06 0.4283983 3.908169e-04
5 3925 STMN1 0.6965907 7.631803e-04 0.5450212 8.437631e-03
6 1296 COL8A2 -1.2868634 7.261643e-07 -1.2888966 9.397150e-08
7 2899 GRIK3 -2.3312172 6.975035e-10 -0.8969046 4.857303e-02
8 8613 PLPP3 0.9733065 1.474275e-04 0.7153388 4.318621e-02
9 23576 DDAH1 0.7785829 5.192707e-03 0.6091387 4.100636e-02
10 3491 CCN1 0.4678656 2.963636e-06 0.4105692 9.041386e-05
11 648740 <NA> 0.6129398 3.756801e-03 0.5676909 3.742487e-02
12 7482 WNT2B 0.6449332 1.707551e-03 0.6721599 2.189161e-04
13 54879 ST7L 1.3190671 2.143140e-23 0.4878723 4.835702e-03
14 6277 S100A6 -0.6507256 1.266693e-10 -0.6579181 5.467558e-13
15 79957 PAQR6 -1.8264594 4.444419e-10 -1.1683542 7.608800e-04
16 10485 MIR9-1HG -0.9291450 2.838604e-04 -1.2607947 1.034161e-04
17 93183 PIGM -1.3311259 3.672953e-07 -0.6802182 3.895651e-02
18 477 ATP1A2 -1.2574533 1.434561e-16 -0.9292025 2.359299e-06
19 8490 RGS5 0.7061001 9.243401e-03 0.5901435 6.181386e-03
20 9019 MPZL1 0.4981399 5.092077e-03 0.5009347 9.496796e-03
21 5396 PRRX1 1.7234056 9.775055e-14 1.1534507 6.426046e-05
22 9588 PRDX6 0.4707179 5.893131e-04 0.3644539 2.151528e-02
23 55220 KLHDC8A -2.1231857 1.760830e-03 -1.4689768 4.847504e-02
24 50486 G0S2 -2.0420221 9.635264e-145 -2.5996040 2.301167e-217
25 7044 LEFTY2 -1.3192934 3.280549e-18 -2.3110081 5.751049e-64
26 84886 C1orf198 0.9699749 1.586808e-06 0.5353448 3.514587e-02
27 10659 CELF2 1.0623173 5.832457e-08 0.7868175 1.708568e-04
28 3799 KIF5B 0.4577931 5.230602e-04 0.4754410 5.092168e-05
29 220963 SLC16A9 1.5093231 9.717264e-18 1.4702889 6.249604e-20
30 5328 PLAU -0.6860737 4.551671e-05 -0.5197041 9.395697e-03
31 9124 PDLIM1 0.4509083 1.314632e-04 0.6513184 1.993098e-08
32 6319 SCD 0.2511798 4.476925e-02 0.7794106 6.387888e-12
33 114815 SORCS1 -2.1231810 2.307478e-02 -2.3863755 2.202177e-02
34 2674 GFRA1 -0.4799768 1.237850e-03 -0.6378438 1.191763e-05
35 402778 IFITM10 -1.6883116 1.798490e-07 -0.9871409 1.595832e-02
36 283298 OLFML1 1.3133104 5.078602e-10 1.5777211 2.403838e-16
37 6157 RPL27A -0.3857288 3.670998e-07 -0.2303211 1.903700e-02
38 27122 DKK3 -0.5580258 4.985218e-09 -0.5931532 3.691467e-10
39 6207 RPS13 -0.4023854 1.385053e-07 -0.3180084 1.061947e-03
40 9537 TP53I11 -1.9584281 3.300614e-16 -1.3950698 1.344610e-07
41 51524 TMEM138 0.5334741 9.492034e-03 0.5147442 2.156053e-02
42 7351 UCP2 1.1143606 2.025606e-02 1.5299811 7.532644e-04
43 11098 PRSS23 0.4307277 1.073122e-05 0.6784633 1.324860e-11
44 1410 CRYAB -0.7085678 3.425418e-16 -0.6623639 4.194395e-13
45 4684 NCAM1 -0.7849245 6.342683e-09 -0.6951515 8.970563e-08
46 6876 TAGLN 0.3837716 1.888557e-06 0.7098218 5.489084e-18
47 53826 FXYD6 -1.5563297 2.641754e-29 -1.7253622 4.449397e-31
48 63876 PKNOX2 -1.2447871 1.637874e-03 -1.7811272 3.247027e-04
49 50863 NTM -1.2825953 1.370990e-02 -1.2557436 3.308547e-02
50 81029 WNT5B -1.4638818 4.656250e-05 -0.8511374 2.355254e-02
51 894 CCND2 0.5412578 2.056792e-02 0.6213173 1.140256e-02
52 8076 MFAP5 0.8323568 1.312028e-08 1.3427802 1.485392e-17
53 11228 RASSF8 1.5726288 4.434900e-04 1.1483820 4.832576e-02
54 3855 KRT7 1.3224258 2.551487e-05 2.2390807 1.133350e-15
55 3489 IGFBP6 -1.1739264 3.487772e-08 -0.5194090 2.079860e-02
56 4327 MMP19 0.9211195 4.177778e-02 1.2420465 1.677874e-03
57 4637 MYL6 0.3799577 8.194798e-04 0.4319203 2.137579e-04
58 4035 LRP1 -0.3603670 4.450603e-02 -0.3576910 4.028103e-02
59 11247 NXPH4 -2.6634395 2.863258e-03 -2.5454342 1.798882e-02
60 22822 PHLDA1 0.7192724 6.432734e-06 0.5243860 5.347219e-03
61 1848 DUSP6 -1.2864987 6.654183e-07 -1.3246108 5.992254e-06
62 10988 METAP2 -0.4486932 3.733085e-03 -0.4181849 4.795325e-02
63 22877 MLXIP -0.8864682 7.710864e-05 -1.3537995 8.103193e-11
64 114795 TMEM132B -3.1403066 4.570484e-06 -3.0132607 5.957135e-10
65 10129 FRY 3.3215631 7.103118e-03 3.5798206 7.133626e-03
66 1910 EDNRB -0.9341303 8.787660e-05 -1.4018162 2.523953e-09
67 1638 DCT -0.9777289 1.598509e-05 -2.1672010 2.513793e-30
68 1282 COL4A1 0.6959730 6.185122e-07 0.3346814 3.788431e-02
69 2621 GAS6 0.6469828 8.399232e-06 0.4991532 2.771146e-03
70 29091 STXBP6 -1.1957346 5.007498e-03 -1.3175027 5.129299e-03
71 6235 RPS29 -0.2925477 6.939818e-05 -0.2161987 1.523302e-02
72 652 BMP4 0.9172466 4.681102e-09 0.9744670 8.103193e-11
73 23002 DAAM1 0.6938355 2.863809e-03 0.5782007 4.677801e-02
74 9517 SPTLC2 0.8748820 3.023905e-02 0.9166731 4.185679e-02
75 12 SERPINA3 -1.6939009 3.691257e-46 -1.0237219 8.432118e-20
76 70 ACTC1 2.4566660 3.961311e-09 2.3862088 2.641230e-08
77 567 B2M 0.4300572 1.118831e-03 0.4063694 1.601715e-04
78 3671 ISLR -1.5492885 2.020700e-55 -0.6997528 6.387888e-12
79 64220 STRA6 -0.8436189 1.277936e-08 -0.8128532 9.165614e-08
80 9915 ARNT2 0.4654090 2.139752e-04 0.6806762 1.790427e-08
81 57214 CEMIP 0.9918949 8.936810e-09 1.0669818 5.193301e-11
82 30812 SOX8 -1.1040177 1.160839e-03 -0.9873133 1.953103e-03
83 124152 IQCK -0.4233033 9.984072e-03 -0.4341487 9.955852e-03
84 1428 CRYM -5.3477355 1.887871e-06 -2.2455586 2.375695e-02
85 4313 MMP2 -1.1477944 2.187632e-19 -0.8585802 8.659959e-16
86 1728 NQO1 0.6514906 2.602651e-06 0.5555884 2.699670e-03
87 92154 MTSS2 0.9485278 1.521300e-05 0.6963852 2.405820e-02
88 91862 MARVELD3 1.4914019 6.669175e-03 1.5623765 7.427253e-03
89 497190 CLEC18B -1.4112298 1.264664e-11 -0.8408839 3.594117e-04
90 2734 GLG1 -0.7611539 1.728431e-08 -0.4129051 8.723320e-03
91 482 ATP1B2 -0.7442227 8.755923e-07 -0.4070386 3.679534e-02
92 1819 DRG2 1.6549430 4.877721e-02 1.8554310 2.740463e-02
93 9349 RPL23 -0.4447861 1.041512e-09 -0.2199463 2.445119e-02
94 3872 KRT17 0.7072854 2.220292e-02 1.3596930 5.484501e-08
95 284119 CAVIN1 0.3711938 7.598398e-03 0.9338717 7.289930e-17
96 2670 GFAP -1.5458422 1.066141e-81 -0.4623582 5.343221e-06
97 10882 C1QL1 -1.1800573 4.585792e-02 -1.3575829 3.915880e-02
98 4804 NGFR -1.8994842 1.471545e-13 -2.1854385 4.715661e-26
99 1277 COL1A1 -0.6243475 4.152227e-12 -0.5539194 3.691467e-10
100 6909 TBX2 -1.6172291 6.673132e-05 -1.4042385 9.532588e-05
101 3691 ITGB4 -1.5170148 8.222125e-10 -0.7373586 1.101639e-02
102 114897 C1QTNF1 -2.0736184 7.925386e-17 -2.0009867 1.870909e-26
103 84617 TUBB6 0.6784353 6.292697e-10 0.8419118 5.824719e-18
104 79959 CEP76 2.1133577 3.622145e-02 2.3607183 4.289137e-02
105 5771 PTPN2 1.5822769 2.975000e-03 1.4786379 1.570613e-02
106 1630 DCC -1.8781777 3.480412e-02 -5.3854841 4.688455e-07
107 6925 TCF4 -0.3524476 2.137204e-02 -0.8766528 2.523953e-09
108 115701 ALPK2 0.9407645 5.057115e-20 1.2657357 9.796637e-33
109 1153 CIRBP -0.4781032 1.217141e-04 -0.3043657 2.673622e-02
110 1264 CNN1 0.7833203 8.186223e-05 1.2267607 3.757565e-15
111 7171 TPM4 0.7593549 4.432673e-11 0.3268238 4.546490e-02
112 348 APOE 1.1060994 7.703717e-09 1.0078352 5.834122e-07
113 255783 INAFM1 -1.1227281 2.626564e-05 -1.3845743 8.253297e-05
114 284297 SSC5D -1.3402850 2.417846e-04 -0.8886371 3.619953e-02
115 130733 TMEM178A -0.5897743 1.879698e-02 -0.8015248 2.229551e-03
116 53335 BCL11A -1.4709084 2.372813e-02 -2.2288475 4.857303e-02
117 7039 TGFA -1.8402630 3.130862e-20 -2.0866510 1.274152e-27
118 54910 SEMA4C -1.0299388 1.576569e-03 -0.8420389 4.919172e-02
119 6160 RPL31 -0.2593406 1.319576e-03 -0.2546111 2.243391e-02
120 9448 MAP4K4 -0.6868182 5.285781e-13 -0.5734919 9.596336e-10
121 2995 GYPC -2.4190113 1.415998e-15 -2.5897350 5.915615e-21
122 116372 LYPD1 -0.6853058 2.175341e-08 -0.5182769 3.838421e-05
123 390 RND3 1.0879074 2.834714e-09 0.5274762 4.546490e-02
124 253782 CERS6 -1.1675559 4.957898e-03 -1.2028556 6.892510e-03
125 1745 DLX1 -1.2542083 3.178833e-05 -1.4832562 9.618358e-07
126 1123 CHN1 0.7343030 1.000126e-05 0.6061334 1.072571e-03
127 2487 FRZB -2.5860101 3.506698e-05 -2.6775791 3.208487e-05
128 23671 TMEFF2 -1.4239778 4.390502e-02 -1.9950630 5.390865e-03
129 26010 SPATS2L 0.8417012 9.779238e-07 0.5132847 2.278601e-03
130 2335 FN1 0.8618042 5.085179e-08 0.5159728 5.347219e-03
131 3485 IGFBP2 0.4209936 6.052721e-06 0.6294041 7.289930e-17
132 3488 IGFBP5 -1.4790171 1.730247e-60 -1.3238131 6.039310e-53
133 80303 EFHD1 -2.6073677 6.139696e-09 -2.5477600 1.515435e-08
134 10123 ARL4C -0.5040582 9.787143e-05 -0.5198076 3.771654e-05
135 57419 SLC24A3 -1.4139082 3.019072e-02 -1.8615651 4.659175e-03
136 3397 ID1 0.7307632 1.742180e-05 0.9582626 8.103193e-11
137 7052 TGM2 0.6840347 5.918459e-04 0.9553814 3.102921e-08
138 441951 ZFAS1 -0.6031713 1.099503e-09 -0.2692960 4.185679e-02
139 56937 PMEPA1 -0.7010615 8.307140e-19 -0.8845874 3.489978e-32
140 6227 RPS21 -0.3018602 8.204456e-04 -0.3142897 7.115799e-03
141 100192386 <NA> -1.9138055 3.039395e-02 -2.8043265 1.898146e-03
142 6453 ITSN1 0.5955656 1.304253e-03 0.6227147 1.035891e-03
143 80781 COL18A1 -0.8032645 1.294700e-05 -1.0810327 2.084319e-11
144 3985 LIMK2 -1.0339131 2.188103e-05 -0.6257838 5.847607e-03
145 54944 <NA> -1.0270303 3.952230e-02 -1.3586023 3.648476e-02
146 7078 TIMP3 -0.4036202 1.521300e-05 -0.6462015 2.397315e-14
147 4627 MYH9 0.2903156 3.693453e-03 0.3375945 9.493447e-04
148 2192 FBLN1 -1.7626343 8.307140e-19 -1.0111310 2.449077e-06
149 10752 CHL1 -0.8174300 7.247512e-04 -1.6241791 1.656380e-13
150 6161 RPL32 -0.2208801 7.113707e-03 -0.2314840 1.568219e-02
151 2199 FBLN2 -1.4666500 2.617758e-04 -1.6215847 6.685872e-04
152 23180 RFTN1 0.5110522 1.313369e-02 0.6579327 9.918696e-04
153 54756 IL17RD -0.3363103 1.102081e-02 -0.4018532 7.357338e-03
154 55079 FEZF2 -1.5300772 2.853931e-04 -1.2334711 1.442041e-02
155 1295 COL8A1 -2.5667320 1.117183e-51 -2.8067329 2.533751e-78
156 100506621 <NA> 1.8591393 1.896477e-09 1.5419284 1.462876e-05
157 151887 CCDC80 0.8400733 1.550300e-13 1.0909859 8.688693e-17
158 57514 ARHGAP31 -0.6484646 1.506550e-02 -0.8011114 4.835702e-03
159 11167 FSTL1 0.9026565 1.367900e-18 0.6720049 4.779641e-13
160 4710 NDUFB4 -0.5832897 2.332886e-08 -0.3109836 1.396695e-02
161 7018 TF -2.2191138 7.809017e-09 -2.7186226 1.812506e-08
162 51421 AMOTL2 0.5824076 2.870027e-02 0.5524496 2.679794e-02
163 5947 RBP1 -1.0346072 3.851251e-48 -1.1250151 1.013389e-56
164 590 BCHE -3.8950563 2.588810e-03 -4.2863525 4.963999e-03
165 5010 CLDN11 0.7786442 7.416085e-08 1.4385772 3.489978e-32
166 2049 EPHB3 -1.7366493 3.513152e-04 -2.0414255 5.942612e-05
167 1427 CRYGS 0.9015175 4.849154e-03 1.9079385 5.453763e-17
168 3280 HES1 -0.3270127 1.310732e-02 -0.3250811 4.690041e-02
169 131583 FAM43A -0.8770903 3.717157e-03 -0.7031054 6.181386e-03
170 6165 RPL35A -0.2663334 4.613388e-04 -0.2290969 1.474304e-02
171 10417 SPON2 -1.6792183 1.085527e-05 -1.6373186 1.499922e-03
172 285489 DOK7 -1.1007513 6.781052e-03 -1.3615172 1.037528e-03
173 54360 CYTL1 -2.8616496 5.812295e-09 -3.4273988 1.444637e-07
174 1400 CRMP1 -1.2791240 2.432843e-07 -0.7019373 1.428682e-02
175 8532 CPZ 0.9776346 1.719013e-07 1.6903718 6.740650e-28
176 83888 FGFBP2 -2.3020082 9.156676e-12 -4.3108924 4.089891e-24
177 51056 LAP3 0.8816155 7.862749e-03 0.7419129 4.857303e-02
178 7345 UCHL1 -0.5710588 6.820231e-06 -0.5653695 2.663678e-06
179 65997 RASL11B -1.7444023 6.820231e-06 -2.2916507 7.434746e-09
180 25849 PARM1 -2.7565914 7.734866e-06 -1.7833252 1.097964e-02
181 79966 SCD5 0.9156362 7.821225e-06 0.6368364 1.721266e-03
182 6164 RPL34 -0.3914409 9.425583e-07 -0.3131570 3.059568e-03
183 1363 CPE 0.9026028 7.977764e-03 1.3201504 8.164630e-06
184 153478 PLEKHG4B 1.0978381 1.536582e-05 0.9747296 5.207002e-04
185 170690 ADAMTS16 -2.1553969 2.241202e-04 -1.4760633 4.088533e-02
186 100505738 MIR4458HG -0.9318569 7.881478e-06 -0.8737341 9.862142e-04
187 56172 ANKH -1.2372352 2.079010e-05 -0.9869900 3.387664e-02
188 4131 MAP1B 0.4133843 2.202179e-04 0.4158426 6.930263e-05
189 645323 LINC00461 -0.5801673 5.283948e-05 -0.5709236 3.766002e-04
190 9547 CXCL14 -0.5235165 1.148369e-10 -0.4632759 1.335559e-07
191 1495 CTNNA1 0.3228209 1.259825e-02 0.3516482 1.056930e-02
192 1809 DPYSL3 -0.7918848 1.518136e-11 -0.7901843 1.915470e-14
193 972 CD74 0.4593239 4.323614e-02 1.4993242 2.671462e-19
194 11346 SYNPO -1.1937925 8.307140e-19 -0.9245496 6.330591e-09
195 2878 GPX3 -1.0164418 8.801801e-26 -0.7308690 1.484571e-13
196 6678 SPARC -0.4396672 1.953837e-09 -0.3373670 1.267784e-04
197 23286 WWC1 1.5686248 3.671663e-06 1.4815662 3.857516e-05
198 8878 SQSTM1 0.4475931 5.491053e-05 0.5283156 5.957135e-10
199 6659 SOX4 -0.3973998 1.168159e-04 -0.3397728 2.715784e-02
200 10590 SCGN -2.5609670 3.273773e-04 -2.2657997 7.608800e-04
201 4188 MDFI -1.1359481 1.479461e-02 -1.1566529 1.795269e-02
202 10231 RCAN2 -1.4933781 1.004177e-02 -2.1589227 9.375633e-05
203 79627 OGFRL1 1.5182381 1.724549e-05 1.1135665 5.674792e-03
204 167681 PRSS35 4.0435832 1.149050e-02 4.1134468 1.112088e-02
205 387066 <NA> -1.0656946 7.617300e-27 -0.3385440 1.548226e-02
206 7101 NR2E1 1.3256192 4.768159e-03 1.3443631 1.404027e-02
207 3910 LAMA4 1.1638947 3.028116e-05 1.2970794 2.967756e-06
208 2697 GJA1 0.6112536 4.987593e-10 0.5420339 8.545475e-09
209 2173 FABP7 -1.2363700 4.004592e-12 -0.6465519 3.678213e-04
210 26002 MOXD1 -0.8866932 8.755923e-07 -0.6483667 4.421584e-03
211 84947 SERAC1 1.1030080 3.872716e-02 1.1984720 4.269294e-02
212 7430 EZR 0.6208804 6.263804e-04 0.8795920 3.688320e-08
213 6648 SOD2 0.6597792 1.936825e-04 0.5997779 3.396741e-03
214 56975 FAM20C -1.0641255 1.989627e-08 -0.4683416 2.778544e-02
215 6624 FSCN1 0.3671651 2.778250e-03 0.4900222 1.291831e-05
216 10457 GPNMB 1.0447754 7.809017e-09 1.4574443 3.569027e-18
217 4852 NPY -2.7004616 2.746461e-03 -3.4530952 1.028876e-02
218 6424 SFRP4 -1.5686024 2.187938e-85 -1.7488886 8.250920e-100
219 2006 ELN -0.9919962 8.029189e-06 -0.7947487 5.390865e-03
220 10371 SEMA3A -1.7778313 1.487989e-02 -3.7214380 1.615111e-06
221 5244 ABCB4 -1.5833379 4.233616e-08 -2.3270915 1.719399e-10
222 5243 ABCB1 -1.2075793 9.159620e-06 -2.4817056 3.528847e-20
223 1278 COL1A2 -2.3263318 2.250375e-68 -2.9836323 5.280241e-106
224 1750 DLX6 -2.0712636 1.500270e-02 -3.2495957 7.155357e-03
225 1749 DLX5 -2.8085778 4.589048e-16 -2.5851513 8.907072e-10
226 83943 IMMP2L 0.4936623 4.856899e-02 0.5922763 2.150495e-02
227 857 CAV1 0.7578834 4.713328e-04 0.8685401 1.553383e-04
228 57464 STRIP2 -0.8663806 1.596751e-03 -0.8831810 5.004934e-03
229 51200 CPA4 3.2736399 9.784024e-04 2.9246067 2.214509e-02
230 4232 MEST 0.9643726 9.353234e-04 1.1818103 2.801103e-06
231 800 CALD1 0.3000359 6.350977e-04 0.3310221 5.092168e-05
232 28996 HIPK2 -0.5164790 7.729593e-06 -0.6035502 2.410705e-07
233 63898 SH2D4A 1.8424114 1.390738e-02 1.9426630 1.399137e-02
234 526 ATP6V1B2 0.4371004 2.044363e-02 0.5162846 1.111914e-02
235 1191 CLU 0.2778341 2.014947e-02 0.4027919 3.473869e-05
236 5368 PNOC -2.4876664 3.864354e-02 -5.4363244 1.046505e-05
237 3084 NRG1 1.9269670 8.288167e-25 1.6209777 2.309162e-14
238 5327 PLAT -1.0654404 1.426133e-05 -0.7292897 1.778405e-02
239 54212 SNTG1 -3.2339115 3.662222e-08 -1.9941244 5.144108e-04
240 767 CA8 -1.3726361 2.869065e-02 -1.3901392 3.368227e-02
241 286183 NKAIN3 -1.0736917 7.302787e-06 -0.7132043 4.659175e-03
242 7381 UQCRB -0.6671588 1.723706e-13 -0.2602459 2.243391e-02
243 6156 RPL30 -0.4589979 1.833585e-09 -0.2216742 4.235332e-02
244 1345 COX6C -0.5370116 4.106892e-09 -0.3059022 2.052665e-02
245 5168 ENPP2 0.8527160 1.101228e-07 0.7599470 8.177880e-07
246 114907 FBXO32 1.1589137 3.709259e-41 0.8963959 2.214941e-18
247 92949 ADAMTSL1 -1.4495735 2.432980e-06 -1.8584701 2.308692e-06
248 7169 TPM2 0.4519311 2.782340e-03 0.8803835 5.668786e-11
249 7094 TLN1 0.4196639 2.246460e-04 0.4401227 1.721266e-03
250 1515 CTSV 1.4388468 3.349723e-02 1.5941814 3.347452e-02
251 19 ABCA1 -0.3793466 3.165081e-02 -0.5800784 4.172341e-03
252 23446 SLC44A1 -0.5902860 4.635741e-02 -0.8323991 6.911771e-05
253 1620 BRINP1 -1.9895159 1.142425e-07 -2.5070024 1.273119e-11
254 253039 CUTALP -1.1174922 6.224565e-03 -0.9852202 3.584199e-02
255 169611 OLFML2A -1.8952074 2.674510e-06 -1.9555276 6.925892e-06
256 100506119 LINC01503 0.5559469 2.680262e-03 0.9130241 3.579174e-08
257 83543 AIF1L -1.2388526 3.130862e-20 -0.5682422 9.922051e-04
258 4570 <NA> -0.8772274 2.663053e-21 -0.3278338 1.585591e-02
259 2824 GPM6B -0.8074180 2.341468e-06 -0.5686222 1.484076e-02
260 7102 TSPAN7 -1.2510598 9.578798e-04 -0.8291136 3.081950e-02
261 51186 TCEAL9 0.4357520 9.519705e-07 0.3011626 3.423865e-03
262 5354 PLP1 -2.2504674 6.574852e-04 -3.1849628 1.981893e-05
263 5358 PLS3 -0.8969021 3.440901e-03 -1.6719493 3.063947e-10
264 10857 PGRMC1 0.8842565 3.302791e-07 0.5478687 3.603326e-03
265 6170 RPL39 -0.2996484 4.105697e-04 -0.3137189 1.464648e-04
266 633 BGN -2.9029508 4.191791e-25 -1.8005635 3.737921e-11
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 1.0440662 0.52919287 1.870555 8.784975e-01
02_TSC2_KO_Grabole_2016 1.9056788 1.48297727 2.448718 3.122349e-07
03_TSC2_Grabole-2016 1.8786968 1.44836988 2.449813 8.381421e-07
04_TSC2-tuber-Martin2017 6.2255599 3.07274755 11.548446 1.980811e-06
05_TSC2-SEN_SEGA-Martin2017 2.6266379 1.98386578 3.451758 5.114790e-11
06_all_EpilepsyGene 0.6630122 0.21220963 1.581249 4.539375e-01
07_high_conf_EpilepsyGene 0.8171989 0.09734763 3.045438 1.000000e+00
08_ASD_Epilepsy_EpilepsyGene 0.4320775 0.01080820 2.476788 7.308581e-01
09_Epi25_dataset 0.0000000 0.00000000 2.328291 4.124445e-01
10_SFARI_all 1.5404546 0.60634143 3.271510 2.347251e-01
11_SFARI_score4plus 1.1705565 0.31300496 3.087989 7.794051e-01
12_DeRubeis_RDNV 0.6557261 0.01632737 3.797089 1.000000e+00
13_Iossifov_RDNV 1.4441535 0.77246671 2.492362 1.885849e-01
14_FMRP_Darnell 1.4716175 0.88915348 2.317771 1.027332e-01
15_Voineagu_M12 0.8973729 0.32395101 2.000942 1.000000e+00
16_Voineagu_M16 3.2821503 1.94389489 5.265616 1.337384e-05
17_ID_genes_Neel 0.6184302 0.16619532 1.618134 5.384706e-01
18_ID_genes_pinto2014 1.5135433 0.59586738 3.213513 2.420997e-01
19_Fromer_SCZ_FunDN 1.2627426 0.63930099 2.265601 4.059027e-01
20_Cocchi_Pruning 2.3423778 0.61946070 6.289339 1.008871e-01
Beta SE Padj
01_Swaminathan2018_DEPDC5KO 0.04312291 0.3466965 1.000000e+00
02_TSC2_KO_Grabole_2016 0.64483829 0.1279523 6.244698e-06
03_TSC2_Grabole-2016 0.63057836 0.1327243 1.676284e-05
04_TSC2-tuber-Martin2017 1.82866339 0.3602506 3.961622e-05
05_TSC2-SEN_SEGA-Martin2017 0.96570466 0.1431925 1.022958e-09
06_all_EpilepsyGene -0.41096184 0.5812341 1.000000e+00
07_high_conf_EpilepsyGene -0.20187270 1.0855072 1.000000e+00
08_ASD_Epilepsy_EpilepsyGene -0.83915038 1.8817858 1.000000e+00
09_Epi25_dataset -Inf NaN 1.000000e+00
10_SFARI_all 0.43207755 0.4757090 1.000000e+00
11_SFARI_score4plus 0.15747931 0.6729671 1.000000e+00
12_DeRubeis_RDNV -0.42201203 1.8841330 1.000000e+00
13_Iossifov_RDNV 0.36752335 0.3192294 1.000000e+00
14_FMRP_Darnell 0.38636210 0.2570651 1.000000e+00
15_Voineagu_M12 -0.10828382 0.5198363 1.000000e+00
16_Voineagu_M16 1.18849879 0.2672475 2.674769e-04
17_ID_genes_Neel -0.48057094 0.6704187 1.000000e+00
18_ID_genes_pinto2014 0.41445343 0.4756074 1.000000e+00
19_Fromer_SCZ_FunDN 0.23328605 0.3472786 1.000000e+00
20_Cocchi_Pruning 0.85116659 0.6786085 1.000000e+00
ReN
getlinmodoutput(targetline = "ReN",targetdiff = "DIFF",targetrapa = "RAPA") entrezgene genname log2FC_2.1 fdr_2.1 log2FC_2.2 fdr_2.2
1 25932 CLIC4 -1.3586050 3.608772e-02 -1.8215486 8.231305e-03
2 6281 S100A10 -1.1420986 1.572252e-04 -0.8493016 4.721390e-02
3 10485 MIR9-1HG 3.7161701 3.294323e-30 2.2183209 1.409849e-07
4 63827 BCAN 2.4450337 9.308562e-07 2.1737736 1.359897e-04
5 7044 LEFTY2 -1.1330094 2.120245e-02 -1.3099004 7.931635e-03
6 80760 ITIH5 -2.7415319 3.833229e-02 -4.4070114 1.396392e-03
7 8519 IFITM1 -1.3637673 3.646454e-02 -2.0016739 3.944249e-03
8 10418 SPON1 8.1507287 4.970328e-04 9.7278024 1.256531e-08
9 387763 C11orf96 1.8720845 3.885333e-04 1.8628924 2.863164e-03
10 8076 MFAP5 -2.7489988 8.505600e-07 -2.7429341 2.822997e-05
11 1848 DUSP6 2.2515685 6.816638e-04 2.4201002 3.353992e-04
12 2621 GAS6 -1.9220378 7.170241e-08 -1.6933339 4.166595e-05
13 57447 NDRG2 2.1523934 4.094364e-08 1.8483757 6.910651e-04
14 4053 LTBP2 -2.8637440 1.193540e-03 -3.0589735 4.632015e-03
15 7057 THBS1 -2.3930607 1.151460e-02 -2.7036418 3.229200e-03
16 302 ANXA2 -0.8531947 7.205165e-03 -0.7342226 4.836928e-02
17 728276 CLEC19A -3.5350995 1.157863e-08 -3.0223898 1.867448e-03
18 1277 COL1A1 -3.1711128 4.294311e-17 -3.7120488 3.370409e-18
19 9021 SOCS3 -2.3976598 1.162410e-10 -1.3447580 2.570643e-02
20 114897 C1QTNF1 -2.0752249 3.520626e-05 -1.4310485 3.285384e-02
21 1463 NCAN 1.5037952 6.339942e-12 1.0406722 2.853093e-03
22 1545 CYP1B1 -3.5604784 8.161597e-08 -2.3708176 3.071266e-05
23 72 ACTG2 -2.5773756 7.368089e-17 -2.2067885 1.614029e-08
24 2335 FN1 -3.2251369 2.439609e-09 -4.0660517 1.970600e-15
25 3488 IGFBP5 -1.5452752 8.161597e-08 -1.4546640 3.094511e-06
26 55502 HES6 2.6453784 3.656844e-17 1.7604937 1.138068e-04
27 24141 LAMP5 1.6018892 1.192717e-02 1.5994225 2.425320e-02
28 1291 COL6A1 -1.3459432 3.235914e-05 -1.3121749 4.726705e-05
29 1292 COL6A2 -2.0253143 2.951469e-02 -2.9808726 1.138068e-04
30 10675 CSPG5 2.2364472 4.596981e-11 1.6496521 8.761854e-05
31 11170 FAM107A 2.1586119 2.320013e-05 1.9427053 8.738364e-04
32 56999 ADAMTS9 3.0400577 4.547679e-02 3.3821872 4.836928e-02
33 1295 COL8A1 -3.1075914 1.715765e-06 -2.8215083 6.250435e-08
34 5648 MASP1 7.8413690 2.008683e-03 7.9383795 3.454438e-03
35 683 BST1 -2.8950449 1.610867e-04 -2.5727092 2.357743e-03
36 23231 SEL1L3 1.5780452 2.444935e-02 1.9759758 2.780093e-03
37 4015 LOX -2.2360570 1.501354e-04 -2.0976670 3.229200e-03
38 9547 CXCL14 -2.5651405 1.134080e-06 -2.2279800 5.293257e-04
39 6678 SPARC -1.1273443 7.922301e-05 -0.9770203 3.229200e-03
40 57451 TENM2 -1.9941895 4.787436e-02 -2.7476467 5.935520e-04
41 51617 NSG2 10.2491172 1.312034e-10 8.6800156 5.616583e-05
42 10590 SCGN 3.6842321 6.432714e-25 1.7929381 7.252548e-03
43 2173 FABP7 0.8660790 1.736082e-02 0.9232129 2.223532e-02
44 1490 CCN2 -2.3098104 1.198764e-07 -1.3937364 4.270771e-02
45 9865 TRIL 2.7217711 1.994616e-02 2.8858121 3.285384e-02
46 3486 IGFBP3 -4.6468508 6.357079e-15 -3.3826860 1.256531e-08
47 1278 COL1A2 -3.8996895 2.345305e-07 -3.5277248 2.940563e-06
48 4747 NEFL -2.0357376 2.370999e-05 -2.6024981 4.420266e-06
49 51050 PI15 -1.0151690 2.950165e-02 -1.3134282 3.229200e-03
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 0.9393747 0.11026176 3.602544 1.000000e+00
02_TSC2_KO_Grabole_2016 2.1315004 1.16761531 3.914827 9.893612e-03
03_TSC2_Grabole-2016 2.7728774 1.43445011 5.703361 1.375979e-03
04_TSC2-tuber-Martin2017 8.0077608 1.56951307 25.514772 7.688118e-03
05_TSC2-SEN_SEGA-Martin2017 3.8659302 2.05161168 7.112128 1.819302e-05
06_all_EpilepsyGene 1.4850928 0.17407594 5.708719 3.987910e-01
07_high_conf_EpilepsyGene 0.0000000 0.00000000 8.556545 1.000000e+00
08_ASD_Epilepsy_EpilepsyGene 0.0000000 0.00000000 9.160823 1.000000e+00
09_Epi25_dataset 0.0000000 0.00000000 13.234037 1.000000e+00
10_SFARI_all 1.1758695 0.02904876 6.935834 5.779460e-01
11_SFARI_score4plus 0.0000000 0.00000000 6.013472 1.000000e+00
12_DeRubeis_RDNV 0.0000000 0.00000000 13.942207 1.000000e+00
13_Iossifov_RDNV 0.5360707 0.01327500 3.146750 1.000000e+00
14_FMRP_Darnell 1.9397821 0.59851826 4.899481 1.947059e-01
15_Voineagu_M12 0.0000000 0.00000000 3.051384 6.361856e-01
16_Voineagu_M16 4.4507001 1.36869328 11.296858 7.551960e-03
17_ID_genes_Neel 0.0000000 0.00000000 3.197407 6.327798e-01
18_ID_genes_pinto2014 0.0000000 0.00000000 4.352008 1.000000e+00
19_Fromer_SCZ_FunDN 3.0422422 0.93731156 7.698986 3.155365e-02
20_Cocchi_Pruning 10.0473664 1.96199349 32.213643 4.188780e-03
Beta SE Padj
01_Swaminathan2018_DEPDC5KO -0.06254084 1.0930394 1.0000000000
02_TSC2_KO_Grabole_2016 0.75682617 0.3070728 0.1978722388
03_TSC2_Grabole-2016 1.01988556 0.3362775 0.0275195782
04_TSC2-tuber-Martin2017 2.08041118 0.8314519 0.1537623625
05_TSC2-SEN_SEGA-Martin2017 1.35220232 0.3232534 0.0003638605
06_all_EpilepsyGene 0.39547727 1.0937454 1.0000000000
07_high_conf_EpilepsyGene -Inf NaN 1.0000000000
08_ASD_Epilepsy_EpilepsyGene -Inf NaN 1.0000000000
09_Epi25_dataset -Inf NaN 1.0000000000
10_SFARI_all 0.16200790 1.8881568 1.0000000000
11_SFARI_score4plus -Inf NaN 1.0000000000
12_DeRubeis_RDNV -Inf NaN 1.0000000000
13_Iossifov_RDNV -0.62348920 1.8869303 1.0000000000
14_FMRP_Darnell 0.66257562 0.5999356 1.0000000000
15_Voineagu_M12 -Inf NaN 1.0000000000
16_Voineagu_M16 1.49306141 0.6016352 0.1510391926
17_ID_genes_Neel -Inf NaN 1.0000000000
18_ID_genes_pinto2014 -Inf NaN 1.0000000000
19_Fromer_SCZ_FunDN 1.11259483 0.6006808 0.6310729981
20_Cocchi_Pruning 2.30731055 0.8333416 0.0837756077
Replicated across cell lines
getlinmodoutput_all = function(targetdiff,
targetrapa){
samplesincl = SampleInfo$DIFF==targetdiff & SampleInfo$RAPA==targetrapa
pvalrep= get(paste0("restab_",
"D244_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$padj<mypval &
get(paste0("restab_",
"D244_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$padj<mypval &
get(paste0("restab_",
"D62_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$padj<mypval &
get(paste0("restab_",
"D62_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$padj<mypval &
get(paste0("restab_",
"ReN_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$padj<mypval &
get(paste0("restab_",
"ReN_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$padj<mypval
betarep = apply(cbind(get(paste0("restab_",
"D244_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$log2FoldChange,
get(paste0("restab_",
"D244_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$log2FoldChange,
get(paste0("restab_",
"D62_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$log2FoldChange,
get(paste0("restab_",
"D62_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$log2FoldChange,
get(paste0("restab_",
"ReN_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$log2FoldChange,
get(paste0("restab_",
"ReN_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$log2FoldChange),
1,
samesign)
idx=which(betarep & pvalrep)
hits=geneids[idx]
restab=data.frame(
entrezgene = geneids[idx],
genname=rowData(ddsMat)[hits,"hgnc"],
D244_log2FC_2.1 = get(paste0("restab_",
"D244_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$log2FoldChange[idx],
D244_fdr_2.1 = get(paste0("restab_",
"D244_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$padj[idx],
D244_log2FC_2.2 = get(paste0("restab_",
"D244_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$log2FoldChange[idx],
D244_fdr_2.2 = get(paste0("restab_",
"D244_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$padj[idx],
D62_log2FC_2.1 = get(paste0("restab_",
"D62_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$log2FoldChange[idx],
D62_fdr_2.1 = get(paste0("restab_",
"D62_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$padj[idx],
D62_log2FC_2.2 = get(paste0("restab_",
"D62_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$log2FoldChange[idx],
D62_fdr_2.2 = get(paste0("restab_",
"D62_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$padj[idx],
ReN_log2FC_2.1 = get(paste0("restab_",
"ReN_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$log2FoldChange[idx],
ReN_fdr_2.1 = get(paste0("restab_",
"ReN_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$padj[idx],
ReN_log2FC_2.2 = get(paste0("restab_",
"ReN_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$log2FoldChange[idx],
ReN_fdr_2.2 = get(paste0("restab_",
"ReN_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$padj[idx])
print(restab)
write.xlsx(restab, file=paste0(output, "/Restab_",
"Repl_All_",
targetdiff, "_",
targetrapa, ".xlsx"))
SamplesSet=SampleInfo[samplesincl,]
plotmatrix = log_2cpm[hits,rownames(SamplesSet)]
rownames(SamplesSet)=SamplesSet$label_rep
colnames(plotmatrix)=SamplesSet$label_rep
rownames(plotmatrix)=rowData(ddsMat)[hits,"hgnc"]
cellcol = Dark8[1:nlevels(SampleInfo$CellLine)]
names(cellcol) = levels(SampleInfo$CellLine)
cellcol = cellcol[as.character(unique(SamplesSet$CellLine))]
gRNAcol = Dark8[c(1:nlevels(SampleInfo$gRNA))+nlevels(SampleInfo$CellLine)]
names(gRNAcol) = levels(SampleInfo$gRNA)
gRNAcol = gRNAcol[as.character(unique(SamplesSet$gRNA))]
diffcol = brewer.pal(3,"Set1")[1:nlevels(SampleInfo$DIFF)]
names(diffcol) = levels(SampleInfo$DIFF)
diffcol = diffcol[as.character(unique(SamplesSet$DIFF))]
rapacol = brewer.pal(3,"Set2")[1:nlevels(SampleInfo$RAPA)]
names(rapacol) = levels(SampleInfo$RAPA)
rapacol = rapacol[as.character(unique(SamplesSet$RAPA))]
ann_colors = list(
DIFF = diffcol,
RAPA = rapacol,
gRNA = gRNAcol,
CellLine=cellcol)
collabels = SamplesSet[,c("CellLine","DIFF","RAPA", "gRNA")] %>%
mutate_all(as.character) %>% as.data.frame()
rownames(collabels)=SamplesSet$label_rep
idx=order(SamplesSet$CellLine, SamplesSet$gRNA)
pheatmap(plotmatrix[,idx],
border_color = NA,
annotation_col = collabels[idx,],show_rownames = F, show_colnames = F,
annotation_colors = ann_colors,
clustering_method = "ward.D2",
cluster_cols = F,
col = colors,
scale = "row",
main = "Normalized log2 counts PROLIF noRAPA")
gene_univers = rownames(ddsMat)
gostres = getGOresults(hits, gene_univers)
toptab = gostres$result
write.xlsx2(toptab, file = paste0(output, "/GOres_",targetdiff,targetrapa,".xlsx"), sheetName = "GO_enrichment")
idx = grepl("GO|KEGG", toptab$source)
titlename = paste(targetdiff,targetrapa)
if(!any(idx)){
p = ggplot() + annotate("text", x = 4, y = 25, size=4,
label = "no significant GO term") +
ggtitle(titlename)+theme_void()+
theme(plot.title = element_text(hjust = 0.5))
} else {
p=GOplot(toptab[idx, ], 10, Title = titlename)
}
print(p)
if(length(hits)>=1){
Resall=data.frame()
for (gl in names(genelists)){
tmp=table(signif=geneids %in% hits, targetgene=geneids %in% genelists[[gl]]$ENTREZ_ID)
resfish=fisher.test(tmp)
res = c(resfish$estimate, unlist(resfish$conf.int), resfish$p.value)
Resall = rbind(Resall, res)
}
colnames(Resall)=c("OR", "CI95L", "CI95U", "P")
rownames(Resall)=names(genelists)
Resall$Beta = log(Resall$OR)
Resall$SE = (log(Resall$OR)-log(Resall$CI95L))/1.96
Resall$Padj=p.adjust(Resall$P, method = "bonferroni")
print(Resall)
multiORplot(Resall, Pval = "P", Padj = "Padj", beta="Beta",SE = "SE",
pheno=paste(targetdiff, targetrapa))
}
}noDiff noRapa
getlinmodoutput_all(targetdiff = "noDIFF",targetrapa = "noRAPA") entrezgene genname D244_log2FC_2.1 D244_fdr_2.1 D244_log2FC_2.2 D244_fdr_2.2
1 151887 CCDC80 0.8069456 2.122272e-15 0.7595701 3.271995e-14
2 9568 GABBR2 1.0262131 4.391028e-02 1.8380988 4.032745e-07
D62_log2FC_2.1 D62_fdr_2.1 D62_log2FC_2.2 D62_fdr_2.2 ReN_log2FC_2.1
1 0.7861593 3.884032e-08 0.544454 5.158658e-06 1.3269840
2 1.8836534 3.992926e-19 1.770097 1.993618e-26 0.8591791
ReN_fdr_2.1 ReN_log2FC_2.2 ReN_fdr_2.2
1 1.910378e-09 0.5349808 2.674684e-06
2 1.299630e-04 0.7804877 1.030234e-16
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 0.0000000 0.00000000 117.67597 1.0000000
02_TSC2_KO_Grabole_2016 1.8802655 0.02394853 147.44493 1.0000000
03_TSC2_Grabole-2016 0.9979352 0.01271854 78.30124 1.0000000
04_TSC2-tuber-Martin2017 0.0000000 0.00000000 638.40262 1.0000000
05_TSC2-SEN_SEGA-Martin2017 6.0612670 0.07719326 474.01693 0.2632349
06_all_EpilepsyGene 0.0000000 0.00000000 185.81492 1.0000000
07_high_conf_EpilepsyGene 0.0000000 0.00000000 574.61522 1.0000000
08_ASD_Epilepsy_EpilepsyGene 0.0000000 0.00000000 615.67354 1.0000000
09_Epi25_dataset 0.0000000 0.00000000 893.42035 1.0000000
10_SFARI_all 0.0000000 0.00000000 301.07655 1.0000000
11_SFARI_score4plus 0.0000000 0.00000000 412.02988 1.0000000
12_DeRubeis_RDNV 0.0000000 0.00000000 938.93111 1.0000000
13_Iossifov_RDNV 0.0000000 0.00000000 137.38433 1.0000000
14_FMRP_Darnell 17.0257674 0.21675750 1321.33550 0.1079356
15_Voineagu_M12 0.0000000 0.00000000 207.85081 1.0000000
16_Voineagu_M16 0.0000000 0.00000000 206.59806 1.0000000
17_ID_genes_Neel 0.0000000 0.00000000 217.73964 1.0000000
18_ID_genes_pinto2014 0.0000000 0.00000000 295.96285 1.0000000
19_Fromer_SCZ_FunDN 0.0000000 0.00000000 141.75165 1.0000000
20_Cocchi_Pruning 0.0000000 0.00000000 806.47010 1.0000000
Beta SE Padj
01_Swaminathan2018_DEPDC5KO -Inf NaN 1
02_TSC2_KO_Grabole_2016 0.631412991 2.226154 1
03_TSC2_Grabole-2016 -0.002066912 2.225830 1
04_TSC2-tuber-Martin2017 -Inf NaN 1
05_TSC2-SEN_SEGA-Martin2017 1.801918851 2.226205 1
06_all_EpilepsyGene -Inf NaN 1
07_high_conf_EpilepsyGene -Inf NaN 1
08_ASD_Epilepsy_EpilepsyGene -Inf NaN 1
09_Epi25_dataset -Inf NaN 1
10_SFARI_all -Inf NaN 1
11_SFARI_score4plus -Inf NaN 1
12_DeRubeis_RDNV -Inf NaN 1
13_Iossifov_RDNV -Inf NaN 1
14_FMRP_Darnell 2.834727924 2.226380 1
15_Voineagu_M12 -Inf NaN 1
16_Voineagu_M16 -Inf NaN 1
17_ID_genes_Neel -Inf NaN 1
18_ID_genes_pinto2014 -Inf NaN 1
19_Fromer_SCZ_FunDN -Inf NaN 1
20_Cocchi_Pruning -Inf NaN 1
noDiff Rapa
try(getlinmodoutput_all(targetdiff = "noDIFF",targetrapa = "RAPA")) [1] entrezgene genname D244_log2FC_2.1 D244_fdr_2.1
[5] D244_log2FC_2.2 D244_fdr_2.2 D62_log2FC_2.1 D62_fdr_2.1
[9] D62_log2FC_2.2 D62_fdr_2.2 ReN_log2FC_2.1 ReN_fdr_2.1
[13] ReN_log2FC_2.2 ReN_fdr_2.2
<0 Zeilen> (oder row.names mit Länge 0)
Error in mapply(setCellValue, cells[seq_len(nrow(cells)), colIndex[ic]], :
Eingaben mit Länge 0 können nicht mit Eingaben anderer Länge gemischt werdenDiff noRapa
try(getlinmodoutput_all(targetdiff = "DIFF",targetrapa = "noRAPA")) [1] entrezgene genname D244_log2FC_2.1 D244_fdr_2.1
[5] D244_log2FC_2.2 D244_fdr_2.2 D62_log2FC_2.1 D62_fdr_2.1
[9] D62_log2FC_2.2 D62_fdr_2.2 ReN_log2FC_2.1 ReN_fdr_2.1
[13] ReN_log2FC_2.2 ReN_fdr_2.2
<0 Zeilen> (oder row.names mit Länge 0)
Error in mapply(setCellValue, cells[seq_len(nrow(cells)), colIndex[ic]], :
Eingaben mit Länge 0 können nicht mit Eingaben anderer Länge gemischt werdenDiff Rapa
try(getlinmodoutput_all(targetdiff = "DIFF",targetrapa = "RAPA")) entrezgene genname D244_log2FC_2.1 D244_fdr_2.1 D244_log2FC_2.2 D244_fdr_2.2
1 7044 LEFTY2 -1.3192934 3.280549e-18 -2.3110081 5.751049e-64
2 3488 IGFBP5 -1.4790171 1.730247e-60 -1.3238131 6.039310e-53
3 1295 COL8A1 -2.5667320 1.117183e-51 -2.8067329 2.533751e-78
4 9547 CXCL14 -0.5235165 1.148369e-10 -0.4632759 1.335559e-07
D62_log2FC_2.1 D62_fdr_2.1 D62_log2FC_2.2 D62_fdr_2.2 ReN_log2FC_2.1
1 -1.146146 0.0151783820 -2.510127 2.217413e-06 -1.133009
2 -1.204226 0.0014575086 -1.284033 3.354261e-03 -1.545275
3 -4.547185 0.0071613815 -3.737934 2.815452e-02 -3.107591
4 -0.806434 0.0007756694 -1.501844 1.611197e-09 -2.565140
ReN_fdr_2.1 ReN_log2FC_2.2 ReN_fdr_2.2
1 2.120245e-02 -1.309900 7.931635e-03
2 8.161597e-08 -1.454664 3.094511e-06
3 1.715765e-06 -2.821508 6.250435e-08
4 1.134080e-06 -2.227980 5.293257e-04No results to show
Please make sure that the organism is correct or set significant = FALSE
[1] "no significant results"
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 0.0000000 0.000000000 33.504610 1.00000000
02_TSC2_KO_Grabole_2016 0.6266413 0.011938369 7.807027 1.00000000
03_TSC2_Grabole-2016 0.3325514 0.006338702 4.143006 0.37442864
04_TSC2-tuber-Martin2017 0.0000000 0.000000000 183.665630 1.00000000
05_TSC2-SEN_SEGA-Martin2017 6.0639067 0.439326230 83.495306 0.09882533
06_all_EpilepsyGene 0.0000000 0.000000000 52.915563 1.00000000
07_high_conf_EpilepsyGene 0.0000000 0.000000000 165.829831 1.00000000
08_ASD_Epilepsy_EpilepsyGene 0.0000000 0.000000000 177.312232 1.00000000
09_Epi25_dataset 0.0000000 0.000000000 254.557976 1.00000000
10_SFARI_all 0.0000000 0.000000000 85.956736 1.00000000
11_SFARI_score4plus 0.0000000 0.000000000 116.219641 1.00000000
12_DeRubeis_RDNV 0.0000000 0.000000000 268.001224 1.00000000
13_Iossifov_RDNV 0.0000000 0.000000000 39.101432 1.00000000
14_FMRP_Darnell 0.0000000 0.000000000 25.798317 1.00000000
15_Voineagu_M12 0.0000000 0.000000000 59.261346 1.00000000
16_Voineagu_M16 0.0000000 0.000000000 58.898397 1.00000000
17_ID_genes_Neel 0.0000000 0.000000000 61.903070 1.00000000
18_ID_genes_pinto2014 0.0000000 0.000000000 84.469151 1.00000000
19_Fromer_SCZ_FunDN 0.0000000 0.000000000 40.336332 1.00000000
20_Cocchi_Pruning 0.0000000 0.000000000 228.948566 1.00000000
Beta SE Padj
01_Swaminathan2018_DEPDC5KO -Inf NaN 1
02_TSC2_KO_Grabole_2016 -0.4673809 2.020723 1
03_TSC2_Grabole-2016 -1.1009609 2.020470 1
04_TSC2-tuber-Martin2017 -Inf NaN 1
05_TSC2-SEN_SEGA-Martin2017 1.8023543 1.339218 1
06_all_EpilepsyGene -Inf NaN 1
07_high_conf_EpilepsyGene -Inf NaN 1
08_ASD_Epilepsy_EpilepsyGene -Inf NaN 1
09_Epi25_dataset -Inf NaN 1
10_SFARI_all -Inf NaN 1
11_SFARI_score4plus -Inf NaN 1
12_DeRubeis_RDNV -Inf NaN 1
13_Iossifov_RDNV -Inf NaN 1
14_FMRP_Darnell -Inf NaN 1
15_Voineagu_M12 -Inf NaN 1
16_Voineagu_M16 -Inf NaN 1
17_ID_genes_Neel -Inf NaN 1
18_ID_genes_pinto2014 -Inf NaN 1
19_Fromer_SCZ_FunDN -Inf NaN 1
20_Cocchi_Pruning -Inf NaN 1
Replicated across primary-HNPC cell lines
getlinmodoutput_D62D224 = function(targetdiff,
targetrapa, targetline){
samplesincl = SampleInfo$DIFF==targetdiff &
SampleInfo$RAPA==targetrapa &
SampleInfo$CellLine %in% targetline
pvalrep= get(paste0("restab_",
"D244_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$padj<mypval &
get(paste0("restab_",
"D244_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$padj<mypval &
get(paste0("restab_",
"D62_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$padj<mypval &
get(paste0("restab_",
"D62_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$padj<mypval
betarep = apply(cbind(get(paste0("restab_",
"D244_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$log2FoldChange,
get(paste0("restab_",
"D244_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$log2FoldChange,
get(paste0("restab_",
"D62_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$log2FoldChange,
get(paste0("restab_",
"D62_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$log2FoldChange),
1,
samesign)
idx=which(betarep & pvalrep)
hits=geneids[idx]
restab=data.frame(
entrezgene = geneids[idx],
genname=rowData(ddsMat)[hits,"hgnc"],
D244_log2FC_2.1 = get(paste0("restab_",
"D244_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$log2FoldChange[idx],
D244_fdr_2.1 = get(paste0("restab_",
"D244_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$padj[idx],
D244_log2FC_2.2 = get(paste0("restab_",
"D244_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$log2FoldChange[idx],
D244_fdr_2.2 = get(paste0("restab_",
"D244_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$padj[idx],
D62_log2FC_2.1 = get(paste0("restab_",
"D62_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$log2FoldChange[idx],
D62_fdr_2.1 = get(paste0("restab_",
"D62_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$padj[idx],
D62_log2FC_2.2 = get(paste0("restab_",
"D62_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$log2FoldChange[idx],
D62_fdr_2.2 = get(paste0("restab_",
"D62_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$padj[idx])
print(restab)
write.xlsx(restab, file=paste0(output, "/Restab_",
"Repl_D62D244_",
targetdiff, "_",
targetrapa, ".xlsx"))
SamplesSet=SampleInfo[samplesincl,]
plotmatrix = log_2cpm[hits,rownames(SamplesSet)]
rownames(SamplesSet)=SamplesSet$label_rep
colnames(plotmatrix)=SamplesSet$label_rep
rownames(plotmatrix)=rowData(ddsMat)[hits,"hgnc"]
cellcol = Dark8[1:nlevels(SampleInfo$CellLine)]
names(cellcol) = levels(SampleInfo$CellLine)
cellcol = cellcol[as.character(unique(SamplesSet$CellLine))]
gRNAcol = Dark8[c(1:nlevels(SampleInfo$gRNA))+nlevels(SampleInfo$CellLine)]
names(gRNAcol) = levels(SampleInfo$gRNA)
gRNAcol = gRNAcol[as.character(unique(SamplesSet$gRNA))]
diffcol = brewer.pal(3,"Set1")[1:nlevels(SampleInfo$DIFF)]
names(diffcol) = levels(SampleInfo$DIFF)
diffcol = diffcol[as.character(unique(SamplesSet$DIFF))]
rapacol = brewer.pal(3,"Set2")[1:nlevels(SampleInfo$RAPA)]
names(rapacol) = levels(SampleInfo$RAPA)
rapacol = rapacol[as.character(unique(SamplesSet$RAPA))]
ann_colors = list(
DIFF = diffcol,
RAPA = rapacol,
gRNA = gRNAcol,
CellLine=cellcol)
collabels = SamplesSet[,c("CellLine","DIFF","RAPA", "gRNA")] %>%
mutate_all(as.character) %>% as.data.frame()
rownames(collabels)=SamplesSet$label_rep
idx=order(SamplesSet$CellLine, SamplesSet$gRNA)
pheatmap(plotmatrix[,idx],
border_color = NA,
annotation_col = collabels[idx,],show_rownames = F, show_colnames = F,
annotation_colors = ann_colors,
clustering_method = "ward.D2",
cluster_cols = F,
col = colors,
scale = "row",
main = "Normalized log2 counts PROLIF noRAPA")
gene_univers = rownames(ddsMat)
gostres = getGOresults(hits, gene_univers)
toptab = gostres$result
write.xlsx2(toptab, file = paste0(output, "/GOres_",targetdiff,targetrapa,".xlsx"), sheetName = "GO_enrichment")
idx = grepl("GO|KEGG", toptab$source)
titlename = paste(targetdiff,targetrapa)
if(!any(idx)){
p = ggplot() + annotate("text", x = 4, y = 25, size=4,
label = "no significant GO term") +
ggtitle(titlename)+theme_void()+
theme(plot.title = element_text(hjust = 0.5))
} else {
p=GOplot(toptab[idx, ], 10, Title = titlename)
}
print(p)
if(length(hits)>=1){
Resall=data.frame()
for (gl in names(genelists)){
tmp=table(signif=geneids %in% hits, targetgene=geneids %in% genelists[[gl]]$ENTREZ_ID)
resfish=fisher.test(tmp)
res = c(resfish$estimate, unlist(resfish$conf.int), resfish$p.value)
Resall = rbind(Resall, res)
}
colnames(Resall)=c("OR", "CI95L", "CI95U", "P")
rownames(Resall)=names(genelists)
Resall$Beta = log(Resall$OR)
Resall$SE = (log(Resall$OR)-log(Resall$CI95L))/1.96
Resall$Padj=p.adjust(Resall$P, method = "bonferroni")
print(Resall)
multiORplot(Resall, Pval = "P", Padj = "Padj", beta="Beta",SE = "SE",
pheno=paste(targetdiff, targetrapa))
}
}noDiff noRapa
try(getlinmodoutput_D62D224(targetdiff = "noDIFF",
targetrapa = "noRAPA",
targetline=c("D62", "D224"))) entrezgene genname D244_log2FC_2.1 D244_fdr_2.1 D244_log2FC_2.2
1 2633 GBP1 2.0297059 2.515639e-02 2.0883616
2 10763 NES 0.3475318 2.516866e-03 0.6871561
3 4811 NID1 -0.7110318 4.728859e-02 -1.2334604
4 6468 FBXW4 0.7390090 2.525435e-02 0.7973168
5 977 CD151 0.4651951 1.184530e-03 0.4485379
6 4193 MDM2 0.5162521 1.420183e-03 0.5722706
7 64093 SMOC1 0.9866785 6.718799e-19 0.6051735
8 9369 NRXN3 -2.0815225 2.496293e-04 -2.9810474
9 2628 GATM 1.0641065 8.803533e-06 0.8997106
10 56963 RGMA 0.6604419 6.084450e-04 0.4291084
11 125144 SNHG29 -0.8703269 1.045102e-07 -0.5452850
12 6426 SRSF1 -0.7835381 1.563324e-03 -0.5706565
13 284184 NDUFAF8 0.5911756 2.083037e-03 0.6861791
14 11031 RAB31 0.5840879 9.078035e-06 0.7492132
15 348 APOE 1.4498686 7.075051e-34 1.2934789
16 27113 BBC3 0.6373515 2.628145e-05 0.6024491
17 3099 HK2 -4.5134193 3.385477e-04 -2.6657547
18 2280 FKBP1A 0.6321454 2.398389e-04 0.7647272
19 3785 KCNQ2 -1.5208703 2.206510e-07 -2.3512731
20 10752 CHL1 -0.4827870 8.236944e-03 -0.5881262
21 151887 CCDC80 0.8069456 2.122272e-15 0.7595701
22 11343 MGLL 1.1144299 9.215220e-17 1.0100009
23 5099 PCDH7 -1.1263769 9.919625e-03 -1.2945977
24 5156 PDGFRA -1.7558863 1.515392e-17 -1.8639525
25 3490 IGFBP7 0.6820844 4.251649e-03 1.0385101
26 3015 H2AZ1 -0.4375541 4.262233e-02 -0.6286706
27 221749 PXDC1 0.9963329 1.487422e-03 1.0337919
28 10590 SCGN -2.3919563 1.044409e-05 -3.9601061
29 221491 SMIM29 0.9451797 9.219084e-05 1.2516034
30 1026 CDKN1A 0.3671832 2.120348e-04 0.5293086
31 3910 LAMA4 1.2757771 6.167079e-05 1.4702063
32 6196 RPS6KA2 0.4482844 1.645518e-02 0.7026317
33 1191 CLU 0.4500957 2.038659e-05 0.3534327
34 9568 GABBR2 1.0262131 4.391028e-02 1.8380988
35 4571 <NA> 3.4044633 2.362771e-119 2.8563893
36 27286 SRPX2 0.9507795 5.249112e-07 0.7486537
37 1641 DCX -0.8457536 7.306344e-03 -0.9610581
D244_fdr_2.2 D62_log2FC_2.1 D62_fdr_2.1 D62_log2FC_2.2 D62_fdr_2.2
1 2.907452e-02 4.3469675 1.478239e-04 4.0111487 9.206477e-05
2 1.662445e-11 0.7597404 9.985796e-14 0.4268953 7.990741e-07
3 3.579051e-03 -1.5148942 1.904365e-03 -1.0105930 2.296366e-02
4 1.758357e-02 1.1765193 1.364798e-03 0.7725283 3.557110e-02
5 5.268446e-03 1.2624849 1.664143e-27 0.3302487 9.754474e-03
6 9.204256e-06 0.6720729 4.176205e-05 0.3624504 1.186010e-02
7 2.779479e-05 0.7195505 1.391368e-07 0.3608222 8.928172e-04
8 1.170221e-06 -1.7172025 2.028184e-05 -1.0867269 7.910845e-04
9 3.609831e-03 0.6518976 3.394949e-02 1.0425253 7.502761e-12
10 2.922212e-02 1.6169697 1.508787e-22 0.7278730 4.458761e-07
11 5.894301e-03 -0.5333552 6.646735e-03 -0.2828075 2.579931e-02
12 1.011060e-02 -0.9535097 1.971245e-06 -0.5774088 6.881405e-04
13 2.647084e-05 0.8491433 5.692768e-12 0.3481626 7.808378e-03
14 4.453646e-09 0.3240090 2.195959e-03 0.2517174 1.169403e-02
15 3.664330e-25 2.0354059 3.708190e-20 1.2386377 5.932062e-11
16 2.306262e-04 1.5019300 2.885492e-09 1.1144906 4.741474e-06
17 4.626470e-07 -1.7911145 3.646131e-03 -1.1136392 3.778682e-03
18 9.299289e-07 0.6962166 2.508668e-05 0.3635890 4.886965e-02
19 1.761040e-10 -0.6122840 2.104394e-03 -0.6171374 3.496026e-05
20 1.121250e-02 -1.0508060 2.599907e-12 -0.4931137 1.022821e-05
21 3.271995e-14 0.7861593 3.884032e-08 0.5444540 5.158658e-06
22 1.558741e-07 0.9202739 4.176205e-05 0.6135539 8.415630e-03
23 1.285023e-03 -2.6030063 5.882622e-03 -1.5811041 1.989404e-02
24 2.069884e-30 -0.9547393 5.308860e-08 -0.4376841 5.750365e-04
25 4.750404e-07 1.4844042 6.295374e-19 1.8282513 1.823991e-53
26 8.081783e-03 -0.7067496 1.619655e-07 -0.4982645 2.218205e-05
27 1.924487e-04 0.5202967 1.478111e-02 0.4275719 3.689260e-02
28 4.182359e-23 -3.2952996 5.370178e-03 -1.0156297 2.414624e-06
29 5.325344e-06 0.9411454 1.543927e-04 0.4827715 4.565178e-02
30 4.230156e-08 1.7451782 3.284453e-77 0.8937057 6.528518e-32
31 2.159632e-06 0.4073207 4.502692e-02 0.4391435 1.254131e-02
32 3.622400e-07 0.8469458 2.974890e-07 0.4754517 4.349091e-03
33 2.737931e-03 0.6341170 6.617167e-18 0.3197075 7.692471e-10
34 4.032745e-07 1.8836534 3.992926e-19 1.7700974 1.993618e-26
35 1.746726e-69 0.9819432 6.551433e-07 0.8385856 2.779733e-06
36 6.254085e-04 6.4021162 4.092541e-03 6.4458707 7.808378e-03
37 5.303766e-03 -0.8995534 1.452689e-07 -0.7023485 1.328081e-05
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 1.2625868 0.14679389 4.935157 6.744007e-01
02_TSC2_KO_Grabole_2016 2.7655238 1.36950627 5.738501 2.719201e-03
03_TSC2_Grabole-2016 2.7011590 1.26585169 6.258904 7.552645e-03
04_TSC2-tuber-Martin2017 3.3527641 0.08190452 20.291197 2.647592e-01
05_TSC2-SEN_SEGA-Martin2017 4.6468999 2.26248697 9.365045 1.651705e-05
06_all_EpilepsyGene 4.2567249 1.09002652 12.056600 1.906575e-02
07_high_conf_EpilepsyGene 6.2687831 0.72255483 24.878549 4.494200e-02
08_ASD_Epilepsy_EpilepsyGene 3.2351898 0.07905632 19.566881 2.728255e-01
09_Epi25_dataset 0.0000000 0.00000000 17.761425 1.000000e+00
10_SFARI_all 3.2416941 0.37557781 12.747177 1.355206e-01
11_SFARI_score4plus 4.4045954 0.50929814 17.378479 8.235315e-02
12_DeRubeis_RDNV 0.0000000 0.00000000 18.708435 1.000000e+00
13_Iossifov_RDNV 1.4746408 0.17134239 5.767836 6.486565e-01
14_FMRP_Darnell 2.6693578 0.80967916 6.930734 5.209565e-02
15_Voineagu_M12 0.0000000 0.00000000 4.094992 1.000000e+00
16_Voineagu_M16 6.1247020 1.85146682 15.966187 2.205729e-03
17_ID_genes_Neel 3.6246884 0.70867756 11.619713 5.794069e-02
18_ID_genes_pinto2014 0.0000000 0.00000000 5.838956 1.000000e+00
19_Fromer_SCZ_FunDN 0.7381642 0.01815291 4.403523 1.000000e+00
20_Cocchi_Pruning 8.7116061 0.99992954 34.823945 2.500176e-02
Beta SE Padj
01_Swaminathan2018_DEPDC5KO 0.2331627 1.0979023 1.000000000
02_TSC2_KO_Grabole_2016 1.0172300 0.3585611 0.054384011
03_TSC2_Grabole-2016 0.9936810 0.3867019 0.151052893
04_TSC2-tuber-Martin2017 1.2097851 1.8938705 1.000000000
05_TSC2-SEN_SEGA-Martin2017 1.5362003 0.3672121 0.000330341
06_all_EpilepsyGene 1.4485001 0.6950500 0.381315031
07_high_conf_EpilepsyGene 1.8355822 1.1023185 0.898840045
08_ASD_Epilepsy_EpilepsyGene 1.1740876 1.8937155 1.000000000
09_Epi25_dataset -Inf NaN 1.000000000
10_SFARI_all 1.1760961 1.0996866 1.000000000
11_SFARI_score4plus 1.4826484 1.1006990 1.000000000
12_DeRubeis_RDNV -Inf NaN 1.000000000
13_Iossifov_RDNV 0.3884144 1.0982173 1.000000000
14_FMRP_Darnell 0.9818379 0.6086506 1.000000000
15_Voineagu_M12 -Inf NaN 1.000000000
16_Voineagu_M16 1.8123301 0.6103836 0.044114575
17_ID_genes_Neel 1.2877683 0.8327158 1.000000000
18_ID_genes_pinto2014 -Inf NaN 1.000000000
19_Fromer_SCZ_FunDN -0.3035889 1.8904773 1.000000000
20_Cocchi_Pruning 2.1646562 1.1044524 0.500035230
noDiff Rapa
try(getlinmodoutput_D62D224(targetdiff = "noDIFF",targetrapa = "RAPA",
targetline=c("D62", "D224"))) entrezgene genname D244_log2FC_2.1 D244_fdr_2.1 D244_log2FC_2.2 D244_fdr_2.2
1 3709 ITPR2 1.0144843 3.199205e-03 1.0716091 1.786538e-03
2 56963 RGMA 0.7056909 6.604404e-06 0.4876214 1.364992e-02
3 361 AQP4 1.5656176 1.853286e-21 1.4074809 5.825739e-17
4 348 APOE 1.1522867 2.550867e-12 1.1986122 8.038100e-11
5 4852 NPY -2.5012943 4.831459e-03 -4.1586786 6.690797e-06
6 23089 PEG10 1.2813683 2.586992e-39 0.3492587 1.840892e-02
7 1749 DLX5 -1.8207920 5.149658e-03 -9.1287072 6.304782e-10
D62_log2FC_2.1 D62_fdr_2.1 D62_log2FC_2.2 D62_fdr_2.2
1 1.4682329 7.883463e-05 1.4707635 7.064746e-04
2 1.1669346 1.509525e-08 1.0344198 3.851921e-03
3 0.7543128 2.751680e-03 0.8155313 5.746483e-03
4 1.0971097 6.637560e-05 1.0393426 2.965233e-03
5 -1.9241887 7.017330e-08 -1.5819410 2.956766e-06
6 0.7098065 2.053550e-03 0.7282390 8.417096e-03
7 -2.2913973 7.064968e-05 -1.8533389 8.417096e-03No results to show
Please make sure that the organism is correct or set significant = FALSE
[1] "no significant results"
OR CI95L CI95U P Beta
01_Swaminathan2018_DEPDC5KO 0.000000 0.00000000 15.34525 1.00000000 -Inf
02_TSC2_KO_Grabole_2016 4.703550 0.76969415 49.40436 0.05372569 1.548318
03_TSC2_Grabole-2016 5.991268 0.72659948 275.31245 0.12490452 1.790303
04_TSC2-tuber-Martin2017 20.133355 0.43452425 168.28928 0.05646495 3.002378
05_TSC2-SEN_SEGA-Martin2017 4.549957 0.66594568 26.91631 0.06378594 1.515118
06_all_EpilepsyGene 0.000000 0.00000000 24.23466 1.00000000 -Inf
07_high_conf_EpilepsyGene 0.000000 0.00000000 75.80669 1.00000000 -Inf
08_ASD_Epilepsy_EpilepsyGene 0.000000 0.00000000 81.09474 1.00000000 -Inf
09_Epi25_dataset 0.000000 0.00000000 116.75990 1.00000000 -Inf
10_SFARI_all 0.000000 0.00000000 39.35942 1.00000000 -Inf
11_SFARI_score4plus 0.000000 0.00000000 53.37643 1.00000000 -Inf
12_DeRubeis_RDNV 0.000000 0.00000000 123.67156 1.00000000 -Inf
13_Iossifov_RDNV 4.301383 0.09335061 35.54219 0.23395033 1.458937
14_FMRP_Darnell 2.838083 0.06162727 23.43810 0.32956955 1.043129
15_Voineagu_M12 0.000000 0.00000000 27.12534 1.00000000 -Inf
16_Voineagu_M16 15.560133 1.47728515 95.50797 0.01219980 2.744712
17_ID_genes_Neel 0.000000 0.00000000 28.41846 1.00000000 -Inf
18_ID_genes_pinto2014 0.000000 0.00000000 38.67674 1.00000000 -Inf
19_Fromer_SCZ_FunDN 0.000000 0.00000000 18.49146 1.00000000 -Inf
20_Cocchi_Pruning 25.135627 0.54163841 210.03663 0.04559469 3.224286
SE Padj
01_Swaminathan2018_DEPDC5KO NaN 1.0000000
02_TSC2_KO_Grabole_2016 0.9235100 1.0000000
03_TSC2_Grabole-2016 1.0763689 1.0000000
04_TSC2-tuber-Martin2017 1.9570823 1.0000000
05_TSC2-SEN_SEGA-Martin2017 0.9804413 1.0000000
06_all_EpilepsyGene NaN 1.0000000
07_high_conf_EpilepsyGene NaN 1.0000000
08_ASD_Epilepsy_EpilepsyGene NaN 1.0000000
09_Epi25_dataset NaN 1.0000000
10_SFARI_all NaN 1.0000000
11_SFARI_score4plus NaN 1.0000000
12_DeRubeis_RDNV NaN 1.0000000
13_Iossifov_RDNV 1.9542498 1.0000000
14_FMRP_Darnell 1.9539692 1.0000000
15_Voineagu_M12 NaN 1.0000000
16_Voineagu_M16 1.2012786 0.2439961
17_ID_genes_Neel NaN 1.0000000
18_ID_genes_pinto2014 NaN 1.0000000
19_Fromer_SCZ_FunDN NaN 1.0000000
20_Cocchi_Pruning 1.9578790 0.9118937
Diff noRapa
try(getlinmodoutput_D62D224(targetdiff = "DIFF",targetrapa = "noRAPA",
targetline=c("D62", "D224"))) entrezgene genname D244_log2FC_2.1 D244_fdr_2.1 D244_log2FC_2.2
1 50486 G0S2 -1.4492217 3.370529e-32 -1.7927431
2 7044 LEFTY2 -1.6863840 1.444934e-19 -2.6934841
3 652 BMP4 1.4247389 3.501929e-09 1.1752283
4 4804 NGFR -2.1767618 3.267739e-23 -2.3203327
5 56937 PMEPA1 -1.1739691 1.378185e-19 -1.1140883
6 80781 COL18A1 -1.0190535 1.418955e-07 -1.0103524
7 7869 SEMA3B -1.3403981 3.060962e-05 -1.2301226
8 7018 TF -1.7913566 9.804860e-08 -2.1881714
9 57537 SORCS2 -1.1432855 4.392572e-07 -1.3209447
10 100505738 MIR4458HG -0.9544000 2.870460e-05 -0.9170490
11 11346 SYNPO -1.0320585 3.175806e-06 -0.8511356
12 1843 DUSP1 1.8428072 9.089214e-06 1.7754384
13 2697 GJA1 0.9786886 1.006861e-11 0.7103970
14 5244 ABCB4 -1.3752686 2.416092e-05 -2.2432327
15 3371 TNC 1.4093005 5.957962e-03 1.4983126
D244_fdr_2.2 D62_log2FC_2.1 D62_fdr_2.1 D62_log2FC_2.2 D62_fdr_2.2
1 4.532054e-17 -1.2769869 3.776809e-02 -3.7478581 2.744552e-36
2 1.215175e-28 -1.8967514 2.076460e-02 -5.4919034 1.299317e-06
3 3.095265e-03 3.4322241 2.358141e-02 3.9413514 1.737453e-02
4 2.270876e-09 -1.8961919 1.638191e-04 -2.0647461 7.699124e-05
5 6.627336e-09 -0.5230080 3.898929e-03 -0.9284119 2.782505e-07
6 6.341399e-05 -0.6429705 4.185984e-03 -1.4012123 9.118276e-11
7 4.896891e-03 -1.6475938 4.752961e-08 -1.4351780 2.091144e-04
8 5.243374e-07 -3.3138202 4.725046e-35 -2.6201244 4.161319e-27
9 1.875633e-06 -0.7871403 4.529303e-02 -1.6736831 1.240910e-04
10 1.585138e-02 -0.6736466 4.960015e-04 -0.9792733 3.598272e-07
11 7.015280e-03 -1.1973194 6.008782e-09 -1.1898142 1.055427e-05
12 2.802331e-03 2.3389517 1.273281e-03 2.5638656 2.811444e-03
13 2.802331e-03 0.7860628 1.505593e-09 0.6923602 6.978354e-08
14 1.296467e-05 -0.7938959 1.121641e-02 -1.7461164 2.042689e-08
15 4.016110e-02 1.4982035 2.413395e-02 2.0004229 2.211218e-03No results to show
Please make sure that the organism is correct or set significant = FALSE
[1] "no significant results"
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 0.0000000 0.00000000 6.167004 1.000000000
02_TSC2_KO_Grabole_2016 1.6460497 0.50777882 5.197577 0.416071164
03_TSC2_Grabole-2016 1.4975117 0.47572921 5.115758 0.607038627
04_TSC2-tuber-Martin2017 18.7449166 2.03117226 84.402907 0.006629492
05_TSC2-SEN_SEGA-Martin2017 0.9322187 0.10205649 4.122830 1.000000000
06_all_EpilepsyGene 0.0000000 0.00000000 9.741362 1.000000000
07_high_conf_EpilepsyGene 0.0000000 0.00000000 30.536195 1.000000000
08_ASD_Epilepsy_EpilepsyGene 0.0000000 0.00000000 32.678358 1.000000000
09_Epi25_dataset 0.0000000 0.00000000 47.215752 1.000000000
10_SFARI_all 0.0000000 0.00000000 15.812671 1.000000000
11_SFARI_score4plus 0.0000000 0.00000000 21.483638 1.000000000
12_DeRubeis_RDNV 0.0000000 0.00000000 49.729830 1.000000000
13_Iossifov_RDNV 0.0000000 0.00000000 7.199790 1.000000000
14_FMRP_Darnell 1.2156917 0.02871371 8.010992 0.575587957
15_Voineagu_M12 0.0000000 0.00000000 10.899210 1.000000000
16_Voineagu_M16 2.7711452 0.06535908 18.311369 0.317900267
17_ID_genes_Neel 0.0000000 0.00000000 11.419272 1.000000000
18_ID_genes_pinto2014 0.0000000 0.00000000 15.542615 1.000000000
19_Fromer_SCZ_FunDN 0.0000000 0.00000000 7.429053 1.000000000
20_Cocchi_Pruning 0.0000000 0.00000000 42.367010 1.000000000
Beta SE Padj
01_Swaminathan2018_DEPDC5KO -Inf NaN 1.0000000
02_TSC2_KO_Grabole_2016 0.49837832 0.6000447 1.0000000
03_TSC2_Grabole-2016 0.40380484 0.5850568 1.0000000
04_TSC2-tuber-Martin2017 2.93092260 1.1338314 0.1325898
05_TSC2-SEN_SEGA-Martin2017 -0.07018781 1.1285923 1.0000000
06_all_EpilepsyGene -Inf NaN 1.0000000
07_high_conf_EpilepsyGene -Inf NaN 1.0000000
08_ASD_Epilepsy_EpilepsyGene -Inf NaN 1.0000000
09_Epi25_dataset -Inf NaN 1.0000000
10_SFARI_all -Inf NaN 1.0000000
11_SFARI_score4plus -Inf NaN 1.0000000
12_DeRubeis_RDNV -Inf NaN 1.0000000
13_Iossifov_RDNV -Inf NaN 1.0000000
14_FMRP_Darnell 0.19531323 1.9110684 1.0000000
15_Voineagu_M12 -Inf NaN 1.0000000
16_Voineagu_M16 1.01926068 1.9117957 1.0000000
17_ID_genes_Neel -Inf NaN 1.0000000
18_ID_genes_pinto2014 -Inf NaN 1.0000000
19_Fromer_SCZ_FunDN -Inf NaN 1.0000000
20_Cocchi_Pruning -Inf NaN 1.0000000
Diff Rapa
try(getlinmodoutput_D62D224(targetdiff = "DIFF",targetrapa = "RAPA",
targetline=c("D62", "D224"))) entrezgene genname D244_log2FC_2.1 D244_fdr_2.1 D244_log2FC_2.2
1 3491 CCN1 0.4678656 2.963636e-06 0.4105692
2 8490 RGS5 0.7061001 9.243401e-03 0.5901435
3 50486 G0S2 -2.0420221 9.635264e-145 -2.5996040
4 7044 LEFTY2 -1.3192934 3.280549e-18 -2.3110081
5 2674 GFRA1 -0.4799768 1.237850e-03 -0.6378438
6 114795 TMEM132B -3.1403066 4.570484e-06 -3.0132607
7 23002 DAAM1 0.6938355 2.863809e-03 0.5782007
8 10882 C1QL1 -1.1800573 4.585792e-02 -1.3575829
9 4804 NGFR -1.8994842 1.471545e-13 -2.1854385
10 2995 GYPC -2.4190113 1.415998e-15 -2.5897350
11 3488 IGFBP5 -1.4790171 1.730247e-60 -1.3238131
12 1295 COL8A1 -2.5667320 1.117183e-51 -2.8067329
13 151887 CCDC80 0.8400733 1.550300e-13 1.0909859
14 7018 TF -2.2191138 7.809017e-09 -2.7186226
15 5947 RBP1 -1.0346072 3.851251e-48 -1.1250151
16 10417 SPON2 -1.6792183 1.085527e-05 -1.6373186
17 83888 FGFBP2 -2.3020082 9.156676e-12 -4.3108924
18 9547 CXCL14 -0.5235165 1.148369e-10 -0.4632759
19 2878 GPX3 -1.0164418 8.801801e-26 -0.7308690
20 23286 WWC1 1.5686248 3.671663e-06 1.4815662
21 6424 SFRP4 -1.5686024 2.187938e-85 -1.7488886
22 83543 AIF1L -1.2388526 3.130862e-20 -0.5682422
D244_fdr_2.2 D62_log2FC_2.1 D62_fdr_2.1 D62_log2FC_2.2 D62_fdr_2.2
1 9.041386e-05 0.9195214 7.581913e-06 0.7819251 2.641835e-02
2 6.181386e-03 0.9423725 2.179796e-03 1.3297066 5.430918e-06
3 2.301167e-217 -2.1437954 2.962521e-18 -2.7798517 3.914474e-23
4 5.751049e-64 -1.1461461 1.517838e-02 -2.5101270 2.217413e-06
5 1.191763e-05 -1.7237479 8.130698e-05 -1.9850405 7.413693e-05
6 5.957135e-10 -2.0420745 9.180844e-15 -1.4932069 6.161726e-06
7 4.677801e-02 0.7554336 2.883318e-02 0.8353463 2.729476e-02
8 3.915880e-02 -1.2462122 5.655205e-06 -1.2834520 1.792262e-03
9 4.715661e-26 -2.2008093 1.158457e-10 -2.1406331 1.813272e-06
10 5.915615e-21 -2.3370979 5.640820e-06 -2.1226178 2.620590e-06
11 6.039310e-53 -1.2042255 1.457509e-03 -1.2840334 3.354261e-03
12 2.533751e-78 -4.5471851 7.161381e-03 -3.7379338 2.815452e-02
13 8.688693e-17 0.7317143 1.740585e-02 0.8723305 1.319498e-03
14 1.812506e-08 -3.7162415 1.267988e-67 -2.8326531 2.204247e-30
15 1.013389e-56 -1.0910735 4.502025e-07 -0.7994095 4.109501e-02
16 1.499922e-03 -2.4640319 1.386561e-02 -2.8331591 2.289093e-03
17 4.089891e-24 -1.9562182 9.567416e-03 -2.3549128 2.393688e-04
18 1.335559e-07 -0.8064340 7.756694e-04 -1.5018443 1.611197e-09
19 1.484571e-13 -1.3013559 3.780855e-08 -2.0926990 6.557503e-11
20 3.857516e-05 1.0141019 4.480737e-03 1.2974451 1.326571e-04
21 8.250920e-100 -0.7815462 4.441654e-04 -1.3426635 1.190509e-07
22 9.922051e-04 -0.9344874 1.208559e-03 -0.9029015 2.547855e-02
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 2.2120492 0.25009058 9.138635 0.24655625
02_TSC2_KO_Grabole_2016 2.2592188 0.89381168 5.842774 0.07047344
03_TSC2_Grabole-2016 1.4422649 0.56990956 3.825944 0.52313027
04_TSC2-tuber-Martin2017 0.0000000 0.00000000 22.192951 1.00000000
05_TSC2-SEN_SEGA-Martin2017 2.8343541 0.97630724 7.397057 0.02770732
06_all_EpilepsyGene 0.0000000 0.00000000 6.377532 1.00000000
07_high_conf_EpilepsyGene 0.0000000 0.00000000 19.996585 1.00000000
08_ASD_Epilepsy_EpilepsyGene 0.0000000 0.00000000 21.419829 1.00000000
09_Epi25_dataset 0.0000000 0.00000000 30.931119 1.00000000
10_SFARI_all 0.0000000 0.00000000 10.356084 1.00000000
11_SFARI_score4plus 0.0000000 0.00000000 14.057433 1.00000000
12_DeRubeis_RDNV 0.0000000 0.00000000 32.566918 1.00000000
13_Iossifov_RDNV 0.0000000 0.00000000 4.713469 1.00000000
14_FMRP_Darnell 0.8100381 0.01956154 5.050315 1.00000000
15_Voineagu_M12 0.0000000 0.00000000 7.136577 1.00000000
16_Voineagu_M16 0.0000000 0.00000000 7.093410 1.00000000
17_ID_genes_Neel 0.0000000 0.00000000 7.477368 1.00000000
18_ID_genes_pinto2014 0.0000000 0.00000000 10.179156 1.00000000
19_Fromer_SCZ_FunDN 0.0000000 0.00000000 4.863581 1.00000000
20_Cocchi_Pruning 0.0000000 0.00000000 27.766996 1.00000000
Beta SE Padj
01_Swaminathan2018_DEPDC5KO 0.7939193 1.1121691 1.0000000
02_TSC2_KO_Grabole_2016 0.8150191 0.4731017 1.0000000
03_TSC2_Grabole-2016 0.3662147 0.4737206 1.0000000
04_TSC2-tuber-Martin2017 -Inf NaN 1.0000000
05_TSC2-SEN_SEGA-Martin2017 1.0418141 0.5437714 0.5541465
06_all_EpilepsyGene -Inf NaN 1.0000000
07_high_conf_EpilepsyGene -Inf NaN 1.0000000
08_ASD_Epilepsy_EpilepsyGene -Inf NaN 1.0000000
09_Epi25_dataset -Inf NaN 1.0000000
10_SFARI_all -Inf NaN 1.0000000
11_SFARI_score4plus -Inf NaN 1.0000000
12_DeRubeis_RDNV -Inf NaN 1.0000000
13_Iossifov_RDNV -Inf NaN 1.0000000
14_FMRP_Darnell -0.2106739 1.8997531 1.0000000
15_Voineagu_M12 -Inf NaN 1.0000000
16_Voineagu_M16 -Inf NaN 1.0000000
17_ID_genes_Neel -Inf NaN 1.0000000
18_ID_genes_pinto2014 -Inf NaN 1.0000000
19_Fromer_SCZ_FunDN -Inf NaN 1.0000000
20_Cocchi_Pruning -Inf NaN 1.0000000
sessionInfo()R version 4.1.2 (2021-11-01)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 18363)
Matrix products: default
locale:
[1] LC_COLLATE=German_Germany.1252 LC_CTYPE=German_Germany.1252
[3] LC_MONETARY=German_Germany.1252 LC_NUMERIC=C
[5] LC_TIME=German_Germany.1252
attached base packages:
[1] stats4 stats graphics grDevices utils datasets methods
[8] base
other attached packages:
[1] gprofiler2_0.2.1 xlsx_0.6.5
[3] limma_3.50.0 flashClust_1.01-2
[5] WGCNA_1.70-3 fastcluster_1.2.3
[7] dynamicTreeCut_1.63-1 knitr_1.37
[9] DESeq2_1.34.0 SummarizedExperiment_1.24.0
[11] Biobase_2.54.0 MatrixGenerics_1.6.0
[13] matrixStats_0.61.0 GenomicRanges_1.46.1
[15] GenomeInfoDb_1.30.1 IRanges_2.28.0
[17] S4Vectors_0.32.3 BiocGenerics_0.40.0
[19] pheatmap_1.0.12 RColorBrewer_1.1-2
[21] compareGroups_4.5.1 forcats_0.5.1
[23] stringr_1.4.0 dplyr_1.0.7
[25] purrr_0.3.4 readr_2.1.2
[27] tidyr_1.1.4 tibble_3.1.6
[29] ggplot2_3.3.5 tidyverse_1.3.1
[31] kableExtra_1.3.4 workflowr_1.7.0
loaded via a namespace (and not attached):
[1] readxl_1.3.1 uuid_1.0-3 backports_1.4.1
[4] Hmisc_4.6-0 systemfonts_1.0.3 lazyeval_0.2.2
[7] splines_4.1.2 BiocParallel_1.28.3 digest_0.6.29
[10] foreach_1.5.2 htmltools_0.5.2 GO.db_3.14.0
[13] fansi_1.0.2 checkmate_2.0.0 magrittr_2.0.2
[16] Rsolnp_1.16 memoise_2.0.1 cluster_2.1.2
[19] doParallel_1.0.16 tzdb_0.2.0 Biostrings_2.62.0
[22] annotate_1.72.0 modelr_0.1.8 officer_0.4.1
[25] svglite_2.0.0 jpeg_0.1-9 colorspace_2.0-2
[28] blob_1.2.2 rvest_1.0.2 haven_2.4.3
[31] xfun_0.29 callr_3.7.0 crayon_1.4.2
[34] RCurl_1.98-1.5 jsonlite_1.7.3 genefilter_1.76.0
[37] impute_1.68.0 iterators_1.0.13 survival_3.2-13
[40] glue_1.6.1 gtable_0.3.0 zlibbioc_1.40.0
[43] XVector_0.34.0 webshot_0.5.2 DelayedArray_0.20.0
[46] scales_1.1.1 DBI_1.1.2 Rcpp_1.0.8
[49] htmlTable_2.4.0 viridisLite_0.4.0 xtable_1.8-4
[52] foreign_0.8-82 bit_4.0.4 preprocessCore_1.56.0
[55] Formula_1.2-4 truncnorm_1.0-8 htmlwidgets_1.5.4
[58] httr_1.4.2 ellipsis_0.3.2 mice_3.14.0
[61] farver_2.1.0 rJava_1.0-6 pkgconfig_2.0.3
[64] XML_3.99-0.8 nnet_7.3-17 sass_0.4.0
[67] dbplyr_2.1.1 locfit_1.5-9.4 utf8_1.2.2
[70] labeling_0.4.2 tidyselect_1.1.1 rlang_1.0.0
[73] later_1.3.0 AnnotationDbi_1.56.2 munsell_0.5.0
[76] cellranger_1.1.0 tools_4.1.2 cachem_1.0.6
[79] cli_3.1.1 generics_0.1.2 RSQLite_2.2.9
[82] broom_0.7.12 evaluate_0.14 fastmap_1.1.0
[85] yaml_2.2.2 processx_3.5.2 bit64_4.0.5
[88] fs_1.5.2 zip_2.2.0 KEGGREST_1.34.0
[91] whisker_0.4 xml2_1.3.3 compiler_4.1.2
[94] rstudioapi_0.13 plotly_4.10.0 png_0.1-7
[97] reprex_2.0.1 geneplotter_1.72.0 bslib_0.3.1
[100] stringi_1.7.6 HardyWeinberg_1.7.4 highr_0.9
[103] ps_1.6.0 gdtools_0.2.3 lattice_0.20-45
[106] Matrix_1.4-0 vctrs_0.3.8 pillar_1.7.0
[109] lifecycle_1.0.1 jquerylib_0.1.4 data.table_1.14.2
[112] bitops_1.0-7 flextable_0.6.10 httpuv_1.6.5
[115] latticeExtra_0.6-29 R6_2.5.1 promises_1.2.0.1
[118] gridExtra_2.3 writexl_1.4.0 codetools_0.2-18
[121] assertthat_0.2.1 xlsxjars_0.6.1 chron_2.3-56
[124] rprojroot_2.0.2 withr_2.4.3 GenomeInfoDbData_1.2.7
[127] parallel_4.1.2 hms_1.1.1 rpart_4.1.16
[130] grid_4.1.2 rmarkdown_2.11 git2r_0.29.0
[133] getPass_0.2-2 lubridate_1.8.0 base64enc_0.1-3